Intestinal surfactant permeation enhancers and their interaction with enterocyte cell membranes in a mucosal explant system

References

• Moroz E, Matoori S, and Leroux JC. Oral delivery of macromolecular drugs: where we are after almost 100years of attempts. Adv Drug Deliv Rev. 2016;101:108-21. doi:10.1016/j.addr.2016.01.010. PMID:26826437
   PubMed Web of Science ®Google Scholar
• Maher S, Mrsny RJ, and Brayden DJ. Intestinal permeation enhancers for oral peptide delivery. Adv Drug Deliv Rev. 2016;106(Pt B):277-319. doi:10.1016/j.addr.2016.06.005; PMID:27320643
   PubMed Web of Science ®Google Scholar
• Aungst BJ. Absorption enhancers: applications and advances. AAPS.J. 2012;14(1):10-18. doi:10.1208/s12248-011-9307-4. PMID:22105442
   PubMed Web of Science ®Google Scholar
• Fasinu P, Pillay V, Ndesendo VM, du Toit LC, Choonara YE. Diverse approaches for the enhancement of oral drug bioavailability. Biopharm Drug Dispos. 2011;32(4):185-209. doi:10.1002/bdd.750. PMID:21480294
   PubMed Web of Science ®Google Scholar
• Yewale C, Patil S, Kolate A, Kore G, Misra A. Oral absorption promoters: opportunities, issues, and challenges. Crit Rev Ther Drug Carrier Syst. 2015;32(5):363-87. doi:10.1615/CritRevTherDrugCarrierSyst.2015011865. PMID:26559432
   PubMed Web of Science ®Google Scholar
• Konig J, Wells J, Cani PD, García-Ródenas CL, MacDonald T, Mercenier A, Whyte J, Troost F, Brummer RJ. Human intestinal barrier function in health and disease. Clin Transl Gastroenterol. 2016;7(10):e196; doi:10.1038/ctg.2016.54. PMID:27763627
   PubMed Web of Science ®Google Scholar
• Blikslager AT, Moeser AJ, Gookin JL, Jones SL, Odle J. Restoration of barrier function in injured intestinal mucosa. Physiol Rev. 2007;87(2):545-64. doi:10.1152/physrev.00012.2006. PMID:17429041
   PubMed Web of Science ®Google Scholar
• France MM and Turner JR. The mucosal barrier at a glance. J Cell Sci. 2017;130(2):307-14. doi:10.1242/jcs.193482. PMID:28062847
   PubMed Web of Science ®Google Scholar
• Lichtenberg D, Robson RJ, and Dennis EA. Solubilization of phospholipids by detergents. Structural and kinetic aspects. Biochim Biophys Acta. 1983;737(2):285-304. doi:10.1016/0304-4157(83)90004-7. PMID:6342675
   PubMed Web of Science ®Google Scholar
• Danielsen EM and Hansen GH. Lipid raft organization and function in brush borders of epithelial cells. Mol Membr Biol. 2006;23(1):71-79. doi:10.1080/09687860500445604. PMID:16611582
   PubMed Web of Science ®Google Scholar
• Delacour D, Salomon J, Robine S, Louvard D. Plasticity of the brush border - the Yin and Yang of intestinal homeostasis. Nat Rev Gastroenterol Hepatol. 2016;13(3):161-74. doi:10.1038/nrgastro.2016.5. PMID:26837713
   PubMed Web of Science ®Google Scholar
• Crawley SW, Mooseker MS, and Tyska MJ. Shaping the intestinal brush border. J Cell Biol. 2014;207(4):441-451. doi:10.1083/jcb.201407015. PMID:25422372
   PubMed Web of Science ®Google Scholar
• Hansen GH, Rasmussen K, Niels-Christiansen LL, Danielsen EM. Endocytic trafficking from the small intestinal brush border probed with FM dye. Am J Physiol Gastrointest Liver Physiol. 2009;297(4):G708-15. doi:10.1152/ajpgi.00192.2009. PMID:19679822
   PubMed Web of Science ®Google Scholar
• Danielsen EM and Hansen GH. Generation of stable lipid raft microdomains in the enterocyte brush border by selective endocytic removal of non-raft membrane. PLoS One. 2013;8(10):e76661; doi:10.1371/journal.pone.0076661. PMID:24124585
   PubMed Web of Science ®Google Scholar
• Hansen GH, Dalskov SM, Rasmussen CR, Immerdal L, Niels-Christiansen LL, Danielsen EM. Cholera toxin entry into pig enterocytes occurs via a lipid raft- and clathrin-dependent mechanism. Biochemistry. 2005;44(3):873-82. doi:10.1021/bi047959+. PMID:15654743
   PubMed Web of Science ®Google Scholar
• Binkley N, Bolognese M, Sidorowicz-Bialynicka A, Vally T, Trout R, Miller C, Buben CE, Gilligan JP, Krause DS, Oral Calcitonin in Postmenopausal Osteoporosis (ORACAL) Investigators. A phase 3 trial of the efficacy and safety of oral recombinant calcitonin: the Oral Calcitonin in Postmenopausal Osteoporosis (ORACAL) Trial. J Bone Miner Res. 2012;27(8):1821-9. doi:10.1002/jbmr.1602. PMID:22437792
   PubMed Web of Science ®Google Scholar
• Hansen GH, Sjöström H, Norén O, Dabelsteen E. Immunomicroscopic localization of aminopeptidase N in the pig enterocyte. Implications for the route of intracellular transport. Eur J Cell Biol. 1987;43(2):253-9. PMID:2885197
   PubMed Web of Science ®Google Scholar
• Danielsen EM, Sjöström H, Norén O, Bro B, Dabelsteen E. Biosynthesis of intestinal microvillar proteins. Characterization of intestinal explants in organ culture and evidence for the existence of pro-forms of the microvillar enzymes. Biochem J. 1982;202(3):647-54. doi:10.1042/bj2020647. PMID:7092836
   PubMed Web of Science ®Google Scholar
• Booth AG and Kenny AJ. A rapid method for the preparation of microvilli from rabbit kidney. Biochem J. 1974;142(3):575-81. doi:10.1042/bj1420575. PMID:4464842
   PubMedGoogle Scholar
• Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227(259):680-5. doi:10.1038/227680a0. PMID:5432063
   PubMed Web of Science ®Google Scholar
• Kagnoff MF, Donaldson RM, Jr., and Trier JS. Organ culture of rabbit small intestine: Prolonged in vitro steady state protein synthesis and secretion and secretory IgA secretion. Gastroenterology. 1972;63(4):541-51. PMID:4627771
   PubMed Web of Science ®Google Scholar
• Lorenzen US, Hansen GH, and Danielsen EM. Organ culture as a model system for studies on enterotoxin interactions with the intestinal epithelium. Methods Mol Biol. 2016;1396:159-166. doi:10.1007/978-1-4939-3344-0_14. PMID:26676046
   PubMedGoogle Scholar
• Danielsen EM, Hansen GH, and Karlsdottir E. Staphylococcus aureus enterotoxins A- and B: Binding to the enterocyte brush border and uptake by perturbation of the apical endocytic membrane traffic. Histochem Cell Biol. 2013;139(4):513-24. doi:10.1007/s00418-012-1055-8. PMID:23180309
   PubMed Web of Science ®Google Scholar
• Danielsen ET and Danielsen EM. Glycol chitosan: A stabilizer of lipid rafts in the intestinal brush border. Biochim Biophys Acta. 2017;1859(3):360-7. doi:10.1016/j.bbamem.2016.12.017. PMID:28034633
   PubMed Web of Science ®Google Scholar
• Moore R, Carlson S, and Madara JL. Rapid barrier restitution in an in vitro model of intestinal epithelial injury. Lab Invest. 1989;60(2):237-44. PMID:2915518
   PubMed Web of Science ®Google Scholar
• McCartney F, Gleeson JP, and Brayden DJ. Safety concerns over the use of intestinal permeation enhancers: a mini-review. Tissue Barriers. 2016;4(2):e1176822; doi:10.1080/21688370.2016.1176822. PMID:27358756
   PubMed Web of Science ®Google Scholar
• Hanani M. Lucifer yellow - an angel rather than the devil. J Cell Mol Med. 2012;16(1):22-31. doi:10.1111/j.1582-4934.2011.01378.x. PMID:21740513
   PubMed Web of Science ®Google Scholar
• Gopalakrishnan S, Pandey N, Tamiz AP, Vere J, Carrasco R, Somerville R, Tripathi A, Ginski M, Paterson BM, Alkan SS. Mechanism of action of ZOT-derived peptide AT-1002, a tight junction regulator and absorption enhancer. Int J Pharm. 2009;365(1-2):121-30. doi:10.1016/j.ijpharm.2008.08.047. PMID:18832018
   PubMed Web of Science ®Google Scholar
• Danielsen EM, Hansen GH, Rasmussen K, Niels-Christiansen LL. Permeabilization of enterocytes induced by absorption of dietary fat. Mol Membr Biol. 2013;30(3):261-72. doi:10.3109/09687688.2013.780642. PMID:23527550
   PubMed Web of Science ®Google Scholar
• Danielsen EM and Hansen GH. Small molecule pinocytosis and clathrin-dependent endocytosis at the intestinal brush border: two separate pathways into the enterocyte. Biochim Biophys Acta. 2016;1858(2):233-243. doi:10.1016/j.bbamem.2015.11.022. PMID:26615917
   PubMed Web of Science ®Google Scholar
• Moss J and Vaughan M. Mechanism of action of choleragen and E. Coli heat-labile enterotoxin: activation of adenylate cyclase by ADP-ribosylation. Mol Cell Biochem. 1981;37(2):75-90. doi:10.1007/BF02354931. PMID:6268961
   PubMed Web of Science ®Google Scholar
• Sixma TK, Kalk KH, van Zanten BA, Dauter Z, Kingma J, Witholt B, Hol WG. Refined structure of escherichia coli heat-labile enterotoxin, a close relative of cholera toxin. J Mol Biol. 1993;230(3):890-918. doi:10.1006/jmbi.1993.1209. PMID:8478941
   PubMed Web of Science ®Google Scholar
• Fukuta S, Magnani JL, Twiddy EM, Holmes RK, Ginsburg V. Comparison of the carbohydrate-binding specificities of cholera toxin and escherichia coli heat-labile enterotoxins LTh-I, LT-IIa, and LT-IIb. Infect Immun.. 1988;56(7):1748-53. PMID:3290106
   PubMed Web of Science ®Google Scholar
• Hochman JH, Fix JA, and LeCluyse EL. In vitro and in vivo analysis of the mechanism of absorption enha.ncement by palmitoylcarnitine. J Pharmacol Exp Ther. 1994;269(2):813-22. PMID:8182550
   PubMed Web of Science ®Google Scholar
• Shima M, Kimura Y, Adachi S, Matsuno R. The relationship between transport-enhancement effects and cell viability by capric acid sodium salt, monocaprin, and dicaproin. Biosci Biotechnol Biochem. 1998;62(1):83-86. doi:10.1271/bbb.62.83. PMID:27393356
   PubMed Web of Science ®Google Scholar
• Sha X et al. Effect of self-microemulsifying drug delivery systems containing labrasol on tight junctions in Caco-2 cells. Eur J Pharm Sci. 2005;24(5):477-86. doi:10.1016/j.ejps.2005.01.001. PMID:15784337
   PubMed Web of Science ®Google Scholar
• Tomita M, Doi N, and Hayashi M. Effects of acylcarnitines on efflux transporting system in Caco-2 cell monolayers. Eur J Drug Metab Pharmacokinet. 2010;35(1-2):1-7. doi:10.1007/s13318-010-0001-1. PMID:21495260
   PubMed Web of Science ®Google Scholar
• Kozlovsky Y, Chernomordik LV, and Kozlov MM. Lipid intermediates in membrane fusion: formation, structure, and decay of hemifusion diaphragm. Biophys J. 2002;83(5):2634-51. doi:10.1016/S0006-3495(02)75274-0. PMID:12414697
   PubMed Web of Science ®Google Scholar
• Kozlovsky Y and Kozlov MM. Stalk model of membrane fusion: solution of energy crisis. Biophys J. 2002;82(2):882-95. doi:10.1016/S0006-3495(02)75450-7. PMID:11806930
   PubMed Web of Science ®Google Scholar
• Han J, Pluhackova K, and Bockmann RA. The multifaceted role of SNARE proteins in membrane fusion. Front Physiol. 2017;8:5; doi:10.3389/fphys.2017.00005. PMID:28163686
   PubMed Web of Science ®Google Scholar
• Pannuzzo M, De Jong DH, Raudino A, Marrink SJ. Simulation of polyethylene glycol and calcium-mediated membrane fusion. J Chem Phys. 2014;140(12):124905; doi:10.1063/1.4869176. PMID:24697479
   PubMed Web of Science ®Google Scholar
• Lentz BR. PEG as a tool to gain insight into membrane fusion. Eur Biophys J. 2007;36(4-5):315-26. doi:10.1007/s00249-006-0097-z. PMID:17039359
   PubMed Web of Science ®Google Scholar
• Hegan PS, Giral H, Levi M, Mooseker MS. Myosin VI is required for maintenance of brush border structure, composition, and membrane trafficking functions in the intestinal epithelial cell. Cytoskeleton (Hoboken.). 2012;69(4):235-51. doi:10.1002/cm.21018. PMID:22328452
   PubMed Web of Science ®Google Scholar