The blood brain barrier: Insights from development and ageing

References

• Altman J, Das GD. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Comp Neurol. 1965;124:319-35. doi:10.1002/cne.901240303. PMID:5861717
   PubMed Web of Science ®Google Scholar
• Allen E. The cessation of mitosis in the central nervous system of the albino rat. J Comp Neurol. 1912;22:547-68.
   Google Scholar
• Lin R, Cai J, Nathan C, Wei X, Schleidt S, Rosenwasser R, Iacovitti L. Neurogenesis is enhanced by stroke in multiple new stem cell niches along the ventricular system at sites of high BBB permeability. Neurobiol Dis. 2015;74:229-39. doi:10.1016/j.nbd.2014.11.016. PMID:25484283
   PubMed Web of Science ®Google Scholar
• Gould E, Beylin A, Tanapat P, Reeves A, Shors TJ. Learning enhances adult neurogenesis in the hippocampal formation. Nat Neurosci. 1999;2:260-5. doi:10.1038/6365. PMID:10195219
   PubMed Web of Science ®Google Scholar
• Ottone C, Parrinello S. Multifaceted control of adult SVZ neurogenesis by the vascular niche. Cell Cycle. 2015;14:2222-5. doi:10.1080/15384101.2015.1049785. PMID:26115376
   PubMed Web of Science ®Google Scholar
• Gómez-Gaviro MV, Lovell-Badge R, Fernández-Avilés F, Lara-Pezzi E. The vascular stem cell niche. J Cardiovasc Transl Res. 2012;5:618-30. doi:10.1007/s12265-012-9371-x. PMID:22644724
   PubMed Web of Science ®Google Scholar
• Kim KJ, Filosa JA. Advanced in vitro approach to study neurovascular coupling mechanisms in the brain microcirculation. J Physiol. 2012;590:1757-70. doi:10.1113/jphysiol.2011.222778. PMID:22310311
   PubMed Web of Science ®Google Scholar
• Nitta T, Hata M, Gotoh S, Seo Y, Sasaki H, Hashimoto N, Furuse M, Tsukita S. Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice. J Cell Biol. 2003;161:653-60. doi:10.1083/jcb.200302070. PMID:12743111
   PubMed Web of Science ®Google Scholar
• Reese TS, Karnovsky MJ. Fine structural localization of a blood-brain barrier to exogenous peroxidase. J Cell Biol. 1967;34:207-17. doi:10.1083/jcb.34.1.207. PMID:6033532
   PubMed Web of Science ®Google Scholar
• Hoshi Y, Uchida Y, Tachikawa M, Inoue T, Ohtsuki S, Terasaki T. Quantitative atlas of blood-brain barrier transporters, receptors, and tight junction proteins in rats and common marmoset. J Pharm Sci. 2013;102:3343-55. doi:10.1002/jps.23575. PMID:23650139
   PubMed Web of Science ®Google Scholar
• Liu H, Li Y, Lu S, Wu Y, Sahi J. Temporal expression of transporters and receptors in a rat primary co-culture blood-brain barrier model. Xenobiotica. 2014;44:941-51. doi:10.3109/00498254.2014.919430. PMID:24827375
   PubMed Web of Science ®Google Scholar
• Maher F, Vannucci SJ, Simpson IA. Glucose transporter proteins in brain. Faseb J. 1994;8:1003-11. PMID:7926364
   PubMed Web of Science ®Google Scholar
• Terasaki T, Hosoya KI. The blood-brain barrier efflux transporters as a detoxifying system for the brain. Adv. Drug Deliv. Rev. 1999;36:195-209. doi:10.1016/S0169-409X(98)00088-X. PMID:10837716
   PubMed Web of Science ®Google Scholar
• Kwon EE, Prineas JW. Blood-brain barrier abnormalities in longstanding multiple sclerosis lesions. An immunohistochemical study. J Neuropathol Exp Neurol. 1994;53:625-36. doi:10.1097/00005072-199411000-00010
   PubMed Web of Science ®Google Scholar
• Zenaro E, Piacentino G, Constantin G. The blood-brain barrier in Alzheimer's disease. Neurobiol Dis. 2017;107:41-56. doi:10.1016/j.nbd.2016.07.007. PMID:27425887
   PubMed Web of Science ®Google Scholar
• Sun Z-Y, Wei J, Xie L, Shen Y, Liu S-Z, Ju G-Z, Shi J-P, Yu Y-Q, Zhang X, Xu Q, et al. The CLDN5 locus may be involved in the vulnerability to schizophrenia. Eur Psychiatry. 2004;19:354-7. doi:10.1016/j.eurpsy.2004.06.007. PMID:15363474
   PubMed Web of Science ®Google Scholar
• Starr JM, Wardlaw J, Ferguson K, MacLullich A, Deary IJ, Marshall I. Increased blood-brain barrier permeability in type II diabetes demonstrated by gadolinium magnetic resonance imaging. J Neurol Neurosurg Psychiatry. 2003;74:70-6. doi:10.1136/jnnp.74.1.70. PMID:12486269
   PubMed Web of Science ®Google Scholar
• Morgan L, Shah B, Rivers LE, Barden L, Groom AJ, Chung R, Higazi D, Desmond H, Smith T, Staddon JM. Inflammation and dephosphorylation of the tight junction protein occludin in an experimental model of multiple sclerosis. Neuroscience. 2007;147:664-73. doi:10.1016/j.neuroscience.2007.04.051. PMID:17560040
   PubMed Web of Science ®Google Scholar
• Carson MJ, Doose JM, Melchior B, Schmid CD, Ploix CC. CNS immune privilege: hiding in plain sight. Immunol Rev. 2006;213:48-65. doi:10.1111/j.1600-065X.2006.00441.x. PMID:16972896
   PubMed Web of Science ®Google Scholar
• Stewart PA, Wiley MJ. Developing nervous tissue induces formation of blood-brain barrier characteristics in invading endothelial cells: A study using quail-chick transplantation chimeras. Dev Biol. 1981;84:183-92. doi:10.1016/0012-1606(81)90382-1. PMID:7250491
   PubMed Web of Science ®Google Scholar
• Daneman R, Zhou L, Kebede AA, Barres BA. Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature. 2010;468:562-6. doi:10.1038/nature09513. PMID:20944625
   PubMed Web of Science ®Google Scholar
• Risau W, Wolburg H. Development of the blood-brain barrier. Trends Neurosci. 1990;13:174-8. doi:10.1016/0166-2236(90)90043-A. PMID:1693235
   PubMed Web of Science ®Google Scholar
• Furuse M, Fujita K, Hiiragi T, Fujimoto K, Tsukita S. Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol. 1998;141:1539-50. doi:10.1083/jcb.141.7.1539. PMID:9647647
   PubMed Web of Science ®Google Scholar
• Furuse M, Hirase T, Itoh M, Nagafuchi A, Yonemura S, Tsukita S, Tsukita S. Occludin: A novel integral membrane protein localizing at tight junctions. J Cell Biol. 1993;123:1777-88. doi:10.1083/jcb.123.6.1777. PMID:8276896
   PubMed Web of Science ®Google Scholar
• Martin-Padura I, Lostaglio S, Schneemann M, Williams L, Romano M, Fruscella P, Panzeri C, Stoppacciaro A, Ruco L, Villa A, et al. Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration. J Cell Biol. 1998;142:117-27. doi:10.1083/jcb.142.1.117. PMID:9660867
   PubMed Web of Science ®Google Scholar
• Umeda K, Ikenouchi J, Katahira-Tayama S, Furuse K, Sasaki H, Nakayama M, Matsui T, Tsukita S, Furuse M, Tsukita S. ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation. Cell. 2006;126:741-54. doi:10.1016/j.cell.2006.06.043. PMID:16923393
   PubMed Web of Science ®Google Scholar
• Etournay R, Zwaenepoel I, Perfettini I, Legrain P, Petit C, El-Amraoui A. Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions. J Cell Sci. 2007;120:2838-50. doi:10.1242/jcs.002568. PMID:17666436
   PubMed Web of Science ®Google Scholar
• Katsube T, Takahisa M, Ueda R, Hashimoto N, Kobayashi M, Togashi S. Cortactin associates with the cell-cell junction protein ZO-1 in both Drosophila and mouse. J Biol Chem. 1998;273:29672-7. doi:10.1074/jbc.273.45.29672. PMID:9792678
   PubMed Web of Science ®Google Scholar
• Daneman R, Zhou L, Agalliu D, Cahoy JD, Kaushal A, Barres BA. The mouse blood-brain barrier transcriptome: A new resource for understanding the development and function of brain endothelial cells. PLoS One. 2010;5:1-16. doi:10.1371/journal.pone.0013741
   Web of Science ®Google Scholar
• Ohtsuki S, Yamaguchi H, Katsukura Y, Asashima T, Terasaki T. mRNA expression levels of tight junction protein genes in mouse brain capillary endothelial cells highly purified by magnetic cell sorting. J Neurochem. 2008;104:147-54. PMID:17971126
   PubMed Web of Science ®Google Scholar
• Krause G, Winkler L, Piehl C, Blasig I, Piontek J, Müller SL. Structure and function of extracellular claudin domains. Ann N Y Acad Sci. 2009;1165:34-43. doi:10.1111/j.1749-6632.2009.04057.x. PMID:19538285
   PubMed Web of Science ®Google Scholar
• Saitou M, Furuse M, Sasaki H, Schulzke JD, Fromm M, Takano H, Noda T, Tsukita S. Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol Biol Cell. 2000;11:4131-42. doi:10.1091/mbc.11.12.4131. PMID:11102513
   PubMed Web of Science ®Google Scholar
• Cording J, Berg J, Kading N, Bellmann C, Tscheik C, Westphal JK, Milatz S, Gunzel D, Wolburg H, Piontek J, et al. In tight junctions, claudins regulate the interactions between occludin, tricellulin and marvelD3, which, inversely, modulate claudin oligomerization. J Cell Sci. 2013;126:554-64. doi:10.1242/jcs.114306. PMID:23203797
   PubMed Web of Science ®Google Scholar
• Ostermann G, Weber KSC, Zernecke A, Schroder A, Weber C. JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes. Nat Immunol. 2002;3:151-8. doi:10.1038/ni755. PMID:11812992
   PubMed Web of Science ®Google Scholar
• Ebnet K, Aurrand-Lions M, Kuhn A, Kiefer F, Butz S, Zander K, Meyer zu Brickwedde M-K, Suzuki A, Imhof BA, Vestweber D. The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity. J Cell Sci. 2003;116:3879-91. doi:10.1242/jcs.00704. PMID:12953056
   PubMed Web of Science ®Google Scholar
• Vorbrodt AW, Dobrogowska DH. Molecular anatomy of intercellular junctions in brain endothelial and epithelial barriers: electron microscopist's view. Brain Res Brain Res Rev. 2003;42:221-42. doi:10.1016/S0165-0173(03)00177-2. PMID:12791441
   PubMed Web of Science ®Google Scholar
• Shepro D, Morel NM. Pericyte physiology. FASEB J. 1993;7:1031-8. PMID:8370472
   PubMed Web of Science ®Google Scholar
• Armulik A, Genové G, Mäe M, Nisancioglu MH, Wallgard E, Niaudet C, He L, Norlin J, Lindblom P, Strittmatter K, et al. Pericytes regulate the blood-brain barrier. Nature. 2010;468:557-61. doi:10.1038/nature09522. PMID:20944627
   PubMed Web of Science ®Google Scholar
• Cuevas P, Gutierrez-Diaz JA, Reimers D, Dujovny M, Diaz FG, Ausman JI. Pericyte endothelial gap junctions in human cerebral capillaries. Anat Embryol (Berl). 1984;170:155-9. doi:10.1007/BF00319000. PMID:6517350
   PubMedGoogle Scholar
• Diaz-Flores L, Gutierrez R, Madrid JF, Varela H, Valladares F, Acosta E, Martín-Vasallo P, Díaz-Flores J Pericytes. Morphofunction, interactions and pathology in a quiescent and activated mesenchymal cell niche. Histol. Histopathol. 2009;24:909-69.
   PubMed Web of Science ®Google Scholar
• Reis M, Czupalla CJ, Ziegler N, Devraj K, Zinke J, Seidel S, Heck R, Thom S, Macas J, Bockamp E, et al. Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression. J Exp Med. 2012;209:1611-27. doi:10.1084/jem.20111580. PMID:22908324
   PubMed Web of Science ®Google Scholar
• Shimizu F, Sano Y, Saito K, Abe MA, Maeda T, Haruki H, Kanda T. Pericyte-derived glial cell line-derived neurotrophic factor increase the expression of claudin-5 in the blood-brain barrier and the blood-nerve barrier. Neurochem Res. 2012;37:401-9. doi:10.1007/s11064-011-0626-8. PMID:22002662
   PubMed Web of Science ®Google Scholar
• Lindahl P, Johansson BR, Leveen P, Betsholtz C. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science. 1997;277:242-5. doi:10.1126/science.277.5323.242. PMID:9211853
   PubMed Web of Science ®Google Scholar
• Neuhaus J. Orthogonal arrays of particles in astroglial cells: quantitative analysis of their density, size, and correlation with intramembranous particles. Glia. 1990;3:241-51. doi:10.1002/glia.440030403. PMID:2144504
   PubMed Web of Science ®Google Scholar
• Alvarez JI, Dodelet-Devillers A, Kebir H, Ifergan I, Fabre PJ, Terouz S, Sabbagh M, Wosik K, Bourbonniere L, Bernard M, et al. The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. Science. 2011;334:1727-31. doi:10.1126/science.1206936. PMID:22144466
   PubMed Web of Science ®Google Scholar
• Hong CS, Ho W, Piazza MG, Ray-Chaudhury A, Zhuang Z, Heiss JD. Characterization of the blood brain barrier in pediatric central nervous system neoplasms. J Interdiscip Histopathol. 2016;21:4062-72.
   Google Scholar
• Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, et al. A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β. Sci Transl Med. 2012;4:147ra111. doi:10.1126/scitranslmed.3003748. PMID:22896675
   PubMed Web of Science ®Google Scholar
• Yi JH, Hazell AS. Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury. Neurochem. Int. 2006;48:394-403. doi:10.1016/j.neuint.2005.12.001. PMID:16473439
   PubMed Web of Science ®Google Scholar
• Tilling T, Korte D, Hoheisel D, Galla H-J. Basement Membrane Proteins Influence Brain Capillary Endothelial Barrier Function In Vitro. J Neurochem. 1998;71:1151-7.
   PubMed Web of Science ®Google Scholar
• Sixt M, Engelhardt B, Pausch F, Hallmann R, Wendler O, Sorokin LM. Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis. J Cell Biol. 2001;153:933-45. doi:10.1083/jcb.153.5.933. PMID:11381080
   PubMed Web of Science ®Google Scholar
• Wu C, Ivars F, Anderson P, Hallmann R, Vestweber D, Nilsson P, Robenek H, Tryggvason K, Song J, Korpos E, et al. Endothelial basement membrane laminin alpha5 selectively inhibits T lymphocyte extravasation into the brain. Nat Med. 2009;15:519-27. doi:10.1038/nm.1957. PMID:19396173
   PubMed Web of Science ®Google Scholar
• Jucker M, Tian M, Norton DD, Sherman C, Kusiak JW. Laminin alpha 2 is a component of brain capillary basement membrane: reduced expression in dystrophic dy mice. Neuroscience. 1996;71:1153-61. doi:10.1016/0306-4522(95)00496-3. PMID:8684619
   PubMed Web of Science ®Google Scholar
• Bechmann I, Galea I, Perry VH. What is the blood-brain barrier (not)? Trends Immunol. 2007;28:5-11. doi:10.1016/j.it.2006.11.007. PMID:17140851
   PubMed Web of Science ®Google Scholar
• Agrawal S, Anderson P, Durbeej M, Van Rooijen N, Ivars F, Opdenakker G, Sorokin LM. Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis. J Exp Med. 2006;203:1007-19. doi:10.1084/jem.20051342. PMID:16585265
   PubMed Web of Science ®Google Scholar
• Berman NEJ, Lee P, Kim J, Williams R, Sandhir R, Gregory E, Brooks WM. Effects of aging on blood brain barrier and matrix metalloproteases following controlled cortical impact in mice. Exp Neurol. 2012;234:50-61. doi:10.1016/j.expneurol.2011.12.016. PMID:22201549
   PubMed Web of Science ®Google Scholar
• Vijg J. Somatic mutations and aging: a re-evaluation. Mutat Res. 2000;447:117-35. doi:10.1016/S0027-5107(99)00202-X. PMID:10686308
   PubMed Web of Science ®Google Scholar
• Shigenaga MK, Hagen TM, Ames BN. Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci. 1994;91:10771-8. doi:10.1073/pnas.91.23.10771. PMID:7971961
   PubMed Web of Science ®Google Scholar
• Semba RD, Nicklett EJ, Ferrucci L. Does Accumulation of Advanced Glycation End Products Contribute to the Aging Phenotype? J Gerontol Ser A. 2010;65A:963-75. doi:10.1093/gerona/glq074
   Web of Science ®Google Scholar
• Oldendorf WH, Cornford ME, Brown WJ. The large apparent work capability of the blood-brain barrier: a study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat. Ann Neurol. 1977;1:409-17. doi:10.1002/ana.410010502. PMID:617259
   PubMed Web of Science ®Google Scholar
• Shen Q, Goderie SK, Jin L, Karanth N, Sun Y, Abramva N, Vincent P, Pumiglia K, Temple S. Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells. Science (80-). 2004;304:1338-40. doi:10.1126/science.1095505
   PubMed Web of Science ®Google Scholar
• Pang WW, Price E A, Sahoo D, Beerman I, Maloney WJ, Rossi DJ, Schrier SL, Weissman IL. Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age. Proc Natl Acad Sci. 2011;108:20012-7. doi:10.1073/pnas.1116110108. PMID:22123971
   PubMed Web of Science ®Google Scholar
• Morrison SJ, Wandycz AM, Akashi K, Globerson A, Weissman IL. The aging of hematopoietic stem cells. Nat Med. 1996;2:1011-6. doi:10.1038/nm0996-1011. PMID:8782459
   PubMed Web of Science ®Google Scholar
• Kuhn HG, Dickinson-Anson H, Gage FH. Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J Neurosci. 1996;16:2027-33. PMID:8604047
   PubMed Web of Science ®Google Scholar
• Daynac M, Morizur L, Chicheportiche A, Mouthon M-A, Boussin FD. Age-related neurogenesis decline in the subventricular zone is associated with specific cell cycle regulation changes in activated neural stem cells. Sci Rep. 2016;6:21505. doi:10.1038/srep21505. PMID:26893147
   PubMed Web of Science ®Google Scholar
• Montagne A, Barnes SR, Sweeney MD, Halliday MR, Sagare AP, Zhao Z, Toga AW, Jacobs RE, Liu CY, Amezcua L, et al. Blood-Brain barrier breakdown in the aging human hippocampus. Neuron. 2015;85:296-302. doi:10.1016/j.neuron.2014.12.032. PMID:25611508
   PubMed Web of Science ®Google Scholar
• Susman M, DiRusso SM, Sullivan T, Risucci D, Nealon P, Cuff S, Haider A, Benzil D. Traumatic brain injury in the elderly: increased mortality and worse functional outcome at discharge despite lower injury severity. J Trauma. 2002;53:219-23-4. doi:10.1097/00005373-200208000-00004
   PubMed Web of Science ®Google Scholar
• Chen CPC, Chen RL, Preston JE. The influence of ageing in the cerebrospinal fluid concentrations of proteins that are derived from the choroid plexus, brain, and plasma. Exp Gerontol. 2012;47:323-8. doi:10.1016/j.exger.2012.01.008. PMID:22532968
   PubMed Web of Science ®Google Scholar
• Elahy M, Jackaman C, Mamo JC, Lam V, Dhaliwal SS, Giles C, Nelson D, Takechi R. Blood-brain barrier dysfunction developed during normal aging is associated with inflammation and loss of tight junctions but not with leukocyte recruitment. Immun Ageing. 2015;12:2. doi:10.1186/s12979-015-0029-9. PMID:25784952
   PubMed Web of Science ®Google Scholar
• Sandhir R, Puri V, Klein RM, Berman NEJ. Differential expression of cytokines and chemokines during secondary neuron death following brain injury in old and young mice. Neurosci Lett. 2004;369:28-32. doi:10.1016/j.neulet.2004.07.032. PMID:15380302
   PubMed Web of Science ®Google Scholar
• Heimann G, Canhos LL, Frik J, Jäger G, Lepko T, Ninkovic J, Götz M, Sirko S. Changes in the Proliferative Program Limit Astrocyte Homeostasis in the Aged Post-Traumatic Murine Cerebral Cortex. Cereb Cortex. 2017;27:4213-28. doi:10.1093/cercor/bhx112. PMID:28472290
   PubMed Web of Science ®Google Scholar
• Wang Y, Jin S, Sonobe Y, Cheng Y, Horiuchi H, Parajuli B, Kawanokuchi J, Mizuno T, Takeuchi H, Suzumura A. Interleukin-1B Induces induces blood-brain barrier disruption by downregulating sonic hedgehog in astrocytes. PLoS One. 2014;9:1-8.
   Web of Science ®Google Scholar
• Raponi E, Agenes F, Delphin C, Assard N, Baudier J, Legraverend C, Deloulme J-C. S100B expression defines a state in which GFAP-expressing cells lose their neural stem cell potential and acquire a more mature developmental stage. Glia. 2007;55:165-77. doi:10.1002/glia.20445. PMID:17078026
   PubMed Web of Science ®Google Scholar
• Brozzi F, Arcuri C, Giambanco I, Donato R. S100B Protein Regulates Astrocyte Shape and Migration via Interaction with Src Kinase: Implications for astrocyte development, activation, and tumor growth. J Biol Chem. 2009;284:8797-811. doi:10.1074/jbc.M805897200. PMID:19147496
   PubMed Web of Science ®Google Scholar
• Gerlai R, Wojtowicz JM, Marks a, Roder J. Overexpression of a calcium-binding protein, S100 beta, in astrocytes alters synaptic plasticity and impairs spatial learning in transgenic mice. Learn Mem. 1995;2:26-39. doi:10.1101/lm.2.1.26. PMID:10467564
   PubMed Web of Science ®Google Scholar
• Mrak RE, Griffinb WST. The role of activated astrocytes and of the neurotrophic cytokine S100B in the pathogenesis of Alzheimer's disease. Neurobiol Aging. 2001;22:915-22. doi:10.1016/S0197-4580(01)00293-7. PMID:11754999
   PubMed Web of Science ®Google Scholar
• Pedersen A, Diedrich M, Kaestner F, Koelkebeck K, Ohrmann P, Ponath G, Kipp F, Abel S, Siegmund A, Suslow T. Memory impairment correlates with increased S100B serum concentrations in patients with chronic schizophrenia. Prog Neuro-Psychopharmacology Biol Psychiatry. 2008;32:1789-92. doi:10.1016/j.pnpbp.2008.07.017
   PubMed Web of Science ®Google Scholar
• Tramontina F, Tramontina AC, Souza DF, Leite MC, Gottfried C, Souza DO, Wofchuk ST, Gonçalves CA. Glutamate uptake is stimulated by extracellular S100B in hippocampal astrocytes. Cell Mol Neurobiol. 2006;26:81-6. PMID:16633903
   PubMed Web of Science ®Google Scholar
• Wu H, Brown EV, Acharya NK, Appelt DM, Marks A, Nagele RG, Venkataraman V. Age-dependent increase of blood-brain barrier permeability and neuron-binding autoantibodies in S100B knockout mice. Brain Res. 2016;1637:154-67.
   PubMed Web of Science ®Google Scholar
• Valencia J V, Mone M, Zhang J, Weetall M, Buxton FP, Hughes TE. Divergent Pathways of Gene Expression Are Activated by the RAGE Ligands S100b and AGE-BSA. Diabetes. 2004;53:743 LP-751. doi:10.2337/diabetes.53.3.743
   Web of Science ®Google Scholar
• Villarreal A, Seoane R, Torres AG, Rosciszewski G, Angelo MF, Rossi A, Barkert PA, Ramos AJ. S100B protein activates a RAGE-dependent autocrine loop in astrocytes: Implications for its role in the propagation of reactive gliosis. J Neurochem. 2014;131(2):190-205. doi:10.1111/jnc.12790. PMID:24923428
   PubMedGoogle Scholar
• Hafezi-Moghadam A, Thomas KL, Wagner DD. ApoE deficiency leads to a progressive age-dependent blood-brain barrier leakage. Am J Physiol Cell Physiol. 2007;292:C1256-62. doi:10.1152/ajpcell.00563.2005. PMID:16870825
   PubMed Web of Science ®Google Scholar
• Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small Gw al, Roses AD, Haines JL, Pericak-Vance MA. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science (80-). 1993;261:921-3. doi:10.1126/science.8346443
   PubMed Web of Science ®Google Scholar
• Nishitsuji K, Hosono T, Nakamura T, Bu G, Michikawa M. Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain barrier model. J Biol Chem. 2011;286:17536-42. doi:10.1074/jbc.M111.225532. PMID:21471207
   PubMed Web of Science ®Google Scholar
• Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, et al. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature. 2012;485:512-6. PMID:22622580
   PubMed Web of Science ®Google Scholar
• Bell RD, Winkler EA, Sagare AP, Singh I, LaRue B, Deane R, Zlokovic B V. Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging. Neuron. 2010;68:409-27. doi:10.1016/j.neuron.2010.09.043. PMID:21040844
   PubMed Web of Science ®Google Scholar
• Bauer M, Karch R, Neumann F, Abrahim A, Wagner CC, Kletter K, Müller M, Zeitlinger M, Langer O. Age dependency of cerebral P-gp function measured with (R)-[11C]verapamil and PET. Eur J Clin Pharmacol. 2009;65:941-6. doi:10.1007/s00228-009-0709-5. PMID:19655132
   PubMed Web of Science ®Google Scholar
• Van Assema DME Lubberink M, Boellaard R, Schuit RC, Windhorst AD, Scheltens P, Lammertsma AA, Van Berckel BNM. P-glycoprotein function at the blood-brain barrier: Effects of age and gender. Mol Imaging Biol. 2012;14:771-6. doi:10.1007/s11307-012-0556-0. PMID:22476967
   PubMed Web of Science ®Google Scholar
• Hebert LE, Weuve J, Scherr PA, Evans DA. Alzheimer disease in the United States (2010-2050) estimated using the 2010 census. Neurology. 2013;80:1778-83. doi:10.1212/WNL.0b013e31828726f5. PMID:23390181
   PubMed Web of Science ®Google Scholar
• Silverberg GD, Miller MC, Messier AA, Majmudar S, Machan JT, Donahue JE, Stopa EG, Johanson CE. Amyloid deposition and influx transporter expression at the blood-brain barrier increase in normal aging. J Neuropathol Exp Neurol. 2010;69:98-108. doi:10.1097/NEN.0b013e3181c8ad2f. PMID:20010299
   PubMed Web of Science ®Google Scholar
• Osgood D, Miller MC, Messier AA, Gonzalez L, Silverberg GD. Aging alters mRNA expression of amyloid transporter genes at the blood-brain barrier. Neurobiol Aging. 2017;57:178-85. doi:10.1016/j.neurobiolaging.2017.05.011. PMID:28654861
   PubMed Web of Science ®Google Scholar
• Lugert S, Basak O, Knuckles P, Haussler U, Fabel K, Götz M, Haas CA, Kempermann G, Taylor V, Giachino C. Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging. Cell Stem Cell. 2010;6:445-56. doi:10.1016/j.stem.2010.03.017. PMID:20452319
   PubMed Web of Science ®Google Scholar
• Louissaint A, Rao S, Leventhal C, Goldman SA. Coordinated interaction of neurogenesis and angiogenesis in the adult songbird brain. Neuron. 2002;34:945-60. doi:10.1016/S0896-6273(02)00722-5. PMID:12086642
   PubMed Web of Science ®Google Scholar
• Tavazoie M, Van der Veken L, Silva-Vargas V, Louissaint M, Colonna L, Zaidi B, Garcia-Verdugo JM, Doetsch F. A Specialized Vascular Niche for Adult Neural Stem Cells. Cell Stem Cell. 2008;3:279-88. doi:10.1016/j.stem.2008.07.025. PMID:18786415
   PubMed Web of Science ®Google Scholar
• Andreu-Agullo C, Morante-Redolat JM, Delgado AC, Farinas I. Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone. Nat Neurosci. 2009;12:1514-23. doi:10.1038/nn.2437. PMID:19898467
   PubMed Web of Science ®Google Scholar
• Delgado AC, Ferron SR, Vicente D, Porlan E, Perez-Villalba A, Trujillo CM, D'Ocon P, Farinas I. Endothelial NT-3 delivered by vasculature and CSF promotes quiescence of subependymal neural stem cells through nitric oxide induction. Neuron. 2014;83:572-85. doi:10.1016/j.neuron.2014.06.015. PMID:25043422
   PubMed Web of Science ®Google Scholar
• Pineda JR, Daynac M, Chicheportiche A, Cebrian-Silla A, Sii Felice K, Garcia-Verdugo JM, Boussin FD, Mouthon M-A. Vascular-derived TGF-β increases in the stem cell niche and perturbs neurogenesis during aging and following irradiation in the adult mouse brain. EMBO Mol Med. 2013;5:548-62. doi:10.1002/emmm.201202197. PMID:23526803
   PubMed Web of Science ®Google Scholar
• Watters AK, Rom S, Hill JD, Dematatis MK, Zhou Y, Merkel SF, Andrews AM, Cena J, Potula R, Skuba A, et al. Identification and Dynamic Regulation of Tight Junction Protein Expression in Human Neural Stem Cells. Stem Cells Dev. 2015;24:1377-89. doi:10.1089/scd.2014.0497. PMID:25892136
   PubMed Web of Science ®Google Scholar
• Shen Q, Wang Y, Kokovay E, Lin G, Chuang SM, Goderie SK, Roysam B, Temple S. Adult SVZ Stem Cells Lie in a Vascular Niche: A Quantitative Analysis of Niche Cell-Cell Interactions. Cell Stem Cell. 2008;3:289-300.doi:10.1016/j.stem.2008.07.026. PMID:18786416
   PubMed Web of Science ®Google Scholar
• Ahlenius H, Visan V, Kokaia M, Lindvall O, Kokaia Z. Neural Stem and Progenitor Cells Retain Their Potential for Proliferation and Differentiation into Functional Neurons Despite Lower Number in Aged Brain. J Neurosci. 2009;29:4408 LP-4419. doi:10.1523/JNEUROSCI.6003-08.2009
   Web of Science ®Google Scholar
• Katsimpardi L, Litterman NK, Schein PA, Miller CM, Loffredo FS, Wojtkiewicz GR, Chen JW, Lee RT, Wagers AJ, Rubin LL. Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science. 2014;344:630-4. doi:10.1126/science.1251141. PMID:24797482
   PubMed Web of Science ®Google Scholar