Curcumin-mediated regulation of intestinal barrier function: The mechanism underlying its beneficial effects

References

• Vogel H, Pelletier J. Curcumin –biological and medicinal properties. Journal de Pharmacie. 1815;I:289
   Google Scholar
• Loeber CC, Buechner AE. Dissertatio inauguralis medica de curcuma officinarum ejusque genuinis virtutibus. In: Praes, Büchnero AE, editors. Diss Inaug Halae. Halle: Halae Magdeburgicae; 1748. p. 28.
   Google Scholar
• Oppenheimer A. Turmeric (curcumin) in biliary diseases. Lancet. 1937;229:619–621. doi:10.1016/S0140-6736(00)98193-5
   Google Scholar
• Schraufstatter E, Bernt H. Antibacterial action of curcumin and related compounds. Nature. 1949;164(4167):456. doi:10.1038/164456a0
   PubMed Web of Science ®Google Scholar
• Aggarwal BB, Sung B. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol Sci. 2009;30(2):85–94. doi:10.1016/j.tips.2008.11.002
   PubMed Web of Science ®Google Scholar
• Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol. 2009 Jan;41(1):40–59. doi:10.1016/j.biocel.2008.06.010
   PubMed Web of Science ®Google Scholar
• Hewlings SJ, Kalman DS. Curcumin: A Review of Its' Effects on Human Health. Foods. 2017;6:92–102.
   Google Scholar
• Ganjali S, Sahebkar A, Mahdipour E, Jamialahmadi K, Torabi S, Akhlaghi S, Ferns G, Parizadeh SM, Ghayour-Mobarhan M. Investigation of the effects of curcumin on serum cytokines in obese individuals: a randomized controlled trial. Scientific World Journal. 2014;2014:898361. doi:10.1155/2014/898361.
   Web of Science ®Google Scholar
• Franco-Robles E, Campos-Cervantes A, Murillo-Ortiz BO, Segovia J, López-Briones S, Vergara P, Pérez-Vázquez V, Solís-Ortiz MS, Ramírez-Emiliano J. Effects of curcumin on brain-derived neurotrophic factor levels and oxidative damage in obesity and diabetes. Appl Physiol Nutr Metab. 2014;39(2):211–218. doi:10.1139/apnm-2013-0133
   PubMed Web of Science ®Google Scholar
• Yang YS1, Su YF, Yang HW, Lee YH, Chou JI, Ueng KC. Lipid-lowering effects of curcumin in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled trial. Phytother Res. 2014;28(12):1770–1777. doi:10.1002/ptr.5197
   PubMed Web of Science ®Google Scholar
• Alwi I, Santoso T, Suyono S, Sutrisna B, Suyatna FD, Kresno SB, Ernie S. The effect of curcumin on lipid level in patients with acute coronary syndrome. Acta Med Indones. 2008;40(4):201–210
   PubMedGoogle Scholar
• Appendino G, Belcaro G, Cornelli U, Luzzi R, Togni S, Dugall M, Cesarone MR, Feragalli B, Ippolito E, Errichi BM, Pellegrini L, Ledda A, Ricci A, Bavera P, Hosoi M, Stuard S, Corsi M, Errichi S, Gizzi G. Potential role of curcumin phytosome (Meriva) in controlling the evolution of diabetic microangiopathy. A pilot study. Panminerva Med. 2011;53(3 Suppl 1):43–49
   PubMedGoogle Scholar
• Steigerwalt R1, Nebbioso M, Appendino G, Belcaro G, Ciammaichella G, Cornelli U, Luzzi R, Togni S, Dugall M, Cesarone MR, Ippolito E, Errichi BM, Ledda A, Hosoi M, Corsi M. Meriva(R), a lecithinized curcumin delivery system, in diabetic microangiopathy and retinopathy. Panminerva Med. 2012;54(1 Suppl 4):11–16
   PubMed Web of Science ®Google Scholar
• Chuengsamarn S, Rattanamongkolgul S, Luechapudiporn R, Phisalaphong C, Jirawatnotai S. Curcumin extract for prevention of type 2 diabetes. Diabetes Care. 2012;35(11):2121–2127. doi:10.2337/dc12-0116
   PubMed Web of Science ®Google Scholar
• Yang H, Xu W, Zhou Z, Liu J, Li X, Chen L, Weng J, Yu Z. Curcumin attenuates urinary excretion of albumin in type II diabetic patients with enhancing nuclear factor erythroid-derived 2-like 2 (Nrf2) system and repressing inflammatory signaling efficacies. Exp Clin Endocrinol Diabetes. 2015;123(6):360–367. doi:10.1055/s-0035-1545345
   PubMed Web of Science ®Google Scholar
• Panahi Y, Kianpour P, Mohtashami R, Jafari R, Simental-Mendía LE, Sahebkar A. Efficacy and safety of phytosomal curcumin in non-alcoholic fatty liver disease: a randomized controlled trial. Drug Res (Stuttg). 2017;67(4):244–251. doi:10.1055/s-0043-100019
   PubMed Web of Science ®Google Scholar
• Rahmani S, Asgary S, Askari G, Keshvari M, Hatamipour M, Feizi A, Sahebkar A. Treatment of non-alcoholic fatty liver disease with curcumin: a randomized placebo-controlled trial. Phytother Res. 2016;30(9):1540–1548. doi:10.1002/ptr.5659
   PubMed Web of Science ®Google Scholar
• Mahammedi H1, Planchat E, Pouget M, Durando X, Curé H, Guy L, Van-Praagh I, Savareux L, Atger M, Bayet-Robert M, Gadea E, Abrial C, Thivat E, Chollet P, Eymard JC. The new combination docetaxel, prednisone and curcumin in patients with castration-resistant prostate cancer: a pilot phase ii study. Oncology. 2016;90(2):69–78 doi:10.1159/000441148
   PubMed Web of Science ®Google Scholar
• Ryan JL, Heckler CE, Ling M, Katz A, Williams JP, Pentland AP, Morrow GR. Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients. Radiat Res. 2013;180(1):34–43. doi:10.1667/RR3255.1
   PubMed Web of Science ®Google Scholar
• Bayet-Robert M, Kwiatkowski F, Leheurteur M, Gachon F, Planchat E, Abrial C, Mouret-Reynier MA, Durando X, Barthomeuf C, Chollet P. Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer. Cancer Biol Ther. 2010;9(1):8–14. doi:10.4161/cbt.9.1.10392
   PubMed Web of Science ®Google Scholar
• Kanai M, Yoshimura K, Asada M, Imaizumi A, Suzuki C, Matsumoto S, Nishimura T, Mori Y, Masui T, Kawaguchi Y, Yanagihara K, Yazumi S, Chiba T, Guha S, Aggarwal BB. A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer. Cancer Chemother Pharmacol. 2011;68(1):157–164. doi:10.1007/s00280-010-1470-2
   PubMed Web of Science ®Google Scholar
• Yu JJ, Pei LB, Zhang Y, Wen ZY, Yang JL. Chronic supplementation of curcumin enhances the efficacy of antidepressants in major depressive disorder: a randomized, double-blind, placebo-controlled pilot study. J Clin Psychopharmacol. 2015;35:406–410
   PubMed Web of Science ®Google Scholar
• Bergman J1, Miodownik C, Bersudsky Y, Sokolik S, Lerner PP, Kreinin A, Polakiewicz J, Lerner V. Curcumin as an add-on to antidepressive treatment: a randomized, double-blind, placebo-controlled, pilot clinical study. Clin Neuropharmacol. 2013;36(3):73–77. doi:10.1097/WNF.0b013e31828ef969
   PubMed Web of Science ®Google Scholar
• Nakagawa Y, Mukai S, Yamada S, Matsuoka M, Tarumi E, Hashimoto T, Tamura C, Imaizumi A, Nishihira J, Nakamura T. Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study. J Orthop. Sci. 2014;19(6):933–939. doi:10.1007/s00776-014-0633-0
   PubMed Web of Science ®Google Scholar
• Appelboom T, Maes N, Albert A. A new curcuma extract (flexofytol®) in osteoarthritis: results from a belgian real-life experience. The Open Rheumatology Journal. 2014;8:77–81. doi:10.2174/1874312901408010077
   PubMedGoogle Scholar
• Belcaro, G., et al., Product-evaluation registry of Meriva(R), a curcuminphosphatidylcholine complex, for the complementary management of osteoarthritis. Panminerva Med. 2010;52(2 Suppl 1):55–62
   PubMed Web of Science ®Google Scholar
• Belcaro G, Cesarone MR, Dugall M, Pellegrini L, Ledda A, Grossi MG, Togni S, Appendino G. Efficacy and safety of Meriva(R), a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Altern Med Rev. 2010;15(4):337–344
   PubMedGoogle Scholar
• Chandran B, Goel A. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res. 2012;26(11):1719–25. doi:10.1002/ptr.4639
   PubMed Web of Science ®Google Scholar
• Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, Walters MA. The essential medicinal chemistry of curcumin – mini perspective. J. Med. Chem. 2017;60:1620–1637. doi:10.1021/acs.jmedchem.6b00975
   PubMed Web of Science ®Google Scholar
• Yang H, Du Z, Wang W, Song M, Sanidad K, Sukamtoh E, Zheng J, Tian L, Xiao H, Liu Z, Zhang G. Structure-activity relationship of curcumin: role of the methoxy group in anti-inflammatory and anticolitis effects of curcumin. J Agric Food Chem. 2017;65(22):4509–4515. doi:10.1021/acs.jafc.7b01792
   PubMed Web of Science ®Google Scholar
• Adiwidjaja J, McLachlan AJ, Boddy AV. Curcumin as a clinically-promising anti-cancer agent: pharmacokinetics and drug interactions. Expert Opin Drug Metab Toxicol. 2017;13(9):953–972. doi:10.1080/17425255.2017.1360279
   PubMed Web of Science ®Google Scholar
• Burapan S, Kim M, Han J. Curcuminoid demethylation as an alternative metabolism by human intestinal microbiota. J Agric Food Chem. 2017;65(16):3305–3310. doi:10.1021/acs.jafc.7b00943
   PubMed Web of Science ®Google Scholar
• Lalles JP. Intestinal alkaline phosphatase: novel functions and protective effects. Nutr Rev. 2014;72:82–94. doi:10.1111/nure.12082
   PubMed Web of Science ®Google Scholar
• Bentala H, Verweij WR, Huizinga-Van der Vlag A, van Loenen-Weemaes AM, Meijer DK, et al. Removal of phosphate from lipid A as a strategy to detoxify lipopolysaccharide. Shock. 2002;18:561–566. doi:10.1097/00024382-200212000-00013
   PubMed Web of Science ®Google Scholar
• Tuin A, Poelstra K, de Jager-Krikken A, Bok L, Raaben W, et al. Role of alkaline phosphatase in colitis in man and rats. Gut. 2009;58:379–387. doi:10.1136/gut.2007.128868
   PubMed Web of Science ®Google Scholar
• Ghosh SS, Bie J, Wang J, Ghosh S. Oral supplementation with non-absorbable antibiotics or curcumin attenuates western diet-induced atherosclerosis and glucose intolerance in LDLR−/− mice–role of intestinal permeability and macrophage activation. PLoS One. 2014;9(9):e108577. doi: 10.1371/journal.pone.0108577
   PubMed Web of Science ®Google Scholar
• Kiffer-Moreira T, Sheen CR, Gasque KC, Bolean M, Ciancaglini P, et al. Catalytic signature of a heat-stable, chimeric human alkaline phosphatase with therapeutic potential. PLoS One. 2014;9:e89374. doi:10.1371/journal.pone.0089374
   PubMed Web of Science ®Google Scholar
• Macfarlane, S., Woodmansey EJ, Macfarlane GT. Colonization of mucin by human intestinal bacteria and establishment of biofilm communities in a two-stage continuous culture system. Appl. Environ. Microbiol. 2005;71:7483–7492 doi:10.1128/AEM.71.11.7483-7492.2005
   PubMed Web of Science ®Google Scholar
• Everard A, Belzer C, Geurts L, Ouwerkerk JP, Druart C, Bindels LB, Guiot Y, Derrien M, Muccioli GG, Delzenne NM, de Vos WM, Cani PD. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci U S A. 2013;110(22):9066–9071. doi:10.1073/pnas.1219451110
   PubMed Web of Science ®Google Scholar
• Deplancke B, Gaskins HR. Microbial modulation of innate defense: goblet cells and the intestinal mucus layer. Am J Clin Nutr. 2001;73(6):1131S–1141S
   PubMed Web of Science ®Google Scholar
• Kissoon-Singh V, Moreau F, Trusevych E, Chadee K. Entamoeba histolytica exacerbates epithelial tight junction permeability and proinflammatory responses in Muc2(−/−) mice. Am J Pathol. 2013;182(3):852–865. doi:10.1016/j.ajpath.2012.11.035
   PubMed Web of Science ®Google Scholar
• Theodoropoulos G, Carraway KL. Molecular signaling in the regulation of mucins. J Cell Biochem. 2007;102:1103–1116. doi:10.1002/jcb.21539
   PubMed Web of Science ®Google Scholar
• Ito H, Satsukawa M, Arai E, Sugiyama K, Sonoyama K, Kiriyama S, Morita T. Soluble fiber viscosity affects both goblet cell number and small intestine mucin secretion in rats. J Nutr. 2009;139:1640–1647. doi:10.3945/jn.109.110171
   PubMed Web of Science ®Google Scholar
• Morita T. Small intestinal goblet cell proliferation induced by ingestion of soluble and insoluble dietary fiber is characterized by an increase in sialylated mucin in rats. J Nutr. 2012;142:1429–1436. doi:10.3945/jn.112.159731
   PubMed Web of Science ®Google Scholar
• Alves AJ Júnior, Pereira JA, Pansani AH, Magro DO, Coy CS, Martinez CA. Tissue sulfomucin and sialomucin content in colon mucosa without intestinal transit subjected to intervention with curcuma longa (curcumin). Acta Cir Bras. 2017;32(3):182–193. doi:10.1590/s0102-865020170030000002
   PubMed Web of Science ®Google Scholar
• Xun W, Shi L, Zhou H, Hou G, Cao T, Zhao C. Effects of curcumin on growth performance, jejunal mucosal membrane integrity, morphology and immune status in weaned piglets challenged with enterotoxigenic Escherichia coli. Int Immunopharmacol. 2015;27(1):46–52. doi:10.1016/j.intimp.2015.04.038
   PubMed Web of Science ®Google Scholar
• Broer S. Amino acid transport across mammalian intestinal and renal epithelia. Physiol Rev. 2008;88:249–86. doi:10.1152/physrev.00018.2006
   PubMed Web of Science ®Google Scholar
• Kunzelmann K, Mall M. Electrolyte transport in the mammalian colon: Mechanisms and Implications for disease. Physiol Rev. 2002;82:245–289. doi:10.1152/physrev.00026.2001
   PubMed Web of Science ®Google Scholar
• Ferraris RP, Diamond J. Regulation of intestinal sugar transport. Physiol Rev. 1997;77:257–302. doi:10.1152/physrev.1997.77.1.257
   PubMed Web of Science ®Google Scholar
• Tsukita S, Furuse M, Itoh M. Multifunctional strands in tight junctions. Nat Rev Mol Cell Biol. 2001;2:285–293. doi:10.1038/35067088
   PubMed Web of Science ®Google Scholar
• Van Itallie CM, Anderson JM. Claudins and epithelial paracellular transport. Annu Rev Physiol. 2006;68:403–29. doi:10.1146/annurev.physiol.68.040104.131404
   PubMed Web of Science ®Google Scholar
• Farquher MG, Palade GE. Junctional complexes in various epithelia. J Cell Biol. 1963;17:375–412. doi:10.1083/jcb.17.2.375
   PubMed Web of Science ®Google Scholar
• Hartsock A, Nelson WJ. Adherens and tight junctions: structure, function and connections to the actin cytoskeleton. Biochim Biophys Acta. 2008;1778:660–669. doi:10.1016/j.bbamem.2007.07.012
   PubMed Web of Science ®Google Scholar
• Schneeberger EE, Lynch RD. Structure, function, and regulation of cellular tight junctions. Am J Physiol. 1992;262:L647–L661
   PubMed Web of Science ®Google Scholar
• Anderson JM. Molecular structure of tight junctions and their role in epithelial transport. News Physiol Sci. 2001;16:126–130
   PubMedGoogle Scholar
• Tsukita S, Furuse M, Itoh M. Multifunctional strands in tight junctions. Nat Rev Mol Cell Biol. 2001;2:285–293. doi:10.1038/35067088
   PubMed Web of Science ®Google Scholar
• El Asmar R, Panigrahi P, Bamford P, et al. Host-dependent zonulin secretion causes the impairment of the small intestine barrier function after bacterial exposure. Gastroenterology. 2002;123:1607–1615. doi:10.1053/gast.2002.36578
   PubMed Web of Science ®Google Scholar
• Fasano A, Not T, Wang W, et al. Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease. Lancet. 2000;355:1518–1519. doi:10.1016/S0140-6736(00)02169-3
   PubMed Web of Science ®Google Scholar
• Wang J, Ghosh SS, Ghosh S. Curcumin improves intestinal barrier function: modulation of intracellular signaling, and organization of tight junctions. Am J Physiol Cell Physiol. 2017 Apr 1;312(4):C438–C445. doi:10.1152/ajpcell.00235.2016
   PubMed Web of Science ®Google Scholar
• Martinez CA, Kadri CJ, Kanno DT, Alves AJ Júnior, Coy CS, Pereira JA. Claudin-3 and occludin content in the glands of colonic mucosa devoid from fecal stream submitted to topical intervention with oil extract of curcuma longa. Acta Cir Bras. 2017;32(1):65–73. doi:10.1590/s0102-865020170108
   PubMed Web of Science ®Google Scholar
• Tian S, Guo R, Wei S, Kong Y, Wei X, Wang W, Shi X, Jiang H. Curcumin protects against the intestinal ischemia-reperfusion injury: involvement of the tight junction protein ZO-1 and TNF-α related mechanism. Korean J Physiol Pharmacol. 2016;20(2):147–152. doi:10.4196/kjpp.2016.20.2.147
   PubMed Web of Science ®Google Scholar
• Porter EM, Bevins CL, Ghosh D, Ganz T. The multifaceted Paneth cell. Cell. Mol. Life Sci. 2002;59:156–170. doi:10.1007/s00018-002-8412-z
   PubMed Web of Science ®Google Scholar
• Zasloff, M. Antimicrobial peptides of multicellular organisms. Nature. 2002;415:389–395. doi:10.1038/415389a
   PubMed Web of Science ®Google Scholar
• Guo C, Rosoha E, Lowry MB, Borregaard N, Gombart AF. Curcumin induces human cathelicidin antimicrobial peptide gene expression through a vitamin D receptor-independent pathway. J Nutr Biochem. 2013;24(5):754–759. doi:10.1016/j.jnutbio.2012.04.002
   PubMed Web of Science ®Google Scholar
• Michielan A, D'Inca R. Intestinal permeability in inflammatory bowel disease: pathogenesis, clinical evaluation, and therapy of leaky gut. Mediators of Inflamm. 2015;1258:628157.
   PubMed Web of Science ®Google Scholar
• Teshima CW, Dieleman LA, Meddings JB. Abnormal intestinal permeability in Crohn's disease pathogenesis. Ann N Y Acad Sci. 2012;1258:159–165. doi:10.1111/j.1749-6632.2012.06612.x
   PubMed Web of Science ®Google Scholar
• Martini E, Krug SM, Siegmund B, Neurath MF, Becker C. Mend your fences: the epithelial barrier and its relationship with mucosal immunity in inflammatory bowel disease. Cell Mol Gastroenterol Hepatol. 2017;4(1):33–46. doi:10.1016/j.jcmgh.2017.03.007
   PubMed Web of Science ®Google Scholar
• Fiddian-Green RG. Gut mucosal ischemia during cardiac surgery. Semin Thorac Cardiovasc Surg. 1990;2(4):389–399
   PubMedGoogle Scholar
• Moreira AP, Texeira TF, Ferreira AB, Peluzio Mdo C, Alfenas Rde C. Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia. Br J Nutr. 2012;108:801–809. doi:10.1017/S0007114512001213
   PubMed Web of Science ®Google Scholar
• Pendyala S, Walker JM, Holt PR. A high-fat diet is associated with endotoxemia that originates from the gut. Gastroenterology. 2012;142:1100–1101. doi:10.1053/j.gastro.2012.01.034
   PubMed Web of Science ®Google Scholar
• Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, Neyrinck AM, Fava F, Tuohy KM, Chabo C, Waget A, Delmee E, Cousin B, Sulpice T, Chamontin B, Ferrieres J, Tanti JF, Gibson GR, Casteilla L, Delzenne NM, Alessi MC, Burcelin R. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007;56:1761–1772. doi:10.2337/db06-1491
   PubMed Web of Science ®Google Scholar
• Davis JE, Gabler NK, Walker-Daniels J, Spurlock ME. Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat. Obesity. 2008;16:1248–1255. doi:10.1038/oby.2008.210
   PubMed Web of Science ®Google Scholar
• Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, Prada PO, Hirabara SM, Schenka AA, Araujo EP, Vassallo J, Curi R, Velloso LA, Saad MJ. Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes. 2007;56:1986–1998. doi:10.2337/db06-1595
   PubMed Web of Science ®Google Scholar
• Everard A, Geurts L, Caesar R, Van Hul M, Matamoros S, Duparc T, Denis RG, Cochez P, Pierard F, Castel J, Bindels LB, Plovier H, Robine S, Muccioli GG, Renauld JC, Dumoutier L, Delzenne NM, Luquet S, Backhed F, Cani PD. Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status. Nat Commun. 2014;5:5648. doi:10.1038/ncomms6648
   PubMed Web of Science ®Google Scholar
• Hosoi T, Yokoyama S, Matsuo S, Akira S, Ozawa K. Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in mice. PloS One. 2010;5:e12537. doi:10.1371/journal.pone.0012537
   PubMed Web of Science ®Google Scholar
• Creely SJ, McTernan PG, Kusminski CM, Fisher FM, Da Silva NF, Khanolkar M, Evans M, Harte AL, Kumar S. Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes. Am J Physiol Endocrinol Metab. 2007;292:E740–E747. doi:10.1152/ajpendo.00302.2006
   PubMed Web of Science ®Google Scholar
• Kallio KA, Hatonen KA, Lehto M, Salomaa V, Mannisto S, Pussinen PJ. Endotoxemia, nutrition, and cardiometabolic disorders. Acta Diabetol. 2015;52:395–404. doi:10.1007/s00592-014-0662-3
   PubMed Web of Science ®Google Scholar
• Emanuele E, Orsi P, Boso M, Broglia D, Brondino N, Barale F, di Nemi SU, Politi P. Low-grade endotoxemia in patients with severe autism. Neurosci Lett. 2010;471:162–165. doi:10.1016/j.neulet.2010.01.033
   PubMed Web of Science ®Google Scholar
• Zhang R, Miller RG, Gascon R, Champion S, Katz J, Lancero M, Narvaez A, Honrada R, Ruvalcaba D, McGrath MS. Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS). J Neuroimmunol. 2009;206:121–124. doi:10.1016/j.jneuroim.2008.09.017
   PubMed Web of Science ®Google Scholar
• Dubin W, Martin TR, Swoveland P, Leturcq DJ, Moriarty AM, Tobias PS, Bleecker ER, Goldblum SE, Hasday JD. Asthma and endotoxin: lipopolysaccharide-binding protein and soluble CD14 in bronchoalveolar compartment. Am J Physiol Lung Cell Mol Physiol. 1996;270:L736–L744. doi:10.1152/ajplung.1996.270.5.L736
   Web of Science ®Google Scholar
• Hasegawa S, Goto S, Tsuji H, Okuno T2, Asahara T, Nomoto K, Shibata A, Fujisawa Y, Minato T, Okamoto A, Ohno K, Hirayama M. Intestinal dysbiosis and lowered serum lipopolysaccharide-binding protein in parkinson's disease. PLoS One. 2015;10(11):e0142164. doi:10.1371/journal.pone.0142164
   PubMed Web of Science ®Google Scholar
• Fasano A. Leaky gut and autoimmune disease. Clinic Rev Allerg Immunol. 2012;42:71–78. doi:10.1007/s12016-011-8291-x
   PubMed Web of Science ®Google Scholar
• Fotis L, Shaikh N, Baszis KW, Samson CM, Lev-Tzion R, French AR, Tarr PI. Serologic evidence of gut-driven systemic inflammation in juvenile idiopathic arthritis. J Rheumatol. 2017;44(11):1624–1631. doi:10.3899/jrheum.161589
   PubMed Web of Science ®Google Scholar
• Ciccia F, Guggino G, Rizzo A, Alessandro R, Luchetti MM, Milling S, Saieva L, Cypers H, Stampone T, Di Benedetto P, Gabrielli A, Fasano A, Elewaut D, Triolo G. Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis. Ann Rheum Dis. 2017;76(6):1123–1132. doi:10.1136/annrheumdis-2016-210000
   PubMed Web of Science ®Google Scholar
• Metcalfe D, Harte AL, Aletrari MO, Al Daghri NM, Al Disi D, Tripathi G, McTernan PG. Does endotoxaemia contribute to osteoarthritis in obese patients? Clin Sci (Lond). 2012;123(11):627–634. doi:10.1042/CS20120073
   PubMed Web of Science ®Google Scholar
• Djuric Z. Obesity-associated cancer risk: the role of intestinal microbiota in the etiology of the host proinflammatory state. Transl Res. 2017;179:155–167. doi:10.1016/j.trsl.2016.07.017
   PubMed Web of Science ®Google Scholar
• Wirthgen E, Hoeflich A. Endotoxin-induced tryptophan degradation along the kynurenine pathway: the role of indolamine 2,3-dioxygenase and aryl hydrocarbon receptor-mediated immunosuppressive effects in endotoxin tolerance and cancer and its implications for immunoparalysis. J Amino Acids. 2015;2015:973548. doi:10.1155/2015/973548
   PubMedGoogle Scholar
• Roderburg C, Luedde T. The role of the gut microbiome in the development and progression of liver cirrhosis and hepatocellular carcinoma. Gut Microbes. 2014;5(4):441–445. doi:10.4161/gmic.29599
   PubMed Web of Science ®Google Scholar
• Che F, Yin J, Quan Y, Xie X, Heng X, Du Y, Wang L. TLR4 interaction with LPS in glioma CD133+ cancer stem cells induces cell proliferation, resistance to chemotherapy and evasion from cytotoxic T lymphocyte-induced cytolysis. Oncotarget. 2017;8(32):53495–53507
   PubMed Web of Science ®Google Scholar
• Bie J, Zhao B, Song J, Ghosh S. Improved insulin sensitivity in high fat- and high cholesterol-fed Ldlr−/− mice with macrophage-specific transgenic expression of cholesteryl ester hydrolase: role of macrophage inflammation and infiltration into adipose tissue. J Biol Chem. 2010;285(18):13630–7. doi:10.1074/jbc.M109.069781
   PubMed Web of Science ®Google Scholar
• Bie J, Zhao B, Ghosh S. Atherosclerotic lesion progression is attenuated by reconstitution with bone marrow from macrophage-specific cholesteryl ester hydrolase transgenic mice. Am J Physiol Regul Integr Comp Physiol. 2011;301(4):R967–R974. doi:10.1152/ajpregu.00277.2011
   PubMed Web of Science ®Google Scholar
• Ghosh SS, Massey HD, Krieg R, Fazelbhoy ZA, Ghosh S, Sica DA, Fakhry I, Gehr TW. Curcumin ameliorates renal failure in 5/6 nephrectomized rats: role of inflammation. Am J Physiol Renal Physiol. 2009;296(5):F1146–F1157. doi:10.1152/ajprenal.90732.2008
   PubMed Web of Science ®Google Scholar
• Ghosh SS, Krieg R, Massey HD, Sica DA, Fakhry I, Ghosh S, Gehr TW. Curcumin and enalapril ameliorate renal failure by antagonizing inflammation in 5/6 nephrectomized rats: role of phospholipase and cyclooxygenase. Am J Physiol Renal Physiol. 2012;302(4):F439–F454. doi:10.1152/ajprenal.00356.2010
   PubMed Web of Science ®Google Scholar
• Ghosh SS, Gehr TW, Ghosh S. Curcumin and chronic kidney disease (CKD): major mode of action through stimulating endogenous intestinal alkaline phosphatase. Molecules. 2014;19(12):20139–20156. doi:10.3390/molecules191220139
   PubMed Web of Science ®Google Scholar
• Ghosh SS, Righi S, Krieg R, Kang L, Carl D, Wang J, Massey HD, Sica DA, Gehr TW, Ghosh S. High fat high cholesterol diet (western diet) aggravates atherosclerosis, hyperglycemia and renal failure in nephrectomized ldl receptor knockout mice: role of intestine derived lipopolysaccharide. PLoS One. 2015;10(11):e0141109. doi:10.1371/journal.pone.0141109
   PubMed Web of Science ®Google Scholar
• Kanter M, Takir M, Mutlu HH, Kanter B, Kostek O, Toprak AE. Protective effects of curcumin on intestinal damage in cholestatic rats. J Invest Surg. 2016;29(3):128–136. doi:10.3109/08941939.2015.1088604
   PubMed Web of Science ®Google Scholar
• Yao Q, Ye X, Wang L, Gu J, Fu T, Wang Y, Lai Y, Wang Y, Wang X, Jin H, Guo Y. Protective effect of curcumin on chemotherapy-induced intestinal dysfunction. Int J Clin Exp Pathol. 2013;6(11):2342–2349
   PubMed Web of Science ®Google Scholar
• McFadden RM, Larmonier CB, Shehab KW, Midura-Kiela M, Ramalingam R, Harrison CA, Besselsen DG, Chase JH, Caporaso JG, Jobin C, Ghishan FK, Kiela PR. The role of curcumin in modulating colonic microbiota during colitis and colon cancer prevention. Inflamm Bowel Dis. 2015;21(11):2483–2494. doi:10.1097/MIB.0000000000000522
   PubMed Web of Science ®Google Scholar
• Zhao HM, Xu R, Huang XY, Cheng SM, Huang MF, Yue HY, Wang X, Zou Y, Lu AP, Liu DY. Curcumin improves regulatory T cells in gut-associated lymphoid tissue of colitis mice. World J Gastroenterol. 2016;22(23):5374–5383. doi:10.3748/wjg.v22.i23.5374
   PubMed Web of Science ®Google Scholar
• Yu Y, Wu S, Li J, Wang R, Xie X, Yu X, Pan J, Xu Y, Zheng L. The effect of curcumin on the brain-gut axis in rat model of irritable bowel syndrome: involvement of 5-HT-dependent signaling. Metab Brain Dis. 2015;30(1):47–55. doi:10.1007/s11011-014-9554-z
   PubMed Web of Science ®Google Scholar
• Cai Y, Lu D, Zou Y, Zhou C, Liu H, Tu C, Li F, Liu L, Zhang S. Curcumin protects against intestinal origin endotoxemia in rat liver cirrhosis by targeting PCSK9. J Food Sci. 2017;82(3):772–780. doi:10.1111/1750-3841.13647
   PubMed Web of Science ®Google Scholar
• Feng D, Zou J, Zhang S, Li X, Lu M. Hypocholesterolemic activity of curcumin is mediated by down-regulating the expression of niemann-pick C1-like 1 in hamsters. J Agric Food Chem. 2017;65(2):276–280. doi:10.1021/acs.jafc.6b04102
   PubMed Web of Science ®Google Scholar
• Oh JG, Hwang DJ, Heo TH. Direct regulation of IL-2 by curcumin. Biochem Biophys Res Commun. 2017 Nov 7;pii:S0006-291X(17) 32216–7
   Google Scholar
• Dempe JS, Scheerle RK, Pfeiffer E, Metzler M. Metabolism and permeability of curcumin in cultured Caco-2 cells. Mol Nutr Food Res. 2013;57(9):1543–1549. doi:10.1002/mnfr.201200113
   PubMed Web of Science ®Google Scholar
• Bartik L, Whitfield GK, Kaczmarska M, Lowmiller CL, Moffet EW, Furmick JK, Hernandez Z, Haussler CA, Haussler MR, Jurutka PW. Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention. J Nutr Biochem. 2010;21(12):1153–1161. doi:10.1016/j.jnutbio.2009.09.012
   PubMed Web of Science ®Google Scholar
• Liu FH, Li SS, Li XX, Wang S, Li MG, Guan L, Luan TG, Liu ZG, Liu ZJ, Yang PC. Vitamin D3 induces vitamin D receptor and HDAC11 binding to relieve the promoter of the tight junction proteins. Oncotarget. 2017;8(35):58781–58789
   PubMed Web of Science ®Google Scholar