Improved oral bioavailability for lutein by nanocrystal technology: formulation development, in vitro and in vivo evaluation

References

• Lin JH, Lee DJ, Chang JS. Lutein in specific marigold flowers and microalgae. J Taiwan Inst Chem Eng. 2015;49:90–94.
   Web of Science ®Google Scholar
• Nimalaratne C, Lopes-Lutz D, Schieber A, et al. A fast isocratic liquid chromatographymethod for the quantification of xanthophylls and their stereoisomers. J Separat Sci. 2016;38:4159–4292.
   Web of Science ®Google Scholar
• Yoo J, Baskaran R, Yoo BK. Self-nanoemulsifying drug delivery system of lutein: physicochemical properties and effect on bioavailability of warfarin. Biomol Ther (Seoul). 2013;21:173–179.
   PubMed Web of Science ®Google Scholar
• Stancanelli R, Løjkner LD, Larsen KL, et al. Structural and spectroscopic features of lutein/butanoyl-β-cyclodextrin nanoassemblies. J Pharm Biomed Anal. 2012;71:214–218.
   PubMed Web of Science ®Google Scholar
• Chena CY, Jesisca, Hsieh CY, et al. Production, extraction and stabilization of lutein from microalga Chlorella sorokiniana MB-1. Bioresource Tech. 2016;200:500–505.
   PubMed Web of Science ®Google Scholar
• Li Y, Zheng JK, Xiao H, et al. Nanoemulsion-based delivery systems for poorly water-soluble bioactive compounds: influence of formulation parameters on polymethoxyflavone crystallization. Food Hydrocolloids. 2012;27:517–528.
   PubMed Web of Science ®Google Scholar
• Kuang PQ, Zhang HC, Bajaj PR, et al. Physicochemical properties and storage stability of lutein microcapsules prepared with maltodextrins and sucrose by spray drying. J Food Sci. 2015;80:359–369.
   Web of Science ®Google Scholar
• Murillo AG, Aguilar D, Norris GH, et al. Compared with powdered lutein, a lutein nanoemulsion increases plasma and liver lutein, protects against hepatic steatosis, and affects lipoprotein metabolism in guinea pigs. J Nutrit. 2016;146:1961–1969.
   PubMed Web of Science ®Google Scholar
• Patravale VB, Date AA, Kulkarni RM. Nanosuspensions: a promising drug delivery strategy. J Pharm Pharmacol. 2004;56:827–840.
   PubMed Web of Science ®Google Scholar
• Gao L, Liu GY, Ma JL, et al. Application of drug nanocrystal technologies on oral drug delivery of poorly soluble drugs. Pharm Res. 2013;30:307–324.
   PubMed Web of Science ®Google Scholar
• Zhang H, Meng Y, Wang XQ, et al. Pharmaceutical and pharmacokinetic characteristics of different type of fenofibrate nanocrystals prepared by different bottom-up approaches. Drug Deliv. 2013;21:588–594.
   PubMed Web of Science ®Google Scholar
• Rabinow BE. Nanosuspensions in drug delivery. Nat Rev Drug Discov. 2004;3:784–796.
   Web of Science ®Google Scholar
• Wang YC, Zheng Y, Zhang L, et al. Stability of nanosuspensions in drug delivery. J Control Release. 2013;172:1126–1141.
   PubMed Web of Science ®Google Scholar
• Lei YY, Kong YD, Sui H, et al. Enhanced oral bioavailability of glycyrrhetinic acid via nanocrystal formulation. Drug Deliv Transl Res. 2016;6:519–525.
   PubMed Web of Science ®Google Scholar
• Mitria K, Shegokara R, Gohlac S, et al. Lutein nanocrystals as antioxidant formulation for oral and dermal delivery. Int J Pharm. 2011;420:141–146.
   PubMedGoogle Scholar
• Vuppalapati L, Cherukuri S, Neeli V, et al. Application of central composite design in optimization of valsartan nanosuspension to enhance its solubility and stability. CDD. 2016;13:143–157.
   PubMed Web of Science ®Google Scholar
• Daraghmeh N, Chowdhry BZ, Leharne SA, et al. Co-processed chitin-mannitol as a new excipient for oro-dispersible tablets. Mar Drugs. 2015;13:1739–1764.
   PubMed Web of Science ®Google Scholar
• Shelar DB, Pawar SK, Vavia PR. Fabrication of isradipine nanosuspension by anti-solvent microprecipitation–high-pressure homogenization method for enhancing dissolution rate and oral bioavailability. Drug Deliv Transl Res. 2013;3:384–391.
   PubMed Web of Science ®Google Scholar
• Waard HD, Hinrichs WLJ, Frijlink HW. A novel bottom-up process to produce drug nanocrystals: controlled crystallization during freeze-drying. J Control Release. 2008;128:179–183.
   PubMed Web of Science ®Google Scholar
• Li DJ, Fang GZ, Liu CQ, et al. Stability of lutein and its esters. Chem Indus Forest Products. 2007;27:112–116.
   Google Scholar
• Rasch MR, Rossinyol E, Hueso JL, et al. Hydrophobic gold nanoparticle self-assembly with phosphatidylcholine lipid: membrane-loaded and janus vesicles. Nano Lett. 2010;10:3733–3739.
   PubMed Web of Science ®Google Scholar
• Bajaj A, Rao MRP, Pardeshi A, et al. Nanocrystallization by evaporative antisolvent technique for solubility and bioavailability enhancement of telmisartan. AAPS PharmSciTech. 2012;13:1331–1340.
   PubMed Web of Science ®Google Scholar
• Kesisoglou F, Panmai S, Wu Y. Nanosizing-oral formulation development and biopharmaceutical evaluation. Adv Drug Deliv Rev. 2007;59:631–644.
   PubMed Web of Science ®Google Scholar
• Tu LX, Yi YN, Wu W, et al. Effects of particle size on the pharmacokinetics of puerarin nanocrystals and microcrystals after oral administration to rat. Int J Pharm. 2013;458:135–140.
   PubMed Web of Science ®Google Scholar
• Liu GP, Zhanga DR, Jiao Y, et al. In vitro and in vivo evaluation of riccardin D nanosuspensions with different particle size. Colloids Surfaces B: Biointerfaces. 2013;102:620–626.
   PubMed Web of Science ®Google Scholar