Chitosan delaying human fibroblast senescence through downregulation of TGF-β signaling pathway

References

• Cristofalo VJ, Kritchevsky D. Cell size and nucleic acid content in the diploid human cell line WI-38 during aging. Med Exp Int J Exp Med. 1969;19:313–320.
   PubMedGoogle Scholar
• Greenberg SB, Grove GL, Cristofalo VJ. Cell size in aging monolayer cultures. In Vitro. 1977;13:297–300.
   PubMedGoogle Scholar
• Mitsui Y, Schneider EL. Relationship between cell replication and volume in senescent human diploid fibroblasts. Mech Ageing Dev. 1976;5:45–56.
   PubMed Web of Science ®Google Scholar
• Dimri GP, Lee X, Basile G, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA. 1995;92:9363–9367.
   PubMed Web of Science ®Google Scholar
• Lee BY, Han JA, Im JS, et al. Senescence-associated beta-galactosidase is lysosomal beta-galactosidase. Aging Cell. 2006;5:187–195.
   PubMed Web of Science ®Google Scholar
• Macieira-Coelho A, Azzarone B. Correlation between contractility and proliferation in human fibroblasts. J Cell Physiol. 1990;142:610–614.
   PubMed Web of Science ®Google Scholar
• Goldstein S. Replicative senescence: the human fibroblast comes of age. Science. 1990;249:1129–1133.
   PubMed Web of Science ®Google Scholar
• Fumagalli M, Rossiello F, Clerici M, et al. Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. Nat Cell Biol. 2012;14:355–365.
   PubMed Web of Science ®Google Scholar
• Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature. 1990;345:458–460.
   PubMed Web of Science ®Google Scholar
• Chen Q, Ames BN. Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. Proc Natl Acad Sci USA. 1994;91:4130–4134.
   PubMed Web of Science ®Google Scholar
• Parrinello S, Samper E, Krtolica A, et al. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol. 2003;5:741–747.
   PubMed Web of Science ®Google Scholar
• Passos JF, Miwa S, von Zglinicki T. Measuring reactive oxygen species in senescent cells. Methods Mol Biol. 2013;965:253–263.
   PubMedGoogle Scholar
• Tchkonia T, Zhu Y, van Deursen J, et al. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J Clin Investig. 2013;123:966–972.
   PubMed Web of Science ®Google Scholar
• Zhu Y, Armstrong JL, Tchkonia T, et al. Cellular senescence and the senescent secretory phenotype in age-related chronic diseases. Curr Opin Clin Nutr Metab Care. 2014;17:324–328.
   PubMed Web of Science ®Google Scholar
• Campisi J. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol. 2001;11:S27–S31.
   PubMed Web of Science ®Google Scholar
• Kiyono T. Molecular mechanisms of cellular senescence and immortalization of human cells. Expert Opin Ther Targets. 2007;11:1623–1637.
   PubMed Web of Science ®Google Scholar
• Piegari E, De Angelis A, Cappetta D, et al. Doxorubicin induces senescence and impairs function of human cardiac progenitor cells. Basic Res Cardiol. 2013;108:334.
   PubMed Web of Science ®Google Scholar
• Choi HR, Cho KA, Kang HT, et al. Restoration of senescent human diploid fibroblasts by modulation of the extracellular matrix. Aging Cell. 2011;10:148–157.
   PubMed Web of Science ®Google Scholar
• Sato Y, Yoshida K, Nozawa S, et al. Establishment of adult mouse Sertoli cell lines by using the starvation method. Reproduction. 2013;145:505–516.
   PubMed Web of Science ®Google Scholar
• Buttiglieri S, Ruella M, Risso A, et al. The aging effect of chemotherapy on cultured human mesenchymal stem cells. Exp Hematol. 2011;39:1171–1181.
   PubMed Web of Science ®Google Scholar
• Tsai CC, Chen YJ, Yew TL, et al. Hypoxia inhibits senescence and maintains mesenchymal stem cell properties through down-regulation of E2A-p21 by HIF-TWIST. Blood. 2011;117:459–469.
   PubMed Web of Science ®Google Scholar
• Tsai CW, Kao YT, Chiang IN, et al. Chitosan treatment delays the induction of senescence in human foreskin fibroblast strains. PLoS One. 2015;10:e0140747.
   PubMed Web of Science ®Google Scholar
• Kas HS. Chitosan: properties, preparations and application to microparticulate systems. J Microencapsul. 1997;14:689–711.
   PubMed Web of Science ®Google Scholar
• Shi C, Zhu Y, Ran X, et al. Therapeutic potential of chitosan and its derivatives in regenerative medicine. J Surg Res. 2006;133:185–192.
   PubMed Web of Science ®Google Scholar
• Yang TL, Lin L, Hsiao YC, et al. Chitosan biomaterials induce branching morphogenesis in a model of tissue-engineered glandular organs in serum-free conditions. Tissue Eng Part A. 2012;18:2220–2230.
   PubMed Web of Science ®Google Scholar
• Cheng NC, Wang S, Young TH. The influence of spheroid formation of human adipose-derived stem cells on chitosan films on stemness and differentiation capabilities. Biomaterials. 2012;33:1748–1758.
   PubMed Web of Science ®Google Scholar
• Chen YH, Chung YC, Wang IJ, et al. Control of cell attachment on pH-responsive chitosan surface by precise adjustment of medium pH. Biomaterials. 2012;33:1336–1342.
   PubMed Web of Science ®Google Scholar
• Lou PJ, Chiu MY, Chou CC, et al. The effect of poly (ethylene-co-vinyl alcohol) on senescence-associated alterations of human dermal fibroblasts. Biomaterials. 2010;31:1568–1577.
   PubMed Web of Science ®Google Scholar
• Giacinti C, Giordano A. RB and cell cycle progression. Oncogene. 2006;25:5220–5227.
   PubMed Web of Science ®Google Scholar
• Hernando E, Nahle Z, Juan G, et al. Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control. Nature. 2004;430:797–802.
   PubMed Web of Science ®Google Scholar
• Ishihara M, Fujita M, Obara K, et al. Controlled releases of FGF-2 and paclitaxel from chitosan hydrogels and their subsequent effects on wound repair, angiogenesis, and tumor growth. Curr Drug Deliv. 2006;3:351–358.
   PubMedGoogle Scholar
• Masuoka K, Ishihara M, Asazuma T, et al. The interaction of chitosan with fibroblast growth factor-2 and its protection from inactivation. Biomaterials. 2005;26:3277–3284.
   PubMed Web of Science ®Google Scholar
• Zerlanko BJ, Bartholin L, Melhuish TA, et al. Premature senescence and increased TGFbeta signaling in the absence of Tgif1. PLoS One. 2012;7:e35460.
   PubMed Web of Science ®Google Scholar
• Abbas T, Dutta A. p21 in cancer: intricate networks and multiple activities. Nat Rev Cancer. 2009;9:400–414.
   PubMed Web of Science ®Google Scholar
• Pandamooz S, Hadipour A, Akhavan-Niaki H, et al. Short exposure to collagenase and coculture with mouse embryonic pancreas improve human dermal fibroblast culture. Biotechnol Appl Biochem. 2012;59:254–261.
   PubMed Web of Science ®Google Scholar
• Tsai CW, Young TH. CD44 expression trends of mesenchymal stem-derived cell, cancer cell and fibroblast spheroids on chitosan-coated surfaces. Pure Appl Chem. 2016;88:843–852.
   Web of Science ®Google Scholar
• Severino J, Allen RG, Balin S, et al. Is beta-galactosidase staining a marker of senescence in vitro and in vivo? Exp Cell Res. 2000;257:162–171.
   PubMed Web of Science ®Google Scholar
• Munoz-Espin D, Serrano M. Cellular senescence: from physiology to pathology. Nat Rev Mol Cell Biol. 2014;15:482–496.
   PubMed Web of Science ®Google Scholar
• Beausejour CM, Krtolica A, Galimi F, et al. Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J. 2003;22:4212–4222.
   PubMed Web of Science ®Google Scholar
• Campisi J, di Fagagna FD. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol. 2007;8:729–740.
   PubMed Web of Science ®Google Scholar
• Senturk S, Mumcuoglu M, Gursoy-Yuzugullu O, et al. Transforming growth factor-beta induces senescence in hepatocellular carcinoma cells and inhibits tumor growth. Hepatology. 2010;52:966–974.
   PubMed Web of Science ®Google Scholar
• Bai H, Gao Y, Hoyle DL, et al. Suppression of transforming growth factor-beta signaling delays cellular senescence and preserves the function of endothelial cells derived from human pluripotent stem cells. Stem Cells Transl Med. 2017;6:589.
   PubMed Web of Science ®Google Scholar
• Lasry A, Ben-Neriah Y. Senescence-associated inflammatory responses: aging and cancer perspectives. Trends Immunol. 2015;36:217–228.
   PubMed Web of Science ®Google Scholar
• Ahmadi F, Oveisi Z, Samani SM, et al. Chitosan based hydrogels: characteristics and pharmaceutical applications. Res Pharm Sci. 2015;10:1–16.
   PubMed Web of Science ®Google Scholar
• Saether HV, Holme HK, Maurstald G, et al. Polyelectrolyte complex formation using alginate and chitosan. Carbohydr Polym. 2008;74:813–821.
   Web of Science ®Google Scholar
• Chen MH, Chen YJ, Liao CC, et al. Formation of salivary acinar cell spheroids in vitro above a polyvinyl alcohol-coated surface. J Biomed Mater Res. 2009;90A:1066–1072.
   Web of Science ®Google Scholar
• Kim JH, Lim IR, Joo HJ, et al. Sphere formation of adipose stem cell engineered by poly-2-hydroxyethyl methacrylate induces in vitro angiogenesis through fibroblast growth factor 2. Biochem Biophys Res Commun. 2015;468:372–379.
   PubMed Web of Science ®Google Scholar
• Li CY, Suardet L, Little JB. Potential role of Waf1/Cip1/P21 as a mediator of Tgf-Beta cytoinhibitory effect. J Biol Chem. 1995;270:4971–4974.
   PubMed Web of Science ®Google Scholar
• Wu JF, Niu J, Li XP, et al. TGF-beta 1 induces senescence of bone marrow mesenchymal stem cells via increase of mitochondrial ROS production. BMC Dev Biol. 2014;14:21.
   PubMed Web of Science ®Google Scholar
• Lin S, Yang JH, Elkahloun AG, et al. Attenuation of TGF-beta signaling suppresses premature senescence in a p21-dependent manner and promotes oncogenic Ras-mediated metastatic transformation in human mammary epithelial cells. Mol Biol Cell. 2012;23:1569–1581.
   PubMed Web of Science ®Google Scholar
• Nicolas FJ, Hill CS. Attenuation of the TGF-beta-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-beta-induced growth arrest. Oncogene. 2003;22:3698–3711.
   PubMed Web of Science ®Google Scholar
• Rabinow BE, Ding YS, Qin C, et al. Biomaterials with permanent hydrophilic surfaces and low-protein adsorption properties. J Biomater Sci Polym E. 1994;6:91–109.
   PubMed Web of Science ®Google Scholar
• Liu SX, Kim JT, Kim S. Effect of polymer surface modification on polymer-protein interaction via hydrophilic polymer grafting. J Food Sci. 2008;73:E143–E150.
   PubMed Web of Science ®Google Scholar
• Martins MCL, Wang D, Ji J, et al. Albumin and fibrinogen adsorption on PU-PHEMA surfaces. Biomaterials. 2003;24:2067–2076.
   PubMed Web of Science ®Google Scholar