5,042
Views
72
CrossRef citations to date
0
Altmetric
Articles

Development of transethosomes formulation for dermal fisetin delivery: Box–Behnken design, optimization, in vitro skin penetration, vesicles–skin interaction and dermatokinetic studies

, ORCID Icon, , , , , & show all
Pages 755-765 | Received 08 Mar 2018, Accepted 20 Apr 2018, Published online: 07 May 2018

References

  • Afaq F. Natural agents: cellular and molecular mechanisms of photoprotection. Arch Biochem Biophys. 2011;508:144–151.
  • Cohen JL. Actinic keratosis treatment as a key component of preventive strategies for nonmelanoma skin cancer. J Clin Aesthet Dermatol. 2010;3:39–44.
  • Bowden GT. Prevention of non-melanoma skin cancer by targeting ultraviolet-B-light signalling. Nat Rev Cancer. 2004;4:23–35.
  • Kurundkar D, Srivastava RK, Chaudhary SC, et al. Vorinostat, an HDAC inhibitor attenuates epidermoid squamous cell carcinoma growth by dampening mTOR signaling pathway in a human xenograft murine model. Toxicol Appl Pharmacol. 2013;266:233–244.
  • Tang X, Zhu Y, Han L, et al. CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice. J Clin Investig. 2007;117:3753–3764.
  • Syed DN, Suh Y, Afaq F, et al. Dietary agents for chemoprevention of prostate cancer. Cancer Lett. 2008;265:167–176.
  • Arai Y, Watanabe S, Kimira M, et al. Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. J Nutr. 2000;130:2243–2250.
  • Syed DN, Afaq F, Maddodi N, et al. Inhibition of human melanoma cell growth by the dietary flavonoid fisetin is associated with disruption of Wnt/beta-catenin signaling and decreased Mitf levels. J Investig Dermatol. 2011;131:1291–1299.
  • Khan N, Afaq F, Khusro FH, et al. Dual inhibition of phosphatidylinositol 3-kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin. Int J Cancer. 2012;130:1695–1705.
  • Hou DX, Fukuda M, Johnson JA, et al. Fisetin induces transcription of NADPH:quinone oxidoreductase gene through an antioxidant responsive element-involved activation. Int J Oncol. 2001;18:1175–1179.
  • Pal HC, Athar M, Elmets CA, et al. Fisetin inhibits UVB-induced cutaneous inflammation and activation of PI3K/AKT/NFκB signaling pathways in SKH-1 hairless mice. Photochem Photobiol. 2015;91:225–234.
  • Pal HC, Sharma S, Elmets CA, et al. Fisetin inhibits growth, induces G(2)/M arrest and apoptosis of human epidermoid carcinoma A431 cells: role of mitochondrial membrane potential disruption and consequent caspases activation. Exp Dermatol. 2013;22:470–475.
  • Pal HC, Sharma S, Strickland LR, et al. Fisetin inhibits human melanoma cell invasion through promotion of mesenchymal to epithelial transition and by targeting MAPK and NFkappaB signaling pathways. PLoS One. 2014;9:e86338.
  • Sabitha M, Sanoj Rejinold N, Nair A, et al. Development and evaluation of 5-fluorouracil loaded chitin nanogels for treatment of skin cancer. Carbohydr Polym. 2013;91:48–57.
  • Mezei M, Gulasekharam V. Liposomes – a selective drug delivery system for the topical route of administration. Lotion dosage form. Life Sci. 1980;26:1473–1477.
  • Verma DD, Verma S, Blume G, et al. Particle size of liposomes influences dermal delivery of substances into skin. Int J Pharm. 2003;258:141–151.
  • Manosroi A, Jantrawut P, Manosroi J. Anti-inflammatory activity of gel containing novel elastic niosomes entrapped with diclofenac diethylammonium. Int J Pharm. 2008;360:156–163.
  • Cevc G, Blume G. Lipid vesicles penetrate into intact skin owing to the transdermal osmotic gradients and hydration force. Biochim Biophys Acta. 1992;1104:226–232.
  • Ahad A, Raish M, Ahmad A, et al. Development and biological evaluation of vesicles containing bile salt of telmisartan for the treatment of diabetic nephropathy. Artif Cells Nanomed Biotechnol. 2018. Forthcoming. doi:10.1080/21691401.2018.1430700
  • Ahad A, Al-Saleh AA, Al-Mohizea AM, et al. Formulation and characterization of novel soft nanovesicles for enhanced transdermal delivery of eprosartan mesylate. Saudi Pharm J. 2017;25:1040–1046.
  • Ahad A, Al-Saleh AA, Al-Mohizea AM, et al. Formulation and characterization of Phospholipon 90 G and tween 80 based transfersomes for transdermal delivery of eprosartan mesylate. Pharm Dev Technol. 2017. Forthcoming. doi:10.1080/10837450.2017.1330345
  • Ahad A, Aqil M, Kohli K, et al. Formulation and optimization of nanotransfersomes using experimental design technique for accentuated transdermal delivery of valsartan. Nanomedicine. 2012;8:237–249.
  • Cevc G. Transfersomes, liposomes and other lipid suspensions on the skin: permeation enhancement, vesicle penetration, and transdermal drug delivery. Crit Rev Ther Drug Carrier Syst. 1996;13:257–388.
  • El Maghraby GM, Williams AC, Barry BW. Interactions of surfactants (edge activators) and skin penetration enhancers with liposomes. Int J Pharm. 2004;276:143–161.
  • Touitou E, Dayan N, Bergelson L, et al. Ethosomes – novel vesicular carriers for enhanced delivery: characterization and skin penetration properties. J Control Release. 2000;65:403–418.
  • Godin B, Touitou E. Erythromycin ethosomal systems: physicochemical characterization and enhanced antibacterial activity. Curr Drug Deliv. 2005;2:269–275.
  • Ahad A, Raish M, Al-Mohizea AM, et al. Enhanced anti-inflammatory activity of carbopol loaded meloxicam nanoethosomes gel. Int J Biol Macromol. 2014;67:99–104.
  • Ahad A, Aqil M, Kohli K, et al. Enhanced transdermal delivery of an anti-hypertensive agent via nanoethosomes: statistical optimization, characterization and pharmacokinetic assessment. Int J Pharm. 2013;443:26–38.
  • Ahad A, Aqil M, Kohli K, et al. Nano vesicular lipid carriers of angiotensin II receptor blocker: anti-hypertensive and skin toxicity study in focus. Artif Cells Nanomed Biotechnol. 2016;44:1002–1007.
  • Song CK, Balakrishnan P, Shim CK, et al. A novel vesicular carrier, transethosome, for enhanced skin delivery of voriconazole: characterization and in vitro/in vivo evaluation. Colloids Surf B Biointerfaces. 2012;92:299–304.
  • Abdulbaqi IM, Darwis Y, Khan NA, et al. Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials. Int J Nanomedicine. 2016;11:2279–2304.
  • Javed MN, Kohli K, Amin S. Risk assessment integrated QbD approach for development of optimized bicontinuous mucoadhesive limicubes for oral delivery of rosuvastatin. AAPS PharmSciTech. 2018;19:1377–1391.
  • Alam MS, Garg A, Pottoo FH, et al. Gum ghatti mediated, one pot green synthesis of optimized gold nanoparticles: investigation of process-variables impact using Box-Behnken based statistical design. Int J Biol Macromol. 2017;104:758–767.
  • Imam SS, Ahad A, Aqil M, et al. Formulation by design based risperidone nano soft lipid vesicle as a new strategy for enhanced transdermal drug delivery: in-vitro characterization, and in-vivo appraisal. Mater Sci Eng C Mater Biol Appl. 2017;75:1198–1205.
  • Ahad A, Aqil M, Ali A. The application of anethole, menthone, and eugenol in transdermal penetration of valsartan: enhancement and mechanistic investigation. Pharm Biol. 2016;54:1042–1051.
  • Ahad A, Aqil M, Kohli K, et al. Interactions between novel terpenes and main components of rat and human skin: mechanistic view for transdermal delivery of propranolol hydrochloride. Curr Drug Deliv. 2011;8:213–224.
  • Ahad A, Aqil M, Kohli K, et al. Design, formulation and optimization of valsartan transdermal gel containing iso-eucalyptol as novel permeation enhancer: preclinical assessment of pharmacokinetics in Wistar albino rats. Expert Opin Drug Deliv. 2014;11:1149–1162.
  • Ahad A, Aqil M, Kohli K, et al. Role of novel terpenes in transcutaneous permeation of valsartan: effectiveness and mechanism of action. Drug Dev Ind Pharm. 2011;37:583–596.
  • Chen Y, Wu Q, Song L, et al. Polymeric micelles encapsulating fisetin improve the therapeutic effect in colon cancer. ACS Appl Mater Interfaces. 2015;7:534–542.
  • Kamran M, Ahad A, Aqil M, et al. Design, formulation and optimization of novel soft nano-carriers for transdermal olmesartan medoxomil delivery: in vitro characterization and in vivo pharmacokinetic assessment. Int J Pharm. 2016;505:147–158.
  • Ahad A, Al-Saleh AA, Al-Mohizea AM, et al. Pharmacodynamic study of eprosartan mesylate-loaded transfersomes Carbopol((R)) gel under Dermaroller((R)) on rats with methyl prednisolone acetate-induced hypertension. Biomed Pharmacother. 2017;89:177–184.
  • Ahad A, Aqil M, Ali A. Investigation of antihypertensive activity of carbopol valsartan transdermal gel containing 1,8-cineole. Int J Biol Macromol. 2014;64:144–149.
  • Iqbal B, Ali J, Baboota S. Silymarin loaded nanostructured lipid carrier: from design and dermatokinetic study to mechanistic analysis of epidermal drug deposition enhancement. J Mol Liq. 2018;255:513–529.
  • Negi P, Singh B, Sharma G, et al. Biocompatible lidocaine and prilocaine loaded-nanoemulsion system for enhanced percutaneous absorption: QbD-based optimisation, dermatokinetics and in vivo evaluation. J Microencapsul. 2015;32:419–431.
  • Dubey V, Mishra D, Dutta T, et al. Dermal and transdermal delivery of an anti-psoriatic agent via ethanolic liposomes. J Control Release. 2007;123:148–154.
  • El Zaafarany GM, Awad GA, Holayel SM, et al. Role of edge activators and surface charge in developing ultradeformable vesicles with enhanced skin delivery. Int J Pharm. 2010;397:164–172.
  • Kirjavainen M, Monkkonen J, Saukkosaari M, et al. Phospholipids affect stratum corneum lipid bilayer fluidity and drug partitioning into the bilayers. J Control Release. 1999;58:207–214.
  • Elsayed MM, Abdallah OY, Naggar VF, et al. Deformable liposomes and ethosomes: mechanism of enhanced skin delivery. Int J Pharm. 2006;322:60–66.
  • Vaddi HK, Ho PC, Chan YW, et al. Terpenes in ethanol: haloperidol permeation and partition through human skin and stratum corneum changes. J Control Release. 2002;81:121–133.
  • McGillis ST, Fein H. Topical treatment strategies for non-melanoma skin cancer and precursor lesions. Semin Cutan Med Surg. 2004;23:174–183.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.