Transdermal delivery system of nanostructured lipid carriers loaded with Celastrol and Indomethacin: optimization, characterization and efficacy evaluation for rheumatoid arthritis

References

• Doss HM, Ganesan R, Rasool M. Trikatu, an herbal compound ameliorates rheumatoid arthritis by the suppression of inflammatory immune responses in rats with adjuvant-induced arthritis and on cultured fibroblast like synoviocytes via the inhibition of the NFκB signaling pathway. Chem-Biol Interact. 2016;258:175–186.
   PubMed Web of Science ®Google Scholar
• Venkatesha SH, Astry B, Nanjundaiah SM, et al. Suppression of autoimmune arthritis by Celastrus-derived Celastrol through modulation of pro-inflammatory chemokines. Bioorg Med Chem. 2012;20:5229–5234.
   PubMed Web of Science ®Google Scholar
• Cascão R, Vidal B, Raquel H, et al. Effective treatment of rat adjuvant-induced arthritis by Celastrol. Autoimmun Rev. 2012;11:856–862.
   PubMed Web of Science ®Google Scholar
• Vitorino C, Almeida J, Gonçalves LM, et al. Co-encapsulating nanostructured lipid carriers for transdermal application: from experimental design to the molecular detail. J Control Release. 2013;167:301–314.
   PubMed Web of Science ®Google Scholar
• Wissing SA, Müller RH. Cosmetic applications for solid lipid nanoparticles (SLN). Int J Pharm. 2003;254:65.
   PubMed Web of Science ®Google Scholar
• Khurana S, Jain NK, Bedi PMS. Nanoemulsion based gel for transdermal delivery of meloxicam: physico-chemical, mechanistic investigation. Life Sci. 2013;92:383–392.
   PubMed Web of Science ®Google Scholar
• Kogan A, Garti N. Microemulsions as transdermal drug delivery vehicles. Adv Colloid Interface Sci. 2006;123–126:369–385.
   PubMed Web of Science ®Google Scholar
• Shakeel F, Baboota S, Ahuja A, et al. Skin permeation mechanism of aceclofenac using novel nanoemulsion formulation. Pharmazie. 2008;63:580–584.
   PubMed Web of Science ®Google Scholar
• Su R, Fan W, Yu Q, et al. Size-dependent penetration of nanoemulsions into epidermis and hair follicles: implications for transdermal delivery and immunization. Oncotarget. 2017;8: 38214–38226.
   PubMedGoogle Scholar
• Garg NK, Singh B, Tyagi RK, et al. Effective transdermal delivery of methotrexate through nanostructured lipid carriers in an experimentally induced arthritis model. Colloids Surf B: Biointerfaces. 2016;147:17–24.
   PubMed Web of Science ®Google Scholar
• Chen Y, Zhou L, Yuan L, et al. Formulation, characterization, and evaluation of in vitro skin permeation and in vivo pharmacodynamics of surface-charged tripterine-loaded nanostructured lipid carriers. Int J Nanomedicine. 2012;7:3023–3033.
   PubMed Web of Science ®Google Scholar
• Guo T, Zhang Y, Li Z, et al. Microneedle-mediated transdermal delivery of nanostructured lipid carriers for alkaloids from Aconitum sinomontanum. Artif Cells Nanomedicine Biotechnol. 2017;1–11.DOI:10.1080/21691401.2017.1376676
   PubMed Web of Science ®Google Scholar
• Ghate VM, Lewis SA, Prabhu P, et al. Nanostructured lipid carriers for the topical delivery of tretinoin. Eur J Pharm Biopharm. 2016;108:253–261.
   PubMed Web of Science ®Google Scholar
• Moghddam SM, Ahad A, Aqil M, et al. Optimization of nanostructured lipid carriers for topical delivery of nimesulide using Box–Behnken design approach. Artif Cells Nanomed Biotechnol. 2017;45(3):617–624.
   PubMed Web of Science ®Google Scholar
• Kumar A, Pathak K, Bali V. Ultra-adaptable nanovesicular systems: a carrier for systemic delivery of therapeutic agents. Drug Discov Today. 2012;17:1233–1241.
   PubMed Web of Science ®Google Scholar
• Hu X, Fan W, Yu Z, et al. Evidence does not support absorption of intact solid lipid nanoparticles via oral delivery. Nanoscale. 2016;8:7024–7035.
   PubMed Web of Science ®Google Scholar
• Xie Y, Hu X, He H, et al. Tracking translocation of glucan microparticles targeting M cells: implications for oral drug delivery. J Mater Chem B. 2016;4:2864–2873.
   PubMed Web of Science ®Google Scholar
• Hu X, Zhang J, Yu Z, et al. Environment-responsive aza-BODIPY dyes quenching in water as potential probes to visualize the in vivo fate of lipid-based nanocarriers. Nanomedicine. 2015;11:1939–1948.
   PubMed Web of Science ®Google Scholar
• Wang X, Xue M, Gu J, et al. Transdermal microemulsion drug delivery system for impairing male reproductive toxicity and enhancing efficacy of Tripterygium Wilfordii Hook f. Fitoterapia. 2012;83:690–698.
   PubMed Web of Science ®Google Scholar
• Jia M, Deng C, Luo J, et al. A novel dexamethasone-loaded liposome alleviates rheumatoid arthritis in rats. Int J Pharm. 2018;540:57–64.
   PubMed Web of Science ®Google Scholar
• Kaur A, Bhoop BS, Chhibber S, et al. Supramolecular nano-engineered lipidic carriers based on diflunisal-phospholipid complex for transdermal delivery: QbD based optimization, characterization and preclinical investigations for management of rheumatoid arthritis. Int J Pharm. 2017;533:206–224.
   PubMed Web of Science ®Google Scholar
• Zeb A, Qureshi OS, Yu C-H, et al. Enhanced anti-rheumatic activity of methotrexate-entrapped ultradeformable liposomal gel in adjuvant-induced arthritis rat model. Int J Pharm. 2017;525:92–100.
   PubMed Web of Science ®Google Scholar
• Joshi SA, Jalalpure SS, Kempwade AA, et al. Fabrication and in-vivo evaluation of lipid nanocarriers based transdermal patch of colchicine. J Drug Deliv Sci Technol. 2017;41:444–453.
   Web of Science ®Google Scholar
• Liu J, Hu W, Chen H, et al. Isotretinoin-loaded solid lipid nanoparticles with skin targeting for topical delivery. Int J Pharm. 2007;328:191–195.
   PubMed Web of Science ®Google Scholar
• Castro GA, Coelho ALLR, Oliveira CA, et al. Formation of ion pairing as an alternative to improve encapsulation and stability and to reduce skin irritation of retinoic acid loaded in solid lipid nanoparticles. Int J Pharm. 2009;381:77–83.
   PubMed Web of Science ®Google Scholar
• Pu Y, Cao D, Xie C, et al. Anti-arthritis effect of a novel quinazoline derivative through inhibiting production of TNF-α mediated by TNF-α converting enzyme in murine collagen-induced arthritis model. Biochem Biophys Res Commun. 2015;462:288–293.
   PubMed Web of Science ®Google Scholar
• Wu Q, Wang Y, Wang Q, et al. The bispecific antibody aimed at the vicious circle of IL-1β and IL-17A, is beneficial for the collagen-induced rheumatoid arthritis of mice through NF-κB signaling pathway. Immunol Lett. 2016;179:68–79.
   PubMed Web of Science ®Google Scholar
• Riley JL, Cruz-Almeida Y, Dasilva Ribeiro MC, et al. Age differences in the time course and magnitude of changes in circulating neuropeptides after pain evocation in humans. J Pain. 2017;18:1078–1086.
   PubMed Web of Science ®Google Scholar
• Zheng B, Hu L, Song X, et al. Analgesic effect of different moxibustion durations in rheumatoid arthritis rats. J Trad Chin Med. 2014;34:90–95.
   PubMed Web of Science ®Google Scholar