Semisynthetic supra plasma expanders: a new class of therapeutics to improve microcircualtion in sickle cell anaemia

References

• Dieterich HJ. Recent developments in European colloid solutions. J Trauma. 2003;54:S26–S30.
   PubMedGoogle Scholar
• Schortgen F, Deye N, Brochard L. Preferred plasma volume expanders for critically ill patients: results of an international survey. Intensive Care Med. 2004;30:2222–2229.
   PubMed Web of Science ®Google Scholar
• Winslow RM, Lohman J, Malavalli A, et al. Comparison of PEG-modified albumin and hemoglobin in extreme hemodilution in the rat. J Appl Physiol. 2004;97:1527–1534.
   PubMed Web of Science ®Google Scholar
• Assaly RA, Azizi M, Kennedy DJ, et al. Plasma expansion by polyethylene-glycol-modified albumin. Clin Sci. 2004;107:263–272.
   PubMed Web of Science ®Google Scholar
• Cabrales P, Tsai AG, Winslow RM, et al. Extreme hemodilution with PEG-hemoglobin vs. PEG-albumin. Am J Physiol Heart Circ Physiol. 2005;289:H2392–2H2400.
   PubMed Web of Science ®Google Scholar
• Martini J, Cabrales P, Ananda K, et al. Survival time in severe hemorrhagic shock after perioperative hemodilution is longer with PEG-conjugated human serum albumin than with HES 130/0.4: a microvascular perspective. Crit Care. 2008;12:R54.
   PubMed Web of Science ®Google Scholar
• Sriram K, Tsai AG, Cabrales P, et al. PEG-albumin supra plasma expansion is due to increased vessel wall shear stress induced by blood viscosity shear thinning. Am J Physiol Heart Circ Physiol. 2012;302:H2489–H2497.
   PubMed Web of Science ®Google Scholar
• Dos Santos JL, Chin CM. Recent insights on the medicinal chemistry of sickle cell disease. Curr Med Chem. 2011;18:2339–2358.
   PubMed Web of Science ®Google Scholar
• Wang WC. The pharmacotherapy of sickle cell disease. Expert Opin Pharmacother. 2008;9:3069–3082.
   PubMed Web of Science ®Google Scholar
• Wood KC, Granger DN. Sickle cell disease: role of reactive oxygen and nitrogen metabolites. Clin Exp Pharmacol Physiol. 2007;34:926–932.
   PubMed Web of Science ®Google Scholar
• Winslow RM. MP4, a new nonvasoactive polyethylene glycol-hemoglobin conjugate. Artif Organs. 2004;28:800–806.
   PubMed Web of Science ®Google Scholar
• Hsai CJ. Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules. United State patent 5,840,701, 1998.
   Google Scholar
• Manjula BN, Acharya AS. In: Nagel, R. L. editors. Methods in molecular medicine: hemoglobin disorders: molecular methods and protocols. Vol. 82, Totowa (NJ): Humana Press; 2003. p. 31–47.
   Google Scholar
• Manjula BN, Tsai A, Upadhya R, et al. Site-specific PEGylation of hemoglobin at Cys-93(beta): correlation between the colligative properties of the PEGylated protein and the length of the conjugated PEG chain. Bioconjugate Chem. 2003;14:464–472.
   PubMed Web of Science ®Google Scholar
• Manjula BN, Tsai AG, Intaglietta M, et al. Conjugation of multiple copies of polyethylene glycol to hemoglobin facilitated through thiolation: influence on hemoglobin structure and function. Protein J. 2005;24:133–463.
   PubMed Web of Science ®Google Scholar
• Meng F, Manjula BN, Smith PK, et al. PEGylation of human serum albumin: reaction of PEG-phenyl-isothiocyanate with protein. Bioconjugate Chem. 2008;19:1352–1360.
   PubMed Web of Science ®Google Scholar
• Baez S. An open cremaster muscle preparation for the study of blood vessels by in vivo microscopy. Microvas Res. 1973;5:384–394.
   PubMed Web of Science ®Google Scholar
• Kaul DK, Fabry ME, Costantini F, et al. In vivo demonstration of red cell-endothelial interaction, sickling and altered microvascular response to oxygen in the sickle transgenic mouse. J Clin Invest. 1995;96:2845–2853.
   PubMed Web of Science ®Google Scholar
• Silva J, Intaglietta M. The correlation of photometric signals derived from in vivo red blood cell flow in microvessels. Microvasc Res. 1974;7:156–169.
   PubMed Web of Science ®Google Scholar
• Wayland H, Johnson PC. Erythrocyte velocity measurement in microvessels by a two-slit photometric method. J Appl Physiol. 1967;22:333–337.
   PubMed Web of Science ®Google Scholar
• Baker M, Wayland H. On-line volume flow rate and velocity profile measurement for blood in microvessels. Microvasc Res. 1974;7:131–143.
   PubMed Web of Science ®Google Scholar
• Lipowsky HH, Usami S, Chien S. In vivo measurements of “apparent viscosity” and microvessel hematocrit in the mesentery of the cat. Microvasc Res. 1980;19:297–319.
   PubMed Web of Science ®Google Scholar
• Kaul DK, Hebbel RP. Hypoxia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice [see comments]. J Clin Invest. 2000;106:411–420.
   PubMed Web of Science ®Google Scholar
• Kaul DK, Liu XD, Choong S, et al. Anti-inflammatory therapy ameliorates leukocyte adhesion and microvascular flow abnormalities in transgenic sickle mice. Am J Physiol Heart Circ Physiol. 2004;287:H293–H301.
   PubMed Web of Science ®Google Scholar
• Vandegriff KD, McCarthy M, Rohlfs RJ, et al. Colloid osmotic properties of modified hemoglobins: chemically cross-linked versus polyethylene glycol surface-conjugated. Biophys Chem. 1997;69:23–30.
   PubMed Web of Science ®Google Scholar
• Migita R, Gonzales A, Gonzales ML, et al. Blood volume and cardiac index in rats after exchange transfusion with hemoglobin-based oxygen carriers. J Appl Physiol (1985). 1997;82:1995–2002.
   PubMed Web of Science ®Google Scholar
• Nath KA, Katusic ZS. Vasculature and kidney complications in sickle cell disease. J Am Soc Nephrol. 2012;23:781–784.
   PubMed Web of Science ®Google Scholar
• Acharya SA, Intaglietta M, Tsai AG, et al. In: Kim HW, Greenburg AG, editors. Hemoglobin-based oxygen carriers as red cell substitutes and oxygen therapeutics. Heidelberg, Germany: Springer-Verlag Berlin Heidelberg; 2013. Chapter 11, Design of non-hypertensive conjugated hemoglobins as novel resuscitation fluids. p. 185–234.
   Google Scholar
• Salazar Vázquez BY, Hightower CM, Yalcin O, et al. Semisynthetic hybrid biopolymers for non-pharmacological intervention of the microcirculation. Curr Drug Metab. 2013;14:540–546.
   PubMed Web of Science ®Google Scholar
• Tasi AG, Cabrales P, Young MK, et al. Microvascular response to cell free Hb infusion in transgenic mouse model of sickle cell anemia. FASEB J. 2009;23(Suppl. 1).
   Google Scholar
• Moloughney JG, Weisleder N. Poloxamer 188 (P188) as a membrane resealing reagent in biomedical applications. Recent Pat Biotechnol. 2012;6:200–211.
   PubMedGoogle Scholar
• Belcher JD, Young M, Chen C, et al. MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation, and vaso-occlusion in transgenic sickle mice. Blood. 2013;122:2757–2764.
   PubMed Web of Science ®Google Scholar
• Vandegriff KD, Young MA, Lohman J, et al. CO-MP4, a polyethylene glycol-conjugated haemoglobin derivative and carbon monoxide carrier that reduces myocardial infarct size in rats. Br J Pharmacol. 2009;154:1649–1661.
   Web of Science ®Google Scholar
• Klaus JA, Kibler KK, Abuchowski A, et al. Early treatment of transient focal cerebral ischemia with bovine PEGylated carboxy hemoglobin transfusion. Artif Cells Blood Substit Immobil Biotechnol. 2010;38:223–229.
   PubMed Web of Science ®Google Scholar
• Ananthakrishnan R, Li Q, O’Shea KM, et al. Carbon monoxide form of PEGylated hemoglobin protects myocardium against ischemia/reperfusion injury in diabetic and normal mice. Artif Cells Nanomed Biotechnol. 2013;41:428–436.
   PubMed Web of Science ®Google Scholar
• Zhang J, Cao S, Kwansa H, et al. Transfusion of hemoglobin-based oxygen carriers in the carboxy state is beneficial during transient focal cerebral ischemia. J Appl Physiol (1985). 2012;113:1709–1717.
   PubMed Web of Science ®Google Scholar