6,056
Views
64
CrossRef citations to date
0
Altmetric
Research Article

Fabrication of hesperidin nanoparticles loaded by poly lactic co-Glycolic acid for improved therapeutic efficiency and cytotoxicity

, ORCID Icon, , &
Pages 378-394 | Received 05 Sep 2018, Accepted 23 Nov 2018, Published online: 29 Jan 2019

References

  • Bharali DJ, Mousa SA. Emerging nanomedicines for early cancer detection and improved treatment: current perspective and future promise. Pharmacol Ther. 2010;128:324–335.
  • Sutradhar KB, Amin L. Nanotechnology in cancer drug delivery and selective targeting. ISRN Nanotechnol. 2014;2014:1–12.
  • Abdollahi A, Ali-Bakhshi A, Farahani Z. Concentration study of high sensitive c - reactive protein and some serum trace elements in patients with benign and malignant breast tumor. Int J Hematol-Oncol Stem Cell Res. 2015;9:180–184.
  • Broustas CG, Lieberman HB. DNA damage response genes and the development of cancer metastasis. Radiat Res. 2014;181:111–130.
  • Singh OP, Nehru RM. Nanotechnology and cancer treatment. Asian J Exp Sci. 2008;22:45–50.
  • Chidambaram M, Manavalan R, Kathiresan K. Nanotherapeutics to overcome conventional cancer chemotherapy limitations. J Pharm Pharm Sci. 2011;14:67–77.
  • Batra P, Sharma AK. Anti-cancer potential of flavonoids: recent trends and future perspectives. 3 Biotechnology. 2013;3:439–459.
  • Del Rio D, Rodriguez-Mateos A, Spencer JP, et al. Dietary (Poly) phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxidants Redox Signal. 2013;18:1818–1892.
  • Devi KP, Rajavel T, Nabavi SF, et al. Hesperidin: a promising anticancer agent from nature. Indust Crops Prod. 2015;76:582–589.
  • Panche AN, Diwan AD, Chandra SR. Flavonoids: an overview. J Nutr Sci. 2016;5:e47.
  • Li C, Schluesener H. Health-promoting effects of the citrus flavanone hesperidin. Crit Rev Food Sci Nutr. 2017;57:613–631.
  • Banjerdpongchai R, Wudtiwai B, Khaw-on P, et al. Hesperidin from citrus seed induces human hepatocellular carcinoma hepg2 cell apoptosis via both mitochondrial and death receptor pathways. Tumor Biol. 2016;37:227–237.
  • Wang Y, Yu H, Zhang J, et al. Hesperidin inhibits HeLa cell proliferation through apoptosis mediated by endoplasmic reticulum stress pathways and cell cycle arrest. BMC Cancer. 2015;15:682.
  • Ghorbani A, Nazari M, Jeddi-Tehrani M, et al. The citrus flavonoid hesperidin induces p53 and inhibits NF-kB activation in order to trigger apoptosis in NALM-6 cells: involvement of PPARγ - dependent mechanism. Eur J Nutr. 2012;51:39–46.
  • Lee KA, Lee SH, Lee YJ, et al. Hesperidin induces apoptosis by inhibiting Sp1 and its regulatory protein in MSTO-211H cells. Biomol Ther. 2012;20:273–279.
  • Saiprasad G, Chitra P, Manikandan R, et al. Hesperidin induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-Kinase/Akt/Mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis. Eur J Cancer. 2014;50:2489–2507.
  • Majumdar S, Srirangam R. Solubility, stability, physicochemical characteristics and in vitro ocular tissue permeability of hesperidin: a natural bioflavonoid. Pharm Res. 2009;26:1217–1225.
  • Loganathan N, Sellappan M. Designing of nanosized bioflavonoids using biodegradable polymeric nanoparticles by plackett burman method. Int Curr Pharm J. 2017;6:9–15.
  • Bilia AR, Isacchi B, Righeschi C, et al. Flavonoids loaded in nanocarriers: an opportunity to increase oral bioavailability and bioefficacy. Fns. 2014;05:1212–1227.
  • Bharali DJ, Siddiqui IA, Adhami VM, et al. Nanoparticle delivery of natural products in the prevention and treatment of cancers: current status and future prospects. Cancer. 2011;3:4024–4045.
  • Malam Y, Loizidou M, Seifalian AM. Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer. Trends Pharmacol Sci. 2009;30:592–599.
  • Sutradhar KB, Amin ML. Nanoemulsions: increasing possibilities in drug delivery. Eur J Nanomed. 2013;5:97–110.
  • Sulaiman GM, Jabir MS, Hameed AH. Nanoscale modification of chrysin for improved of therapeutic efficiency and cytotoxicity. Artif Cells, Nanomed Biotechnol. 2018;1–13. DOI: 10.1080/21691401.2018.1434661.
  • Sulaiman GM, Al Sammarrae KW, Ad’hiah AH, et al. Chemical characterization of Iraqi propolis samples and assessing their antioxidant potentials. Food Chem Toxicol. 2011;49:2415–2421.
  • Frisch MJ, Trucks GW, Schlegel HB, et al. Gaussian 09, Revision A.02, Gaussian Inc., Wallingford, CT, USA; 2009.
  • Benhusein GM, Mutch E, Aburawi S, et al. Genotoxic effect induced by hydrogen peroxide in human hepatoma cells using comet assay. Libyan J Med. 2010;5:1-6. DOI: 10.3402/ljm.v5i0.4637.
  • Abd El-Rahman SN, Al-Jameel SS. Protection of curcumin and curcumin nanoparticles against cisplatin induced nephrotoxicity in male rats. Scholars Acad J Biosci. 2014;2:214–223.
  • Dokoumetzidis A, Macheras P. A century of dissolution research: from noyes and whitney to the biopharmaceutics classification system. Int J Pharm. 2006;321:1–11.
  • Tzeng CW, Yen FL, Wu TH, et al. Enhancement of dissolution and antioxidant activity of kaempferol using a nanoparticle engineering process. J Agric Food Chem. 2011;59:5073–5080.
  • Gurushankar K, Gohulkumar M, Prasad NR, et al. Synthesis, characterization and in vitro anti-cancer evaluation of hesperetin-loaded nanoparticles in human oral carcinoma (KB) cells. Adv Nat Sci: Nanosci Nanotechnol. 2014;5:015006.
  • Rejinold NS, Muthunarayanan M, Chennazhi KP, et al. 5-fluorouracil loaded fibrinogen nanoparticles for cancer drug delivery applications. Int J Biol Macromol. 2011;48:98–105.
  • Krishnakumar N, Sulfikkarali N, Rajendra Prasad N, et al. Enhanced anticancer activity of naringenin-loaded nanoparticles in human cervical (HeLa) cancer cells. Biomed Prev Nutr. 2011;1:223–231.
  • Gao H, Chen Y, Ma H, et al. Preparation and characterization of hesperidin - PEG 6000 complex. J Chem Soc Pakistan. 2014;36:848–851.
  • Torrado G, Fraile S, Torrado S, et al. Process-induced crystallite size and dissolution changes elucidated by a variety of analytical methods. Int J Pharm. 1998;166:55–63.
  • Khadka P, Ro J, Kim H, et al. Pharmaceutical particle technologies: an approach to improve drug solubility, dissolution and bioavailability. Asian J Pharm Sci. 2014;9:304–316.
  • Cho SA, Cha SR, Park SM, et al. Effects of hesperidin loaded poly (lacticco-glycolic acid) scaffolds on growth behavior of costal cartilage cells in vitro and in vivo. J Biomaterials Sci Polym Ed. 2014;25:625–640.
  • Moghimi SM, Hunter AC. Poloxamers and poloxamines in nanoparticle engineering and experimental medicine. Trends Biotechnol. 2000;18:412–420.
  • Mauludin R, Muller RH. Physicochemical properties of hesperidin nanocrystal. Int J Pharm Pharmaceu Sci. 2013;5:954–960.
  • Sulaiman GM. Molecular structure and anti-proliferative effect of galangin in HCT-116 cells: in vitro study. Food Sci Biotechnol. 2016;25:247–252.
  • Mishra K. Structure-activity relationship of antioxidative property of hesperidin. Int J Pharm Erud. 2013;2:40–53.
  • Kalpana KB, Srinivasan M, Menon VP. Evaluation of antioxidant activity of hesperidin and its protective effect on H2O2 induced oxidative damage on pBR322 DNA and RBC cellular membrane. Mol Cell Biochem. 2009;323:21–29.
  • Cai W, Chen Y, Xie L, et al. Characterization and density functional theory study of the antioxidant activity of quercetin and its sugar-containing analogues. Eur Food Res Technol. 2014;238:121–128.
  • Hosseinimehr SJ, Jalayer Z, Naghshvar F, et al. Hesperidin inhibits cyclophosphamide-induced tumor growth delay in mice. Integr Cancer Ther. 2012;11:251–256.
  • Choi J, Reipa V, Hitchins VM, et al. Physicochemical characterization and in vitro hemolysis evaluation of silver nanoparticles. Toxicol Sci. 2011;123:133–143.
  • Coutinho L, Oliveira H, Pacheco AR, et al. Hesperetin-etoposide combinations induce cytotoxicity in U2OS cells: implications on therapeutic developments for osteosarcoma. DNA Repair (Amst). 2017;50:36–42.
  • Al-Ashaal HA, El-Sheltawy ST. Antioxidant capacity of hesperidin from citrus peel using electron spin resonance and cytotoxic activity against human carcinoma cell lines. Pharm Biol. 2011;49:276–282.
  • Makin G, Hickman JA. Apoptosis and cancer chemotherapy. Cell Tissue Res. 2000;301:143–152.
  • Natarajan N, Thamaraiselvan R, Lingaiah H, et al. Effect of flavonone hesperidin on the apoptosis of human mammary carcinoma cell line MCF-7. Biomed Prev Nutr. 2011;1:207–215.
  • Park HJ, Kim MJ, Ha E, et al. Apoptotic effect of hesperidin through caspase3 activation in human colon cancer cells, SNU-C4. Phytomedicine. 2008;15:147–151.
  • Chahar MK, Sharma N, Dobhal MP, et al. Flavonoids: a versatile source of anticancer drugs. Phcog Rev. 2011;5:1–12.
  • Gaspar J, Laires A, Monteiro M, et al. Quercetin and the mutagenicity of wines. Mutagenesis. 1993;8:51–55.
  • Flower NA, Brabu B, Revathy M, et al. Characterization of synthesized silver nanoparticles and assessment of its genotoxicity potentials using the alkaline comet assay. Mutat Res. 2012;742:61–65.
  • Valavanidis A, Vlachogianni T, Fiotakis C. 8-hydroxy-2'-deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health, Part C: Environ Carcinogen Ecotoxicol Rev. 2009;27:120–139.
  • Baskar R, Lee KA, Yeo R, et al. Cancer and radiation therapy: current advances and future directions. Int J Med Sci. 2012;9:193–199.