3,875
Views
29
CrossRef citations to date
0
Altmetric
Research Article

Enhanced anti-proliferative and pro-apoptotic effects of metformin encapsulated PLGA-PEG nanoparticles on SKOV3 human ovarian carcinoma cells

, , , & ORCID Icon
Pages 737-746 | Received 08 Oct 2018, Accepted 29 Dec 2018, Published online: 20 Mar 2019

References

  • Smith RA, Andrews KS, Brooks D, et al. Cancer screening in the United States, 2017: a review of current American Cancer Society guidelines and current issues in cancer screening. CA: A Cancer J for Clinicians. 2017;67:100–121.
  • De Souza C. Effect of germline polymorphisms on somatic mutations in High Grade Serous ovarian cancer. Poster session presented at: The University of New Mexico. Shared knowledge Conference; 2017 November 11;. Albuquerque, New Mexico.
  • Maasomi ZJ, Pilehvar-Soltanahmadi Y, Dadashpour M, et al. Synergistic anticancer effects of silibinin and chrysin in T47D breast cancer cells. Asian Pac J Cancer Prev. 2017;18:1283.
  • Chatran M, Pilehvar-Soltanahmadi Y, Dadashpour M, et al. Synergistic anti-proliferative effects of metformin and silibinin combination on T47D breast cancer cells via hTERT and cyclin D1 inhibition. Drug Res (Stuttg). 2018;68:710–716.
  • Farajzadeh R, Pilehvar-Soltanahmadi Y, Dadashpour M, et al. Nano-encapsulated metformin-curcumin in PLGA/PEG inhibits synergistically growth and hTERT gene expression in human breast cancer cells. Artificial Cells, Nanomed Biotechnol. 2017;46(5):1–9.
  • Liu B, Fan Z, Edgerton SM, et al. Metformin induces unique biological and molecular responses in triple negative breast cancer cells. Cell Cycle. 2009;8:2031–2040.
  • Shafiei-Irannejad V, Samadi N, Salehi R, et al. Reversion of multidrug resistance by co-encapsulation of doxorubicin and metformin in poly (lactide-co-glycolide)-d-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles. Pharma Res. 2018;35:119.
  • Dadashpour M, Pilehvar‐Soltanahmadi Y, Zarghami N, et al. Emerging importance of phytochemicals in regulation of stem cells fate via signaling pathways. Phytother Res. 2017;31:1651–1668.
  • Javidfar S, Pilehvar-Soltanahmadi Y, Farajzadeh R, et al. The inhibitory effects of nano-encapsulated metformin on growth and hTERT expression in breast cancer cells. J Drug Del Sci Technol. 2017;43:19–26.
  • Jafari-Gharabaghlou D, Pilehvar-Soltanahmadi Y, Dadashpour M, et al. Combination of metformin and phenformin synergistically inhibits proliferation and hTERT expression in human breast cancer cells. Iranian J Basic Med Sci. 2018;21:1167.
  • Rasouli S, Zarghami N. Synergistic growth inhibitory effects of chrysin and metformin combination on breast cancer cells through hTERT and cyclin D1 suppression. Asian Pac J Cancer Prev. 2018;19:977–982.
  • Ngwuluka NC, Kotak DJ, Devarajan PV. Design and characterization of metformin-loaded solid lipid nanoparticles for colon cancer. AAPS PharmSciTech. 2017;18:358–368.
  • Farajzadeh R, Zarghami N, Serati-Nouri H, et al. Macrophage repolarization using CD44-targeting hyaluronic acid–polylactide nanoparticles containing curcumin. Artificial Cells, Nanomed Biotechnol. 2018;46:2013–2021.
  • Anari E, Akbarzadeh A, Zarghami N. Chrysin-loaded PLGA-PEG nanoparticles designed for enhanced effect on the breast cancer cell line. Artificial Cells, Nanomed Biotechnol. 2016;44:1410–1416.
  • Mohammadian F, Abhari A, Dariushnejad H, et al. Upregulation of Mir-34a in AGS gastric cancer cells by a PLGA-PEG-PLGA chrysin nano formulation. Asian Pac J Cancer Prev. 2016;16:8259–8263.
  • Dadashpour M, Pilehvar-Soltanahmadi Y, Mohammadi SA, et al. Watercress-based electrospun nanofibrous scaffolds enhance proliferation and stemness preservation of human adipose-derived stem cells. Artificial Cells, Nanomed Biotechnol. 2018;46:819–830.
  • Pilehvar-Soltanahmadi Y, Nouri M, Martino MM, et al. Cytoprotection, proliferation and epidermal differentiation of adipose tissue-derived stem cells on emu oil based electrospun nanofibrous mat. Exp Cell Res. 2017;357:192–201.
  • Firouzi-Amandi A, Dadashpour M, Nouri M, et al. Chrysin-nanoencapsulated PLGA-PEG for macrophage repolarization: possible application in tissue regeneration. Biomed Pharmacother. 2018;105:773–780.
  • Amirsaadat S, Pilehvar-Soltanahmadi Y, Zarghami F, et al. Silibinin-loaded magnetic nanoparticles inhibit hTERT gene expression and proliferation of lung cancer cells. Artificial Cells, Nanomed Biotechnol. 2013 2017;45:1649–1656.
  • Dadashpour M, Firouzi-Amandi A, Pourhassan-Moghaddam M, et al. Biomimetic synthesis of silver nanoparticles using Matricaria chamomilla extract and their potential anticancer activity against human lung cancer cells. Mater Sci Eng C Mater Biol Appl. 2018;92:902–912.
  • Schulten H-J. Pleiotropic effects of metformin on cancer. Ijms. 2018;19:2850.
  • Rattan R, Graham RP, Maguire JL, et al. Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo. Neoplasia 2011;13:483–491.
  • Hart PC, Sheikh S, Lengyel E, et al. Metformin inhibits TGFβ-induced stromal ECM remodeling to impede invasion in ovarian cancer. Paper presented at the 2017 AACR Annual Meeting; 2017 April 1–5; Chicago, USA.
  • Mert I, Chhina J, Allo G, et al. Synergistic effect of MEK inhibitor and metformin combination in low grade serous ovarian cancer. Gynecol Oncol. 2017;146(2):319–326.
  • Montazeri M, Pilehvar-Soltanahmadi Y, Mohaghegh M, et al. Antiproliferative and apoptotic effect of dendrosomal curcumin nanoformulation in P53 mutant and wide-type cancer cell lines. Acamc. 2017;17:662–673.
  • Anganeh MT, Mirakabad FST, Izadi M, et al. The comparison between effects of free curcumin and curcumin loaded PLGA-PEG on telomerase and TRF1 expressions in calu-6 lung cancer cell line. Int J Biosci. 2014;4:134–145.
  • Mohammadinejad S, Akbarzadeh A, Rahmati-Yamchi M, et al. Preparation and evaluation of chrysin encapsulated in PLGA-PEG nanoparticles in the T47-D breast cancer cell line. Asian Pac J Cancer Prev. 2015;16:3753–3758.
  • Rezvantalab S, Drude NI, Moraveji MK, et al. PLGA-based nanoparticles in cancer treatment. Front in Pharmacol. 2018;9:1–19.
  • Mohammadian F, Pilehvar-Soltanahmadi Y, Mofarrah M, et al. Down regulation of miR-18a, miR-21 and miR-221 genes in gastric cancer cell line by chrysin-loaded PLGA-PEG nanoparticles. Artificial Cells, Nanomed Biotechnol. 2016;44:1972–1978.
  • Amirsaadat S, Pilehvar-Soltanahmadi Y, Zarghami F, et al. The effects of nanoencapsulated curcumin-Fe3O4 on proliferation and hTERT gene expression in lung cancer cells. Acamc. 2017;17:1363–1373.
  • Mohammadian F, Abhari A, Dariushnejad H, et al. Effects of chrysin-PLGA-PEG nanoparticles on proliferation and gene expression of miRNAs in gastric cancer cell line. Iranian Journal of Cancer Prevention 2016;9:e4190.
  • Mohammadian F, Pilehvar-Soltanahmadi Y, Zarghami F, et al. Upregulation of miR-9 and Let-7a by nanoencapsulated chrysin in gastric cancer cells. Artificial Cells, Nanomed Biotechnol. 2017;45:1201–1206.
  • Lotfi-Attari J, Pilehvar-Soltanahmadi Y, Dadashpour M, et al. Co-delivery of curcumin and chrysin by polymeric nanoparticles inhibit synergistically growth and hTERT gene expression in human colorectal cancer cells. Nutrition and Cancer. 2017;69:1290–1299.
  • Aslan B, Ozpolat B, Sood AK, et al. Nanotechnology in cancer therapy. J Drug Target. 2013;21:904–913.
  • Cetin M, Atila A, Sahin S, et al. Preparation and characterization of metformin hydrochloride loaded-Eudragit® RSPO and Eudragit® RSPO/PLGA nanoparticles. Pharma Dev Technol. 2013;18:570–576.
  • Sharma N, Rana S, Shivkumar HG, et al. Solid lipid nanoparticles as a carrier of matformin for transdermal delivery. Int J Drug Del. 2013;5:137.
  • Lekshmi UMD, Reddy PN. Preliminary toxicological report of metformin hydrochloride loaded polymeric nanoparticles. Toxicol Int. 2012;19:267.
  • Snima K, Jayakumar R, Unnikrishnan A, et al. O-Carboxymethyl chitosan nanoparticles for metformin delivery to pancreatic cancer cells. Carbohydr Polym. 2012;89:1003–1007.
  • Snima K, Jayakumar R, Lakshmanan V-K. In vitro and in vivo biological evaluation of O-carboxymethyl chitosan encapsulated metformin nanoparticles for pancreatic cancer therapy. Pharm Res. 2014;31:3361–3370.
  • Dekanty A, Barrio L, Milan M. Contributions of DNA repair, cell cycle checkpoints and cell death to suppressing the DNA damage-induced tumorigenic behavior of Drosophila epithelial cells. Oncogene 2015;34:978.
  • Chunyan W, Valiyaveettil S. Correlation of biocapping agents with cytotoxic effects of silver nanoparticles on human tumor cells. RSC Adv. 2013;3:14329–14338.
  • Cai X, Hu X, Tan X, et al. Metformin induced AMPK activation, G0/G1 phase cell cycle arrest and the inhibition of growth of esophageal squamous cell carcinomas in vitro and in vivo. PLoS One. 2015;10:e0133349.
  • Xie W, Wang L, Sheng H, et al. Metformin induces growth inhibition and cell cycle arrest by upregulating MicroRNA34a in renal cancer cells. Med Sci Monit. 2017;23:29.
  • Queiroz EA, Puukila S, Eichler R, et al. Metformin induces apoptosis and cell cycle arrest mediated by oxidative stress, AMPK and FOXO3a in MCF-7 breast cancer cells. PloS One. 2014;9:e98207.
  • Montazeri M, Sadeghizadeh M, Pilehvar-Soltanahmadi Y, et al. Dendrosomal curcumin nanoformulation modulate apoptosis-related genes and protein expression in hepatocarcinoma cell lines. Int J Pharma. 2016;509:244–254.
  • Hengartner MO. The biochemistry of apoptosis. Nature 2000;407:770.
  • Alibakhshi A, Ranjbari J, Pilehvar-Soltanahmadi Y, et al. An update on phytochemicals in molecular target therapy of cancer: potential inhibitory effect on telomerase activity. Cmc. 2016;23:2380–2393.
  • Zavari-Nematabad A, Alizadeh-Ghodsi M, Hamishehkar H, et al. Development of quantum-dot-encapsulated liposome-based optical nanobiosensor for detection of telomerase activity without target amplification. Anal Bioanal Chem. 2017;409:1301–1310.
  • Rogalska A, Forma E, Ciesielski P, et al. Effect of metformin on apoptosis induction in ovarian cancer cells. pm. 2014;13( 3):155.
  • Holysz H, Lipinska N, Paszel-Jaworska A, et al. Telomerase as a useful target in cancer fighting—the breast cancer case. Tumor Biol. 2013;34:1371–1380.