Development and evaluation of doxorubicin self nanoemulsifying drug delivery system with Nigella Sativa oil against human hepatocellular carcinoma

References

• Forner A, Reig M, Bruix J. Hepatocellular carcinoma. Lancet. 2018;391:1301–1314.
   PubMed Web of Science ®Google Scholar
• Usmani A, Mishra A, Ahmad M. Nanomedicines: a theranostic approach for hepatocellular carcinoma. Artif Cells Nanomed Biotechnol. 2018;46:680–690.
   PubMed Web of Science ®Google Scholar
• Usmani A, Mishra A. Current updates on risk factors of hepatocellular carcinoma. Res Rev. 2017;8:23–31.
   Google Scholar
• Tam K. The roles of doxorubicin in hepatocellular carcinoma. ADMET and DMPK. 2013;1:29–44.
   Google Scholar
• Frederick CA, Williams LD, Ughetto G, et al. Structural comparison of anticancer drug-DNA complexes: adriamycin and daunomycin. Biochemistry. 1990;29:2538–2549.
   PubMed Web of Science ®Google Scholar
• Di CX, Han L, Zhang H, et al. Diallyl disulfide attenuated carbon ion irradiation-induced apoptosis in mouse testis through changing the ratio of Tap73/ΔNp73 via mitochondrial pathway. Sci Rep. 2015;5:16020.
   PubMed Web of Science ®Google Scholar
• Subedi RK, Kang KW, Choi HK. Preparation and characterization of solid lipid nanoparticles loaded with doxorubicin. Eur J Pharm Sci. 2009;37:508–513.
   PubMed Web of Science ®Google Scholar
• Pereverzeva E, Treschalin I, Bodyagin D, et al. Influence of the formulation on the tolerance profile of nanoparticle-bound doxorubicin in healthy rats: focus on cardio-and testicular toxicity. Int J Pharm. 2007;337:346–356.
   PubMed Web of Science ®Google Scholar
• Chen L, Ye HL, Zhang G, et al. Autophagy inhibition contributes to the synergistic interaction between EGCG and doxorubicin to kill the hepatoma Hep3B cells. PloS One. 2014;9:e85771.
   PubMed Web of Science ®Google Scholar
• Chang JE, Yoon IS, Sun PL, et al. Anticancer efficacy of photodynamic therapy with hematoporphyrin-modified, doxorubicin-loaded nanoparticles in liver cancer. J Photochem Photobiol B Biol. 2014;140:49–56.
   PubMed Web of Science ®Google Scholar
• Ohkawa K, Hatano T, Yamada K, et al. Bovine serum albumin-doxorubicin conjugate overcomes multidrug resistance in a rat hepatoma. Cancer Res. 1993;53:4238–4242.
   PubMed Web of Science ®Google Scholar
• Jiang SP, He SN, Li YL, et al. Preparation and characteristics of lipid nanoemulsion formulations loaded with doxorubicin. Int J Nanomed. 2013;8:31–41.
   PubMed Web of Science ®Google Scholar
• Sabeti B, Noordin MI, Mohd S, et al. Development and characterization of liposomal doxorubicin hydrochloride with palm oil. BioMed Res Int. 2014;2014:1–6.
   Web of Science ®Google Scholar
• Yin H, Bae YH. Physicochemical aspects of doxorubicin-loaded pH-sensitive polymeric micelle formulations from a mixture of poly (L-histidine)-b-poly (L-lactide)-b-poly (ethylene glycol). Eur J Pharm Biopharm. 2009;71:223–230.
   PubMed Web of Science ®Google Scholar
• Rapoport N, Nam KH, Gupta R, et al. Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions. J Control Release. 2011;153:4–15.
   PubMed Web of Science ®Google Scholar
• Sharma PC, Yelne MB, and Dennis TJ. Database on medicinal plants used in Ayurveda; Central Council for research on ayurveda and Siddha, Gvernment of India, New Delhi. 2005;6:420–440.
   Google Scholar
• Sultan MT, Butt MS, Anjum FM, et al. Nutritional profile of indigenous cultivar of black cumin seeds and antioxidant potential of its fixed and essential oil. Pak J Bot. 2009;41(3):1321–1330.
   Web of Science ®Google Scholar
• Al-Oqail MM, Al-Sheddi ES, Al-Massarani SM, et al. Nigella sativa seed oil suppresses cell proliferation and induces ROS dependent mitochondrial apoptosis through p53 pathway in hepatocellular carcinoma cells. S Afr J Bot. 2017;112:70–78.
   Web of Science ®Google Scholar
• Salomi MJ, Nair SC, Panikkar KR. Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice. Nutr Cancer. 1991;16:67–72.
   PubMed Web of Science ®Google Scholar
• Swamy SM, Tan BK. Cytotoxic and immunopotentiating effects of ethanolic extract of Nigella sativa L. seeds. J Ethnopharmacol. 2000;70:1–7.
   PubMed Web of Science ®Google Scholar
• Farah IO, Begum RA. Cellular responses to oxidative stress using MCF-7 breast carcinoma, black seed (N. Sativa L) extracts and H2O2. Proc Amer Assoc Cancer Res. 2004;45:452–453.
   Google Scholar
• Mahmoud SS, Torchilin VP. Hormetic/cytotoxic effects of Nigella sativa seed alcoholic and aqueous extracts on MCF-7 breast cancer cells alone or in combination with doxorubicin. Cell Biochem Biophys. 2013;66:451–460.
   PubMed Web of Science ®Google Scholar
• Hosseini A, Shafiee-Nick R., Mousavi SH Combination of Nigella sativa with Glycyrrhiza glabra and Zingiber officinale augments their protective effects on doxorubicin-induced toxicity in h9c2 cells. Iran J Basic Med Sci. 2014;17:993.
   PubMed Web of Science ®Google Scholar
• Ahmed MA, Hassanein KM. Cardio protective effects of Nigella sativa oil on lead induced cardio toxicity: anti inflammatory and antioxidant mechanism. J Physiol Pathophysiol. 2013;4:72–80.
   Google Scholar
• Ebru U, Burak U, Yusuf S, et al. Cardioprotective effects of Nigella sativa oil on cyclosporine A-induced cardiotoxicity in rats. Basic Clin Pharmacol Toxicol. 2008;103:574–580.
   PubMed Web of Science ®Google Scholar
• Effenberger-Neidnicht K, Schobert R. Combinatorial effects of thymoquinone on the anti-cancer activity of doxorubicin. Cancer Chemother Pharmacol. 2011;67:867–874.
   PubMed Web of Science ®Google Scholar
• Singh B, Beg S, Khurana RK, et al. Recent advances in self-emulsifying drug delivery systems (SEDDS). Crit Rev Ther Drug Carrier Syst. 2014;31(2):121–185.
   Web of Science ®Google Scholar
• Seo YG, Kim DH, Ramasamy T, et al. Development of docetaxel-loaded solid self-nanoemulsifying drug delivery system (SNEDDS) for enhanced chemotherapeutic effect. Int J Pharm. 2013;452:412–420.
   PubMed Web of Science ®Google Scholar
• Aboul Fotouh K, Allam AA, El-Badry M, et al. Development and in vitro/in vivo performance of self-nanoemulsifying drug delivery systems loaded with candesartan cilexetil. Eur J Pharm Sci. 2017;109:503–513.
   PubMed Web of Science ®Google Scholar
• AOAC (Association of Official Analytical Chemists). Official methods of analysis. Gaithersburg MD. AOAC (Association of Official Analytical Chemists). Official methods of analysis. Washington, USA; 2000; 26–49.
   Google Scholar
• Janakiraman N, Johnson M, Sahaya SS. GC–MS analysis of bioactive constituents of Peristrophe bicalyculata (Retz.) Nees.(Acanthaceae). Asian Pac J Trop Biomed. 2012;2:S46–S49.
   Google Scholar
• Kalam MA, Raish M, Ahmed A, et al. Oral bioavailability enhancement and hepatoprotective effects of thymoquinone by self-nanoemulsifying drug delivery system. Mater Sci Eng C. 2017;76:319–329.
   PubMed Web of Science ®Google Scholar
• Sandhu PS, Kumar R, Katare OP, et al. Surface-tailored nanomixed micelles containing quercetin–salicylic acid physical complex for enhanced cellular and in vivo activities: a quality by design perspective. Nanomedicine. 2017;11:1281–1303.
   Web of Science ®Google Scholar
• Elnaggar YS, El-Massik MA, Abdallah OY. Self-nanoemulsifying drug delivery systems of tamoxifen citrate: design and optimization. Int J Pharm. 2009;380:133–141.
   PubMed Web of Science ®Google Scholar
• Shakeel F, Haq N, El-Badry M, et al. Ultra fine super self-nanoemulsifying drug delivery system (SNEDDS) enhanced solubility and dissolution of indomethacin. J Mol Liq. 2013;180:89–94.
   Web of Science ®Google Scholar
• Ahmad M, Sahabjada JA, Hussain A, et al. Development of a new rutin nanoemulsion and its application on prostate carcinoma PC3 cell line. Excli J. 2017;16:810.
   PubMed Web of Science ®Google Scholar
• Balakumar K, Raghavan CV, selvan NT, et al. Self nanoemulsifying drug delivery system (SNEDDS) of rosuvastatin calcium: design, formulation, bioavailability and pharmacokinetic evaluation. Colloids Surf B Biointerfaces. 2013;112:337–343.
   PubMed Web of Science ®Google Scholar
• Di C, Sun C, Li H, et al. Diallyl disulfide enhances carbon ion beams-induced apoptotic cell death in cervical cancer cells through regulating Tap73/DeltaNp73. Cell Cycle. 2015;14:3725–3733.
   PubMed Web of Science ®Google Scholar
• Siddiqui S, Ahamad MS, Jafri A, et al. Piperine triggers apoptosis of human oral squamous carcinoma through cell cycle arrest and mitochondrial oxidative stress. Nutr Cancer. 2017;69(5):791–799.
   Web of Science ®Google Scholar
• Sandhu PS, Kumar R, Beg S, et al. Natural lipids enriched self-nano-emulsifying systems for effective co-delivery of tamoxifen and naringenin: systematic approach for improved breast cancer therapeutics. Nanomedicine. 2017;13:170313.
   Web of Science ®Google Scholar
• Ahamad MS, Siddiqui S, Jafri A, et al. Induction of apoptosis and antiproliferative activity of naringenin in human epidermoid carcinoma cell through ROS generation and cell cycle arrest. PloS One. 2014;9:e110003.
   PubMed Web of Science ®Google Scholar
• Manocha B, Margaritis A. Controlled release of doxorubicin from doxorubicin/γ-polyglutamic acid ionic complex. J Nanomat. 2010; 2010:1–12.
   Web of Science ®Google Scholar
• Patel J, Patel A, Raval M, et al. Formulation and development of a self-nanoemulsifying drug delivery system of irbesartan. J Adv Pharm Tech Res. 2011;2:9.
   PubMedGoogle Scholar
• Azeem A, Rizwan M, Ahmad FJ, et al. Nanoemulsion components screening and selection: a technical note. Aaps Pharmscitech. 2009;10:69–76.
   PubMed Web of Science ®Google Scholar
• Nasr A, Gardouh A, Ghorab M. Novel solid self-nanoemulsifying drug delivery system (S-SNEDDS) for oral delivery of olmesartan medoxomil: design, formulation, pharmacokinetic and bioavailability evaluation. Pharmaceutics. 2016;8:20.
   PubMed Web of Science ®Google Scholar
• Bansal T, Mustafa G, Khan ZI, et al. Solid self-nanoemulsifying delivery systems as a platform technology for formulation of poorly soluble drugs. Crit Rev Ther Drug Carrier Syst. 2008;25:63–116.
   PubMed Web of Science ®Google Scholar
• Yoo JH, Shanmugam S, Thapa P, et al. Novel self-nanoemulsifying drug delivery system for enhanced solubility and dissolution of lutein. Arch Pharm Res. 2010;33:417–426.
   PubMed Web of Science ®Google Scholar
• Srivastava S, Gupta P, Singh RP, et al. Synthesis, spectroscopic characterization, theoretical study and anti-hepatic cancer activity study of 4-(1E, 3Z, 6E)-3-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-5-oxohepta-1, 3, 6-trien-1-yl)-2-methoxyphenyl 4-nitrobenzoate, a novel curcumin congener. J Mol Struct. 2017;1141:678–686.
   Web of Science ®Google Scholar