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Research Article

The therapeutic effect of secretome from human umbilical cord-derived mesenchymal stem cells in age-related osteoporosis

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Pages 1357-1366 | Received 05 Mar 2019, Accepted 13 Mar 2019, Published online: 12 Apr 2019

References

  • Hennemann A. Osteoporosis: prevention, diagnosis and therapy. Med Monatsschr Pharm. 2002;25:164–167.
  • Raisz LG. Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Invest. 2005;115:3318–3325.
  • Rodríguez JP, Montecinos L, Ríos S, et al. Mesenchymal stem cells from osteoporotic patients produce a type I collagen deficient extracellular matrix favoring adipogenic differentiation. J Cell Biochem. 2015;79:557–565.
  • Jones G, Nguyen T, Sambrook PN, et al. Symptomatic fracture incidence in elderly men and women: the Dubbo Osteoporosis Epidemiology Study (DOES). Osteoporosis Int. 1994;4:277–282.
  • Seeman E. Bone quality—the material and structural basis of bone strength and fragility. N Engl J Med. 2006;354:2250–2261.
  • Khosla S, Hofbauer LC. Osteoporosis treatment: recent developments and ongoing challenges. Lancet Diabet Endocrinol. 2017;5:898–9075.
  • Sun Y, Li W, Lu Z, et al. Rescuing replication and osteogenesis of aged mesenchymal stem cells by exposure to a young extracellular matrix. Faseb J. 2011;25:1474–1485.
  • Mirsaidi A, Genelin K, Vetsch JR, et al. Therapeutic potential of adipose-derived stromal cells in age-related osteoporosis. Biomaterials. 2014;35:7326–7335.
  • Conboy IM, Conboy MJ, Wagers AJ, et al. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature. 2005;433:760–764.
  • Tran C, Damaser MS. Stem cells as drug delivery methods: application of stem cell secretome for regeneration. Adv Drug Deliv Rev. 2015;82:1–11.
  • An G, Zhang WB, Ma DK, et al. Influence of VEGF/BMP-2 on the proliferation and osteogenetic differentiation of rat bone mesenchymal stem cells on PLGA/gelatin composite scaffold. Europ Rev Med Pharmacol Sci. 2017;21:2316.
  • Burova E, Borodkina A, Shatrova A, et al. Sublethal oxidative stress induces the premature senescence of human mesenchymal stem cells derived from endometrium. Oxid Med Cell Longev. 2013;2013:1–12.
  • Wang Y, Liang M, Zheng Z, et al. Adhesion prevention after laminectomy using silk‐polyethylene glycol hydrogels. Adv Healthcare Mater. 2015;4:2120–2127.
  • Wang X, Kluge J, Leisk GG, et al. Sonication-induced gelation of silk fibroin for cell encapsulation. Biomaterials. 2008;29:1054–1064.
  • Madrigal M, Rao KS, Riordan NH. A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods. J Transl Med. 2014;12:260.
  • Ramaswamy Y, Lim KS, Zreiqat H, et al. Stem cells for bone regeneration: role of trophic factors. In: Alessandro Rozim Zorzi, Joao Batista de Miranda, editors. Advanced Techniques in Bone Regeneration. London: IntechOpen; 2016. p. 357–374.
  • Ludin A, Gur-Cohen S, Golan K, et al. Reactive oxygen species regulate hematopoietic stem cell self-renewal, migration and development, as well as their bone marrow microenvironment. Antiox Redox Signal. 2014;21:1605–1619.
  • Atashi F, Modarressi A, Pepper MS. The role of reactive oxygen species in mesenchymal stem cell adipogenic and osteogenic differentiation: a review. Stem Cells Dev. 2015;24:1150–1163.
  • Chiba Y, Shimada A, Kumagai N, et al. The senescence-accelerated mouse (SAM): a higher oxidative stress and age-dependent degenerative diseases model. Neurochem Res. 2009;34:679–687.
  • Moerman EJ, Teng K, Lipschitz DA, et al. Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways. Aging Cell. 2004;3:379–389.
  • Zhang W, Ou G, Hamrick M, et al. Age-related changes in the osteogenic differentiation potential of mouse bone marrow stromal cells. J Bone Miner Res. 2008;23:1118–1128.
  • Rodríguez JP, Garat S, Gajardo H, et al. Abnormal osteogenesis in osteoporotic patients is reflected by altered mesenchymal stem cells dynamics. J Cell Biochem. 2015;75:414–423.
  • Liu HY, Huang CF, Lin TC, et al. Delayed animal aging through the recovery of stem cell senescence by platelet rich plasma. Biomaterials. 2014;35:9767–9776.
  • Wang KX, Xu LL, Rui YF, et al. The effects of secretion factors from umbilical cord derived mesenchymal stem cells on osteogenic differentiation of mesenchymal stem cells. PLoS One. 2015;10:e0120593
  • Liu HY, Wu AT, Tsai CY, et al. The balance between adipogenesis and osteogenesis in bone regeneration by platelet-rich plasma for age-related osteoporosis. Biomaterials. 2011;32:6773–6780.
  • Eiró N, Sendon-Lago J, Seoane S, et al. Potential therapeutic effect of the secretome from human uterine cervical stem cells against both cancer and stromal cells compared with adipose tissue stem cells. Oncotarget. 2014;5:10692–10708.
  • Zhu CT, Li T, Zhang P, et al. Beneficial effects of low-level laser irradiation on senile osteoporosis in rats. Eur Rev Med Pharmacol Sci. 2007;21:5230–5238.
  • Pietschmann P, Skalicky M, Kneissel M, et al. Bone structure and metabolism in a rodent model of male senile osteoporosis. Exp Gerontol. 2007;42:1099–1108.
  • Xu R, Shen X, Si Y, et al. MicroRNA-31a-5p from aging BMSCs links bone formation and resorption in the aged bone marrow microenvironment. Aging Cell. 2018;17:e12794.
  • Zhou Y, Dong Y, Xu QG, et al. Mussel oligopeptides protect human fibroblasts from hydrogen peroxide (H2O2)-induced premature senescence. Arch Gerontol Geriatr. 2014;58:293–299.
  • Pellizzaro C, Coradini D, Daniotti A, et al. Modulation of cell cycle-related protein expression by sodium butyrate in human non-small cell lung cancer cell lines. Int J Cancer. 2001;91:654–657.
  • Cheng H, Qiu L, Ma J, et al. Replicative senescence of human bone marrow and umbilical cord derived mesenchymal stem cells and their differentiation to adipocytes and osteoblasts. Mol Biol Rep. 2011;38:5161–5168.
  • Krause KH. Aging: a revisited theory based on free radicals generated by NOX family NADPH oxidases. Exp Gerontol. 2007;42:256–262.
  • Guicheux J, Wittrant Y, et al. Oxidative stress in bone remodelling and disease. Trends Mol Med. 2009;15:468–477.
  • Zhou L, Chen X, Liu T, et al. SIRT1-dependent anti-senescence effects of cell-deposited matrix on human umbilical cord mesenchymal stem cells. J Tissue Eng Regen Med. 2018;12:e1008–e1021.
  • Lecka-Czernik B, Rosen CJ, Kawai M, et al. Skeletal aging and the adipocyte program. Cell Cycle. 2010;9:3672–3678.
  • Justesen J, Stenderup K, Eriksen EF, et al. Maintenance of osteoblastic and adipocytic differentiation potential with age and osteoporosis in human marrow stromal cell cultures. Calcif Tissue Int. 2002;71:36–44.
  • Leng X, Liu B, Su B, et al. In situ ultrasound imaging of silk hydrogel degradation and neovascularization. J Tissue Eng Regen Med. 2017;11:822–830.
  • Ma D, An G, Liang M, et al. A composited PEG-silk hydrogel combining with polymeric particles delivering rhBMP-2 for bone regeneration. Mater Sci Eng C Mater Biol Appl. 2016;65:221–231.
  • Bai L, Li D, Li J, et al. Bioactive molecules derived from umbilical cord mesenchymal stem cells. Acta Histochemica. 2016;118:761–769.
  • Yun YR, Jang JH, Jeon E, et al. Administration of growth factors for bone regeneration. Regen Med. 2012;7:369–385.
  • Erlebacher A, Filvaroff EH, Ye JQ, et al. Osteoblastic responses to TGF-beta during bone remodeling. Mol Biol Cell. 1998;9:1903.