The use of TLR2 modified BMSCs for enhanced bone regeneration in the inflammatory micro-environment

References

• Cochran DL. Inflammation and bone loss in periodontal disease. J Periodontol. 2008;79:1569–1576.
   PubMed Web of Science ®Google Scholar
• Oliver RC, Brown LJ. Periodontal diseases and tooth loss. Periodontol 2000. 1993;2:117–127.
   PubMedGoogle Scholar
• Heitz‐Mayfield LJ. Peri‐implant diseases: diagnosis and risk indicators. J Clin Periodontol. 2008;35:292–304.
   PubMed Web of Science ®Google Scholar
• Zhang W, Zhang X, Wang S. comparison of the use of adipose tissue–derived and bone marrow–derived stem cells for rapid bone regeneration. J Dent Res. 2013;92:1136–1141.
   PubMed Web of Science ®Google Scholar
• Niemeyer P, Fechner K, Milz S, et al. Comparison of mesenchymal stem cells from bone marrow and adipose tissue for bone regeneration in a critical size defect of the sheep tibia and the influence of platelet-rich plasma. Biomaterials. 2010;31:3572–3579.
   PubMed Web of Science ®Google Scholar
• Kaigler D, Pagni G, Park CH, et al. Stem cell therapy for craniofacial bone regeneration: a randomized, controlled feasibility trial. Cell Transplant. 2013;22:767–777.
   PubMed Web of Science ®Google Scholar
• Aderem A, Ulevitch RJ. Toll-like receptors in the induction of the innate immune response. Nature. 2000;406:782.
   PubMed Web of Science ®Google Scholar
• Medzhitov R, Janeway C. The toll receptor family and microbial recognition. Trends Microbiol. 2000;8:452–456.
   PubMed Web of Science ®Google Scholar
• Heumann D, Roger T. Initial responses to endotoxins and gram-negative bacteria. Clinica Chimica Acta. 2002;323:59–72.
   PubMed Web of Science ®Google Scholar
• Hashimoto M, Asai Y, Ogawa T. Separation and structural analysis of lipoprotein in a lipopolysaccharide preparation from Porphyromonas gingivalis. Int Immunol. 2004;16:1431–1437.
   PubMed Web of Science ®Google Scholar
• West XZ, Malinin NL, Merkulova AA, et al. Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands. Nature. 2010;467:972.
   PubMed Web of Science ®Google Scholar
• Wu J-Y, Chen C-H, Wang C-Z, et al. Low-power laser irradiation suppresses inflammatory response of human adipose-derived stem cells by modulating intracellular cyclic AMP level and NF-κB activity. PLoS One. 2013;8:e54067.
   PubMed Web of Science ®Google Scholar
• Opitz CA, Litzenburger UM, Lutz C, et al. Toll‐like receptor engagement enhances the immunosuppressive properties of human bone marrow‐derived mesenchymal stem cells by inducing indoleamine‐2, 3‐dioxygenase‐1 via interferon‐β and protein kinase R. Stem Cells. 2009;27:909–919.
   PubMed Web of Science ®Google Scholar
• Hwa Cho H, Bae YC, Jung JS. Role of toll-like receptors on human adipose-derived stromal cells. Stem Cells. 2006;24:2744–2752.
   PubMed Web of Science ®Google Scholar
• Schwandner R, Dziarski R, Wesche H, et al. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol Chem. 1999;274:17406–17409.
   PubMed Web of Science ®Google Scholar
• Zhang W, Wang G, Liu Y, et al. The synergistic effect of hierarchical micro/nano-topography and bioactive ions for enhanced osseointegration. Biomaterials. 2013;34:3184–3195.
   PubMed Web of Science ®Google Scholar
• Zhang M, Jiang F, Zhang X, et al. The effects of platelet‐derived growth factor‐BB on human dental pulp stem cells mediated dentin‐pulp complex regeneration. Stem Cells Transl Med. 2017;6:2126–2134.
   PubMed Web of Science ®Google Scholar
• Dai J, Wang J, Lu J, et al. The effect of co-culturing costal chondrocytes and dental pulp stem cells combined with exogenous FGF9 protein on chondrogenesis and ossification in engineered cartilage. Biomaterials. 2012;33:7699–7711.
   PubMed Web of Science ®Google Scholar
• Chen B, Sun H-H, Wang H-G, et al. The effects of human platelet lysate on dental pulp stem cells derived from impacted human third molars. Biomaterials. 2012;33:5023–5035.
   PubMed Web of Science ®Google Scholar
• Glowacki AJ, Yoshizawa S, Jhunjhunwala S, et al. Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes. Proc Natl Acad Sci. 2013;110:18525–18530.
   PubMed Web of Science ®Google Scholar
• Schipani E, Maes C, Carmeliet G, et al. Regulation of osteogenesis‐angiogenesis coupling by HIFs and VEGF. J Bone MinerRes. 2009;24:1347–1353.
   Web of Science ®Google Scholar
• Wan C, Shao J, Gilbert SR, et al. Role of HIF-1alpha in skeletal development. Ann N Y Acad Sci. 2010;1192:322–326.
   PubMed Web of Science ®Google Scholar
• Vives‐Pi M, et al. Evidence of expression of endotoxin receptors CD14, toll‐like receptors TLR4 and TLR2 and associated molecule MD‐2 and of sensitivity to endotoxin (LPS) in islet beta cells. Clin Exp Immunol. 2003;133:208–218.
   PubMed Web of Science ®Google Scholar
• Texereau J, Chiche J-D, Taylor W, et al. The importance of toll-like receptor 2 polymorphisms in severe infections. Clin Infect Dis. 2005;41:S408–S415.
   PubMed Web of Science ®Google Scholar
• Satta N, Kruithof EK, Reber G, et al. Induction of TLR2 expression by inflammatory stimuli is required for endothelial cell responses to lipopeptides. Mol Immunol. 2008;46:145–157.
   PubMed Web of Science ®Google Scholar
• McCurdy JD, Olynych TJ, Maher LH, et al. Cutting edge: distinct Toll-like receptor 2 activators selectively induce different classes of mediator production from human mast cells. J Immunol. 2003;170:1625–1629.
   PubMed Web of Science ®Google Scholar
• Redecke V, Hacker H, Datta SK, et al. Cutting edge: activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma. J Immunol. 2004;172:2739–2743.
   PubMed Web of Science ®Google Scholar
• Medzhitov R. Toll-like receptors and innate immunity. Nat Rev Immunol. 2001;1:135.
   PubMed Web of Science ®Google Scholar
• Takeda K, Akira S. Toll-like receptors in innate immunity. Int Immunol. 2004;17:1–14.
   Web of Science ®Google Scholar
• Urbonaviciute V, Fürnrohr BG, Meister S, et al. Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLE. J Exp Med. 2008;205:3007–3018.
   PubMed Web of Science ®Google Scholar
• Takeuchi O, Hoshino K, Kawai T, et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity. 1999;11:443–451.
   PubMed Web of Science ®Google Scholar
• Rey S, Semenza GL. Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling. Cardiovasc Res. 2010;86:236–242.
   PubMed Web of Science ®Google Scholar
• Zou D, Zhang Z, He J, et al. Blood vessel formation in the tissue-engineered bone with the constitutively active form of HIF-1α mediated BMSCs. Biomaterials. 2012;33:2097–2108.
   PubMed Web of Science ®Google Scholar
• Fukuda R, Hirota K, Fan F, et al. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem. 2002;277:38205–38211.
   PubMed Web of Science ®Google Scholar
• Riddle RC, Khatri R, Schipani E, et al. Role of hypoxia-inducible factor-1α in angiogenic–osteogenic coupling. J Mol Med. 2009;87:583–590.
   PubMed Web of Science ®Google Scholar
• Deng Y, Zhou H, Zou D, et al. The role of miR-31-modified adipose tissue-derived stem cells in repairing rat critical-sized calvarial defects. Biomaterials. 2013;34:6717–6728.
   PubMed Web of Science ®Google Scholar
• Wade WG. The oral microbiome in health and disease. Pharmacol Res. 2013;69:137–143.
   PubMed Web of Science ®Google Scholar