1,574
Views
4
CrossRef citations to date
0
Altmetric
Research Article

OB-RGRP regulates the phosphorylation of JAK2 and STAT3 in primary rat adipocytes

ORCID Icon, , , , , & show all
Pages 3664-3670 | Received 24 Feb 2019, Accepted 08 Jun 2019, Published online: 06 Sep 2019

References

  • Working Group on Obesity in China. The guidelines for prevention and control of overweight and obesity in Chinese adults. Acta Nutr Sin. 2004;26:1–4.
  • Enriori PJ, Sinnayah P, Simonds SE, et al. Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance. J Neurosci. 2011;31:12189–12197.
  • Knobelspies H, Zeidler J, Hekerman P, et al. Mechanism of attenuation of leptin signaling under chronic ligand stimulation. BMC Biochem. 2010;11:2.
  • Guohui W, Zhao F, Yuan K, et al. The direct effect of leptin on adipocyte. Chinese J Aesth Med. 2007;16:1346–1349.
  • Huan JN, Li J, Han Y, et al. Adipocyte-selective reduction of the leptin receptors induced by antisense RNA leads to increased adiposity, dyslipidemia, and insulin resistance. J Biol Chem. 2003;278:45638–45650.
  • Cowan E, Burch KJ, Green BD, et al. Obestatin as a key regulator of metabolism and cardiovascular function with emerging therapeutic potential for diabetes. Br J Pharmacol. 2016;173:2165–2181.
  • Rozzo A, Meneghel-Rozzo T, Delakorda SL, et al. Exocytosis of insulin: in vivo maturation of mouse endocrine pancreas. Ann N Y Acad Sci. 2009;1152:53–62.
  • Couturier C, Sarkis C, Séron K, et al. Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity. Proc Natl Acad Sci USA. 2007;104:19476–19481.
  • Bailleul B, Akerblom I, Strosberg AD. The leptin receptor promoter controls expression of a second distinct protein. Nucleic Acids Res. 1997;25:2752–2758.
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25:402–408.
  • Bailleul B, Rouille Y, Seron K, et al. LEPROTL1 and OB-RGRP genes for screening compounds that act on the gain or loss of weight or on diabetes in a human or animal subject. 2006. PAT - US2006068429. Publication: 2006-03-30.
  • Bailleul B, Rouille Y, Seron K, et al. Use of the genes leprotl1 and ob-RGRP for the screening of active compounds for weight gain or loss or diabetes in human or animal subjects. 2004. PAT - CA2518761. Publication: 2004-09-23.
  • Crippen TL. Insecticide resistance of Alphitobius diaperinus to β-Cyfluthrin and commercial insecticides on various surfaces common in poultry operations. Proc Natl Acad Sci USA. 2013;104:19476–19481.
  • Mullen M, Gonzalez-Perez RR. Leptin-Induced JAK/STAT Signaling and Cancer Growth. Vaccines (Basel). 2016;4:26.
  • Erkasap S, Erkasap N, Bradford B, et al. The effect of leptin and resveratrol on JAK/STAT pathways and Sirt-1 gene expression in the renal tissue of ischemia/reperfusion induced rats. Bll. 2017;118:443–448.
  • Landry DA, Sormany F, Haché J, et al. Steroidogenic genes expressions are repressed by high levels of leptin and the JAK/STAT signaling pathway in MA-10 Leydig cells. Mol Cell Biochem. 2017;433:79–95.
  • Zheng XJ, Yang ZX, Dong YJ, et al. Downregulation of leptin inhibits growth and induces apoptosis of lung cancer cells via the Notch and JAK/STAT3 signaling pathways. Biology Open. 2016;5:794–800.
  • Wu K, Tan XY, Xu YH, et al. JAK and STAT members of yellow catfish Pelteobagrus fulvidraco and their roles in leptin affecting lipid metabolism. Gen Comp Endocrinol. 2016;226:14–26.
  • Ding CH, Shi YF, Ru D, et al. Influence of acupuncture on gastrointestinal front-mu points on leptin receptor and JAK-STAT signaling pathway. Acta Univ Tradit Med Sin Pharmacol Shanghai 2017;31:81–84.
  • Wang T, Fahrmann JF, Lee H, et al. JAK/STAT3-regulated fatty acid β-oxidation is critical for breast cancer stem cell self-renewal and chemoresistance. Cell Metab. 2018;27:136–150.
  • Rogers LJ, Basnakian AG, Orloff MS, et al. 2-Amino-1-methyl-6-phenylimidazo(4,5-b) pyridine (PhIP) induces gene expression changes in JAK/STAT and MAPK pathways related to inflammation, diabetes and cancer. Nutr Metab (Lond). 2016;13:54.
  • Yan L, Zhang Z, Song M. Nucleus accumbens microinjection Jak/Stat3 inhibitor regulate energy metabolism of Lasiopodomys brandtii. Sichuan J Zool. 2018;37:57–61.
  • Hosoi T, Kohda T, Matsuzaki S, et al. Key role of heat shock protein 90 in leptin-induced STAT3 activation and feeding regulation. Br J Pharmacol. 2016;173:2434–2445.