Integrated metabolomics and 16S rRNA sequencing to investigate the regulation of Chinese yam on antibiotic-induced intestinal dysbiosis in rats

References

• Tamma PD, Miller MA, Cosgrove SE. Rethinking how antibiotics are prescribed: incorporating the 4 moments of antibiotic decision making into clinical practice. JAMA. 2019;321:139–140.
   PubMed Web of Science ®Google Scholar
• Bajaj JS, Kakiyama G, Savidge T, et al. Antibiotic-associated disruption of microbiota composition and function in cirrhosis is restored by fecal transplant. Hepatology. 2018;68:1549–1558.
   PubMed Web of Science ®Google Scholar
• Block JP, Bailey LC, Gillman MW, et al. Early antibiotic exposure and weight outcomes in young children. Pediatrics. 2018;142:e20180290.
   PubMed Web of Science ®Google Scholar
• Boutin RCT, Dwyer Z, Farmer K, et al. Perinatal antibiotic exposure alters composition of murine gut microbiota and may influence later responses to peanut antigen. Allergy Asthma Clin Immunol. 2018;14:42.
   PubMed Web of Science ®Google Scholar
• Haak BW, Lankelma JM, Hugenholtz F, et al. Long-term impact of oral vancomycin, ciprofloxacin and metronidazole on the gut microbiota in healthy humans. J Antimicrob Chemother. 2019;74:782–786.
   PubMed Web of Science ®Google Scholar
• Palleja A, Mikkelsen KH, Forslund SK, et al. Recovery of gut microbiota of healthy adults following antibiotic exposure. Nat Microbiol. 2018;3:1255–1265.
   PubMed Web of Science ®Google Scholar
• Raymond F, Ouameur AA, Déraspe M, et al. The initial state of the human gut microbiome determines its reshaping by antibiotics. ISME J. 2016;10:707–720.
   PubMed Web of Science ®Google Scholar
• Mahana D, Trent CM, Kurtz ZD, et al. Antibiotic perturbation of the murine gut microbiome enhances the adiposity, insulin resistance, and liver disease associated with high-fat diet. Genome Med. 2016;8:48.
   PubMed Web of Science ®Google Scholar
• Lee SC, Tsai CC, Chen JC, et al. Effects of “Chinese yam” on hepato-nephrotoxicity of acetaminophen in rats. Acta Pharmacol Sin. 2002;23:503–508.
   PubMed Web of Science ®Google Scholar
• Ma JK, Meng X, Kang AN, et al. Effects of rhizome extract of Dioscorea batatas and its active compound, allantoin, on the regulation of myoblast differentiation and mitochondrial biogenesis in C2C12 myotubes. Molecules. 2018;23:2023.
   PubMed Web of Science ®Google Scholar
• Liu Y, Li H, Fan Y, et al. Antioxidant and antitumor activities of the extracts from Chinese Yam (Dioscorea opposite Thunb.) flesh and peel and the effective compounds. J Food Sci. 2016;81:H1553–H1564.
   PubMed Web of Science ®Google Scholar
• Qiao Y, Xu L, Tao X, et al. Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation. Toxicol Lett. 2018;284:37–45.
   PubMed Web of Science ®Google Scholar
• Zhang MH, Fang ZY, Li AN, et al. Yam polysaccharide improves sperm viability and protects sperm DNA integrity in vitro. Nat J Androl. 2017;13:1020–1024.
   Google Scholar
• Cai Y, Liu W, Lin Y, et al. Compound polysaccharides ameliorate experimental colitis by modulating gut microbiota composition and function. J Gastroenterol Hepatol. 2018. DOI:10.1111/jgh.14583
   Web of Science ®Google Scholar
• Zeng M, Zhang L, Li M, et al. Estrogenic effects of the extracts from the Chinese yam (Dioscorea opposite Thunb.) and its effective compounds in vitro and in vivo. Molecules. 2018;23:11.
   PubMed Web of Science ®Google Scholar
• Zeng M, Zhang L, Zhang B, Li B, et al. Chinese yam extract and adenosine attenuated LPS-induced cardiac dysfunction by inhibiting RAS and apoptosis via the ER-mediated activation of SHC/Ras/Raf1 pathway. Phytomedicine. 2019;61:152857.
   PubMed Web of Science ®Google Scholar
• Zheng XJ, Xie GX, Zhao AH, et al. The footprints of gut microbial-mammalian co-metabolism. J Proteome Res. 2011;10:5512–5522.
   PubMed Web of Science ®Google Scholar
• Yu M, Jia HM, Zhou C, et al. Urinary and fecal metabonomics study of the protective effect of Chaihu-Shu-Gan-San on antibiotic-induced gut microbiota dysbiosis in rats. Sci Rep. 2017;7:46551.
   PubMed Web of Science ®Google Scholar
• Fadrosh DW, Ma B, Gajer P, et al. An improved dual-indexing approach for multiplexed 16S rRNA gene sequencing on the Illumina MiSeq platform. Microbiome. 2014;2:6.
   PubMed Web of Science ®Google Scholar
• Li S, Li J, Mao G, Wu T, et al. Fucosylated chondroitin sulfate from Isostichopus badionotus alleviates metabolic syndromes and gut microbiota dysbiosis induced by high-fat and high-fructose diet. Int J Biol Macromol. 2019;124:377–388.
   PubMed Web of Science ®Google Scholar
• Yang J, Zhang S, Wu J, et al. Imipenem and normal saline with cyclophosphamide have positive effects on the intestinal barrier in rats with sepsis. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2018;162:90–98.
   PubMed Web of Science ®Google Scholar
• Rababa HA, Hijjawi TB, Alzoubi KH, et al. The nephroprotective effect of N-acetyl-l-cysteine and atorvastatin against imipenem induced nephrotoxicity. Curr Mol Pharmacol. 2018;10:155–161.
   Web of Science ®Google Scholar
• Tahri A, Lahyani A, Kallel R, et al. Exposure to imipenem/cilastatin causes nephrotoxicity and even urolithiasis in Wistar rats. Toxicology. 2018;404–405:59–67.
   PubMed Web of Science ®Google Scholar
• Tahri A, Ksouda K, Kallel R, et al. A carbapenem antibiotic imipenem/cilastatin induces an oxidative stress-status and gonadotoxic effects in « wistar » rats. Biomed Pharmacother. 2017;95:308–316.
   PubMed Web of Science ®Google Scholar
• Harrison MP, Jones DV, Pickford RJ, et al. β-hydroxybutyrate: a urinary marker of imipenem induced nephrotoxicity in the cynomolgus monkey detected by high field 1 H NMR spectroscopy. Biochem Pharmacol. 1991;41:2045–2049.
   PubMed Web of Science ®Google Scholar
• Li SYC, Miao LJ, Liang YJ, et al. Study on the effect of yam and spleen and stomach. Chin Med Pharmacol Clin. 1994;1:19–21.
   Google Scholar
• Chen GL, Zhu LR, Sha NA, et al. Effect of total saponin of Dioscorea on chronic hyperuricemia and expression of URAT1 in rats. Zhongguo Zhong Yao Za Zhi. 2013;38:2348–2353.
   PubMedGoogle Scholar
• Shihai Z, Xiangfang Z, Xiangbing S, et al. Novel metabolic and physiological functions of branched chain amino acids: a review. J Anim Sci Biotechnol. 2017;8:10.
   PubMed Web of Science ®Google Scholar
• Dai ZL, Zhang J, Wu G, et al. Utilization of amino acids by bacteria from the pig small intestine. Amino Acids. 2010;39:1201–1215.
   PubMed Web of Science ®Google Scholar
• Falke JJ, Bass RB, Butler SL, et al. The two-component signaling pathway of bacterial chemotaxis: a molecular view of signal transduction by receptors, kinases, and adaptation enzymes. Annu Rev Cell Dev Biol. 1997;13:457.
   PubMed Web of Science ®Google Scholar
• Bradford SE, Nadler JV. Aspartate release from rat hippocampal synaptosomes. Neuroscience. 2004;128:751–765.
   PubMed Web of Science ®Google Scholar
• Bakken IJ, Aasly J, Unsg RG, et al. [U-13C] aspartate metabolism in cultured cortical astrocytes and cerebellar granule neurons studied by NMR spectroscopy. Glia. 2015;23:271–277.
   Google Scholar
• Bakken IJ, White LR, Aasly J, et al. Lactate formation from [U-13C] aspartate in cultured astrocytes: compartmentation of pyruvate metabolism. Neurosci Lett. 1997;237:117–120.
   PubMed Web of Science ®Google Scholar