Matrine derivate MASM protects murine MC3T3-E1 osteoblastic cells against dexamethasone-induced apoptosis via the regulation of USP14/p53

References

• Schäcke H, Döcke W-D, Asadullah K. Mechanisms involved in the side effects of glucocorticoids. Pharmacol Ther. 2002;96(1):23–43.
   PubMed Web of Science ®Google Scholar
• den Uyl D, Bultink IE, Lems WF. Advances in glucocorticoid-induced osteoporosis. Curr Rheumatol Rep. 2011;13(3):233–240.
   PubMed Web of Science ®Google Scholar
• Civitelli R, Ziambaras K. Epidemiology of glucocorticoid-induced osteoporosis. J Endocrinol Investig. 2008;31(7):2–6.
   PubMedGoogle Scholar
• Weinstein RS. Clinical practice. Glucocorticoid-induced bone disease. N Engl J Med. 2011;365(1):62–70.
   PubMed Web of Science ®Google Scholar
• Weinstein RS, Jilka RL, Parfitt AM, et al. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. J Clin Invest. 1998;102(2):274–282.
   PubMed Web of Science ®Google Scholar
• Gohel A, McCarthy M-B, Gronowicz G. Estrogen prevents glucocorticoid-induced apoptosis in osteoblasts in vivo and in vitro. Endocrinology. 1999;140(11):5339–5347.
   PubMed Web of Science ®Google Scholar
• Canalis E. Mechanisms of glucocorticoid action in bone. Curr Osteoporos Rep. 2005;3(3):98–102.
   PubMedGoogle Scholar
• O’brien CA, Jia D, Plotkin LI, et al. Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength. Endocrinology. 2004;145(4):1835–1841.
   PubMed Web of Science ®Google Scholar
• Li H, Qian W, Weng X, et al. Glucocorticoid receptor and sequential P53 activation by dexamethasone mediates apoptosis and cell cycle arrest of osteoblastic MC3T3-E1 cells. PLoS One. 2012;7(6):e37030.
   PubMed Web of Science ®Google Scholar
• Dai C, Gu W. p53 post-translational modification: deregulated in tumorigenesis. Trends in Mol Med. 2010;16(11):528–536.
   PubMed Web of Science ®Google Scholar
• Lee J, Gu W. The multiple levels of regulation by p53 ubiquitination. Cell Death Differ. 2010;17(1):86.
   PubMed Web of Science ®Google Scholar
• Dayal S, Sparks A, Jacob J, et al. Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53. J Biol Chem. 2009;284(8):5030–5041.
   PubMed Web of Science ®Google Scholar
• Li M, Chen D, Shiloh A, et al. Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature. 2002;416(6881):648.
   PubMed Web of Science ®Google Scholar
• Liu J, Xia H, Kim M, et al. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell. 2011;147(1):223–234.
   PubMed Web of Science ®Google Scholar
• Huang J, Xu H. Matrine: bioactivities and structural modifications. Curr Top Med Chem. 2016;16(28):3365–3378.
   PubMed Web of Science ®Google Scholar
• Yang Y, Xiu J, Zhang X, et al. Antiviral effect of matrine against human enterovirus 71. Molecules. 2012;17(9):10370–10376.
   PubMed Web of Science ®Google Scholar
• Sun D, Wang J, Yang N, et al. Matrine suppresses airway inflammation by downregulating SOCS3 expression via inhibition of NF-κB signaling in airway epithelial cells and asthmatic mice. Biochem Biophys Res Commun. 2016;477(1):83–90.
   PubMed Web of Science ®Google Scholar
• Kan Q-C, Zhu L, Liu N, et al. Matrine suppresses expression of adhesion molecules and chemokines as a mechanism underlying its therapeutic effect in CNS autoimmunity. Immunol Res. 2013;56(1):189–196.
   PubMed Web of Science ®Google Scholar
• Xu X, Yan Y, Pan J, et al. Exploring antipruritic and analgesic effects of matrine by allergic contact dermatitis mouse model through behavioral analysis. J Pharma Biomed Sci. 2017;7(4):77–81.
   PubMed Web of Science ®Google Scholar
• Liu Z, Zhang Y, Tang Z, et al. Matrine attenuates cardiac fibrosis by affecting ATF6 signaling pathway in diabetic cardiomyopathy. Eur J Pharmacol. 2017;804:21–30.
   PubMed Web of Science ®Google Scholar
• Li H, Tan G, Jiang X, et al. Therapeutic effects of matrine on primary and metastatic breast cancer. Am J Chin Med. 2010;38(06):1115–1130.
   PubMed Web of Science ®Google Scholar
• Hu MJ, Zeng H, Wu YL, et al. Synergistic effects of matrine and 5‐fluorouracil on tumor growth of the implanted gastric cancer in nude mice. Chin Dig Dis. 2005;6(2):68–71.
   PubMedGoogle Scholar
• Cho Y, Lee JH, Kim JH, et al. Matrine suppresses KRAS‐driven pancreatic cancer growth by inhibiting autophagy‐mediated energy metabolism. Mol Oncol. 2018;12(7):1203.
   PubMed Web of Science ®Google Scholar
• Chen X, Zhi X, Pan P, et al. Matrine prevents bone loss in ovariectomized mice by inhibiting RANKL-induced osteoclastogenesis. The FASEB J. 2017;31(11):4855–4865.
   PubMed Web of Science ®Google Scholar
• Chen X, Zhi X, Cao L, et al. Matrine derivate MASM uncovers a novel function for ribosomal protein S5 in osteoclastogenesis and postmenopausal osteoporosis. Cell death Dis. 2017;8(9):e3037.
   PubMed Web of Science ®Google Scholar
• Yu B, Chang J, Liu Y, et al. Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-kappaB. Nat Med. 2014;20(9):1009–1017.
   PubMed Web of Science ®Google Scholar
• Liu Y, Qi Y, Bai Z-h, et al. A novel matrine derivate inhibits differentiated human hepatoma cells and hepatic cancer stem-like cells by suppressing PI3K/AKT signaling pathways. Acta Pharmacol Sin. 2017;38(1):120.
   PubMed Web of Science ®Google Scholar
• Kaneshiro S, Ebina K, Shi K, et al. IL-6 negatively regulates osteoblast differentiation through the SHP2/MEK2 and SHP2/Akt2 pathways in vitro. J Bone Min Metabol. 2014;32(4):378–392.
   PubMed Web of Science ®Google Scholar
• Manolagas SC. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocrine Rev. 2000;21(2):115–137.
   PubMed Web of Science ®Google Scholar
• Liu X-S, Jiang J, Jiao X-Y, et al. Matrine-induced apoptosis in leukemia U937 cells: involvement of caspases activation and MAPK-independent pathways. Planta med. 2006;72(6):501–506.
   PubMed Web of Science ®Google Scholar
• Luo C, Zhu Y, Jiang T, et al. Matrine induced gastric cancer MKN45 cells apoptosis via increasing pro-apoptotic molecules of Bcl-2 family. Toxicology. 2007;229(3):245–252.
   PubMed Web of Science ®Google Scholar
• Liu T, Song Y, Chen H, et al. Matrine inhibits proliferation and induces apoptosis of pancreatic cancer cells in vitro and in vivo. Biol Pharma Bull. 2010;33(10):1740–1745.
   PubMed Web of Science ®Google Scholar
• Liang CZ, Zhang JK, Shi Z, et al. Matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2. Cancer Chemother Pharmacol. 2012;69(2):317–331.
   PubMed Web of Science ®Google Scholar
• Yang N, Han F, Cui H, et al. Matrine suppresses proliferation and induces apoptosis in human cholangiocarcinoma cells through suppression of JAK2/STAT3 signaling. Pharmacol Rep. 2015;67(2):388–393.
   PubMed Web of Science ®Google Scholar
• Zhao P, Zhou R, Zhu X-Y, et al. Matrine attenuates focal cerebral ischemic injury by improving antioxidant activity and inhibiting apoptosis in mice. Int J Mol Med. 2015;36(3):633–644.
   PubMed Web of Science ®Google Scholar
• Yu J, Yang S, Wang X, et al. Matrine improved the function of heart failure in rats via inhibiting apoptosis and blocking beta3adrenoreceptor/endothelial nitric oxide synthase pathway. Mol Med Rep. 2014;10(6):3199–3204.
   PubMed Web of Science ®Google Scholar
• Amaral JD, Xavier JM, Steer CJ, et al. The role of p53 in apoptosis. Discov Med. 2010;9(45):145–152.
   PubMed Web of Science ®Google Scholar
• Woods DB, Vousden KH. Regulation of p53 function. Exper Cell Res. 2001;264(1):56–66.
   PubMed Web of Science ®Google Scholar
• Kwon S-K, Saindane M, Baek K-H. p53 stability is regulated by diverse deubiquitinating enzymes. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer. 2017;1868(2):404–411.
   PubMed Web of Science ®Google Scholar
• Li S, Jiang H, Gu X. Echinacoside suppresses dexamethasone-induced growth inhibition and apoptosis in osteoblastic MC3T3-E1 cells. Exp Ther Med. 2018;16(2):643–648.
   PubMed Web of Science ®Google Scholar
• Yip K, Reed J. Bcl-2 family proteins and cancer. Oncogene. 2008;27(50):6398.
   PubMed Web of Science ®Google Scholar