Protective effects of phenformin on zebrafish embryonic neurodevelopmental toxicity induced by X-ray radiation

References

• Cole AM, Scherwath A, Ernst G, et al. Self-reported cognitive outcomes in patients with brain metastases before and after radiotherapy. Strahlenther Onkol. 2016;192:75–76.
   PubMed Web of Science ®Google Scholar
• Crossen JR, Garwood D, Glatstein E, et al. Neurobehavioral sequelae of cranial irradiation in adults – a review of radiation-induced encephalopathy. JCO. 1994;12(3):627–642.
   PubMed Web of Science ®Google Scholar
• Dropcho EJ. Neurotoxicity of radiation therapy. Neurol Clin. 2010;28(1):217.
   PubMed Web of Science ®Google Scholar
• Press RH, Buchwald ZS, Steuer C, et al. Report of neurotoxicity after concurrent whole brain radiation therapy and checkpoint blockade immunotherapy for patients with brain metastases. Int J Radiat Oncol. 2018;102(3):e340.
   PubMed Web of Science ®Google Scholar
• Kim S, Jang BS, Jung U, et al. Gamma-irradiation is more efficient at depleting hippocampal neurogenesis than D-galactose/NaNO2. Neurosci Lett. 2011;498(1):47–51.
   PubMed Web of Science ®Google Scholar
• Lee TC, Greene-Schloesser D, Payne V, et al. Chronic administration of the angiotensin-converting enzyme inhibitor, ramipril, prevents fractionated whole-brain irradiation-induced perirhinal cortex-dependent cognitive impairment. Radiat Res. 2012;178(1):46–56.
   PubMed Web of Science ®Google Scholar
• Huang TT, Zou Y, Corniola R. Oxidative stress and adult neurogenesis-effects of radiation and superoxide dismutase deficiency. Semin Cell Dev Biol. 2012;23(7):738–744.
   PubMed Web of Science ®Google Scholar
• Azzam EI, Jay-Gerin JP, Pain D. Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury. Cancer Lett. 2012;327(1-2):48–60.
   PubMed Web of Science ®Google Scholar
• Gan L, Wang ZH, Si J, et al. Protective effect of mitochondrial-targeted antioxidant MitoQ against iron ion Fe-56 radiation induced brain injury in mice. Toxicol Appl Pharmacol. 2018;341:1–7.
   PubMed Web of Science ®Google Scholar
• Ji SJ, Tian Y, Lu Y, et al. Irradiation-induced hippocampal neurogenesis impairment is associated with epigenetic regulation of bdnf gene transcription. Brain Res. 2014;1577:77–88.
   PubMed Web of Science ®Google Scholar
• Monje ML, Vogel H, Masek M, et al. Impaired human hippocampal neurogenesis after treatment for central nervous system. Ann Neurol. 2007;62(5):515–520.
   PubMed Web of Science ®Google Scholar
• Rola R, Raber J, Rizk A, et al. Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice. Exp Neurol. 2004;188(2):316–330.
   PubMed Web of Science ®Google Scholar
• Redmond KJ, Mahone EM, Terezakis S, et al. Association between radiation dose to neuronal progenitor cell niches and temporal lobes and performance on neuropsychological testing in children: a prospective study. Neuro-Oncol. 2013;15(3):360–369.
   PubMed Web of Science ®Google Scholar
• Binder DK, Scharfman HE. Brain-derived neurotrophic factor. Growth Factors. 2004;22(3):123–131.
   PubMed Web of Science ®Google Scholar
• Maisonpierre PC, Le Beau MM, Espinosa R, et al. Human and rat brain-derived neurotrophic factor and neurotrophin-3 – gene structures, distributions, and chromosomal localizations. Genomics. 1991;10(3):558–568.
   PubMed Web of Science ®Google Scholar
• Lipsky RH, Marini AM. Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity. Ann Ny Acad Sci. 2007;1122(1):130–143.
   PubMed Web of Science ®Google Scholar
• Lee E, Son H. Adult hippocampal neurogenesis and related neurotrophic factors. BMB Rep. 2009;42(5):239–244.
   PubMed Web of Science ®Google Scholar
• Pardon MC. Role of neurotrophic factors in behavioral processes: implications for the treatment of psychiatric and neurodegenerative disorders. Vitam Horm. 2010;82:185–200.
   PubMed Web of Science ®Google Scholar
• Oh SB, Park HR, Jang YJ, et al. Baicalein attenuates impaired hippocampal neurogenesis and the neurocognitive deficits induced by gamma-ray radiation. Br J Pharmacol. 2013;168(2):421–431.
   PubMed Web of Science ®Google Scholar
• Forbes ME, Paitsel M, Bourland JD, et al. Systemic effects of fractionated, whole-brain irradiation in young adult and aging rats. Radiat Res. 2013;180(3):326–333.
   PubMed Web of Science ®Google Scholar
• Zhang YQ, Cheng ZH, Wang CL, et al. Neuroprotective effects of kukoamine a against radiation-induced rat brain injury through inhibition of oxidative stress and neuronal apoptosis. Neurochem Res. 2016;41(10):2549–2558.
   PubMed Web of Science ®Google Scholar
• Spina MB, Squinto SP, Miller J, et al. Selective and nonselective protective effects of brain-derived neurotrophic factor for dopaminergic-neurons invitro – reply. J Neurochem. 1993;60(4):1582–1583.
   PubMed Web of Science ®Google Scholar
• Grant MM, Barber VS, Griffiths HR. The presence of ascorbate induces expression of brain derived neurotrophic factor in SH-SY5Y neuroblastorna cells after peroxide insult, which is associated with increased survival. Proteomics. 2005;5(2):534–540.
   PubMed Web of Science ®Google Scholar
• Li X, Zha X, Wang Y, et al. Toxic effects and foundation of proton radiation on the early-life stage of zebrafish development. Chemosphere. 2018;200:302–312.
   PubMed Web of Science ®Google Scholar
• Si J, Zhou R, Zhao BQ, et al. Effects of ionizing radiation and HLY78 on the zebrafish embryonic developmental toxicity. Toxicology. 2019;411:143–153.
   PubMed Web of Science ®Google Scholar
• Wang YP, Zhou X, Zhao BQ, et al. Early embryonic exposure of ionizing radiations disrupts zebrafish pigmentation. J Cell Physiol. 2019;234(1):940–949.
   Web of Science ®Google Scholar
• Zhou R, Zhang H, Wang Z, et al. The developmental toxicity and apoptosis in zebrafish eyes induced by carbon-ion irradiation. Life Sci. 2015;139:114–122.
   PubMed Web of Science ®Google Scholar
• Yuan P, Ito K, Perez-Lorenzo R, et al. Phenformin enhances the therapeutic benefit of BRAF(V600E) inhibition in melanoma. Proc Natl Acad Sci USA. 2013;110(45):18226–18231.
   PubMed Web of Science ®Google Scholar
• Orecchioni S, Reggiani F, Talarico G, et al. The biguanides metformin and phenformin inhibit angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells. Int J Cancer. 2015;136(6):E534–E544.
   PubMed Web of Science ®Google Scholar
• Miskimins WK, Ahn HJ, Kim JY, et al. Synergistic anti-cancer effect of phenformin and oxamate. PLoS One. 2014;9(1):e85576.
   PubMed Web of Science ®Google Scholar
• Kimmel CB, Ballard WW, Kimmel SR, et al. Stages of embryonic-development of the zebrafish. Dev Dyn. 1995;203(3):253–310.
   PubMed Web of Science ®Google Scholar
• Richendrfer H, Pelkowski SD, Colwill RM, et al. On the edge: pharmacological evidence for anxiety-related behavior in zebrafish larvae. Behav Brain Res. 2012;228(1):99–106.
   PubMed Web of Science ®Google Scholar
• Colwill RM, Creton R. Locomotor behaviors in zebrafish (Danio rerio) larvae. Behav Process. 2011;86(2):222–229.
   PubMed Web of Science ®Google Scholar
• Ulhaq M, Orn S, Carlsson G, et al. Locomotor behavior in zebrafish (Danio rerio) larvae exposed to perfluoroalkyl acids. Aquatic Toxicol. 2013;144:332–340.
   PubMed Web of Science ®Google Scholar
• Wang ZG, Zhou R, Jiang D, et al. Toxicity of graphene quantum dots in zebrafish embryo. Biomed Environ Sci. 2015;28(5):341–351.
   PubMed Web of Science ®Google Scholar
• Gagnaire B, Cavalie I, Pereira S, et al. External gamma irradiation-induced effects in early-life stages of zebrafish, Danio rerio. Aquatic Toxicol. 2015;169:69–78.
   PubMed Web of Science ®Google Scholar
• Cacialli P, D'Angelo L, de Girolamo P, et al. Morpho-functional features of the gonads of Danio rerio: the role of brain-derived neurotrophic factor. Anat Rec. 2018;301(1):140–147.
   Google Scholar
• Zhou R, Song JE, Si J, et al. Effects of Ru(CO)3Cl-glycinate on the developmental toxicities induced by X-ray and carbon-ion irradiation in zebrafish embryos. Mutat Res-Fund Mol M. 2016;793:41–50.
   PubMed Web of Science ®Google Scholar
• Wang K, Ma J, He M, et al. Toxicity assessments of near-infrared upconversion luminescent LaF3:Yb, Er in early development of zebrafish embryos. Theranostics. 2013;3(4):258–266.
   PubMed Web of Science ®Google Scholar
• Zhang ZJ, Cheang LC, Wang MW, et al. Ethanolic extract of fructus Alpinia oxyphylla protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish. Cell Mol Neurobiol. 2012;32(1):27–40.
   PubMed Web of Science ®Google Scholar
• Parlak V. Evaluation of apoptosis, oxidative stress responses, AChE activity and body malformations in zebrafish (Danio rerio) embryos exposed to deltamethrin. Chemosphere. 2018;207:397–403.
   PubMed Web of Science ®Google Scholar
• Hu M, Hu N, Ding D, et al. Developmental toxicity and oxidative stress induced by gamma irradiation in zebrafish embryos. Radiat Environ Biophys. 2016;55(4):441–450.
   PubMed Web of Science ®Google Scholar
• Si J, Zhou R, Song J, et al. Toxic effects of Fe-56 ion radiation on the zebrafish (Danio rerio) embryonic development. Aquatic Toxicol. 2017;186:87–95.
   PubMed Web of Science ®Google Scholar
• Anisimov VN, Ukraintseva SV, Anikin IV, et al. Effects of phentermine and phenformin on biomarkers of aging in rats. Gerontology. 2005;51(1):19–28.
   PubMed Web of Science ®Google Scholar
• Abdulwahid Arif I, Ahmad Khan H. Environmental toxins and Parkinson's disease: putative roles of impaired electron transport chain and oxidative stress. Toxicol Ind Health. 2010;26(2):121–128.
   PubMed Web of Science ®Google Scholar
• Dimberg Y, Vazquez M, Soderstrom S, et al. Effects of X-irradiation on nerve growth factor in the developing mouse brain. Toxicol Lett. 1997;90(1):35–43.
   PubMed Web of Science ®Google Scholar
• Shi X, Zhou B. The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos. Toxicol Sci. 2010;115(2):391–400.
   PubMed Web of Science ®Google Scholar
• Lane DP. Cancer. p53, guardian of the genome. Nature. 1992;358(6381):15–16.
   PubMed Web of Science ®Google Scholar
• Bates S, Vousden KH. p53 in signaling checkpoint arrest or apoptosis. Curr Opin Genet Dev. 1996;6(1):12–18.
   PubMed Web of Science ®Google Scholar