miR-155 is high-expressed in polycystic ovarian syndrome and promotes cell proliferation and migration through targeting PDCD4 in KGN cells

References

• Conway G, Dewailly D, Diamanti-Kandarakis E, et al. The polycystic ovary syndrome: a position statement from the European society of endocrinology. Eur J Endocrinol. 2014;171(4):P1–29.
   PubMed Web of Science ®Google Scholar
• Yildiz BO. Approach to the patient: contraception in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2015;100(3):794–802.
   PubMed Web of Science ®Google Scholar
• Gonzalez F, Sia CL, Shepard MK, et al. Inflammation in response to glucose ingestion is independent of excess abdominal adiposity in normal-weight women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2012;97(11):4071–4079.
   PubMed Web of Science ®Google Scholar
• Sorensen AE, Wissing ML, Salo S, et al. MicroRNAs related to polycystic ovary syndrome (PCOS). Genes. 2014;5(3):684–708.
   PubMed Web of Science ®Google Scholar
• Ambros V. microRNAs: tiny regulators with great potential. Cell. 2001;107(7):823–826.
   PubMed Web of Science ®Google Scholar
• Murri M, Insenser M, Fernandez-Duran E, et al. Non-targeted profiling of circulating microRNAs in women with polycystic ovary syndrome (PCOS): effects of obesity and sex hormones. Metabolism. 2018;86:49–60.
   PubMed Web of Science ®Google Scholar
• Cortez MA, Bueso-Ramos C, Ferdin J, et al. MicroRNAs in body fluids–the mix of hormones and biomarkers. Nat Rev Clin Oncol. 2011;8(8):467–477.
   PubMed Web of Science ®Google Scholar
• Lao G, Liu P, Wu Q, et al. Mir-155 promotes cervical cancer cell proliferation through suppression of its target gene LKB1. Tumor Biol. 2014;35(12):11933–11938.
   PubMedGoogle Scholar
• Long W, Zhao C, Ji C, et al. Characterization of serum microRNAs profile of PCOS and identification of novel non-invasive biomarkers. Cell Physiol Biochem. 2014;33(5):1304–1315.
   PubMedGoogle Scholar
• Sirotkin AV, Ovcharenko D, Grossmann R, et al. Identification of microRNAs controlling human ovarian cell steroidogenesis via a genome-scale screen. J Cell Physiol. 2009;219(2):415–420.
   PubMed Web of Science ®Google Scholar
• Murri M, Insenser M, Fernandez-Duran E, et al. Effects of polycystic ovary syndrome (PCOS), sex hormones, and obesity on circulating miRNA-21, miRNA-27b, miRNA-103, and miRNA-155 expression. J Clin Endocrinol Metab. 2013;98(11):E1835–E1844.
   PubMed Web of Science ®Google Scholar
• Sirotkin AV, Laukova M, Ovcharenko D, et al. Identification of microRNAs controlling human ovarian cell proliferation and apoptosis. J Cell Physiol. 2010;223(1):49–56.
   PubMed Web of Science ®Google Scholar
• Tam W. Identification and characterization of human BIC, a gene on chromosome 21 that encodes a noncoding RNA. Gene. 2001;274(1–2):157–167.
   PubMed Web of Science ®Google Scholar
• Pedersen IM, Otero D, Kao E, et al. Onco-miR-155 targets SHIP1 to promote TNFalpha-dependent growth of B cell lymphomas. EMBO Mol Med. 2009;1(5):288–295.
   PubMed Web of Science ®Google Scholar
• Costinean S, Sandhu SK, Pedersen IM, et al. Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein beta are targeted by miR-155 in B cells of Emicro-MiR-155 transgenic mice. Blood. 2009;114(7):1374–1382.
   PubMed Web of Science ®Google Scholar
• Jiang S, Zhang HW, Lu MH, et al. MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene. Cancer Res. 2010;70(8):3119–3127.
   PubMed Web of Science ®Google Scholar
• Arancio W, Calogero Amato M, Magliozzo M, et al. Serum miRNAs in women affected by hyperandrogenic polycystic ovary syndrome: the potential role of miR-155 as a biomarker for monitoring the estroprogestinic treatment. Gynecol Endocrinol. 2018;34(8):704–708.
   PubMed Web of Science ®Google Scholar
• Villavicencio A, Goyeneche A, Telleria C, et al. Involvement of Akt, Ras and cell cycle regulators in the potential development of endometrial hyperplasia in women with polycystic ovarian syndrome. Gynecol Oncol. 2009;115(1):102–107.
   PubMed Web of Science ®Google Scholar
• Wu Y, Li P, Zhang D, et al. Metformin and pioglitazone combination therapy ameliorate polycystic ovary syndrome through AMPK/PI3K/JNK pathway. Exp Ther Med. 2018;15(2):2120–2127.
   PubMed Web of Science ®Google Scholar
• Shah KN, Patel SS. Phosphatidylinositide 3-kinase inhibition: a new potential target for the treatment of polycystic ovarian syndrome. Pharm Biol. 2016;54(6):975–983.
   PubMed Web of Science ®Google Scholar
• Huang X, Liu C, Hao C, et al. Identification of altered microRNAs and mRNAs in the cumulus cells of PCOS patients: miRNA-509-3p promotes oestradiol secretion by targeting MAP3K8. Reproduction. 2016;151(6):643–655.
   PubMed Web of Science ®Google Scholar
• Xiang Y, Song Y, Li Y, et al. miR-483 is down-regulated in polycystic ovarian syndrome and inhibits KGN cell proliferation via targeting insulin-like growth factor 1 (IGF1). Med Sci Monit. 2016;22:3383–3393.
   PubMed Web of Science ®Google Scholar
• Jiang L, Huang J, Li L, et al. MicroRNA-93 promotes ovarian granulosa cells proliferation through targeting CDKN1A in polycystic ovarian syndrome. J Clin Endocrinol Metab. 2015;100(5):E729–E738.
   PubMed Web of Science ®Google Scholar
• Nishi Y, Yanase T, Mu Y, et al. Establishment and characterization of a steroidogenic human granulosa-like tumor cell line, KGN, that expresses functional follicle-stimulating hormone receptor. Endocrinology. 2001;142(1):437–445.
   PubMed Web of Science ®Google Scholar
• Song J, Luo S, Li SW. miRNA-592 is downregulated and may target LHCGR in polycystic ovary syndrome patients. Reprod Biol. 2015;15(4):229–237.
   PubMed Web of Science ®Google Scholar
• Goodarzi MO, Dumesic DA, Chazenbalk G, et al. Polycystic ovary syndrome: etiology, pathogenesis and diagnosis. Nat Rev Endocrinol. 2011;7(4):219–231.
   PubMed Web of Science ®Google Scholar
• Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009;136(2):215–233.
   PubMed Web of Science ®Google Scholar
• Shibuya H, Iinuma H, Shimada R, et al. Clinicopathological and prognostic value of microRNA-21 and microRNA-155 in colorectal cancer. Oncology. 2010;79(3–4):313–320.
   PubMed Web of Science ®Google Scholar
• Lankat-Buttgereit B, Goke R. The tumour suppressor Pdcd4: recent advances in the elucidation of function and regulation. Biol Cell. 2009;101(6):309–317.
   PubMed Web of Science ®Google Scholar
• Sheedy FJ, Palsson-McDermott E, Hennessy EJ, et al. Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21. Nat Immunol. 2010;11(2):141–147.
   PubMed Web of Science ®Google Scholar
• Rodrigues PM, Afonso MB, Simao AL, et al. Inhibition of NF-kappaB by deoxycholic acid induces miR-21/PDCD4-dependent hepatocellular apoptosis. Sci Rep. 2015;5(1):17528.
   PubMedGoogle Scholar
• Liu X, Cheng Y, Yang J, et al. An essential role of PDCD4 in vascular smooth muscle cell apoptosis and proliferation: implications for vascular disease. Am J Physiol Cell Physiol. 2010;298(6):C1481–C1488.
   PubMed Web of Science ®Google Scholar
• Matsuhashi S, Hamajima H, Xia J, et al. Control of a tumor suppressor PDCD4: Degradation mechanisms of the protein in hepatocellular carcinoma cells. Cell Signal. 2014;26(3):603–610.
   PubMed Web of Science ®Google Scholar
• Liu F, Song D, Wu Y, et al. MiR-155 inhibits proliferation and invasion by directly targeting PDCD4 in non-small cell lung cancer. Thorac Cancer. 2017;8(6):613–619.
   PubMed Web of Science ®Google Scholar
• Chien CS, Shen KH, Huang JS, et al. Antimetastatic potential of fisetin involves inactivation of the PI3K/Akt and JNK signaling pathways with downregulation of MMP-2/9 expressions in prostate cancer PC-3 cells. Mol Cell Biochem. 2010;333(1–2):169–180.
   PubMed Web of Science ®Google Scholar
• Lue H, Dewor M, Leng L, et al. Activation of the JNK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on CXCR4 and CD74. Cell Signal. 2011;23(1):135–144.
   PubMed Web of Science ®Google Scholar
• Zuo WN, Zhu H, Li LP, et al. MiR-155 promotes proliferation and inhibits apoptosis of nasopharyngeal carcinoma cells through targeting PTEN-PI3K/AKT pathway. Eur Rev Med Pharmacol Sci. 2019;23(18):7935–7942.
   PubMed Web of Science ®Google Scholar
• Hao Y, Huang J, Ma Y, et al. Asiatic acid inhibits proliferation, migration and induces apoptosis by regulating Pdcd4 via the PI3K/Akt/mTOR/p70S6K signaling pathway in human colon carcinoma cells. Oncol Lett. 2018;15(6):8223–8230.
   PubMed Web of Science ®Google Scholar
• Bitomsky N, Bohm M, Klempnauer KH. Transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun. Oncogene. 2004;23(45):7484–7493.
   PubMed Web of Science ®Google Scholar