Cell microencapsulation techniques for cancer modelling and drug discovery

References

• Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. doi: 10.3322/caac.21660.
   PubMed Web of Science ®Google Scholar
• Wong CH, Siah KW, Lo AW. Estimation of clinical trial success rates and related parameters. Biostatistics. 2019;20(2):273–286. doi: 10.1093/biostatistics/kxx069.
   PubMed Web of Science ®Google Scholar
• Bussard KM, Mutkus L, Stumpf K, et al. Tumor-associated stromal cells as key contributors to the tumor microenvironment. Breast Cancer Res. 2016;18(1):84. doi: 10.1186/s13058-016-0740-2.
   PubMed Web of Science ®Google Scholar
• Henke E, Nandigama R, Ergün S. Extracellular matrix in the tumor microenvironment and its impact on cancer therapy. Front Mol Biosci. 2020;6:160. doi: 10.3389/fmolb.2019.00160.
   PubMed Web of Science ®Google Scholar
• Edmondson R, Broglie JJ, Adcock AF, et al. Three-dimensional cell culture systems and their applications in drug discovery and cell-based biosensors. ASSAY Drug Dev Technol. 2014;12(4):207–218. doi: 10.1089/adt.2014.573.
   PubMed Web of Science ®Google Scholar
• Huang H, Ding Y, Sun XS, et al. Peptide hydrogelation and cell encapsulation for 3D culture of MCF-7 breast cancer cells. PLoS One. 2013;8(3):e59482. doi: 10.1371/journal.pone.0059482.
   PubMed Web of Science ®Google Scholar
• Luca AC, Mersch S, Deenen R, et al. Impact of the 3D microenvironment on phenotype, gene expression, and EGFR inhibition of colorectal cancer cell lines. PLoS One. 2013;8(3):e59689. doi: 10.1371/journal.pone.0059689.
   PubMed Web of Science ®Google Scholar
• Lagies S, Schlimpert M, Neumann S, et al. Cells grown in three-dimensional spheroids mirror in vivo metabolic response of epithelial cells. Commun Biol. 2020;3(1):1–10. doi: 10.1038/s42003-020-0973-6.
   PubMed Web of Science ®Google Scholar
• Szot CS, Buchanan CF, Freeman JW, et al. 3D in vitro bioengineered tumors based on collagen I hydrogels. Biomaterials. 2011;32(31):7905–7912. doi: 10.1016/j.biomaterials.2011.07.001.
   PubMed Web of Science ®Google Scholar
• Loessner D, Stok KS, Lutolf MP, et al. Bioengineered 3D platform to explore cell-ECM interactions and drug resistance of epithelial ovarian cancer cells. Biomaterials. 2010;31(32):8494–8506. doi: 10.1016/j.biomaterials.2010.07.064.
   PubMed Web of Science ®Google Scholar
• Butcher DT, Alliston T, Weaver VM. A tense situation: forcing tumour progression. Nat Rev Cancer. 2009;9(2):108–122. doi: 10.1038/nrc2544.
   PubMed Web of Science ®Google Scholar
• Imparato G, Urciuolo F, Netti PA. In vitro three-dimensional models in cancer research: a review. Int Mater Rev. 2015;60(6):297–311. doi: 10.1179/1743280415Y.0000000003.
   Web of Science ®Google Scholar
• Mak IWY, Evaniew N, Ghert M. Lost in translation: animal models and clinical trials in cancer treatment. Am J Translat Res. 2014;6(2):114–118.
   PubMed Web of Science ®Google Scholar
• Smalley KSM, Lioni M, Herlyn M. Life isn’t flat: taking cancer biology to the next dimension. In Vitro Cell Dev Biol Anim. 2006;42(8-9):242–247. doi: 10.1290/0604027.1.
   PubMed Web of Science ®Google Scholar
• Kapałczyńska M, Kolenda T, Przybyła W, et al. 2D and 3D cell cultures – a comparison of different types of cancer cell cultures. Arch Med Sci. 2018;14(4):910–919. doi: 10.5114/AOMS.2016.63743.
   PubMed Web of Science ®Google Scholar
• Lin R-Z, Chang H-Y. Recent advances in three-dimensional multicellular spheroid culture for biomedical research. Biotechnol J. 2008;3(9-10):1172–1184. doi: 10.1002/biot.200700228.
   PubMedGoogle Scholar
• Thiele J, Ma Y, Bruekers SMC, et al. 25th anniversary article: designer hydrogels for cell cultures: a materials selection guide. Adv Mater. 2014;26(1):125–148. doi: 10.1002/adma.201302958.
   PubMed Web of Science ®Google Scholar
• Ferreira LP, Gaspar VM, Mano JF. Design of spherically structured 3D in vitro tumor models -Advances and prospects. Acta Biomater. 2018;75:11–34. doi: 10.1016/J.ACTBIO.2018.05.034.
   PubMed Web of Science ®Google Scholar
• Lim F, Sun AM. Microencapsulated islets as bioartificial endocrine pancreas. Science. 1979;210(4472):908–910. doi: 10.1126/SCIENCE.6776628.
   Web of Science ®Google Scholar
• Du J, Yarema KJ. Cell microencapsulation for tissue engineering and regenerative medicine. In: J.M. Karp, W. Zhao, editors. Micro-and Nanoeng Cell Surface, vol 1. William Andrew Publishing, 2014. pp. 215–239. doi: 10.1016/B978-1-4557-3146-6.00010-6.
   Google Scholar
• Serra M, Correia C, Malpique R, et al. Microencapsulation technology: a powerful tool for integrating expansion and cryopreservation of human embryonic stem cells. PLoS One. 2011;6(8):e23212. doi: 10.1371/JOURNAL.PONE.0023212.
   PubMed Web of Science ®Google Scholar
• Malpique R, et al. Alginate encapsulation as a novel strategy for the cryopreservation of neurospheres. Tissue Eng Part C Methods. 2010;16:965–977. doi: 10.1089/TEN.TEC.2009.0660.
   PubMed Web of Science ®Google Scholar
• Murua A, Portero A, Orive G, et al. Cell microencapsulation technology: towards clinical application. J Controlled Release. 2008;132(2):76–83. doi: 10.1016/j.jconrel.2008.08.010.
   PubMed Web of Science ®Google Scholar
• Dubrot J, et al. Delivery of immunostimulatory monoclonal antibodies by encapsulated hybridoma cells. Cancer Immunol Immunoth. 2010;59(11):1621–1631. doi: 10.1007/S00262-010-0888-Z.
   PubMed Web of Science ®Google Scholar
• Heidebach T, Först P, Kulozik U. Microencapsulation of probiotic cells for food applications. Crit Rev Food Sci Nutr. 2012;52(4):291–311. doi: 10.1080/10408398.2010.499801.
   PubMed Web of Science ®Google Scholar
• Zhang X, Wang W, Yu W, et al. Development of an in vitro multicellular tumor spheroid model using microencapsulation and its application in anticancer drug screening and testing. Biotechnol Progress. 2005;21(4):1289–1296. doi: 10.1021/bp050003l.
   PubMed Web of Science ®Google Scholar
• Oudin MJ, Weaver VM. Physical and chemical gradients in the tumor microenvironment regulate tumor cell invasion, migration, and metastasis. Cold Spring Harb Symp Quant Biol. 2016;81(1):189–205. doi: 10.1101/sqb.2016.81.030817.
   PubMedGoogle Scholar
• Shannon AM, Bouchier-Hayes DJ, Condron CM, et al. Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies. Cancer Treat Rev. 2003;29(4):297–307. doi: 10.1016/S0305-7372(03)00003-3.
   PubMed Web of Science ®Google Scholar
• Asthana A, Kisaalita WS. Microtissue size and hypoxia in HTS with 3D cultures. Drug Discov Today. 2012;17(15-16):810–817. doi: 10.1016/j.drudis.2012.03.004.
   PubMed Web of Science ®Google Scholar
• Ishihara S, Haga H. Matrix stiffness contributes to cancer progression by regulating transcription factors. Cancers (Basel). 2022;14(4):1049. doi: 10.3390/cancers14041049.
   PubMed Web of Science ®Google Scholar
• Monteiro CF, Custódio CA, Mano JF. Bioengineering a humanized 3D tri-culture osteosarcoma model to assess tumor invasiveness and therapy response. Acta Biomater. 2021;134:204–214. doi: 10.1016/J.ACTBIO.2021.07.034.
   PubMed Web of Science ®Google Scholar
• Crooks CA, Douglas JA, Broughton RL, et al. Microencapsulation of mammalian cells in a HEMA-MMA copolymer: effects on capsule morphology and permeability. J Biomed Mater Res. 1990;24(9):1241–1262. doi: 10.1002/JBM.820240908.
   PubMed Web of Science ®Google Scholar
• Bhatia SR, Khattak SF, Roberts SC. Polyelectrolytes for cell encapsulation. Curr Opin Colloid Interface Sci. 2005;10(1-2):45–51. doi: 10.1016/j.cocis.2005.05.004.
   Web of Science ®Google Scholar
• McGuigan AP, Bruzewicz DA, Glavan A, et al. Cell encapsulation in Sub-mm sized gel modules using replica molding. PLoS One. 2008;3(5):e2258. doi: 10.1371/JOURNAL.PONE.0002258.
   PubMed Web of Science ®Google Scholar
• Chan ES, Lee BB, Ravindra P, et al. Prediction models for shape and size of ca-alginate macrobeads produced through extrusion–dripping method. J Colloid Interface Sci. 2009;338(1):63–72. doi: 10.1016/J.JCIS.2009.05.027.
   PubMed Web of Science ®Google Scholar
• Davarcı F, Turan D, Ozcelik B, et al. The influence of solution viscosities and surface tension on calcium-alginate microbead formation using dripping technique. Food Hydrocoll. 2017;62:119–127. doi: 10.1016/j.foodhyd.2016.06.029.
   Web of Science ®Google Scholar
• Costa ALR, Willerth SM, de la Torre LG, et al. Trends in hydrogel-based encapsulation technologies for advanced cell therapies applied to limb ischemia. Mater Today Bio. 2022;13:100221. doi: 10.1016/J.MTBIO.2022.100221.
   PubMedGoogle Scholar
• D, PonceletIn. Microencapsulation: fundamentals, methods and applications. In: V. M. Blitz, Jonathan P., Gun’ko, editors. Surface chemistry in biomedical and environmental science. Dordrecht, The Netherlands: Springer, 2006. pp. 23–34. doi: 10.1007/1-4020-4741-X.
   Google Scholar
• Manojlovic V, Djonlagic J, Obradovic B, et al. Immobilization of cells by electrostatic droplet generation: a model system for potential application in medicine. Int J Nanomedicine. 2006;1(2):163–171. p. doi: 10.2147/NANO.2006.1.2.163.
   PubMed Web of Science ®Google Scholar
• Heinzen C, Berger A, Marison I. Use of vibration technology for jet Break-Up for encapsulation of cells and liquids in monodisperse microcapsules. In: C. Heinzen, A. Berger, and I. Marison, editors. Fundamentals of cell immobilisation biotechnology, vol 8a. Dordrecht, The Netherlands: Springer, 2004. pp. 257–275. doi: 10.1007/978-94-017-1638-3_14.
   Google Scholar
• Preibisch I, Niemeyer P, Yusufoglu Y, et al. Polysaccharide-Based aerogel bead production via jet cutting method. Materials 2018. 2018;11(8):1287. doi: 10.3390/ma11081287.
   Google Scholar
• Teunou E, Poncelet D. Rotary disc atomisation for microencapsulation applications-prediction of the particle trajectories. J Food Eng. 2005;71:345–353. doi: 10.1016/j.jfoodeng.2004.10.048.
   Web of Science ®Google Scholar
• Leong J-Y, Lam W-H, Ho K-W, et al. Advances in fabricating spherical alginate hydrogels with controlled particle designs by ionotropic gelation as encapsulation systems. Particuology. 2016;24:44–60. doi: 10.1016/j.partic.2015.09.004.
   Web of Science ®Google Scholar
• Smit T, Calitz C, Willers C, et al. Characterization of an alginate encapsulated LS180 spheroid model for anti-colorectal cancer compound screening. ACS Med Chem Lett. 2020;11(5):1014–1021. doi: 10.1021/ACSMEDCHEMLETT.0C00076/SUPPL_FILE/ML0C00076_SI_001.PDF.
   PubMed Web of Science ®Google Scholar
• Yeon JH, Chung SH, Baek C, et al. A simple pipetting-based method for encapsulating live cells into multi-layered hydrogel droplets. BioChip J. 2018;12(3):184–192. doi: 10.1007/s13206-018-2307-z.
   Web of Science ®Google Scholar
• Antunes J, Gaspar VM, Ferreira L, et al. In-air production of 3D co-culture tumor spheroid hydrogels for expedited drug screening. Acta Biomater. 2019;94:392–409. doi: 10.1016/j.actbio.2019.06.012.
   PubMed Web of Science ®Google Scholar
• Rios De La Rosa JM, Wubetu J, Tirelli N, et al. Colorectal tumor 3D in vitro models: advantages of biofabrication for the recapitulation of early stages of tumour development. Biomed Phys Eng Express. 2018;4(4):045010. doi: 10.1088/2057-1976/aac1c9.
   Google Scholar
• Ertekin Ö, Monavari M, Krüger R, et al. 3D hydrogel-based microcapsules as an in vitro model to study tumorigenicity, cell migration and drug resistance. Acta Biomater. 2022;142:208–220. doi: 10.1016/J.ACTBIO.2022.02.010.
   PubMed Web of Science ®Google Scholar
• Xu X-X, Liu C, Liu Y, et al. Encapsulated human hepatocellular carcinoma cells by alginate gel beads as an in vitro metastasis model. Exp Cell Res. 2013;319(14):2135–2144. doi: 10.1016/j.yexcr.2013.05.013.
   PubMed Web of Science ®Google Scholar
• Schrader J, Gordon-Walker TT, Aucott RL, et al. Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells. Hepatology. 2011;53(4):1192–1205. doi: 10.1002/HEP.24108.
   PubMed Web of Science ®Google Scholar
• Choudhury N, Meghwal M, Das K. Microencapsulation: an overview on concepts, methods, properties and applications in foods. Food Front. 2021;2(4):426–442. doi: 10.1002/FFT2.94.
   Google Scholar
• Singh MN, Hemant KSY, Ram M, et al. Microencapsulation: a promising technique for controlled drug delivery. Res Pharm Sci. 2010;5(2):65.
   PubMedGoogle Scholar
• Spyropoulosa F, Hancocks RD, Norton IT. Food-grade emulsions prepared by membrane emulsification techniques. Procedia Food Sci. 2011;1:920–926. doi: 10.1016/j.profoo.2011.09.139.
   Google Scholar
• Pradhan S, Clary JM, Seliktar D, et al. A three-dimensional spheroidal cancer model based on PEG-fibrinogen hydrogel microspheres. Biomaterials. 2017;115:141–154. doi: 10.1016/j.biomaterials.2016.10.052.
   PubMed Web of Science ®Google Scholar
• van Vliet LD, Hollfelder F. Microfluidic droplets and their applications: diagnosis, drug screening and the discovery of therapeutic enzymes. IFMBE Proc. 2020;69:361–368. doi: 10.1007/978-981-13-5859-3_63/FIGURES/5.
   Google Scholar
• Vladisavljević GT, Kobayashi I, Nakajima M. Production of uniform droplets using membrane, microchannel and microfluidic emulsification devices. Microfluid Nanofluid. 2012;13(1):151–178. doi: 10.1007/s10404-012-0948-0.
   Web of Science ®Google Scholar
• Shewan HM, Stokes JR. Review of techniques to manufacture micro-hydrogel particles for the food industry and their applications. J Food Eng. 2013;119(4):781–792. doi: 10.1016/j.jfoodeng.2013.06.046.
   Web of Science ®Google Scholar
• Fridman IB, et al. High-throughput microfluidic 3D biomimetic model enabling quantitative description of the human breast tumor microenvironment. Acta Biomater. 2021;132:473–488. doi: 10.1016/J.A2021.06.025CTBIO.
   PubMed Web of Science ®Google Scholar
• Berger Fridman I, Ugolini GS, Vandelinder V, et al. High throughput microfluidic system with multiple oxygen levels for the study of hypoxia in tumor spheroids. Biofabrication. 2021;13(3):035037. doi: 10.1088/1758-5090/ABDB88.
   Web of Science ®Google Scholar
• Wu Z, Gong Z, Ao Z, et al. Rapid microfluidic formation of uniform Patient-Derived breast tumor spheroids. ACS Appl Bio Mater. 2020;3(9):6273–6283. doi: 10.1021/acsabm.0c00768.
   PubMedGoogle Scholar
• Li Y, Hai M, Zhao Y, et al. Controlled generation of cell-laden hydrogel microspheres with core-shell scaffold mimicking microenvironment of tumor. Chinese Phys B. 2018;27(12):128703. doi: 10.1088/1674-1056/27/12/128703.
   Web of Science ®Google Scholar
• Kingsley DM, Roberge CL, Rudkouskaya A, et al. Laser-based 3D bioprinting for spatial and size control of tumor spheroids and embryoid bodies. Acta Biomater. 2019;95:357–370. doi: 10.1016/j.actbio.2019.02.014.
   PubMed Web of Science ®Google Scholar
• Sakai S, Inamoto K, Liu Y, et al. Multicellular tumor spheroid formation in duplex microcapsules for analysis of chemosensitivity. Cancer Sci. 2012;103(3):549–554. doi: 10.1111/j.1349-7006.2011.02187.x.
   PubMed Web of Science ®Google Scholar
• Jun JC, Rathore A, Younas H, et al. Hypoxia-Inducible factors and cancer. Curr Sleep Med Rep. 2017;3(1):1–10. doi: 10.1007/S40675-017-0062-7.
   PubMedGoogle Scholar
• Duran M, Serrano A, Nikulin A, et al. Microcapsule production by droplet microfluidics: a review from the material science approach. Mater Des. 2022;223:111230. doi: 10.1016/j.matdes.2022.111230.
   Web of Science ®Google Scholar
• Nisisako T, Ando T, Hatsuzawa T. High-volume production of single and compound emulsions in a microfluidic parallelization arrangement coupled with coaxial annular world-to-chip interfaces. Lab Chip. 2012;12(18):3426–3435. doi: 10.1039/C2LC40245A/.
   PubMed Web of Science ®Google Scholar
• Visser CW, Kamperman T, Karbaat LP, et al. In-air microfluidics enables rapid fabrication of emulsions, suspensions, and 3D modular (bio)materials. Sci Adv. 2018;4(1):eaao1175. doi: 10.1126/SCIADV.AAO1175/SUPPL_FILE/AAO1175_SM.PDF.
   PubMed Web of Science ®Google Scholar
• De Lora JA, Velasquez JL, Carroll NJ, et al. Centrifugal generation of droplet-based 3D cell cultures. SLAS Technol. 2020;25(5):436–445. doi: 10.1177/2472630320915837/ATTACHMENT/578A34E8-F542-4826-9A89-971D95EBA568/MMC1-SUPPL.PDF.
   PubMed Web of Science ®Google Scholar
• De Lora JA, Fencl FA, Macias Gonzalez ADY, et al. Oil-Free acoustofluidic droplet generation for multicellular tumor spheroid culture. ACS Appl Bio Mater. 2019;2(9):4097–4105. doi: 10.1021/ACSABM.9B00617/ASSET/IMAGES/LARGE/MT9B00617_0005.JPEG.
   PubMedGoogle Scholar
• Thakuri PS, Ham SL, Luker GD, et al. Multiparametric analysis of oncology drug screening with aqueous two-phase tumor spheroids. Mol Pharmaceutics. 2016;13(11):3724–3735. doi: 10.1021/ACS.MOLPHARMACEUT.6B00527/ASSET/IMAGES/LARGE/MP-2016-00527S_0008.JPEG.
   PubMed Web of Science ®Google Scholar
• Piacentini E, Dragosavac M, Giorno L. Pharmaceutical particles design by membrane emulsification: preparation methods and applications in drug delivery. Curr Pharm Des. 2018;23(2):302–318. doi: 10.2174/1381612823666161117160940.
   Web of Science ®Google Scholar
• Morelli S, Holdich RG, Dragosavac MM. Microparticles for cell encapsulation and colonic delivery produced by membrane emulsification. J Memb Sci. 2017;524:377–388. doi: 10.1016/j.memsci.2016.11.058.
   Web of Science ®Google Scholar