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Emerging Microbes & Infections Volume 8, 2019 - Issue 1
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Letter

Single-dose replicon particle vaccine provides complete protection against Crimean-Congo hemorrhagic fever virus in mice

Florine E. M. Scholtea Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, USAORCID Iconhttps://orcid.org/0000-0003-2110-3087View further author information
ORCID Icon,
Jessica R. Spenglera Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, USAORCID Iconhttps://orcid.org/0000-0002-5383-0513View further author information
ORCID Icon,
Stephen R. Welcha Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, USAORCID Iconhttps://orcid.org/0000-0002-6905-8521View further author information
ORCID Icon,
Jessica R. Harmona Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, USAView further author information
,
JoAnn D. Coleman-McCraya Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, USAView further author information
,
Brendan T. Freitasb Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, USAORCID Iconhttps://orcid.org/0000-0001-5847-5904View further author information
ORCID Icon,
Markus H. Kainulainena Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, USAView further author information
,
Scott D. Peganb Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, USAORCID Iconhttps://orcid.org/0000-0002-2958-5319View further author information
ORCID Icon,
Stuart T. Nichola Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, USAView further author information
,
Éric Bergerona Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-3398-8628View further author information
ORCID Icon &
Christina F. Spiropouloua Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, USAORCID Iconhttps://orcid.org/0000-0001-8406-3161View further author information
ORCID Icon show all
Pages 575-578 | Received 20 Dec 2018, Accepted 18 Mar 2019, Published online: 04 Apr 2019

References

  • Negredo A, de la Calle-Prieto F, Palencia-Herrejón E, et al. Autochthonous Crimean–Congo hemorrhagic fever in Spain. N Engl J Med. 2017;377(2):154–161. doi:10.1056/NEJMoa1615162.
  • Buttigieg KR, Dowall SD, Findlay-Wilson S, et al. A novel vaccine against Crimean-Congo haemorrhagic fever protects 100% of animals against lethal challenge in a mouse model. PLoS One. 2014;9(3):e91516. doi:10.1371/journal.pone.0091516.
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  • Bergeron É, Zivcec M, Chakrabarti AK, et al. Recovery of recombinant Crimean Congo hemorrhagic fever virus reveals a function for non-structural glycoproteins cleavage by Furin. PLoS Pathog. 2015;11(5):e1004879. doi:10.1371/journal.ppat.1004879.
  • Welch SR, Scholte FEM, Flint M, et al. Identification of 2′-deoxy-2′-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus. Antiviral Res. 2017;147(November):91–99. doi:10.1016/j.antiviral.2017.10.008.
  • Zivcec M, Metcalfe MG, Albariño CG, et al. Assessment of Inhibitors of pathogenic Crimean-Congo hemorrhagic fever virus strains using virus-like particles. PLoS Negl Trop Dis. 2015;9(12):e0004259. doi:10.1371/journal.pntd.0004259.
  • Spengler JR, Kelly Keating M, McElroy AK, et al. Crimean-Congo hemorrhagic fever in humanized mice reveals glial cells as primary targets of neurological infection. J Infect Dis. 2017;216(11):1386–1397. doi:10.1093/infdis/jix215.
  • Scholte FEM, Zivcec M, Dzimianski JV, et al. Crimean-Congo hemorrhagic fever virus suppresses innate immune responses via a ubiquitin and ISG15 specific protease. Cell Rep. 2017;20(10):2396–2407. doi:10.1016/j.celrep.2017.08.040.
  • Kolumam GA, Thomas S, Thompson LJ, et al. Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection. J Exp Med. 2005;202(5):637–650. doi:10.1084/jem.20050821.

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