6,626
Views
76
CrossRef citations to date
0
Altmetric
Original Articles

The incidence and prevalence of hospital-acquired (carbapenem-resistant) Acinetobacter baumannii in Europe, Eastern Mediterranean and Africa: a systematic review and meta-analysis

ORCID Icon, ORCID Icon, , ORCID Icon, & ORCID Icon
Pages 1747-1759 | Received 04 Oct 2019, Accepted 21 Nov 2019, Published online: 05 Dec 2019

References

  • ECDC. Carbapenem-resistant Acinetobacter baumanni in healthcare settings. Stockholm: European Centre for Disease Prevention and Control; 2016.
  • Kempf M, Rolain JM. Emergence of resistance to carbapenems in Acinetobacter baumannii in Europe: clinical impact and therapeutic options. Int J Antimicrob Agents. 2012;39(2):105–114.
  • Higgins PG, Dammhayn C, Hackel M, et al. Global spread of carbapenem-resistant Acinetobacter baumannii. J Antimicrob Chemother. 2010;65(2):233–238.
  • Tacconelli E, Carrara E, Savoldi A, et al. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. Lancet Infect Dis. 2018;18(3):318–327.
  • Kim UJ, Kim HK, An JH, et al. Update on the epidemiology, treatment, and outcomes of carbapenem-resistantAcinetobacter infections. Chonnam Med J. 2014;50(2):37–44.
  • Kohlenberg A, Brummer S, Higgins PG, et al. Outbreak of carbapenem-resistant Acinetobacter baumannii carrying the carbapenemase OXA-23 in a German university medical centre. J Med Microbiol. 2009;58(Pt 11):1499–1507.
  • Abdulzahra AT, Khalil MAF, Elkhatib WF. First report of colistin resistance among carbapenem-resistant Acinetobacter baumannii isolates recovered from hospitalized patients in Egypt. New Microbes New Infect. 2018;26:53–58.
  • Fournier PE, Richet H. The epidemiology and control of Acinetobacter baumannii in health care facilities. Clin Infect Dis. 2006;42(5):692–699.
  • Munoz-Price LS, Weinstein RA. Acinetobacter infection. N Engl J Med. 2008;358(12):1271–1281.
  • Djahmi N, Dunyach-Remy C, Pantel A, et al. Epidemiology of carbapenemase-producing Enterobacteriaceae and Acinetobacter baumannii in Mediterranean countries. Biomed Res Int. 2014;2014:305784.
  • Lowings M, Ehlers MM, Dreyer AW, et al. High prevalence of oxacillinases in clinical multidrug-resistant Acinetobacter baumannii isolates from the Tshwane region, South Africa - an update. BMC Infect Dis. 2015;15(1):521–530.
  • Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151(4):264–269. w64.
  • Hoy D, Brooks P, Woolf A, et al. Assessing risk of bias in prevalence studies: modification of an existing tool and evidence of interrater agreement. J Clin Epidemiol. 2012;65(9):934–939.
  • Wu X, Long E, Lin H, et al. Prevalence and epidemiological characteristics of congenital cataract: a systematic review and meta-analysis. Sci Rep. 2016;6:28564.
  • Team RC. R: A language and environment for statistical computing. Vienna: R Foundation for Statistical Computing; 2014.
  • Agodi A, Auxilia F, Barchitta M, et al. Antibiotic consumption and resistance: results of the SPIN-UTI project of the GISIO-SItI. Epidemiol Prev. 2015;39(4):94–98.
  • ECDC. European Surveillance of healthcare care associated infections in intensive care units. ECDC HAIICU protcol V1.01 standard and light. Stockholm: European Centre for Disease Prevention and Control; 2010.
  • Atıcı S, Soysal A, Kadayifci EK, et al. Healthcare-associated infections in a newly opened pediatric intensive care unit in Turkey: results of four-year surveillance. J Infect Dev Ctries. 2016;10(3):254–259.
  • Garner JS, Jarvis WR, Emori TG, et al. CDC definitions for nosocomial infections, 1988. Am J Infect Control. 1988;16(3):128–140.
  • Custovic A, Smajlovic J, Tihic N, et al. Epidemiological monitoring of nosocomial infections caused by acinetobacter baumannii. Med Arch. 2014;68(6):402–406.
  • Duszynska W, Litwin A, Rojek S, et al. Analysis of Acinetobacter baumannii hospital infections in patients treated at the intensive care unit of the University Hospital, Wroclaw, Poland: A 6-year, single-center, retrospective study. Infect Drug Resist. 2018;11:629–635.
  • Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control. 2008;36(5):309–332.
  • El-Nawawy A, Ashraf GA, Antonios MAM, et al. Incidence of multidrug-resistant organism among children admitted to pediatric intensive care unit in a developing country. Microb Drug Resist. 2018;24(8):1198–1206.
  • Sehulster L, Chinn RY. Guidelines for environmental infection control in health-care facilities. Recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee (HICPAC). MMWR Recomm Rep. 2003;52(Rr-10):1–42.
  • Kolpa M, Wałaszek M, Gniadek A, et al. Incidence, microbiological profile and risk factors of healthcare-associated infections in intensive care units: a 10 year observation in a provincial hospital in southern Poland. Int J Environ Res Public Health. 2018;15(1):112–127.
  • ECDC. European surveillance of healthcare-associated infections in intensive care units – HAI-Net ICU protocol, version 1.02. Stockholm: European Centre for Disease Prevention and Control; 2015.
  • Kostakoğlu U, Saylan S, Karataş M, et al. Cost analysis and evaluation of nosocomial infections in intensive care units. Turk J Med Sci. 2016;46(5):1385–1392.
  • Nageeb W, Kamel M, Zakaria S, et al. Phenotypic characterization of Acinetobacter baumannii isolates from intensive care units at a tertiary-care hospital in Egypt. East Mediterr Health J. 2014;20(3):203–211.
  • Öncül O, Öksüz S, Acar A, et al. Nosocomial infection characteristics in a burn intensive care unit: analysis of an eleven-year active surveillance. Burns. 2014;40(5):835–841.
  • National Nosocomial Infections Surveillance System. National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control. 2004;32(8):470–485.
  • Sileem AE, Said AM, Meleha MS. Acinetobacter baumannii in ICU patients: A prospective study highlighting their incidence, antibiotic sensitivity pattern and impact on ICU stay and mortality. Egyp J Chest Dis Tuberc. 2017;66(4):693–698.
  • Vincent JL, Bihari DJ, Suter P, et al. The prevalence of nosocomial infection in intensive care units in Europe. Results of the European prevalence of infection in intensive care (EPIC) study. EPIC International Advisory Committee. JAMA. 1995;274(8):639–644.
  • Uwingabiye J, Lemnouer A, Baidoo S, et al. Intensive care unit-acquired Acinetobacter baumannii infections in a Moroccan teaching hospital: epidemiology, risk factors and outcome. GERMS. 2017;7(4):193–205.
  • Yetkin F, Yakupogullari Y, Kuzucu C, et al. Pathogens of intensive care unit-acquired infections and their antimicrobial resistance: a 9-year analysis of data from a university hospital. Jundishapur J Microbiol. 2018;11(10):e67716.
  • Yılmaz S, Yıldırım Y, Yılmaz Z, et al. Determining of the prevalence of nosocomial infections and causative gram negative bacilli in the intensive care unit. Duzce Med. J. 2014;16(2):39–42.
  • Ahoyo TA, Bankolé HS, Adéoti FM, et al. Prevalence of nosocomial infections and anti-infective therapy in Benin: results of the first nationwide survey in 2012. Antimicrob Resist Infect Control. 2014;3(1):17–22.
  • Gashaw M, Berhane M, Bekele S, et al. Emergence of high drug resistant bacterial isolates from patients with health care associated infections at Jimma University medical center: a cross sectional study. Antimicrob Resist Infect Control. 2018;7(1):138–145.
  • Kołpa M, Wałaszek M, Różańska A, et al. Hospital-wide surveillance of healthcare-associated infections as a source of information about specific hospital needs. A 5-year observation in a multiprofile provincial hospital in the south of Poland. Int J Environ Res Public Health. 2018;15(9):1956–1965.
  • ECDC. Surveillance of healthcare-associated infections in Europe, 2007. Stockholm: European Centre for Disease Prevention and Control; 2012.
  • Kritsotakis EI, Kontopidou F, Astrinaki E, et al. Prevalence, incidence burden, and clinical impact of healthcare-associated infections and antimicrobial resistance: a national prevalent cohort study in acute care hospitals in Greece. Infect Drug Resist. 2017;10:317–328.
  • ECDC. Point prevalence survey of healthcare-associated infections and antimicrobial use in European acute care hospitals. protocol version 4.3. full scale survey and codebook. Stockholm: European Centre for Disease Prevention and Control; 2012.
  • Matta R, Hallit R, Bawab W, et al. Epidemiology and microbiological profile comparison between community and hospital acquired infections: a multicenter retrospective study in Lebanon. J Infect Public Health. 2018;11(3):405–411.
  • Armin S, Karimi A, Fallah F, et al. Antimicrobial resistance patterns of Acinetobacter baumannii, Pseudomonas aeruginosa and Staphylococcus aureus isolated from patients with nosocomial infections admitted to Tehran hospitals. Arch Pediatr Infect Dis. 2015;3(4):e32554.
  • Atilla A, Tomak L, Katrancı AO, et al. Mortality risk factors in burn care units considering the clinical significance of acinetobacter infections. Turk J Trauma Emergency Surg. 2015;21(1):34–38.
  • Gecgel SK, Demircan N. The epidemiology of pathogen microorganisms in hospital acquired infections. Int J Clin Exp Med. 2016;9(11):22310–22316.
  • Kuzdan C, Soysal A, Çulha G, et al. Three-year study of health care-associated infections in a Turkish pediatric ward. J Infect Dev Ctries. 2014;8(11):1415–1420.
  • Wałaszek M. The analysis of the occurrence of nosocomial infections in the neurosurgical ward in the district hospital from 2003-2012. Przegla¸d Epidemiologiczny. 2015;69(3):507–514. 619–623.
  • Cei M, Pardelli R, Sani S, et al. Local resistance patterns to antimicrobials in internal medicine: a focused report from the REGIMEN (REGistro Infezioni in MEdicina INterna) study. Clin Exp Med. 2014;14(1):77–82.
  • Hafeez A, Munir T, Najeeb S, et al. ICU pathogens: a continuous challenge. J Coll Physicians and Surgeons Pakistan. 2016;26(7):577–580.
  • Vincent JL, Rello J, Marshall J, et al. International study of the prevalence and outcomes of infection in intensive care units. JAMA. 2009;302(21):2323–2329.
  • Teerawattanapong N, Panich P, Kulpokin D, et al. A systematic review of the burden of multidrug-resistant healthcare-associated infections among intensive care unit patients in Southeast Asia: the rise of multidrug-resistant Acinetobacter baumannii. Infect Control Hosp Epidemiol. 2018;39(5):525–533.
  • Zhen X, Chen Y, Hu X, et al. The difference in medical costs between carbapenem-resistant Acinetobacter baumannii and non-resistant groups: a case study from a hospital in Zhejiang province, China. Eur J Clin Microbiol Infect Dis. 2017;36(10):1989–1994.
  • Magill SS, Edwards JR, Bamberg W, et al. Multistate point-prevalence survey of health care-associated infections. N Engl J Med. 2014;370(13):1198–1208.
  • Chen Y, Zhao JY, Shan X, et al. A point-prevalence survey of healthcare-associated infection in fifty-two Chinese hospitals. J Hosp Infect. 2017;95(1):105–111.
  • Gupta V, Ye G, Olesky M, et al. National prevalence estimates for resistant Enterobacteriaceae and Acinetobacter species in hospitalized patients in the United States. Int J Infect Dis. 2019;85:203–211.
  • Ling ML, Apisarnthanarak A, Madriaga G. The burden of healthcare-associated infections in Southeast Asia: a systematic literature review and meta-analysis. Clin Infect Dis. 2015;60(11):1690–1699.
  • Patwardhan RB, Dhakephalkar PK, Niphadkar KB, et al. A study on nosocomial pathogens in ICU with special reference to multiresistant Acinetobacter baumannii harbouring multiple plasmids. Indian J Med Res. 2008;128(2):178–187.
  • Gulati S, Kapil A, Das B, et al. Nosocomial infections due to Acinetobacter baumannii in a neurosurgery ICU. Neurol India. 2001;49(2):134–137.
  • Yue D, Song C, Zhang B, et al. Hospital-wide comparison of health care-associated infection among 8 intensive care units: a retrospective analysis for 2010-2015. Am J Infect Control. 2017;45(1):e7–e13.
  • Luna CM, Rodriguez-Noriega E, Bavestrello L, et al. Gram-negative infections in adult intensive care units of Latin America and the Caribbean. Crit Care Res Pract. 2014;2014:480463.
  • Allegranzi B, Nejad SB, Combescure C, et al. Burden of endemic health-care-associated infection in developing countries: systematic review and meta-analysis. The Lancet. 2011;377(9761):228–241.
  • McCann E, Srinivasan A, DeRyke CA, et al. Carbapenem-Nonsusceptible Gram-negative pathogens in ICU and non-ICU settings in US hospitals in 2017: a multicenter study. Open Forum Infect Dis. 2018;5(10):ofy241.
  • European Centre for Disease Prevention and Control. Healthcare-associated infections acquired in intensive care units, in annual epidemiological report for 2016, ECDC, Editor. Stockolm: European Centre for Disease Prevention and Control; 2018.
  • Manenzhe RI, Zar HJ, Nicol MP, et al. The spread of carbapenemase-producing bacteria in Africa: a systematic review. J Antimicrob Chemother. 2015;70(1):23–40.
  • World Health Organization. Worldwide country situation analysis: response to antimicrobial resistance; 2015.
  • Rodriguez-Acelas AL, de Abreu Almeida M, Engelman B, et al. Risk factors for health care-associated infection in hospitalized adults: systematic review and meta-analysis. Am J Infect Control. 2017;45(12):e149–e156.
  • Sharland M, Pulcini C, Harbarth S, et al. Classifying antibiotics in the WHO essential medicines list for optimal use-be AWaRe. Lancet Infect Dis. 2018;18(1):18–20.