Advanced search
Publication Cover
Emerging Microbes & Infections Volume 9, 2020 - Issue 1
Submit an article Journal homepage
38,782
Views
449
CrossRef citations to date
0
Altmetric
Letter

Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension

Juan Menga National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, People’s Republic of China;b Shenzhen Bay Laboratory, Shenzhen, People’s Republic of ChinaView further author information
,
Guohui Xiaoa National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, People’s Republic of China;b Shenzhen Bay Laboratory, Shenzhen, People’s Republic of ChinaView further author information
,
Juanjuan Zhanga National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, People’s Republic of ChinaView further author information
,
Xing Hea National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, People’s Republic of ChinaView further author information
,
Min Oua National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, People’s Republic of ChinaView further author information
,
Jing Bia National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, People’s Republic of ChinaView further author information
,
Rongqing Yanga National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, People’s Republic of ChinaView further author information
,
Wencheng Dia National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, People’s Republic of ChinaView further author information
,
Zhaoqin Wanga National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, People’s Republic of ChinaView further author information
,
Zigang Lib Shenzhen Bay Laboratory, Shenzhen, People’s Republic of ChinaView further author information
,
Hong Gaoa National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, People’s Republic of ChinaCorrespondence[email protected]
View further author information
,
Lei Liua National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, People’s Republic of ChinaCorrespondence[email protected]
View further author information
&
Guoliang Zhanga National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, People’s Republic of China;b Shenzhen Bay Laboratory, Shenzhen, People’s Republic of China;c Lead ContactCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3617-5449View further author information
ORCID Icon show all
Pages 757-760 | Received 08 Mar 2020, Accepted 17 Mar 2020, Published online: 31 Mar 2020

References

  • Wu Z, McGoogan JM. Characteristics of and important Lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a Report of 72 314 cases from the Chinese Center for disease control and Prevention. JAMA. 2020.
  • Wang Z, Chen Z, Zhang L, et al. Status of Hypertension in China: Results from the China Hypertension Survey, 2012-2015. Circulation: CIRCULATIONAHA.117.032380.
  • Hampl V, Herget J, Bíbová J, et al. Intrapulmonary activation of the angiotensin-converting enzyme type 2/angiotensin 1-7/G-protein-coupled Mas receptor axis attenuates pulmonary hypertension in Ren-2 transgenic rats exposed to chronic hypoxia. Physiol Res. 2015;64(1):25–38.
  • Zhou P, Yang XL, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020.
  • Kuba K, Imai Y, Rao S, et al. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury. Nat. Med. 2005;11(8):875–879. doi: 10.1038/nm1267
  • Moon JY. Recent Update of renin-angiotensin-aldosterone. Sys Pathogenesis Hypertens. 2013;11(2):41–45.
  • Yang P, Gu H, Zhao Z, et al. Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury. Sci Rep. 2015;4(1):7027. doi: 10.1038/srep07027
  • Liu Y, Yang Y, Zhang C, et al. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Beijing: Science China Life sciences; 2020.
  • Hsu WT, Galm BP, Schrank G, et al. Effect of renin-angiotensin-aldosterone system inhibitors on short-Term mortality After sepsis: a population-based aohort study. Hypertension. 2020;75(2):483–491. doi: 10.1161/HYPERTENSIONAHA.119.13197
  • Wang X, Khaidakov M, Ding Z, et al. Cross-talk between inflammation and angiotensin II: studies based on direct transfection of cardiomyocytes with AT1R and AT2R cDNA. Exp Biol Med. 2012;237(12):1394–1401. doi: 10.1258/ebm.2012.012123
  • Ye R, Liu Z. ACE2 exhibits protective effects against LPS-induced acute lung injury in mice by inhibiting the LPS-TLR4 pathway. Exp Mol Pathol. 2020;113:104350. doi: 10.1016/j.yexmp.2019.104350
  • Gage JR, Fonarow G, Hamilton M, et al. Beta Blocker and angiotensin-converting enzyme Inhibitor therapy Is associated with decreased Th1/Th2 cytokine ratios and inflammatory cytokine production in patients with chronic heart failure. Neuroimmunomodulation. 2004;11(3):173–180. doi: 10.1159/000076766

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.