2,956
Views
6
CrossRef citations to date
0
Altmetric
Articles

High anal swab viral load predisposes adverse clinical outcomes in severe COVID-19 patients

, , ORCID Icon, , , , , , , , , , , , , ORCID Icon, & ORCID Icon show all
Pages 2706-2713 | Received 17 Sep 2020, Accepted 27 Nov 2020, Published online: 24 Dec 2020

References

  • Ren LL, Wang YM, Wu ZQ, et al. Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study. Chin Med J (Engl). 2020;13(9):1015–1024.
  • Coronavirus disease 2019 (COVID-19) Situation Report. Weekly Epidemiological Update, 2020. World Health Organization. Accessed August 30, 2020. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200831-weekly-epi-update-3.pdf?sfvrsn=d7032a2a_4.
  • Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506.
  • Zhu N, Zhang D, Wang W, et al. A Novel coronavirus from patients with Pneumonia in China, 2019. N Engl J Med. 2020;382(8):727–733.
  • Montalvan V, Lee J, Bueso T, et al. Neurological manifestations of COVID-19 and other coronavirus infections: A systematic review. Clin Neurol Neurosurg. 2020;194, 105921. doi:10.1016/j.clineuro.2020.105921
  • Deza Leon MP, Redzepi A, McGrath E, et al. COVID-19 Associated Pediatric Multi-system Inflammatory syndrome. J Pediatric Infect Dis Soc. 2020;9(3):407–408.
  • Zheng S, Fan J, Yu F, et al. Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study. Br Med J. 2020;369:m1443. doi:10.1136/bmj.m1443
  • Cao B, Wang Y, Wen D, et al. A trial of lopinavir-ritonavir in Adults hospitalized with severe covid-19. N Engl J Med. 2020;382(19):1787–1799.
  • Liu Y, Yan LM, Wan L, et al. Viral dynamics in mild and severe cases of COVID-19. Lancet Infect Dis. 2020;20(6):656–657.
  • Hung IF, Cheng VC, Wu AK, et al. Viral loads in clinical specimens and SARS manifestations. Emerg Infect Dis. 2004;10(9):1550–1557.
  • Chen X, Zhao B, Qu Y, et al. Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients. Clin Infect Dis. 2020; Apr 17;71(8):1937–1942.
  • Sun J, Xiao J, Sun R, et al. Prolonged Persistence of SARS-CoV-2 RNA in Body Fluids. Emerg Infect Dis. 2020;26(8):1834–1838.
  • Liu Y, Wang Y, Wang X, et al. Development of two TaqMan real-time reverse transcription-PCR assays for the detection of severe acute respiratory syndrome coronavirus-2. Biosafety and Health. 2020 Jul 23. doi:10.1016/j.bsheal.2020.07.009
  • Wölfel R, Corman VM, Guggemos W, et al. Virological assessment of hospitalized patients with COVID-2019. Nature. 2020;581(7809):465–469.
  • Cheung KS, Hung IFN, Chan PPY, et al. Gastrointestinal manifestations of SARS-CoV-2 infection and virus load in fecal samples from a Hong Kong Cohort: Systematic Review and Meta-analysis. Gastroenterology. 2020;159(1):81–95.
  • Huang Y, Chen S, Yang Z, et al. SARS-CoV-2 viral load in clinical samples from critically Ill patients. Am J Respir Crit Care Med. 2020;201(11):1435–1438.
  • Poon LL, Guan Y, Nicholls JM, et al. The aetiology, origins, and diagnosis of severe acute respiratory syndrome. Lancet Infect Dis. 2004;4(11):663–671.
  • Peiris JS, Chu CM, Cheng VC, et al. Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. Lancet. 2003;361(9371):1767–1772.
  • Zhou J, Li C, Liu X, et al. Infection of bat and human intestinal organoids by SARS-CoV-2. Nat Med. 2020;26(7):1077–1083.
  • Kim YI, Kim SG, Kim SM, et al. Infection and Rapid transmission of SARS-CoV-2 in Ferrets. Cell Host Microbe. 2020;27(5):704–709.
  • Xiao F, Tang M, Zheng X, et al. Evidence for gastrointestinal infection of SARS-CoV-2. Gastroenterology. 2020;158(6):1831–1833.
  • Oh MD, Park WB, Choe PG, et al. Viral load kinetics of MERS coronavirus infection. N Engl J Med. 2016;375(13):1303–1305.
  • Corman VM, Albarrak AM, Omrani AS, et al. Viral shedding and Antibody Response in 37 patients With Middle East respiratory syndrome coronavirus infection. Clin Infect Dis. 2016;62(4):477–483.
  • Liu Y, Yang Y, Zhang C, et al. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Sci China Life Sci. 2020;63(3):364–374.
  • Fajnzylber J, Regan J, Coxen K, et al. SARS-CoV-2 viral load is associated with increased disease severity and mortality. Nat Commun. 2020;11(1):5493.
  • Yan R, Zhang Y, Li Y, et al. Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science. 2020;367(6485):1444–1448.
  • Lu G, Hu Y, Wang Q, et al. Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature. 2013;500(7461):227–231.
  • Ziegler CGK, Allon SJ, Nyquist SK, et al. SARS-CoV-2 receptor ACE2 Is an Interferon-Stimulated gene in Human Airway epithelial Cells and Is detected in specific Cell Subsets across Tissues. Cell. 2020;181(5):1016–1035.
  • Leung WK, To KF, Chan PK, et al. Enteric involvement of severe acute respiratory syndrome-associated coronavirus infection. Gastroenterology. 2003;125(4):1011–1017.