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Antimicrobial Agents

Determinants of fluconazole resistance and echinocandin tolerance in C. parapsilosis isolates causing a large clonal candidemia outbreak among COVID-19 patients in a Brazilian ICU

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Pages 2264-2274 | Received 17 May 2022, Accepted 21 Aug 2022, Published online: 27 Sep 2022

References

  • Arastehfar A, Carvalho A, Nguyen MH, et al. COVID-19-associated candidiasis (CAC): an underestimated complication in the absence of immunological predispositions? . J Fungi (Basel, Switzerland). 2020;6.
  • Arastehfar A, Shaban T, Zarrinfar H, et al. Candidemia among Iranian patients with severe COVID-19 admitted to ICUs. J Fungi (Basel, Switzerland). 2021;7:56–57.
  • Prestel C, Anderson E, Forsberg K, et al. Candida auris outbreak in a COVID-19 Specialty Care Unit - Florida, July-August 2020. MMWR Morb Mortal Wkly Rep. 2021;70:56–57.
  • Rajni E, Singh A, Tarai B, et al. A high frequency of Candida auris blood stream infections in Coronavirus disease 2019 patients admitted to intensive care units, northwestern India: a case control study. Open Forum Infect Dis. 2021;8:ofab452.
  • Arastehfar A, Ünal N, Hoşbul T, et al. Candidemia among Coronavirus disease 2019 patients in Turkey admitted to intensive care units: a retrospective multicenter study. Open Forum Infect Dis. 2022;9:ofac078.
  • Thomaz DY, Del Negro GMB, Ribeiro LB, et al. A Brazilian inter-hospital candidemia outbreak caused by fluconazole-resistant Candida parapsilosis in the COVID-19 Era. J Fungi (Basel, Switzerland). 2022;8:259.
  • Thomaz DY, de Almeida Jr JN, Sejas ONE, et al. Environmental clonal spread of azole-resistant Candida parapsilosis with Erg11-Y132F mutation causing a large candidemia outbreak in a Brazilian Cancer Referral Center. J Fungi. 2021;64(10).
  • Arastehfar A, Daneshnia F, Hilmioğlu-Polat S, et al. First report of candidemia clonal outbreak caused by emerging fluconazole-resistant Candida parapsilosis isolates harboring Y132F and/or Y132F+K143R in Turkey. Antimicrob Agents Chemother. 2020. doi:10.1128/AAC.01001-20.
  • Arastehfar A, Hilmioğlu-Polat S, Daneshnia F, et al. Clonal candidemia outbreak by Candida parapsilosis carrying Y132F in Turkey: evolution of a persisting challenge. Front Cell Infect Microbiol. 2021;11:676177.
  • Arastehfar A, Daneshnia F, Hilmioglu-Polat S, et al. Genetically related micafungin-resistant Candida parapsilosis blood isolates harbouring novel mutation R658G in hotspot 1 of Fks1p: a new challenge? J Antimicrob Chemother. 2021;76:418–422.
  • Clancy CJ, Buehrle DJ, Nguyen MH. PRO: the COVID-19 pandemic will result in increased antimicrobial resistance rates. JAC-antimicrobial Resist. 2020;2:dlaa049.
  • Lai C-C, Chen S-Y, Ko W-C, et al. Increased antimicrobial resistance during the COVID-19 pandemic. Int J Antimicrob Agents. 2021;57:106324.
  • Souza ACR, Fuchs BB, Pinhati HMS, et al. Candida parapsilosis resistance to fluconazole: molecular mechanisms and in vivo impact in infected Galleria mellonella Larvae. Antimicrob Agents Chemother. 2015;59:6581–6587.
  • Zhang L, Xiao M, Watts MR, et al. Development of fluconazole resistance in a series of Candida parapsilosis isolates from a persistent candidemia patient with prolonged antifungal therapy. BMC Infect Dis. 2015;15:340.
  • Grossman NT, Pham CD, Cleveland AA, et al. Molecular mechanisms of fluconazole resistance in Candida parapsilosis isolates from a U.S. surveillance system. Antimicrob Agents Chemother. 2015;59:1030–1037.
  • Arastehfar A, Lass-flörl C, Garcia-rubio R, et al. The quiet and underappreciated rise of drug-resistant invasive fungal pathogens. J Fungi. 2020;59(10):6629–6633.
  • Branco J, Silva AP, Silva RM, et al. Fluconazole and voriconazole resistance in Candida parapsilosis is conferred by gain-of-function mutations in MRR1 transcription factor gene. Antimicrob Agents Chemother. 2015;59:6629–6633.
  • Martí-Carrizosa M, Sánchez-Reus F, March F, et al. Implication of Candida parapsilosis FKS1 and FKS2 mutations in reduced echinocandin susceptibility. Antimicrob Agents Chemother. 2015;59:3570–3573.
  • Liang J, Macesic N, Blakeway L. Comment on: genetically related micafungin-resistant Candida parapsilosis blood isolates harbouring novel mutation R658G in hotspot 1 of Fks1p: a new challenge? J Antimicrob Chemother. 2022. doi:10.1093/jac/dkac091.
  • Healey KR, Perlin DS. Fungal resistance to echinocandins and the MDR phenomenon in Candida glabrata. J Fungi (Basel, Switzerland). 2018;4:319–331.
  • Berman J, Krysan DJ. Drug resistance and tolerance in fungi. Nat Rev Microbiol. 2020;18:319–331.
  • Morio F, Lombardi L, Butler G. The CRISPR toolbox in medical mycology: state of the art and perspectives. PLoS Pathog. 2020;16:e1008201.
  • Morio F, Lombardi L, Binder U, et al. Precise genome editing using a CRISPR-Cas9 method highlights the role of CoERG11 amino acid substitutions in azole resistance in Candida orthopsilosis. J Antimicrob Chemother. 2019;74:2230–2238.
  • Stielow JB, Lévesque CA, Seifert KA, et al. One fungus, which genes? development and assessment of universal primers for potential secondary fungal DNA barcodes. Persoonia. 2015;35:242–263.
  • Clinical and Laboratory Standards Institute. Reference method for broth dilution antifungal susceptibility testing of yeasts; approved standard M27-A3. 3rd ed. Wayne (PA): CLSI; 2008.
  • Pfaller MA, Diekema DJ. Progress in antifungal susceptibility testing of candida spp. by use of Clinical and Laboratory Standards Institute broth microdilution methods, 2010 to 2012. J Clin Microbiol. 2012;50:2846–2856.
  • Pulcrano G, Roscetto E, Iula VD, et al. MALDI-TOF mass spectrometry and microsatellite markers to evaluate Candida parapsilosis transmission in neonatal intensive care units. Eur J Clin Microbiol Infect Dis Off Publ Eur Soc Clin Microbiol. 2012;31:2919–2928.
  • Choi YJ, Kim Y-J, Yong D, et al. Fluconazole-resistant Candida parapsilosis bloodstream isolates with Y132F mutation in ERG11 gene, South Korea. Emerg Infect Dis. 2018;11.
  • Zhang L, Yu S-Y, Chen SC-A, et al. Molecular characterization of Candida parapsilosis by microsatellite typing and emergence of clonal antifungal drug resistant strains in a multicenter surveillance in China. Front Microbiol. 2020;11:1320.
  • Carreté L, Ksiezopolska E, Pegueroles C, et al. Patterns of genomic variation in the opportunistic pathogen Candida glabrata suggest the existence of mating and a secondary association with humans. Curr Biol. 2018;28:15–27.e7.
  • Arastehfar A, Daneshnia F, Najafzadeh MJ, et al. Evaluation of molecular epidemiology, clinical characteristics, antifungal susceptibility profiles, and molecular mechanisms of antifungal resistance of Iranian Candida parapsilosis species complex blood isolates. Front Cell Infect Microbiol. 2020;10:206.
  • Pekmezovic M, Hovhannisyan H, Gresnigt MS, et al. Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells. Nat Microbiol. 2021;6:643–657.
  • Daneshnia F, Hilmioğlu-Polat S, Ilkit M, et al. Determinants of fluconazole resistance and the efficacy of fluconazole and milbemycin oxim combination in sensitizing Candida parapsilosis isolates from Brazil and Turkey. Front Fungal Biol. 2022;25(4):402–408.
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25:402–408.
  • Lombardi L, Oliveira-Pacheco J, Butler G. Plasmid-based CRISPR-Cas9 gene editing in multiple Candida species. mSphere. 2019;4:e000033.
  • Peng D, Tarleton R. EuPaGDT: a web tool tailored to design CRISPR guide RNAs for eukaryotic pathogens. Microb Genomics. 2015;1:e000033.
  • Wu X, Kriz AJ, Sharp PA. Target specificity of the CRISPR-Cas9 system. Quant Biol (Beijing, China). 2014;2:59–70.
  • Németh T, Nosanchuk J D, Vagvolgyi C, et al. Enhancing the chemical transformation of Candida parapsilosis. Virulence. 2021;12:937–950.
  • Nishimoto AT, Sharma C, Rogers PD. Molecular and genetic basis of azole antifungal resistance in the opportunistic pathogenic fungus Candida albicans. J Antimicrob Chemother. 2020;75:257–270. doi:10.1093/jac/dkz400.
  • Andes DR, Safdar N, Baddley JW, et al. Impact of treatment strategy on outcomes in patients with candidemia and other forms of invasive candidiasis: a patient-level quantitative review of randomized trials. Clin Infect Dis an Off Publ Infect Dis Soc Am. 2012;54:1110–1122.
  • Pappas PG, Kauffman CA, Andes DR, et al. Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis. 2016;62:1–50.
  • Pinhati HMS, Casulari LA, Souza ACR, et al. Outbreak of candidemia caused by fluconazole resistant Candida parapsilosis strains in an intensive care unit. BMC Infect Dis. 2016;16:433.
  • Binder U, Arastehfar A, Schnegg L, et al. Efficacy of LAMB against emerging azole- and multidrug-resistant Candida parapsilosis isolates in the Galleria mellonella model. J Fungi (Basel, Switzerland). 2020;6:337.
  • Shields RK, Kline EG, Healey KR, et al. Spontaneous mutational frequency and FKS mutation rates vary by echinocandin agent against Candida glabrata. Antimicrob Agents Chemother. 2019;63:e01692-18.
  • Hou X, Healey KR, Shor E, et al. Novel FKS1 and FKS2 modifications in a high-level echinocandin resistant clinical isolate of Candida glabrata. Emerg Microbes Infect. 2019;8:1619–1625.
  • Tóth R, Nosek J, Mora-Montes HM, et al. Candida parapsilosis: from genes to the bedside. Clin Microbiol Rev. 2019;32:87–93.
  • Rajendran R, Sherry L, Nile CJ, et al. Biofilm formation is a risk factor for mortality in patients with candida albicans bloodstream infection-Scotland, 2012-2013. Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis. 2016;22:87–93.