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Emerging Microbes & Infections Volume 11, 2022 - Issue 1
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Coronaviruses

Omicron infections profile and vaccination status among 1881 liver transplant recipients: a multi-centre retrospective cohort

Ensi Maa Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Jingwen Aib Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China;c National Medical Center for Infectious Diseases, Shanghai, People’s Republic of ChinaView further author information
,
Yi Zhangb Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China;c National Medical Center for Infectious Diseases, Shanghai, People’s Republic of ChinaView further author information
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Jianming Zhengb Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China;c National Medical Center for Infectious Diseases, Shanghai, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0003-1471-9078View further author information
ORCID Icon,
Xiaogang Gaod Department of Organ Transplantation, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, People’s Republic of ChinaView further author information
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Junming Xue Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ChinaView further author information
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Hao Yinf Organ Transplant Center, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, People’s Republic of ChinaView further author information
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Zhiren Fug Liver Transplantation Center, Department of General Surgery, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ChinaView further author information
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Hao Xinga Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, People’s Republic of ChinaView further author information
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Li Lia Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, People’s Republic of ChinaView further author information
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Liying Sunh Liver Transplantation Center, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China;i Clinical Center for Pediatric Liver Transplantation, Capital Medical University, Beijing, People’s Republic of ChinaView further author information
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Heyu Huangj Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, People’s Republic of ChinaView further author information
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Quanbao Zhanga Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, People’s Republic of ChinaView further author information
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Linlin Xua Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, People’s Republic of ChinaView further author information
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Yanting Jina Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, People’s Republic of ChinaView further author information
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Rui Chend Department of Organ Transplantation, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, People’s Republic of ChinaView further author information
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Guoyue Lvj Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, People’s Republic of ChinaCorrespondence[email protected]
View further author information
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Zhijun Zhuh Liver Transplantation Center, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China;i Clinical Center for Pediatric Liver Transplantation, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence[email protected]
View further author information
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Wenhong Zhangb Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China;c National Medical Center for Infectious Diseases, Shanghai, People’s Republic of ChinaCorrespondence[email protected]
View further author information
&
Zhengxin Wanga Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, People’s Republic of ChinaCorrespondence[email protected]
View further author information
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Pages 2636-2644 | Received 23 Jun 2022, Accepted 11 Oct 2022, Published online: 04 Nov 2022

References

  • Coronavirus Resource Center. https://coronavirus.jhu.edu/map.html.
  • Zhang X, Zhang W, Chen S. Shanghai’s life-saving efforts against the current omicron wave of the COVID-19 pandemic. Lancet. May 28 2022;399(10340):2011–2012. doi:10.1016/S0140-6736(22)00838-8.
  • Fan X, Lu S, Bai L, et al. Preliminary study of the protectiveness of vaccination against the COVID-19 in the outbreak of VOC Omicron BA.2 – Jilin City, Jilin Province, China, March 3-April 12, 2022. China CDC Wkly. May 6 2022;4(18):377–380. doi:10.46234/ccdcw2022.081.
  • People with Certain Medical Conditions. https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/people-with-medical-conditions.html.
  • Cheung PH, Chan CP, Jin DY. Lessons learned from the fifth wave of COVID-19 in Hong Kong in early 2022. Emerg Microbes Infect. Dec 2022;11(1):1072–1078. doi:10.1080/22221751.2022.2060137.
  • Okumura K, Nishida S, Dhand A. Trends in COVID-19 mortality among solid organ transplant recipients: implications for prevention. Transplantation. Apr 20 2022. doi:10.1097/TP.0000000000004170
  • Peters LL, Raymer DS, Pal JD, et al. Association of COVID-19 vaccination with risk of COVID-19 infection, hospitalization, and death in heart transplant recipients. JAMA Cardiol. Jun 1 2022;7(6):651–654. doi:10.1001/jamacardio.2022.0670.
  • Lopez Bernal J, Andrews N, Gower C, et al. Effectiveness of Covid-19 vaccines against the B.1.617.2 (delta) variant. N Engl J Med. Aug 12 2021;385(7):585–594. doi:10.1056/NEJMoa2108891.
  • Jara A, Undurraga EA, Gonzalez C, et al. Effectiveness of an inactivated SARS-CoV-2 vaccine in Chile. N Engl J Med. Jul 7 2021. doi:10.1056/NEJMoa2107715
  • Thompson MG, Stenehjem E, Grannis S, et al. Effectiveness of Covid-19 vaccines in ambulatory and inpatient care settings. N Engl J Med. Sep 8 2021. doi:10.1056/NEJMoa2110362
  • Li XN, Huang Y, Wang W, et al. Effectiveness of inactivated SARS-CoV-2 vaccines against the Delta variant infection in Guangzhou: a test-negative case-control real-world study. Emerg Microbes Infect. Dec 2021;10(1):1751–1759. doi:10.1080/22221751.2021.1969291.
  • Regev-Yochay G, Gonen T, Gilboa M, et al. Efficacy of a fourth dose of Covid-19 mRNA vaccine against Omicron. N Engl J Med. Mar 16 2022. doi:10.1056/NEJMc2202542
  • Bar-On YM, Goldberg Y, Mandel M, et al. Protection against Covid-19 by BNT162b2 booster across age groups. N Engl J Med. Dec 23 2021;385(26):2421–2430. doi:10.1056/NEJMoa2115926.
  • Cao Z, Zhang C, Zhao S, et al. COVID-19 vaccines in patients with decompensated cirrhosis: a retrospective cohort on safety data and risk factors associated with unvaccinated status. Infect Dis Poverty. May 16 2022;11(1):56. doi:10.1186/s40249-022-00982-0.
  • Tu ZH, Jin PB, Chen DY, et al. Evaluating the response and safety of inactivated COVID-19 vaccines in liver transplant recipients. Infect Drug Resist. 2022;15:2469–2474. doi:10.2147/IDR.S359919.
  • Wang J, Zhang Q, Ai J, et al. Safety and immunogenicity of SARS-CoV-2 vaccines in Chinese patients with cirrhosis: a prospective multicenter study. Hepatol Int. Jun 2022;16(3):691–701. doi:10.1007/s12072-022-10332-9.
  • Ai J, Wang J, Liu D, et al. Safety and immunogenicity of SARS-CoV-2 vaccines in patients with chronic liver diseases (CHESS-NMCID 2101): a multicenter study. Clin Gastroenterol Hepatol. Dec 20 2021. doi:10.1016/j.cgh.2021.12.022
  • Dufour JF, Marjot T, Becchetti C, et al. COVID-19 and liver disease. Gut. Jun 14 2022. doi:10.1136/gutjnl-2021-326792
  • Torjesen I. Covid-19: peak of viral shedding is later with omicron variant, Japanese data suggest. Br Med J. Jan 13 2022;376:89. doi:10.1136/bmj.o89.
  • Shen Y, Ai J, Lin N, et al. An open, prospective cohort study of VV116 in Chinese participants infected with SARS-CoV-2 omicron variants. Emerg Microbes Infect. Dec 2022;11(1):1518–1523. doi:10.1080/22221751.2022.2078230.
  • Health Commission of Changchun. http://wjw.changchun.gov.cn/xwzx/tzgg/.
  • Burra P, Russo FP. Sars-Cov-2 vaccination in liver transplant recipients: the ‘holy grail’ in a hostile environment. Liver Int. Jun 2022;42(6):1225–1228. doi:10.1111/liv.15226.
  • Guarino M, Esposito I, Portella G, et al. Humoral response to 2-dose BNT162b2 mRNA COVID-19 vaccination in liver transplant recipients. Clin Gastroenterol Hepatol. Jul 2022;20(7):1534–1541. doi:10.1016/j.cgh.2022.01.012.
  • Rabinowich L, Grupper A, Baruch R, et al. Low immunogenicity to SARS-CoV-2 vaccination among liver transplant recipients. J Hepatol. Aug 2021;75(2):435–438. doi:10.1016/j.jhep.2021.04.020.
  • Rashidi-Alavijeh J, Frey A, Passenberg M, et al. Humoral response to SARS-Cov-2 vaccination in liver transplant recipients – a single-center experience. Vaccines. Jul 4 2021;9:7. doi:10.3390/vaccines9070738.
  • Vinson AJ, Anzalone AJ, Sun J, et al. The risk and consequences of breakthrough SARS-CoV-2 infection in solid organ transplant recipients relative to non-immunosuppressed controls. Am J Transplant. Jun 8 2022. doi:10.1111/ajt.17117
  • Dumortier J. Liver injury after mRNA-based SARS-CoV-2 vaccination in a liver transplant recipient. Clin Res Hepatol Gastroenterol. Jan 2022;46(1):101743. doi:10.1016/j.clinre.2021.101743.
  • Hume SJ, Jackett LA, Testro AG, et al. A case series of patients with acute liver allograft rejection after anti-SARS-CoV-2 mRNA vaccination. Transplantation. Apr 14 2022. doi:10.1097/TP.0000000000004166
  • Shroff H, Satapathy SK, Crawford JM, et al. Liver injury following SARS-CoV-2 vaccination: a multicenter case series. J Hepatol. Jan 2022;76(1):211–214. doi:10.1016/j.jhep.2021.07.024.
  • Saharia KK, Husson JS, Niederhaus SV, et al. Humoral immunity against SARS-CoV-2 variants including omicron in solid organ transplant recipients after three doses of a COVID-19 mRNA vaccine. Clin Transl Immunol. 2022;11(5):e1391.doi:10.1002/cti2.1391.
  • Prieto J, Rammauro F, Lopez M, et al. Low immunoglobulin G antibody levels against severe acute respiratory disease coronavirus 2 after 2-dose vaccination among liver transplantation recipients. Liver Transpl. May 2022;28(5):891–894. doi:10.1002/lt.26400.
  • Ai J, Wang J, Liu D, et al. Safety and immunogenicity of SARS-CoV-2 vaccines in patients with chronic liver diseases (CHESS-NMCID 2101): a multicenter study. Clin Gastroenterol Hepatol. Jul 2022;20(7):1516–1524. doi:10.1016/j.cgh.2021.12.022.
  • Qi X, Wang J, Zhang Q, et al. Safety and immunogenicity of COVID-19 vaccination in patients with hepatocellular carcinoma (CHESS-NMCID 2101): a multicenter prospective study. J Med Virol. Jul 10 2022. doi:10.1002/jmv.27992
  • Wang J, Hou Z, Liu J, et al. Safety and immunogenicity of COVID-19 vaccination in patients with non-alcoholic fatty liver disease (CHESS2101): a multicenter study. J Hepatol. Aug 2021;75(2):439–441. doi:10.1016/j.jhep.2021.04.026.
  • Tang R, Li C, Wu G, et al. Safety analysis of COVID-19 vaccines in liver transplant recipients: a two-center study. Hepatobiliary Surg Nutr. Feb 2022;11(1):166–168. doi:10.21037/hbsn-21-392.
  • Davidov Y, Tsaraf K, Cohen-Ezra O, et al. Immunogenicity and adverse effects of the 2-dose BNT162b2 messenger RNA vaccine among liver transplantation recipients. Liver Transpl. Feb 2022;28(2):215–223. doi:10.1002/lt.26366.
  • Wang L, Kaelber DC, Xu R, et al. COVID-19 breakthrough infections, hospitalizations and mortality in fully vaccinated patients with hematologic malignancies: A clarion call for maintaining mitigation and ramping-up research. Blood Rev. Jul 2022;54:100931. doi:10.1016/j.blre.2022.100931.
  • Coll E, Fernandez-Ruiz M, Sanchez-Alvarez JE, et al. COVID-19 in transplant recipients: The Spanish experience. Am J Transplant. May 2021;21(5):1825–1837. doi:10.1111/ajt.16369.
  • Jara A, Undurraga EA, Zubizarreta JR, et al. Effectiveness of homologous and heterologous booster doses for an inactivated SARS-CoV-2 vaccine: a large-scale prospective cohort study. Lancet Glob Health. Jun 2022;10(6):e798–e806. doi:10.1016/S2214-109X(22)00112-7.
  • Price AM, Olson SM, Newhams MM, et al. BNT162b2 protection against the omicron variant in children and adolescents. N Engl J Med. May 19 2022;386(20):1899–1909. doi:10.1056/NEJMoa2202826.
  • Premikha M, Chiew CJ, Wei WE, et al. Comparative effectiveness of mRNA and inactivated whole virus vaccines against COVID-19 infection and severe disease in Singapore. Clin Infect Dis. Apr 12 2022. doi:10.1093/cid/ciac288
  • Werbel WA, Boyarsky BJ, Ou MT, et al. Safety and immunogenicity of a third dose of SARS-CoV-2 vaccine in solid organ transplant recipients: a case series. Ann Intern Med. Sep 2021;174(9):1330–1332. doi:10.7326/L21-0282.

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