Jerantinine B Enhances the Mitochondria-Mediated Apoptosis by p53 Activation in Human Glioblastoma Cells via a Combination with δ-Tocotrienol

References

• Shirode, A.B., Sylvester, P.W. (2010). Synergistic anticancer effects of combined γ-tocotrienol and celecoxib treatment are associated with suppression in Akt and NFkB signaling. Biomed. Pharmacother. 64: 327–332. doi: 10.1016/j.biopha.2009.09.018
   PubMed Web of Science ®Google Scholar
• Lim, K.H., Hiraku, O., Komiyama, K., Kam, T.S (2008). Jerantinines A-G, cytotoxic Aspidosperma alkaloids from Tabernaemontana corymbosa. J. Nat. Prod. 71: 1591–1594. doi: 10.1021/np800435c
   PubMed Web of Science ®Google Scholar
• Abubakar, I.B. and Loh, H.S. (2016). A review on ethnobotany, pharmacology and phytochemistry of Tabernaemontana corymbosa. J. Pharm. Pharmacol. 68(4): 423–432. doi: 10.1111/jphp.12523
   PubMed Web of Science ®Google Scholar
• Abubakar, I.B., Lim, K.H., Kam, T.S., Loh, H.S. (2016). Synergistic cytotoxic effects of combined δ-tocotrienol and jerantinine B on human brain and colon cancers. J. Ethnopharmacol. 184: 107–118. doi: 10.1016/j.jep.2016.03.004
   PubMed Web of Science ®Google Scholar
• Qazzaz, M.E., Raja. V.J., Lim, K.H., Kam, T.S., Lee, B.J., Gershkovich, P., Bradshaw, T.D. (2016). In vitro anticancer properties and biological evaluation of novel natural alkaloid jerantinine B. Cancer Lett. 370: 185–197.
   Google Scholar
• Carén, H., Pollard, S.M., Beck, S. (2013). The good, the bad and the ugly: epigenetic mechanisms in glioblastoma. Mol. Aspects Med. 34: 849–862. doi: 10.1016/j.mam.2012.06.007
   PubMed Web of Science ®Google Scholar
• Frank, J., Chin, X.W.D., Schrader, C., Eckert, G.P., Rimbach, G. (2012). Do tocotrienols have potential as neuroprotective dietary factors? Ageing Res. Rev. 11: 163–180. doi: 10.1016/j.arr.2011.06.006
   PubMed Web of Science ®Google Scholar
• Savita, K., Viren, P., Cameron, R., Sashwati, R., Sen, C.K. (2007). Delivery of orally supplemented α-tocotrienol to vital organs of rats and tocopherol-transport protein deficient mice. Free Radic. Biol. Med. 39: 1310–1319.
   Web of Science ®Google Scholar
• Lim, S.W., Loh, H.S., Ting, K.N., Bradshaw, T.D., Zeenathul, N.A. (2014). Antiproliferation and induction of caspase-8-dependent mitochondria-mediated apoptosis by β-tocotrienol in human lung and brain cancer cell lines. Biomed. Pharmacother. 68: 1105–1115. doi: 10.1016/j.biopha.2014.10.006
   PubMed Web of Science ®Google Scholar
• Abubakar, I.B., Lim, K.H., Kam, T.S., Loh, H.S. (2017). Enhancement of apoptotic activities on brain cancer cells via the combination of γ-tocotrienol and jerantinine A. Phytomedicine. 30: 74–84. doi: 10.1016/j.phymed.2017.03.004
   PubMed Web of Science ®Google Scholar
• Hodul, P.J., Dong, Y., Husain, K., Pimiento, J.M., Chen. J., Zhang, A., Francois, R., Pledger, W.J., Coppola, D., Sebti, S.M., Chen, D.T., Malafa, M.P. (2013). Vitamin E δ-tocotrienol induces p27Kip1-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism. PLoS One. 8: e52526. doi: 10.1371/journal.pone.0052526
   PubMed Web of Science ®Google Scholar
• Lim, S.W., Loh, H.S., Ting, K.N., Bradshaw, T.D., Zeenathul, N.A. (2014). Cytotoxicity and apoptotic activities of alpha-, gamma- and delta-tocotrienol isomers on human cancer cells. BMC Complement. Altern. Med. 14: 469. doi: 10.1186/1472-6882-14-469
   PubMed Web of Science ®Google Scholar
• Fridman, J.S., Lowe, S.W. (2003). Control of apoptosis by p53. Oncogene. 22: 9030–9040. doi: 10.1038/sj.onc.1207116
   PubMed Web of Science ®Google Scholar
• Tsai, A.C., Wang, C.Y., Liou, J.P., Pai, H.C., Hsiao, C.J., Chang, J.Y., Wang, J.C., Teng, C.M., Pan, S.L. (2014). Orally active microtubule-targeting agent, MPT0B271, for the treatment of human non-small cell lung cancer, alone and in combination with erlotinib. Cell Death Dis. 5: e1162. doi: 10.1038/cddis.2014.128
   PubMed Web of Science ®Google Scholar
• Elmore, S. (2007). Apoptosis: a review of programmed cell death. Toxicol. Pathol. 35: 495–516. doi: 10.1080/01926230701320337
   PubMed Web of Science ®Google Scholar
• Chipuk, J.E. (2004). Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science. 303: 1010–1014. doi: 10.1126/science.1092734
   PubMed Web of Science ®Google Scholar