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Articles

Quantitative Analysis of Gymnemagenin in Gymnema sylvestre Leaves and in Herbal Formulation by a Validated HPTLC Method

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Pages 211-219 | Received 11 Mar 2020, Accepted 16 Jun 2020, Published online: 13 Jul 2020

References

  • Kirtikar, K.R. and Basu, B.D. (1998). Indian Medicinal Plants-III, International Book Distributors, Deharadun, India, p. 1625.
  • Kapoor, L.D. (1990). Handbook of Ayurvedic Medicinal Plants. Boca Raton, FL: CRC Press, Inc; pp. 200-201.
  • Sahu, N.P., Mahato, S.B., Sarkar, S.K., Poddar, G. (1996). Triterpenoid saponins from Gymnema sylvestre. Phytochemistry. 41(4): 1181-1185. doi: 10.1016/0031-9422(95)00782-2
  • Sugihara, Y., Nojima, H., Matsuda, H., Murakami, T., Yoshikawa, M., Kimura, I. (2000). Antihyperglycemic effects of gymnemic acid IV, a compound derived from Gymnema sylvestre leaves in streptozotocin-diabetic mice. J. Asian Nat. Prod. Res. 2(4): 321-327. doi: 10.1080/10286020008041372
  • Daisy, P., Eliza, J., Mohamed, F.K.A. (2009). A novel dihydroxy gymnemic triacetate isolated from Gymnema sylvestre possessing normoglycemic and hypolipidemic activity on STZ-induced diabetic rats. J. Ethnopharmacol. 126(2): 339-344. doi: 10.1016/j.jep.2009.08.018
  • Alkefai, N.H., Ahamad, J., Amin, S., Mir S.R. (2018). Arylated gymnemic acids from Gymnema sylvestre R.Br. as potential α-glucosidase inhibitors. Phytochem. Lett. 25: 196-202. doi: 10.1016/j.phytol.2018.04.021
  • Alkefai, N.H., Sharma, M., Ahamad, J., Amin, S., Mir, S.R. (2019). New olean-15-ene type gymnemic acids from Gymnema sylvestre (Retz.) R.Br. and their antihyperglycemic activity through α -glucosidase inhibition. Phytochem. Lett. 32: 83-89. doi: 10.1016/j.phytol.2019.05.005
  • Shanmugasundaram, E.R.B., Gopinath, K.L., Shanmugasundaram, K.R., Rajendran, V.M. (1990). Possible regeneration of the islets of Langerhans in streptozotocin-diabetic rats given Gymnema sylvestre leaf extracts. J. Ethnopharmacol. 30: 265-279. doi: 10.1016/0378-8741(90)90106-4
  • Persaud, S.J., Al-Majed, H., Rahman, A., Jones, P.M. (1999). Gymnema sylvestre stimulates insulin release in-vitro by increased membrane permeability. J. Endocrinol. 163: 207-212. doi: 10.1677/joe.0.1630207
  • Masayuki, Y., Toshiyuki, M., Masashi, K., Yuhao, L., Nubotoshi, M., Johji, Y., Hisash, M. (1997). Medicinal foodstuffs (IX): the inhibitors of glucose absorption from the leaves of Gymnema sylvestre R.Br. (Asclepiadaceae): structures of gymneomosides A and B. Chem. Pharmaceut. Bull. 45(10): 1671-1676. doi: 10.1248/cpb.45.1671
  • Sethi, P.D. (1996). HPTLC: High Performance Thin Layer Chromatography, CBS Publishers and Distributors, New Delhi, India.
  • Ahamad, J., Alkefai, N.H., Amin, S., Mir S.R. (2015). Development and validation of HPTLC-densitometry method for the quantification of swertiamarin in traditional bitters and formulations. J. Planar Chromat. 2015; 28(1): 61-68. doi: 10.1556/JPC.28.2015.1.10
  • Ahamad, J., Amin, S., Mir S.R. (2015). Simultaneous quantification of gymnemic acid as gymnemagenin and charantin as β-sitosterol using validated HPTLC densitometric method. J. Chromatogr. Sci. 53(7), 1203-1209. doi: 10.1093/chromsci/bmu166
  • Puratchimani, V., and Jha, S. (2004). Standardisation of Gymnema sylvestre R.Br. with reference to gymnemagenin by high performance thin-layer chromatography. Phytochem. Anal. 15: 164-166. doi: 10.1002/pca.763
  • Raju, V.S., Kannababu, S., Subbaraju, G.V. (2006). Standardisation of Gymnema sylvestre R.Br. by high performance thin-layer chromatography: an improved method. Phytochem. Anal. 19: 192-196. doi: 10.1002/pca.905
  • Trivedi, P.D. and Pundarikakshudu K. (2008). A validated high performance thin-layer chromatographic method for the estimation of gymnemic acids through gymnemagenin in Gymnema sylvestre, materials, extracts and formulations. Inter. J. App. Sci. Eng. 6(1): 19-28.
  • Ahamad, J., Amin, S., Mir, S.R. (2014). Optimization of ultrasonic-assisted extraction of gymnemic acid from Gymnema sylvestre leaves using response surface methodology. Anal. Chem. Lett. 4(2): 104-112.
  • ICH. (2005). Validation of Analytical Procedures: Text and Methodology. ICH-Q2 (R1), International Conference on Harmonization: Geneva.
  • Hong-Min, L., Fumiyuki, K., Yoshisuke, T. (1992). Isolation and structure elucidation of gymnemic acids, antisweet principles Gymnema sylvestre. Chem. Pharm. Bull. 40(6): 1366-1375. doi: 10.1248/cpb.40.1366
  • Miller, J.N. and Miller, J.C. (2000). Statistics and chemometrics for analytical chemistry, 4th edn., Prentice Hall, New York.

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