871
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Flavonoids fractions of Adansonia digitata L. fruits protects adult Wistar rats from mercury chloride-induced hepatorenal toxicity: histopathological and biochemical studies

ORCID Icon, , , , &
Pages 205-215 | Received 18 Jan 2022, Accepted 25 Mar 2022, Published online: 08 Apr 2022

References

  • Caglayan C, Kandemir FM, Darendelioğlu E, et al. Rutin ameliorates mercuric chloride-induced hepatotoxicity in rats via interfering with oxidative stress, Inflammation and apoptosis. J Trace Elem Med Biol. 2019;56:60–68.
  • Kandemir FM, Yildirim S, Kucukler S, et al. Therapeutic efficacy of zingerone against vancomycin-induced oxidative stress, inflammation, apoptosis and aquaporin 1 permeability in rat kidney. Biomed Pharmacother. 2018;105:981–991. biopha.2018.06.048.
  • Bernhoft RA. Mercury toxicity and treatment: a review of the literature. J Environ Pub Health. 2012. [ CrossRef] [PubMed.;2012. 1–10.
  • Joshi D, Mittal DK, Shukla S, et al. N-acetyl cysteine and selenium protects mercuric chloride-induced oxidative stress and antioxidant defense system in liver and kidney of rats: a histopathological approach. J Trace Elem Med Biol. 2014;28(2):218–226.
  • Venkatesan RS, Sadiq AM. Effect of morin-5′-sulfonic acid sodium salt on the expression of apoptosis related proteins caspase 3, Bax and Bcl 2 due to the mercury induced oxidative stress in albino rats. Biomed Pharmacother. 2017;85:202–208.
  • Carranza-Torres IE, Viveros-Valdéz E, Guzmán-Delgado NE, et al. Protective effects of phenolic acids on mercury-induced DNA damage in precision-cut kidney slices. Ijbm. 2019;22(4):36775.
  • Bridges CC, Zalups RK, Joshee L. Toxicological significance of renal Bcrp: another potential transporter in the elimination of mercuric ions from proximal tubular cells. Toxicol Appl Pharmacol. 2015;285(2):110–117.
  • Goyer RA, Clarkson TW. Toxic effects of metals. In: Klaassen CD, editor. Casarett and Doull’s Toxicology: the basic science of poisons. 4th ed. New York: McGraw-Hill; 2001. p. 811–867.
  • Mahboob M, Shireen KF, Atkinson A, et al. Lipid peroxidation and antioxidant enzyme activity in different organs of mice exposed to low level of mercury. J Environ Science Health B. 2001;36(5):687–689.
  • Miller DM, Lund BO, Woods JS. Reactivity of Hg (II) with superoxide: evidence for the catalytic dismutation of superoxide by Hg (II). J Biochem Toxicol. 1991;6(4):293–298.
  • Ibrahim ATA, Banaee M, Sureda A. Selenium protection against mercury toxicity on the male reproductive system of Clarias gariepinus. Comp Biochem Physiol Part - C: Toxicol Pharmaco. 2019;225:108583.
  • Singh N, Abhishek K, Vivek KG, et al. Biochemical and molecular bases of lead-induced toxicity in mammalian systems and possible mitigations. Chem Res Toxicol. 2018;31(10):1009–1021.
  • Chen F, Zhou CC, Yang Y, et al. GM1 ameliorates leadinduced cognitive deficits and brain damage through activating the SIRT1/CREB/BDNF pathway in the developing male rat Hippocampus. Biol Trace Elem Res. 2019;190(2):425–436.
  • Aksu EH, Kandemir FM, Altun S, et al. Ameliorative effect of carvacrol on cisplatin-induced reproductive damage in male rats. Jbmt. 2016;30(10):513–520.
  • Raeeszadeh M, Moradi M, Ayar P, et al. The antioxidant effect of Medicago sativa L. (Alfalfa) ethanolic extract against mercury chloride (HgCl2) toxicity in rat liver and kidney: an in vitro and in vivo study. Evid -Based Complementary Altern Med. 2021:10. Article ID 8388002. DOI:10.1155/2021/8388002.
  • Li HD, Meng XM, Huang C, et al. Application of herbal traditional Chinese medicine in the treatment of acute kidney injury. Front Pharmacol. 2019;10:376.
  • Yakubu OE, Nwodo OFC, Shaibu C, et al. In vitro determination of antioxidant activities of the fractions obtained from Adansonia Digitata L. (baobab) stem bark ethanolic extract using different parameters. Curr Trends Biomed Eng Biosci. 2019. DOI:10.19080/CTBEB.2019.17.555973.
  • Makena W, Otong ES, Dibal NI, et al. Aqueous fruit pulp extract of Adansonia digitata (L) protects against lead-acetate-induced hepato-renal damage in rat model. Beni-Suef Univ J Basic Appl Sci. 2021;10(1):59.
  • Braca A, Sinisgalli C, De Leo M, et al. Phytochemical profile, antioxidant and antidiabetic activities of Adansonia digitata L. (Baobab) from Mali, as a source of health-promoting compounds. Molecules. 2018;23(12):3104.
  • Ghoneim MAM, Hassan AI, Mahmoud MG, et al. Protective effect of Adansonia digitata against isoproterenol-induced myocardial injury in rats. Anim Biotechnol. 2016;27(2):84–95.
  • Tembo DT, Holmes MJ, Marshall LJ. Effect of thermal treatment and storage on bioactive compounds, organic acids and antioxidant activity of baobab fruit (Adansonia digitata) pulp from Malawi. J Food Compos Anal. 2017;58:40–51.
  • Mohammad FE, Hasan WA, Mohamed EG. Natural antioxidant flavonoids in formalin-induced mice paw inflammation; inhibition of mitochondrial sorbitol dehydrogenase activity. J Biochem Mol. 2017;31(7):1–8.
  • Kandemir FM, Caglayan C, Aksu EH, et al. Protective effect of rutin on mercury chloride-induced reproductive damage in male rats. Andrologia. 2019; 1–9. 10.1111/and.13524
  • Celik H, Kucukler S, Comakli S, et al. Morin attenuates ifosfamide-induced neurotoxicity in rats via suppression of oxidative stress, neuroinflammation and neuronal apoptosis. Neurotoxicology. 2019;76:126–137.
  • Cook NC, Samman S. Flavonoids-chemistry, metabolism, cardioprotective effects, and dietary resources. J Nutr Biochem. 1996;7(2):66–76.
  • Association of Official Analytical Chemists (AOAC). Official methods of analysis XI Edition: Association of official analytical chemists. 11th ed. Washington D.C: The Association; 1970.
  • Won WS, Shin KH, Kang SS. Chemistry and Pharmacology of Flavone –C- Glycoside from ziziphus seeds. Kor J Pharmacog. 1980;11(3–4):141–148.
  • Salman MA, Kotb AM, Haridy AM, et al. Hepato- and nephroprotective effects of bradykinin potentiating factor from scorpion (Buthus occitanus) venom on mercuric chloride-treated rats. EXCLI J. 2016;15:807–816.
  • Akanji MA, Adeyemi OS, Oguntoye SO, et al. Psidium guajava extract reduces trypanosomosis associated lipid peroxidation and raises glutathione concentrations in infected animals. EXCLI J. 2009;8:148–154.
  • Aebi H. Catalase in vitro. Methods Enzymol. 1984;105:121–126. PMID:6727660.
  • Fridovich I. Superoxide dismutases; An adaptation to a paramagnetic gas. J Biol Chem. 1989;264(14):7761–7764. PMID:2542241.
  • Rukkumani R, Aruna K, Varma PS, et al. Comparative effects of curcumin and an analog of curcumin on alcohol and PUFA induced oxidative stress. J Pharm Pharm. 2004;7(2):274–283. PMID:15367386.
  • Deng Y, Xu Z, Liu W, et al. Effects of lycopene and proanthocyanidins on hepatotoxicity induced by mercuric chloride in rats. Biol Trace Elem Res. 2012;146(2):213–223.
  • Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: an overview. Sci World J.2013;2013:1–16.
  • Godoy P, Hewitt NJ, Albrecht U, et al. Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol. 2013;87(8):1315–1530.
  • Nabil A, Elshemy MM, Asem M, et al. Protective effect of DPPD on mercury chloride-induced hepatorenal toxicity in rats. J Toxicol. 2020:7. 10.1155/2020/4127284. Article ID 4127284.
  • Sokeng AJT, Sobolevb AP, Lorenzo AD, et al. Metabolite characterization of powdered fruits and leaves from Adansonia digitata L. (baobab): a multi-methodological approach. Food Chem. 2019;272:93–108.
  • Ahmad S, Mahmood R. Mercury chloride toxicity in human erythrocytes: enhanced generation of ROS and RNS, hemoglobin oxidation, impaired antioxidant power, and inhibition of plasma membrane redox system. Environmental Science and Pollution Research International. 2019;26(6):5645–5657.
  • Aslanturk A, Uzunhisarcikli M, Kalender S, et al. Sodium selenite and vitamin E in preventing mercuric chloride induced renal toxicity in rats. Food Chem Toxicol. 2014;70:185–190.
  • Joshi D, Mittal DK, Shukla S, et al. Curcuma longa Linn. extract and curcumin protect CYP 2E1 enzymatic activity against mercuric chloride-induced hepatotoxicity and oxidative stress: a protective approach. Exp Toxicol Pathol. 2017;69(6):373–382.
  • Andreucci M, Faga T, Pisani A, et al. Quercetin protects against radiocontrast medium toxicity in human renal proximal tubular cells. J Cell Physiol. 2018;233(5):4116–4125. CrossRef] [PubMed.
  • Korkina LG, Afanas’ev IB. Antioxidant and chelating properties of flavonoids. Adv Pharmacol. 1997;38:151–163.
  • Bridges CC, Zalups RK. Mechanisms involved in the transport of mercuric ions in target tissues. Archives of Toxicology. 2017;91(1):63–81.
  • Ma Y, Shi Y, Li L, et al. Toxicological effects of mercury chloride on laying performance, egg quality, serum biochemistry, and histopathology of liver and kidney in laying hens. Biol Trace Elem Res. 2018;185(2):465–474.
  • Vargas-Mendoza N, Madrigal-Santillan E, Morales-Gonzalez A, et al. Hepatoprotective effect of silymarin. World J Hepatol. 2014;6(3):144–149. CrossRef] [PubMed.
  • Tailleux A, Wouters K, Staels B, et al. Roles of PPARs in NAFLD: potential therapeutic targets. Biochim Biophys Acta. 2012;1821(5):809–818.
  • Van De Wier B, Koek GH, Bast A, et al. Haenen the potential of flavonoids in the treatment of non-alcoholic fatty liver disease. Crit Rev Food Sci Nutr. 2017;57(4):834–855.
  • Jia Y, Kim JY, Jun H-J, et al. Cyanidin is an agonistic ligand for peroxisome proliferator-activated receptor-alpha reducing hepatic lipid. Biochim Biophys Acta. 2013;1831(4):698–708.
  • Malek MA, Hoang MH, Jia Y, et al. Ombuin-3-O-beta-D-glucopyranoside from Gynostemma pentaphyllum is a dual agonistic ligand of peroxisome proliferator-activated receptors alpha and delta/beta. Biochem Biophys Res Commun. 2013;430(4):1322–1328.
  • Cho KW, Kim YO, Andrade JE, et al. Dietary naringenin increases hepatic peroxisome proliferators-activated receptor alpha protein expression and decreases plasma triglyceride and adiposity in rats. Eur J Nutr. 2011;50(2):81–88.
  • Goto T, Teraminami A, Lee J-Y, et al. Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese–diabetic mice. J Nutr Biochem. 2012;23(7):768–776.
  • Wang W, Ma B-L, Xu C-G, et al. Dihydroquercetin protects against renal fibrosis by activating the Nrf2 pathway. Phytomedicine. 2020;69:153185.
  • Ruiz S, Pergola PE, Zager RA, et al. Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease. Kidney Int. 2013;83(6):1029–1041. CrossRef.