Ameliorative effect of quercetin on pancreatic damage in rodent: a meta-analysis

References

• Agrawal S, Zaritsky JJ, Fornoni A, et al. Dyslipidaemia in nephrotic syndrome: mechanisms and treatment. Nat Rev Nephrol. 2018;14:57–70. doi: 10.1038/nrneph.2017.155
   PubMed Web of Science ®Google Scholar
• Hamad Zubi ZB, Hamad Alfarisi HA. Hyperlipidemia and male infertility. Egypt J Basic Appl Sci. 2021;8:385–396. doi: 10.1080/2314808X.2021.1977080
   Google Scholar
• Oh RC, Lanier JB. Management of hypertriglyceridemia. Am Fam Physician. 2007;75:1365–1371. https://www.aafp.org/pubs/afp/issues/2007/0501/p1365.html
   PubMed Web of Science ®Google Scholar
• Pretis N, Amodio A, Frulloni L. Hypertriglyceridemic pancreatitis: epidemiology, pathophysiology and clinical management. United Eur Gastroenterol J. 2018;6:649–655. doi: 10.1177/2050640618755002
   PubMed Web of Science ®Google Scholar
• Kichler A, Jang S. Chronic pancreatitis: epidemiology, diagnosis, and management updates. Drugs. 2020;80:1155–1168. doi: 10.1007/s40265-020-01360-6
   PubMed Web of Science ®Google Scholar
• Thupakula S, Nimmala SSR, Ravula H, et al. Emerging biomarkers for the detection of cardiovascular diseases. Egypt Heart J. 2022;74:1–17. doi: 10.1186/S43044-022-00317-2
   PubMedGoogle Scholar
• Tejada S, Martorell M, Capo X, et al. Coumarin and derivates as lipid lowering agents. Curr Top Med Chem. 2016;17:391–398. doi: 10.2174/1568026616666160824102322
   Web of Science ®Google Scholar
• Chavan S, Dias R, Magdum C. Garuga pinnata attenuates oxidative stress and liver damage in chemically induced hepatotoxicity in rats. Egypt J Basic Appl Sci. 2021;8:235–251. doi: 10.1080/2314808X.2021.1961207
   Google Scholar
• Fakhrudin N, Wiyono T, Putra AR, et al. The evaluation on anti-platelet and antithrombosis activities of cinnamomum sintoc bark extract. Thai J Pharm Sci. 2019;43:219–226. http://www.tjps.pharm.chula.ac.th/ojs/index.php/tjps/article/view/43
   Google Scholar
• Wiyono T, Frediansyah A, Sholikhah EN, et al. UHPLC-ESI-MS analysis of Javanese Tamarindus indica leaves from various tropical zones and their beneficial properties in relation to antiobesity. J Appl Pharm Sci. 2022;12:137–147. doi: 10.7324/JAPS.2022.120814
   Google Scholar
• Ji X, Shi S, Liu B, et al. Bioactive compounds from herbal medicines to manage dyslipidemia. Biomed Pharmacother. 2019;118:109338. doi: 10.1016/j.biopha.2019.109338
   PubMed Web of Science ®Google Scholar
• Batiha G-S, Beshbishy AM, Ikram M, et al. The pharmacological activity, biochemical properties,and pharmacokinetics of the major natural polyphenolic flavonoid: quercetin. Foods. 2020;9:374. doi: 10.3390/foods9030374
   PubMed Web of Science ®Google Scholar
• Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021:n71. doi: 10.1136/bmj.n71
   Google Scholar
• Harzing A. Publish or Perish (Software) 2007. https://harzing.com/resources/publish-or-perish (accessed May 1, 2022).
   Google Scholar
• Abdou HM, Hamaad FA, Ali EY, et al. Antidiabetic efficacy of Trifolium alexandrinum extracts hesperetin and quercetin in ameliorating carbohydrate metabolism and activating IR and AMPK signaling in the pancreatic tissues of diabetic rats. Biomed Pharmacother. 2022;149:112838. doi: 10.1016/j.biopha.2022.112838
   PubMed Web of Science ®Google Scholar
• Adewole S, Caxton-Martins E, Ojewole J. Protective effect of quercetin on the morphology of pancreatic β-cells of streptozotocin-treated diabetic rats. Afr J Tradit Complement Altern Med. 2007;4:64–74. doi: 10.4314/ajtcam.v4i1.31196
   Web of Science ®Google Scholar
• Arya A, Jamil Al-Obaidi MM, Shahid N, et al. Synergistic effect of quercetin and quinic acid by alleviating structural degeneration in the liver, kidney and pancreas tissues of STZ-induced diabetic rats: a mechanistic study. Food Chem Toxicol. 2014;71:183–196. doi: 10.1016/j.fct.2014.06.010
   PubMed Web of Science ®Google Scholar
• Carvalho KMMB, Morais TC, de Melo TS, et al. The natural flavonoid quercetin ameliorates cerulein-induced acute pancreatitis in mice. Biol Pharm Bull. 2010;33:1534–1539. doi: 10.1248/bpb.33.1534
   PubMed Web of Science ®Google Scholar
• Coskun O, Kanter M, Korkmaz A, et al. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and β-cell damage in rat pancreas. Pharmacol Res. 2005;51:117–123. doi: 10.1016/j.phrs.2004.06.002
   PubMed Web of Science ®Google Scholar
• El-Far AH, Lebda MA, Noreldin AE, et al. Quercetin attenuates pancreatic and renal D-Galactose-induced aging-related oxidative alterations in rats. Int J Mol Sci. 2020;21:4348. doi: 10.3390/ijms21124348
   PubMed Web of Science ®Google Scholar
• El-Rahman SNA, Al-Jameel SS. Synergistic effect of quercetin nanoparticles on liver and pancreas tissues and oxidative stress of streptozotocin-induced diabetic rats. Asian J Chem. 2017;29:1003–1010. doi: 10.14233/ajchem.2017.20389
   Google Scholar
• Junyuan Z, Hui X, Chunlan H, et al. Quercetin protects against intestinal barrier disruption and inflammation in acute necrotizing pancreatitis through TLR4/MyD88/p38 MAPK and ERS inhibition. Pancreatology. 2018;18:742–752. doi: 10.1016/j.pan.2018.08.001
   PubMed Web of Science ®Google Scholar
• Kahraman A, Vurmaz A, Koca HB, et al. The effect of quercetin on cerulein-induced acute pancreatitis. Med Express. 2017;4:1–7. doi: 10.5935/medicalexpress.2017.05.02
   Google Scholar
• Kalailingam P, Balasubramanian K, Kannaian B, et al. Isolation and quantification of flavonoids from ethanol extract of Costus igneus rhizome (CiREE) and impact of CiREE on hypoglycaemic, electron microscopic studies of pancreas in streptozotocin (STZ)-induced diabetic rats. Biomed Prev Nutr. 2013;3:285–297. doi: 10.1016/j.bionut.2013.01.001
   Google Scholar
• Li J-M, Wang W, Fan C-Y, et al. Quercetin preserves β -Cell Mass and function in fructose-induced hyperinsulinemia through modulating pancreatic Akt/FoxO1 Activation. Evid Based Complement Alternat Med. 2013;2013:1–12. doi: 10.1155/2013/303902
   Web of Science ®Google Scholar
• Lin C-F, Kuo Y-T, Chen T-Y, et al. Quercetin-Rich Guava (Psidium guajava) Juice in combination with trehalose reduces autophagy, apoptosis and pyroptosis formation in the kidney and pancreas of type ii diabetic rats. Molecules. 2016;21:334. doi: 10.3390/molecules21030334
   PubMed Web of Science ®Google Scholar
• Nur Syimal’ain A, Nooraain H, N S, et al. Effect of azadirachta excelsa and quercetin on the endocrine pancreas of the experimentally induced diabetic rats: histological and insulin secretion. Adv Nat Appl Sci. 2017;11:35+. https://go.gale.com/ps/anonymous?id=GALE%7CA601551043&v=2.1&it=r&linkaccess=abs&issn=19950772
   Google Scholar
• Omar H-D, Ragaa SM, Elghaffar SKA, et al. Berberine, Quercetin and O-Coumaric acid phytochemicals ameliorate the impact of experimentally fed high-fat/high-sucrose diet on pancreas β-cells and glycemic control indices. Austin J Endocrinol Diabetes. 2016;3:1–6. https://austinpublishinggroup.com/endocrinology-diabetes/fulltext/ajed-v3-id1042.php
   Google Scholar
• Oyedemi SO, Nwaogu G, Chukwuma CI, et al. Quercetin modulates hyperglycemia by improving the pancreatic antioxidant status and enzymes activities linked with glucose metabolism in type 2 diabetes model of rats: in silico studies of molecular interaction of quercetin with hexokinase and catalase. J Food Biochem. 2020;44:1–16. doi: 10.1111/jfbc.13127
   Web of Science ®Google Scholar
• Rasheed RA, Elshikh MS, Mohamed MO, et al. Quercetin mitigates the adverse effects of high fat diet on pancreatic and renal tissues in adult male albino rats. J King Saud Univ - Sci. 2022;34:101946. doi: 10.1016/j.jksus.2022.101946
   Web of Science ®Google Scholar
• Rifaai RA, El-Tahawy NF, Ali Saber E. Effect of quercetin on the endocrine pancreas of the experimentally induced diabetes in male albino rats: a histological and immunohistochemical study. J Diabetes Metab. 2012;3:1000182. doi: 10.4172/2155-6156.1000182
   Google Scholar
• Vessal M, Hemmati M, Vasei M. Antidiabetic effects of quercetin in streptozocin-induced diabetic rats. Comp Biochem Physiol - C Toxicol Pharmacol. 2003;135:357–364. doi: 10.1016/S1532-0456(03)00140-6
   PubMed Web of Science ®Google Scholar
• Zheng J, Wu J, Chen J, et al. Therapeutic effects of quercetin on early inflammation in hypertriglyceridemia-related acute pancreatitis and its mechanism. Pancreatology. 2016;16:200–210. doi: 10.1016/j.pan.2016.01.005
   PubMed Web of Science ®Google Scholar
• Hooijmans CR, Rovers MM, De Vries RB, et al. SYRCLE’s risk of bias tool for animal studies. BMC Med Res Methodol. 2014;14:43. doi: 10.1186/1471-2288-14-43
   PubMed Web of Science ®Google Scholar
• De Brito WA, Ferreira MRA, De Sousa Dantas D, et al. Biological activities of Eugenia uniflora L. (pitangueira) extracts in oxidative stress-induced pathologies: a systematic review and meta‐analysis of animal studies. Pharmanutrition. 2022;20:100290. doi: 10.1016/j.phanu.2022.100290
   Web of Science ®Google Scholar
• Hayanti SY, Hidayat C, Jayanegara A, et al. Effect of vitamin E supplementation on c hicken sperm quality: a meta-analysis. Vet World. 2022;15:419–426. doi: 10.14202/vetworld.2022.419-426
   PubMed Web of Science ®Google Scholar
• Team RC. R: a language and environment for statistical computing (Software) 2020. https://www.r-project.org/ (accessed May 1, 2022).
   Google Scholar
• Zhao J-B. Animal models of pancreatitis: can it be translated to human pain study? World J Gastroenterol. 2013;19:7222. doi: 10.3748/wjg.v19.i42.7222
   PubMed Web of Science ®Google Scholar
• Kiss L, Fűr G, Pisipati S, et al. Mechanisms linking hypertriglyceridemia to acute pancreatitis. Acta Physiol. 2023;237:1–21. DOI:10.1111/apha.13916
   Web of Science ®Google Scholar
• Li D, Jiang C, Mei G, et al. Quercetin alleviates ferroptosis of pancreatic β cells in type 2 diabetes. Nutrients. 2020;12:1–15. doi: 10.3390/nu12102954
   Web of Science ®Google Scholar
• El-Tantawy WH, Temraz A, Hozaien HE, et al. Anti-hyperlipidemic activity of an extract from roots and rhizomes of {Panicum} repens {L}. on high cholesterol diet-induced hyperlipidemia in rats. Z Naturforschung C J Biosci. 2015;70:139–144. doi: 10.1515/znc-2014-4147
   PubMed Web of Science ®Google Scholar
• Shao Y, Yu Y, Li C, et al. Synergistic effect of quercetin and 6-gingerol treatment in streptozotocin induced type 2 diabetic rats and poloxamer P-407 induced hyperlipidemia. RSC Adv. 2016;6:12235–12242. doi: 10.1039/C5RA16493A
   Web of Science ®Google Scholar
• Vijayakumar K, Rengarajan RL, Radhakrishnan R, et al. Hypolipidemic effect of psidium guajava leaf extract against hepatotoxicity in rats. Pharmacogn Mag. 2018;14:4–8. doi: 10.4103/pm.pm_167_17
   PubMed Web of Science ®Google Scholar
• Zeni ALB, Moreira TD, Dalmagro AP, et al. Evaluation of phenolic compounds and lipid-lowering effect of {Morus} nigra leaves extract. An Acad Bras Cienc. 2017;89:2805–2815. doi: 10.1590/0001-3765201720160660
   PubMed Web of Science ®Google Scholar
• Bule M, Abdurahman A, Nikfar S, et al. Antidiabetic effect of quercetin: a systematic review and meta-analysis of animal studies. Food Chem Toxicol. 2019;125:494–502. doi: 10.1016/j.fct.2019.01.037
   PubMed Web of Science ®Google Scholar
• Henagan TM, Lenard NR, Gettys TW, et al. Dietary quercetin supplementation in mice increases skeletal muscle pgc1α expression, improves mitochondrial function and attenuates insulin resistance in a time-specific manner. PLoS ONE. 2014;9:e89365. doi: 10.1371/journal.pone.0089365
   PubMed Web of Science ®Google Scholar
• Shi G-J, Li Y, Cao Q-H, et al. In vitro and in vivo evidence that quercetin protects against diabetes and its complications: a systematic review of the literature. Biomed Pharmacother. 2019;109:1085–1099. doi: 10.1016/j.biopha.2018.10.130
   PubMed Web of Science ®Google Scholar
• Ozgen S, Kilinc OK, Selamoğlu Z. Antioxidant activity of quercetin: a mechanistic review. Turk J Agric - Food Sci Technol. 2016;4:1134. doi: 10.24925/turjaf.v4i12.1134-1138.1069
   Google Scholar
• Rusmana D, Wahyudianingsih R, Elisabeth M, et al. Antioxidant activity of phyllanthus niruri extract, rutin and quercetin. Indones Biomed J. 2017;9:84. doi: 10.18585/inabj.v9i2.281
   Web of Science ®Google Scholar
• Kim H. Cerulein pancreatitis: oxidative stress, inflammation, and apoptosis. Gut Liver. 2008;2:74–80. doi: 10.5009/gnl.2008.2.2.74
   PubMed Web of Science ®Google Scholar
• Oh YS, Bae GD, Baek DJ, et al. Fatty acid-induced lipotoxicity in pancreatic beta-cells during development of type 2 diabetes. Front Endocrinol. 2018;9:384. doi: 10.3389/fendo.2018.00384
   PubMed Web of Science ®Google Scholar
• Wang N, Zhang J, Qin M, et al. Amelioration of streptozotocin‑induced pancreatic β cell damage by morin: involvement of the AMPK‑FOXO3‑catalase signaling pathway. Int J Mol Med. 2017:1409–1418. doi: 10.3892/ijmm.2017.3357
   Google Scholar
• Pandey KB, Rizvi SI. Markers of oxidative stress in erythrocytes and plasma during aging in humans. Oxid Med Cell Longev. 2010;3:2–12. doi: 10.4161/oxim.3.1.10476
   PubMed Web of Science ®Google Scholar
• Alía M, Mateos R, Ramos S, et al. Influence of quercetin and rutin on growth and antioxidant defense system of a human hepatoma cell line (HepG2). Eur J Nutr. 2006;45:19–28. doi: 10.1007/s00394-005-0558-7
   PubMed Web of Science ®Google Scholar
• Granado-Serrano AB, Martín MA, Bravo L, et al. Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: involvement of p38. Chem Biol Interact. 2012;195:154–164. doi: 10.1016/j.cbi.2011.12.005
   PubMed Web of Science ®Google Scholar
• Ayala A, Muñoz MF, Argüelles S. Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev. 2014;2014. 1–31. doi:10.1155/2014/360438
   Web of Science ®Google Scholar
• Tzifi F, Economopoulou C, Gourgiotis D, et al. The Role of BCL2 family of apoptosis regulator proteins in acute and chronic leukemias. Adv Hematol. 2012;2012:1–15. doi: 10.1155/2012/524308
   Google Scholar
• Guo Y, Tong Y, Zhu H, et al. Quercetin suppresses pancreatic ductal adenocarcinoma progression via inhibition of SHH and TGF-β/Smad signaling pathways. Cell Biol Toxicol. 2021;37:479–496. doi: 10.1007/s10565-020-09562-0
   PubMed Web of Science ®Google Scholar
• Herr. Dietary polyphenol quercetin targets pancreatic cancer stem cells. Int J Oncol. 2010;37:551–561. 10.3892/ijo_00000704
   PubMed Web of Science ®Google Scholar
• Nwaeburu CC, Bauer N, Zhao Z, et al. Up-regulation of microRNA let-7c by quercetin inhibits pancreatic cancer progression by activation of Numbl. Oncotarget. 2016;7:58367–58380. doi: 10.18632/oncotarget.11122
   PubMedGoogle Scholar
• Sak K. Site-specific anticancer effects of dietary flavonoid quercetin. Nutr Cancer. 2014;66:177–193. doi: 10.1080/01635581.2014.864418
   PubMed Web of Science ®Google Scholar
• Valentich MA, Eynard AR, Barotto NN, et al. Effect of the co-administration of phenobarbital, quercetin and mancozeb on nitrosomethylurea-induced pancreatic tumors in rats. Food Chem Toxicol. 2006;44:2101–2105. doi: 10.1016/j.fct.2006.07.013
   PubMed Web of Science ®Google Scholar
• Elreedy HA, Elfiky AM, Mahmoud AA, et al. Neuroprotective effect of quercetin through targeting key genes involved in aluminum chloride induced Alzheimer’s disease in rats. Egypt J Basic Appl Sci. 2023;10:174–184. doi: 10.1080/2314808X.2022.2164136
   Google Scholar
• Kandemir K, Tomas M, McClements DJ, et al. Recent advances on the improvement of quercetin bioavailability. Trends Food Sci Technol. 2022;119:192–200. doi: 10.1016/j.tifs.2021.11.032
   Web of Science ®Google Scholar
• Amer SS, Mamdouh W, Nasr M, et al. Quercetin loaded cosm-nutraceutical electrospun composite nanofibers for acne alleviation: preparation, characterization and experimental clinical appraisal. Int J Pharm. 2022;612:121309. doi: 10.1016/j.ijpharm.2021.121309
   PubMedGoogle Scholar