Anesthesia and dementia: An up-to-date review of the existing literature

References

• Ågren-Wilsson, A., Lekman, A., Sjöberg, W., Rosengren, L., Blennow, K., Bergenheim, A. T., & Malm, J. (2007). CSF biomarkers in the evaluation of idiopathic normal pressure hydrocephalus. Acta neurologica Scandinavica, 116(5), 333–339. https://doi.org/10.1111/j.1600-0404.2007.00890.x
   PubMed Web of Science ®Google Scholar
• Aiello Bowles, E. J., Larson, E. B., Pong, R. P., Walker, R. L., Anderson, M. L., Yu, O., Gray, S. L., Crane, P. K., & Dublin, S. (2016). Anesthesia exposure and risk of dementia and Alzheimer’s Disease: A prospective study. Journal of the American Geriatrics Society, 64(3), 602–607. https://doi.org/10.1111/jgs.14024
   PubMed Web of Science ®Google Scholar
• Alam, A., Hana, Z., Jin, Z., Suen, K. C., & Ma, D. (2018). Surgery, neuroinflammation and cognitive impairment. EBioMedicine, 37, 547–556. https://doi.org/10.1016/j.ebiom.2018.10.021
   PubMed Web of Science ®Google Scholar
• Avidan, M. S., & Evers, A. S. (2011). Review of clinical evidence for persistent cognitive decline or incident dementia attributable to surgery or general anesthesia. Journal of Alzheimer’s Disease: JAD, 24(2), 201–216. https://doi.org/10.3233/jad-2011-101680
   PubMed Web of Science ®Google Scholar
• Avidan, M. S., Searleman, A. C., Storandt, M., Barnett, K., Vannucci, A., Saager, L., Xiong, C., Grant, E. A., Kaiser, D., Morris, J. C., & Evers, A. S. (2009). Long-term cognitive decline in older subjects was not attributable to noncardiac surgery or major illness. Anesthesiology, 111(5), 964–970. https://doi.org/10.1097/aln.0b013e3181bc9719
   PubMed Web of Science ®Google Scholar
• Bagheri, S. C., & Jo, C. (2013). Clinical review of oral and maxillofacial surgery-E-book. Elsevier Health Sciences.
   Google Scholar
• Bellenguez, C., Küçükali, F., Jansen, I. E., Kleineidam, L., Moreno-Grau, S., Amin, N., Naj, A. C., Campos-Martin, R., Grenier-Boley, B., Andrade, V., Holmans, P. A., Boland, A., Damotte, V., van der Lee, S. J., Costa, M. R., Kuulasmaa, T., Yang, Q., de Rojas, I., Bis, J. C., … Lambert, J.-C. (2022). New insights into the genetic etiology of Alzheimer’s disease and related dementias. Nature Genetics, 54(4), 412–436.
   PubMed Web of Science ®Google Scholar
• Belrose, J. C., & Noppens, R. R. (2019). Anesthesiology and cognitive impairment: A narrative review of current clinical literature. BMC Anesthesiology, 19(1), 1–12. https://doi.org/10.1186/s12871-019-0903-7
   PubMed Web of Science ®Google Scholar
• Bilotta, F., Qeva, E., & Matot, I. (2016). Anesthesia and cognitive disorders: A systematic review of the clinical evidence. Expert Review of Neurotherapeutics, 16(11), 1311–1320. https://doi.org/10.1080/14737175.2016.1203256
   PubMed Web of Science ®Google Scholar
• Browndyke, J. N., Wright, M. C., Yang, R., Syed, A., Park, J., Hall, A., Martucci, K., Devinney, M. J., Shaw, L., Waligorska, T., Moretti, E. W., Whitson, H. E., Cohen, H. J., Mathew, J. P., & Berger, M. (2021). Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: Secondary analysis of a prospective cohort study. British Journal of Anaesthesia, 127(6), 917–928. https://doi.org/10.1016/j.bja.2021.08.012
   PubMed Web of Science ®Google Scholar
• Cai, Y., Hu, H., Liu, P., Feng, G., Dong, W., Yu, B., Zhu, Y., Song, J., & Zhao, M. (2012). Association between the Apolipoprotein E4 and postoperative cognitive dysfunction in elderly patients undergoing intravenous anesthesia and inhalation anesthesia. Anesthesiology, 116(1), 84–93. https://doi.org/10.1097/ALN.0b013e31823da7a2
   PubMed Web of Science ®Google Scholar
• Cao, L., Wang, K., Gu, T., Du, B., & Song, J. (2014). Association between APOE epsilon 4 allele and postoperative cognitive dysfunction: A meta-analysis. The International Journal of Neuroscience, 124(7), 478–485. https://doi.org/10.3109/00207454.2013.860601
   PubMed Web of Science ®Google Scholar
• Cerejeira, J., Batista, P., Nogueira, V., Vaz-Serra, A., & Mukaetova-Ladinska, E. B. (2013). The stress response to surgery and postoperative delirium. Journal of Geriatric Psychiatry and Neurology, 26(3), 185–194. https://doi.org/10.1177/0891988713495449
   PubMed Web of Science ®Google Scholar
• Cerejeira, J., Firmino, H., Vaz-Serra, A., & Mukaetova-Ladinska, E. B. (2010). The neuroinflammatory hypothesis of delirium. Acta neuropathologica, 119(6), 737–754. https://doi.org/10.1007/s00401-010-0674-1
   PubMed Web of Science ®Google Scholar
• Chen, P.-L., Yang, C.-W., Tseng, Y.-K., Sun, W.-Z., Wang, J.-L., Wang, S.-J., Oyang, Y.-J., & Fuh, J.-L. (2014). Risk of dementia after anaesthesia and surgery. The British Journal of Psychiatry: The Journal of Mental Science, 204(3), 188–193. https://doi.org/10.1192/bjp.bp.112.119610
   PubMed Web of Science ®Google Scholar
• Choi, G. J., Kang, H., Baek, C. W., Jung, Y. H., Kim, J. W., & Woo, Y. C. (2017). Relationship between general anesthesia and Alzheimer disease. Medicine, 96(51), e9314. https://doi.org/10.1097/MD.0000000000009314
   PubMed Web of Science ®Google Scholar
• Chen, Y. C., Oyang, Y. J., Lin, T. Y., & Sun, W. Z. (2020). Risk assessment of dementia after hysterectomy: Analysis of 14-year data from the National Health Insurance Research Database in Taiwan. Journal of the Chinese Medical Association, 83(4), 394–399. https://doi.org/10.1097/JCMA.0000000000000286
   PubMed Web of Science ®Google Scholar
• Cottrell, J. E., & Hartung, J. (2020). Anesthesia and cognitive outcome in elderly patients: A narrative viewpoint. Journal of Neurosurgical Anesthesiology, 32(1), 9–17. https://doi.org/10.1097/ana.0000000000000640
   PubMed Web of Science ®Google Scholar
• Cui, R.-S., Wang, K., & Wang, Z.-L. (2018). Sevoflurane anesthesia alters cognitive function by activating inflammation and cell death in rats. Experimental and Therapeutic Medicine, 15, 4127–4130. https://doi.org/10.3892/etm.2018.5976
   PubMed Web of Science ®Google Scholar
• Culley, D. J., Baxter, M. G., Yukhananov, R., & Crosby, G. (2004). Long-term impairment of acquisition of a spatial memory task following isoflurane–nitrous oxide anesthesia in rats. Anesthesiology, 100(2), 309–314. https://doi.org/10.1097/00000542-200402000-00020
   PubMed Web of Science ®Google Scholar
• Culley, D. J., Baxter, M., Yukhananov, R., & Crosby, G. (2003). The memory effects of general anesthesia persist for weeks in young and aged rats. Anesthesia& Analgesia, 96, 1004–1009. https://doi.org/10.1213/01.ane.0000052712.67573.12
   PubMed Web of Science ®Google Scholar
• Deiner, S., & Silverstein, J. H. (2009). Postoperative delirium and cognitive dysfunction. British Journal of Anaesthesia, 103, i41–i46. https://doi.org/10.1093/bja/aep291
   PubMed Web of Science ®Google Scholar
• de Oliveira, F. F., de Almeida, S. S., Chen, E. S., Smith, M. C., Naffah-Mazzacoratti, M. D. G., & Bertolucci, P. H. F. (2018). Lifetime risk factors for functional and cognitive outcomes in patients with Alzheimer’s disease. Journal of Alzheimer’s Disease, 65(4), 1283–1299. https://doi.org/10.3233/JAD-180303
   PubMed Web of Science ®Google Scholar
• Dokkedal, U., Wod, M., Thinggaard, M., Hansen, T. G., Rasmussen, L. S., Christensen, K., & Mengel-From, J. (2020). Apolipoprotein E ε4 and cognitive function after surgery in middle-aged and elderly Danish twins. European Journal of Anaesthesiology, 37(11), 984–991. https://doi.org/10.1097/EJA.0000000000001250
   PubMed Web of Science ®Google Scholar
• Dong, Y., Zhang, G., Zhang, B., Moir, R. D., Xia, W., Marcantonio, E. R., Culley, D. J., Crosby, G., Tanzi, R. E., & Xie, Z. (2009). The common inhalational anesthetic sevoflurane induces apoptosis and increases β-amyloid protein levels. Archives of Neurology, 66(5), 620–631. https://doi.org/10.1001/archneurol.2009.48
   PubMedGoogle Scholar
• Eckenhoff, R. G., & Planel, E. (2013). Anesthesia, surgery and neurodegeneration. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 47, 121. https://doi.org/10.1016/j.pnpbp.2013.10.012
   PubMed Web of Science ®Google Scholar
• Eckenhoff, R. G., Johansson, J. S., Wei, H., Carnini, A., Kang, B., Wei, W., Pidikiti, R., Keller, J. M., & Eckenhoff, M. F. (2004). Inhaled anesthetic enhancement of amyloid-β oligomerization and cytotoxicity. Anesthesiology, 101(3), 703–709. https://doi.org/10.1097/00000542-200409000-00019
   PubMed Web of Science ®Google Scholar
• Etzioni, D. A., Liu, J. H., Maggard, M. A., & Ko, C. Y. (2003). The aging population and its impact on the surgery workforce. Annals of Surgery, 238(2), 170–177. https://doi.org/10.1097/01.SLA.0000081085.98792.3d
   PubMed Web of Science ®Google Scholar
• Fan, W., Mai, L., Zhu, X., Huang, F., & He, H. (2020). The role of microglia in perioperative neurocognitive disorders. Frontiers in Cellular Neuroscience, 14, 261. https://doi.org/10.3389/fncel.2020.00261
   PubMed Web of Science ®Google Scholar
• Fodale, V., Santamaria, L. B., Schifilliti, D., & Mandal, P. K. (2010). Anaesthetics and postoperative cognitive dysfunction: A pathological mechanism mimicking Alzheimer’s disease. Anaesthesia, 65(4), 388–395. https://doi.org/10.1111/j.1365-2044.2010.06244.x
   PubMed Web of Science ®Google Scholar
• Geng, Y-j., Wu, Q-h., & Zhang, R-q (2017). Effect of propofol, sevoflurane, and isoflurane on postoperative cognitive dysfunction following laparoscopic cholecystectomy in elderly patients: A randomized controlled trial. Journal of Clinical Anesthesia, 38, 165–171. https://doi.org/10.1016/j.jclinane.2017.02.007
   PubMed Web of Science ®Google Scholar
• Giannouli, V., & Tsolaki, M. (2021a). Frontotemporal dementia and financial capacity: Facing the Cerberus of overestimation or underestimation? Australasian Psychiatry, 30(1), 41–43. https://doi.org/10.1177/10398562211005444
   PubMed Web of Science ®Google Scholar
• Giannouli, V., & Tsolaki, M. (2021b). APOE ɛ4 allele and financial capacity performance in mild Alzheimer’s disease: A pilot study. Journal of Alzheimer’s Disease Reports, 5(1), 93–97. https://doi.org/10.3233/ADR-200254
   PubMedGoogle Scholar
• Guo, L., Lin, F., Dai, H., Du, X., Yu, M., Zhang, J., Huang, H., Ge, W., Tao, G., & Pan, L. (2020). Impact of sevoflurane versus propofol anesthesia on post-operative cognitive dysfunction in elderly cancer patients: A double-blinded randomized controlled trial. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 26, e919293. https://doi.org/10.12659/msm.919293
   PubMed Web of Science ®Google Scholar
• Hamer, M., & Chida, Y. (2009). Physical activity and risk of neurodegenerative disease: A systematic review of prospective evidence. Psychological Medicine, 39(1), 3–11. https://doi.org/10.1017/S0033291708003681
   PubMed Web of Science ®Google Scholar
• Hampel, H., Mesulam, M.-M., Cuello, A. C., Farlow, M. R., Giacobini, E., Grossberg, G. T., Khachaturian, A. S., Vergallo, A., Cavedo, E., Snyder, P. J., & Khachaturian, Z. S. (2018). The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease. Brain: A Journal of Neurology, 141(7), 1917–1933. https://doi.org/10.1093/brain/awy132
   PubMed Web of Science ®Google Scholar
• Inouye, S. K., Marcantonio, E. R., Kosar, C. M., Tommet, D., Schmitt, E. M., Travison, T. G., Saczynski, J. S., Ngo, L. H., Alsop, D. C., & Jones, R. N. (2016). The short‐term and long‐term relationship between delirium and cognitive trajectory in older surgical patients. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 12(7), 766–775. https://doi.org/10.1016/j.jalz.2016.03.005
   PubMed Web of Science ®Google Scholar
• Jain, K. K. (2021). Drug-induced disorders of memory and dementia. In Drug-induced neurological disorders (pp. 209–231). Springer.
   Google Scholar
• Karvandian, K., Amiri, A. A., Ramezani, N., & Amiri, A. A. (2020). Short-term memory impairment in patients undergoing general anesthesia and its contributing factors. Saudi Journal of Anaesthesia, 14(4), 454. https://doi.org/10.4103/sja.SJA_651_19
   PubMed Web of Science ®Google Scholar
• Kawano, T., Yamanaka, D., Aoyama, B., Tateiwa, H., Shigematsu-Locatelli, M., Nishigaki, A., Iwata, H., Locatelli, F. M., & Yokoyama, M. (2018). Involvement of acute neuroinflammation in postoperative delirium-like cognitive deficits in rats. Journal of Anesthesia, 32(4), 506–517. https://doi.org/10.1007/s00540-018-2504-x
   PubMed Web of Science ®Google Scholar
• Knopman, D. S., Petersen, R. C., Cha, R. H., Edland, S. D., & Rocca, W. A. (2005). Coronary artery bypass grafting is not a risk factor for dementia or Alzheimer disease. Neurology, 65(7), 986–990. https://doi.org/10.1212/01.wnl.0000171954.92119.c7
   PubMed Web of Science ®Google Scholar
• Kwon, Y. S., Lee, S.-H., Kim, C., Yu, H., Sohn, J.-H., Lee, J. J., & Kim, D.-K. (2022). Risk of dementia according to surgery type: A nationwide cohort study. Journal of Personalized Medicine, 12(3), 468. https://doi.org/10.3390/jpm12030468
   PubMed Web of Science ®Google Scholar
• Laalou, F.-Z., Carre, A.-C., Forestier, C., Sellal, F., Langeron, O., & Pain, L. (2008). Physiopathologie de la dysfonction cognitive postopératoire du sujetâgé: hypothèsesactuelles. Journal de Chirurgie, 145(4), 323–330. https://doi.org/10.1016/S0021-7697(08)74310-2
   PubMedGoogle Scholar
• Lee, J. J., Choi, G. J., Kang, H., Baek, C. W., Jung, Y. H., Shin, H. Y., Park, Y. H., & Woo, Y. C. (2020). Relationship between surgery under general anesthesia and the development of dementia: A systematic review and meta-analysis. BioMed Research International, 2020, 1–22. https://doi.org/10.1155/2020/3234013
   Web of Science ®Google Scholar
• Lee, W. L., Lin, L. T., & Wang, P. H. (2021). Does the combination of hysterectomy and general anesthesia increase the risk of subsequent development of dementia? Journal of the Chinese Medical Association: JCMA, 84(1), 1–12. https://doi.org/10.1097/JCMA.0000000000000436
   PubMed Web of Science ®Google Scholar
• Lee, T. A., Wolozin, B., Weiss, K. B., & Bednar, M. M. (2005). Assessment of the emergence of Alzheimer’s disease following coronary artery bypass graft surgery or percutaneous transluminal coronary angioplasty1. Journal of Alzheimer’s Disease: JAD, 7(4), 319–324. https://doi.org/10.3233/jad-2005-7408
   PubMed Web of Science ®Google Scholar
• Li, Y., Chen, D., Wang, H., Wang, Z., Song, F., Li, H., Ling, L., Shen, Z., Hu, C., Peng, J., Li, W., Xing, W., Pan, J., Liang, H., Zhou, Q., Cai, J., He, Z., Peng, S., Zeng, W., & Zuo, Z. (2021). Intravenous versus volatile anesthetic effects on postoperative cognition in elderly patients undergoing laparoscopic abdominal surgery. Anesthesiology, 134(3), 381–394. https://doi.org/10.1097/aln.0000000000003680
   PubMed Web of Science ®Google Scholar
• Liu, J., Huang, K., Zhu, B., Zhou, B., Ahmad Harb, A. K., Liu, L., & Wu, X. (2021). Neuropsychological tests in post-operative cognitive dysfunction: Methods and applications. Frontiers in Psychology, 12, 684307. https://doi.org/10.3389/fpsyg.2021.684307
   PubMed Web of Science ®Google Scholar
• Liu, X., Yu, Y., & Zhu, S. (2018). Inflammatory markers in postoperative delirium (POD) and cognitive dysfunction (POCD): A meta-analysis of observational studies. Plos One, 13(12), e0209284. https://doi.org/10.1371/journal.pone.0195659
   PubMed Web of Science ®Google Scholar
• Liu, Y., Pan, N., Ma, Y., Zhang, S., Guo, W., Li, H., Zhou, J., Liu, G., & Gao, M. (2013). Inhaled sevoflurane may promote progression of amnestic Mild Cognitive Impairment: A prospective, randomized parallel-group study. The American Journal of the Medical Sciences, 345(5), 355–360. https://doi.org/10.1097/maj.0b013e31825a674d
   PubMed Web of Science ®Google Scholar
• Lu, X., Jin, X., Yang, S., & Xia, Y. (2018). The correlation of the depth of anesthesia and postoperative cognitive impairment: A meta-analysis based on randomized controlled trials. Journal of Clinical Anesthesia, 45, 55–59. https://doi.org/10.1016/j.jclinane.2017.12.002
   PubMed Web of Science ®Google Scholar
• Mardini, F., Tang, J. X., Li, J. C., Arroliga, M. J., Eckenhoff, R. G., & Eckenhoff, M. F. (2017). Effects of propofol and surgery on neuropathology and cognition in the 3xTgAD Alzheimer transgenic mouse model. British Journal of Anaesthesia, 119(3), 472–480. https://doi.org/10.1093/bja/aew397
   PubMed Web of Science ®Google Scholar
• Marques, A. F., & Lapa, T. A. (2018). Anesthesia and Alzheimer disease – current perceptions. Brazilian Journal of Anesthesiology (English Edition), 68(2), 174–182. https://doi.org/10.1016/j.bjane.2017.09.008
   Google Scholar
• Moller, J. T., Cluitmans, P., Rasmussen, L. S., Houx, P., Rasmussen, H., Canet, J., Rabbitt, P., Jolles, J., Larsen, K., Hanning, C. D., Langeron, O., Johnson, T., Lauven, P. M., Kristensen, P. A., Biedler, A., van Beem, H., Fraidakis, O., Silverstein, J. H., Beneken, J. E. W., & Gravenstein, J. S. (1998). Long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study. The Lancet, 351(9106), 857–861. https://doi.org/10.1016/S0140-6736(97)07382-0
   PubMed Web of Science ®Google Scholar
• Palotás, A., Reis, H. J., Bogáts, G., Babik, B., Racsmány, M., Engvau, L., Kecskeméti, E., Juhász, A., Vieira, L. B., Teixeira, A. L., Mukhamedyarovi, M. A., Rizvanov, A. A., Yalvaç, M. E., Guimarães, M. M., Ferreira, C. N., Zefirov, A. L., Kiyasov, A. P., Wang, L., Janka, Z., & Kálmán, J. (2010). Coronary artery bypass surgery provokes Alzheimer’s disease-like changes in the cerebrospinal fluid. Journal of Alzheimer’s Disease: JAD, 21(4), 1153–1164. https://doi.org/10.3233/jad-2010-100702
   PubMed Web of Science ®Google Scholar
• Papon, M.-A., Whittington, R. A., El-Khoury, N. B., & Planel, E. (2011). Alzheimer’s disease and anesthesia. Frontiers in Neuroscience, 4, 272–277. https://doi.org/10.3389/fnins.2010.00272
   PubMed Web of Science ®Google Scholar
• Planel, E., Richter, K. E. G., Nolan, C. E., Finley, J. E., Liu, L., Wen, Y., Krishnamurthy, P., Herman, M., Wang, L., Schachter, J. B., Nelson, R. B., Lau, L.-F., & Duff, K. E. (2007). Anesthesia leads to Tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 27(12), 3090–3097. https://doi.org/10.1523/jneurosci.4854-06.2007
   PubMed Web of Science ®Google Scholar
• Praticò, C., Quattrone, D., Lucanto, T., Amato, A., Penna, O., Roscitano, C., & Fodale, V. (2005). Drugs of anesthesia acting on central cholinergic system may cause post-operative cognitive dysfunction and delirium. Medical Hypotheses, 65(5), 972–982. https://doi.org/10.1016/j.mehy.2005.05.037
   PubMed Web of Science ®Google Scholar
• Ramaiah, R., & Lam, A. M. (2009). Postoperative cognitive dysfunction in the elderly. Anesthesiology Clinics, 27(3), 485–496. https://doi.org/10.1016/j.anclin.2009.07.011
   PubMedGoogle Scholar
• Run, X., Liang, Z., Zhang, L., Iqbal, K., Grundke-Iqbal, I., & Gong, C.-X. (2009). Anesthesia induces phosphorylation of Tau. Journal of Alzheimer’s Disease: JAD, 16(3), 619–626. https://doi.org/10.3233/jad-2009-1003
   PubMed Web of Science ®Google Scholar
• Satizabal, C. L., Beiser, A. S., Chouraki, V., Chêne, G., Dufouil, C., & Seshadri, S. (2016). Incidence of dementia over three decades in the Framingham Heart Study. The New England Journal of Medicine, 374(6), 523–532. https://doi.org/10.1056/nejmoa1504327
   PubMed Web of Science ®Google Scholar
• Sauër, A. M., Kalkman, C., & van Dijk, D. (2009). Postoperative cognitive decline. Journal of Anesthesia, 23(2), 256–259. https://doi.org/10.1007/s00540-009-0744-5
   PubMed Web of Science ®Google Scholar
• Schenning, K., Murchison, C., Mattek, N., Silbert, L., Kaye, J., & Quinn, J. (2016). Surgery is associated with ventricular enlargement as well as cognitive and functional decline. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 12(5), 590–597. https://doi.org/10.1016/j.jalz.2015.10.004
   PubMed Web of Science ®Google Scholar
• Seitz, D. P., Shah, P. S., Herrmann, N., Beyene, J., & Siddiqui, N. (2011). Exposure to general anesthesia and risk of Alzheimer’s disease: A systematic review and meta-analysis. BMC Geriatrics, 11(1), 83. https://doi.org/10.1186/1471-2318-11-83
   PubMedGoogle Scholar
• Seitz, D., Hussain, M., Eckenhoff, R., & Berger, M. (2014). General anesthetic and the risk of dementia in elderly patients: Current insights. Clinical Interventions in Aging, 9, 1619–1628. https://doi.org/10.2147/cia.s49680
   PubMed Web of Science ®Google Scholar
• Selnes, O. A., Royall, R. M., Grega, M. A., Borowicz, L. M., Jr., Quaskey, S., & McKhann, G. M. (2001). Cognitive changes 5 years after coronary artery bypass grafting. Archives of Neurology, 58(4), 598–604. https://doi.org/10.1001/archneur.58.4.598
   PubMedGoogle Scholar
• Shao, H., Zhang, Y., Dong, Y., Yu, B., Xia, W., & Xie, Z. (2014). Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer’s disease transgenic mice. Journal of Alzheimer’s Disease: JAD, 41(2), 499–513. https://doi.org/10.3233/jad-132792
   PubMed Web of Science ®Google Scholar
• Sprung, J., Roberts, R. O., Knopman, D. S., Olive, D. M., Gappa, J. L., Sifuentes, V. L., Behrend, T. L., Farmer, J. D., Weingarten, T. N., Hanson, A. C., Schroeder, D. R., Petersen, R. C., & Warner, D. O. (2016). Association of Mild Cognitive Impairment with exposure to general anesthesia for surgical and nonsurgical procedures. Mayo Clinic Proceedings, 91(2), 208–217. https://doi.org/10.1016/j.mayocp.2015.10.023
   PubMed Web of Science ®Google Scholar
• Steinmetz, J., & Rasmussen, L. S. (2018). Anesthesia and the risk of dementia in the elderly. La PresseMédicale, 47(4), e45–e51. https://doi.org/10.1016/j.lpm.2018.03.013
   Google Scholar
• Sun, J. Y. (2020). Anesthesia and Alzheimer’s: A review. Journal of Anaesthesiology, Clinical Pharmacology, 36(3), 297–302. https://doi.org/10.4103/joacp.joacp_118_19
   PubMed Web of Science ®Google Scholar
• Tang, J. X., Baranov, D., Hammond, M., Shaw, L. M., Eckenhoff, M. F., & Eckenhoff, R. G. (2011). Human Alzheimer and inflammation biomarkers after anesthesia and surgery. Anesthesiology, 115(4), 727–732. https://doi.org/10.1097/aln.0b013e31822e9306
   PubMed Web of Science ®Google Scholar
• Tang, J. X., Mardini, F., Janik, L. S., Garrity, S. T., Li, R. Q., Bachlani, G., Eckenhoff, R. G., & Eckenhoff, M. F. (2013). Modulation of murine Alzheimer pathogenesis and behavior by surgery. Annals of Surgery, 257(3), 439–448. https://doi.org/10.1097/sla.0b013e318269d623
   PubMed Web of Science ®Google Scholar
• Tao, G., Zhang, J., Zhang, L., Dong, Y., Yu, B., Crosby, G., Culley, D. J., Zhang, Y., & Xie, Z. (2014). Sevoflurane induces tau phosphorylation and glycogen synthase kinase 3β activation in young mice. Anesthesiology, 121(3), 510–527. https://doi.org/10.1097/aln.0000000000000278
   PubMed Web of Science ®Google Scholar
• Terrando, N., Eriksson, L. I., Ryu, J. K., Yang, T., Monaco, C., Feldmann, M., Jonsson Fagerlund, M., Charo, I. F., Akassoglou, K., & Maze, M. (2011). Resolving postoperative neuroinflammation and cognitive decline. Annals of Neurology, 70(6), 986–995. https://doi.org/10.1002/ana.22664
   PubMed Web of Science ®Google Scholar
• Thaler, A., Siry, R., & Cai, L. (2012). Memory loss, Alzheimer’s disease and general anesthesia: A preoperative concern. Journal of Anesthesia & Clinical Research, 3(2), 1000192. https://doi.org/10.4172/2155-6148.1000192
   PubMedGoogle Scholar
• Torpy, J. M., Lynm, C., & Golub, R. M. (2011). Regional anesthesia. JAMA, 306(7), 781–781. https://doi.org/10.1001/jama.306.7.781
   PubMedGoogle Scholar
• Vanderweyde, T., Bednar, M. M., Forman, S. A., & Wolozin, B. (2010). Iatrogenic risk factors for Alzheimer’s disease: Surgery and anesthesia. Journal of Alzheimer’s Disease, 22(s3), S91–S104. https://doi.org/10.3233/JAD-2010-100843
   PubMedGoogle Scholar
• Velkers, C., Berger, M., Gill, S. S., Eckenhoff, R., Stuart, H., Whitehead, M., Austin, P. C., Rochon, P. A., & Seitz, D. (2021). Association between exposure to general versus regional anesthesia and risk of dementia in older adults. Journal of the American Geriatrics Society, 69(1), 58–67. https://doi.org/10.1111/jgs.16834
   PubMed Web of Science ®Google Scholar
• Wan, Y., Xu, J., Ma, D., Zeng, Y., Cibelli, M., & Maze, M. (2007). Postoperative impairment of cognitive function in rats. Anesthesiology, 106(3), 436–443. https://doi.org/10.1097/00000542-200703000-00007
   PubMed Web of Science ®Google Scholar
• Wan, Y., Xu, J., Meng, F., Bao, Y., Ge, Y., Lobo, N., Vizcaychipi, M. P., Zhang, D., Gentleman, S. M., Maze, M., & Ma, D. (2010). Cognitive decline following major surgery is associated with gliosis, β-amyloid accumulation, and τ phosphorylation in old mice. Critical Care Medicine, 38(11), 2190–2198. https://doi.org/10.1097/ccm.0b013e3181f17bcb
   PubMed Web of Science ®Google Scholar
• Wang, P., Velagapudi, R., Kong, C., Rodriguiz, R. M., Wetsel, W. C., Yang, T., Berger, M., Gelbard, H. A., Colton, C. A., & Terrando, N. (2020). Neurovascular and immune mechanisms that regulate postoperative delirium superimposed on dementia. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 16(5), 734–749. https://doi.org/10.1002/alz.12064
   PubMed Web of Science ®Google Scholar
• Whittington, R. A., Bretteville, A., Dickler, M. F., & Planel, E. (2013). Anesthesia and tau pathology. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 47, 147–155. https://doi.org/10.1016/j.pnpbp.2013.03.004
   PubMed Web of Science ®Google Scholar
• Whittington, R. A., Virág, L., Marcouiller, F., Papon, M.-A., El Khoury, N. B., Julien, C., Morin, F., Emala, C. W., & Planel, E. (2011). Propofol directly increases Tau Phosphorylation. PloS One, 6(1), e16648. https://doi.org/10.1371/journal.pone.0016648
   PubMed Web of Science ®Google Scholar
• Woodhouse, A., Fernandez-Martos, C. M., Atkinson, R. A. K., Hanson, K. A., Collins, J. M., O’Mara, A. R., Terblanche, N., Skinner, M. W., Vickers, J. C., & King, A. E. (2018). Repeat propofol anesthesia does not exacerbate plaque deposition or synapse loss in APP/PS1 Alzheimer’s disease mice. BMC Anesthesiology, 18(1), 47. https://doi.org/10.1186/s12871-018-0509-5
   PubMedGoogle Scholar
• Xie, Z., Culley, D. J., Dong, Y., Zhang, G., Zhang, B., Moir, R. D., Frosch, M. P., Crosby, G., & Tanzi, R. E. (2008). The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid β-protein level in vivo. Annals of Neurology, 64(6), 618–627. https://doi.org/10.1002/ana.21548
   PubMed Web of Science ®Google Scholar
• Xu, Z., Dong, Y., Wang, H., Culley, D. J., Marcantonio, E. R., Crosby, G., Tanzi, R. E., Zhang, Y., & Xie, Z. (2014). Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice. Scientific Reports, 4(1), 3766. https://doi.org/10.1038/srep03766
   PubMedGoogle Scholar
• Xue, X., Lv, Y., Leng, Y., & Zhang, Y. (2020). Autophagy activation attenuates the neurotoxicity of local anesthetics by decreasing caspase-3 activity in rats. Brazilian Journal of Anesthesiology (English Edition), 70(6), 627–634. https://doi.org/10.1016/j.bjane.2020.11.001
   Google Scholar
• Yang, T., Velagapudi, R., & Terrando, N. (2020). Neuroinflammation after surgery: From mechanisms to therapeutic targets. Nature Immunology, 21(11), 1319–1326. https://doi.org/10.1038/s41590-020-00812-1
   PubMed Web of Science ®Google Scholar
• Yu, Y., Yang, Y., Tan, H., Boukhali, M., Khatri, A., Yu, Y., Hua, F., Liu, L., Li, M., Yang, G., Dong, Y., Zhang, Y., Haas, W., & Xie, Z. (2020). Tau contributes to sevoflurane-induced neurocognitive impairment in neonatal mice. Anesthesiology, 133(3), 595–610. https://doi.org/10.1097/ALN.0000000000003452
   PubMed Web of Science ®Google Scholar
• Zuo, C., & Zuo, Z. (2010). Spine surgery under General Anesthesia may not increase the risk of Alzheimer’s Disease. Dementia and Geriatric Cognitive Disorders, 29(3), 233–239. https://doi.org/10.1159/000295114
   PubMed Web of Science ®Google Scholar
• Zuo, Z. (2012). Are volatile anesthetics neuroprotective or neurotoxic? Medical Gas Research, 2(1), 10. https://doi.org/10.1186/2045-9912-2-10
   PubMedGoogle Scholar