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Review

Current Knowledge on the Biology, Ecology, and Commercial Exploitation of the Sea Cucumber Cucumaria frondosa

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References

  • Abuzaytoun R. 2017. Seasonal variation of lipid and carotenoid content of Cucumaria frondosa viscera oil and the development of methods for its quality control. PhD, Dalhousie University.
  • Abuzaytoun R, Budge S, Hansen LT, MacKinnon S. 2020. Modification of the ferrous oxidation‐xylenol orange method for determination of peroxide value in highly pigmented sea cucumber viscera lipid. J Am Oil Chem Soc. 1–8.
  • Adrian TE, Collin DC. 2003. Methods for inducing apoptosis and inhibiting proliferation in cancer cells. 20040072902. [accessed 2020 Sept 09]. https://patents.justia.com/patent/20040072902.
  • Adrian TE, Collin DC. 2005. Anticancer glycoside compounds. 7144867. [accessed 2020 Sept 09]. https://patents.justia.com/patent/7144867.
  • Adrian TE, Collin PD, Newman RA. 2018. Compositions of matter and methoods to treat cancer. 20200054657. [accessed 2020 Sept 09]. https://patents.justia.com/patent/20200054657.
  • Al Marzouqi N, Iratni R, Nemmar A, Arafat K, Al Sultan MA, Yasin J, Collin P, Mester J, Adrian TE, Attoub S. 2011. Frondoside A inhibits human breast cancer cell survival, migration, invasion and the growth of breast tumor xenografts. Eur J Pharmacol. 668(1-2):25–34. doi:https://doi.org/10.1016/j.ejphar.2011.06.023
  • Al Shemaili J, Mensah-Brown E, Parekh K, Thomas SA, Attoub S, Hellman B, Nyberg F, Adem A, Collin P, Adrian TE. 2014. Frondoside A enhances the antiproliferative effects of gemcitabine in pancreatic cancer. Eur J Cancer. 50(7):1391–1398. doi:https://doi.org/10.1016/j.ejca.2014.01.002
  • Al Shemaili J, Parekh K, Thomas SA, Kelly DL, Ding X-Z, Attoub S, Collin SP, Adrian TE. 2013. Studies on the mechanism of action of Frondoside A in pancreatic cancer. Pancreatology. 13(2):e13. doi:https://doi.org/10.1016/j.pan.2012.12.097
  • Aminin DL, Agafonova IG, Kalinin VI, Silchenko AS, Avilov SA, Stonik VA, Collin PD, Woodward C. 2008. Immunomodulatory properties of Frondoside A, a major triterpene glycoside from the North Atlantic commercially harvested sea cucumber Cucumaria frondosa. J Med Food. 11(3):443–453. doi:https://doi.org/10.1089/jmf.2007.0530
  • Ammendolia J, Hamel J-F, Mercier A. 2018. Behavioural responses to hydrostatic pressure in selected echinoderms suggest hyperbaric constraint of bathymetric range. Mar Biol. 165:145.
  • Ampofo E, Später T, Nalbach L, Menger MD, Laschke MW. 2020. The marine-derived triterpenoid Frondoside A inhibits thrombus formation. Mar Drugs. 18(2):111.
  • Anderson SC, Flemming JM, Watson R, Lotze HK. 2011. Serial exploitation of global sea cucumber fisheries. Fish Fish. 12(3):317–339.
  • Anisimova NA, Jørgensen LL, Lyubin PA, Manushin IE. 2010. Mapping and monitoring of benthos in the Barents Sea and Svalbard waters: results from the joint Russian-Norwegian benthic programme 2006-2008. IMR-PINRO Joint Report Series, 1–2010.
  • Anonymous. 2020. Dried wild iceland sea cucumber. [accessed March 21]. https://www.amazon.co.uk/Dried-Iceland-Cucumber-x51B0-x5C9B/dp/B079L58KSH/ref=olp_product_details?ie=UTF8&me=. [Online].
  • Arts L. 1910. Ueber die ersten Entwicklungsstadien von Cucumaria frondosa unter Berucksichtigung einiger anormaler Verhaltnisse Bergens Museums Aarbok No. 13. Bergen, Norway:
  • Attoub S, Arafat K, Gélaude A, Al Sultan MA, Bracke M, Collin P, Takahashi T, Adrian TE, De Wever O. 2013. Frondoside A suppressive effects on lung cancer survival, tumor growth, angiogenesis, invasion, and metastasis. PLoS One. 8(1):e53087. doi:https://doi.org/10.1371/journal.pone.0053087
  • Avataq. 2006. Unikkaangualaurtaa: Let's tell a story. Quebec, Canada, Avataq Cultural Institute
  • Avilov SA, Drozdova OA, Kalinin VI, Kalinovsky AI, Stonik VA, Gudimova EN, Riguera R, Jiménez C. 1998. Frondoside C, a new nonholostane triterpene glycoside from the sea cucumber Cucumaria frondosa: structure and cytotoxicity of its desulfated derivative. Can J Chem. 76(2):137–141.
  • Avilov SA, Kalinin VI, Silchenko AS, Aminin DL, Agafonova IG, Stonik VA, Collin PD, Woodward C. 2005. Process for isolating sea cucumber saponin Frondoside A, and immunomodulatory methods of use. 7163702. [accessed 2020 Sept 09]. https://patents.justia.com/patent/7163702.
  • Barrett L, Way E, Winger PD. 2007. Newfoundland sea cucumber drag reference manual. Can Tech Rep Fish Aquat Sci 2736. Fisheries and Oceans Canada.
  • Beauregard KA, Truong NT, Zhang H, Lin W, Beck G. 2001. The detection and isolation of a novel antimicrobial peptide from the echinoderm Cucumaria frondosa In: Beck G, Sugumaran M, Cooper E. editors. Phylogenetic perspectives on the vertebrate immune system. Boston, MA: Springer
  • Bordbar S, Anwar F, Saari N. 2011. High-value components and bioactives from sea cucumbers for functional foods-a review. Mar Drugs. 9(10):1761–1805. doi:https://doi.org/10.3390/md9101761
  • Bradshaw V, Ryan C. 1990. Experimental harvesting and processing of sea cucumber (Cucumaria frondosa) in Saint Mary's Bay, Nova Scotia. Fisheries Development and Fishermen's Service Division and Department of Fisheries and Oceans, Scotia-Fundy Region. Report 161:33.
  • Brown NAW, Wilson DR, Gagnon P. 2019. Plasticity in the antipredator behavior of the orange-footed sea cucumber under shifting hydrodynamic forces . Curr Zool. 65(6):685–695. doi:https://doi.org/10.1093/cz/zoy100
  • Brown NP, Eddy SD. 2015. Echinoderm aquaculture. Hoboken, NJ: Wiley Online Library.
  • Brown WI, Shick JM. 1979. Bimodal gas exchange and the regulation of oxygen uptake in holothurians. Biol Bull. 156(3):272–288.
  • Bruckner AW. 2001. The recent status of sea cucumber fisheries in the continental United States of America. SPC Beche-de-mer Inf Bull. 2002:39–46.
  • Bruckner AW. 2005. The recent status of sea cucumber fisheries in the continental United States of America. SPC Beche-de-mer Inf Bull. 2005:39–46.
  • Campagna S, Lambert J, Archambault P. 2005. Abondance et distribution du concombre de mer (Cucumaria frondosa) et prises accidentelles obtenues par dragage entre Matane et Cap-Gaspe (Quebec) en 2004. Rapp. tech. can. sci. halieut. aquat. 2620: ix + 61 p. [in French].
  • Capadona JR, Shanmuganathan K, Tyler DJ, Rowan SJ, Weder C. 2008. Stimuli-responsive polymer nanocomposites inspired by the sea cucumber dermis. Science. 319(5868):1370–1374. doi:https://doi.org/10.1126/science.1153307
  • Caulier G, Hamel J-F, Mercier A. 2020. From coelomocytes to colored aggregates: cellular components and processes involved in the immune response of the holothuroid Cucumaria frondosa. Biol Bull. 239: 000–000.
  • Che H, Zhang L, Ding L, Xie W, Jiang X, Xue C, Zhang T, Wang Y. 2020. EPA-enriched ethanolamine plasmalogen and EPA-enriched phosphatidylethanolamine enhance BDNF/TrkB/CREB signaling and inhibit neuronal apoptosis in vitro and in vivo. Food Funct. 11(2):1729–1739. doi:https://doi.org/10.1039/c9fo02323b
  • Chen Y, Feindel S, Harbor WB, Kirshenbaum SR. 2003. A preliminary study of the marine sea cucumber (Cucumaria frondosa) fishery. Northeast Consortium Program Development Grant.
  • Cheung SCH, Wu DYH. 2012. Globalization of Chinese food. Honolulu: University of Hawaii Press.
  • Clark D, Emberley J, Clark C, Peppard B. 2010. Update of the 2009 summer Scotian Shelf and Bay of Fundy research vessel survey. DFO Can Sci Advis Sec Res. 72. Doc. 2010/008.
  • Clark HL. 1902. Contributions from the biological laboratory of the US fish commission at Woods Hole, Massachusetts. The echinoderms of the Woods Hole region. Bulletin of the United States Fish Commission.
  • Clark HL. 1904. Echinoderms of the Woods Hole region. Bull United States Fish Comm. 22:545–576.
  • Coady LW. 1973. Aspects of the reproductive biology of Cucumaria frondosa (Gunnerus, 1770) and Psolus fabricii (Düben and Koren, 1846) (Echinodermata: Holothuroidea) in the shallow waters of the Avalon Peninsula Newfoundland. MSc thesis. Memorial University of Newfoundland, Canada, 110 p. M.Sc.
  • Collin P, Adrian TE, Roginsky A, Newman RA, Woodward C, Mehta R, Ding Z, Pinegin B, Kalinin V, Aminin D. Frondanol A5: A novel nutrapreventive and therapeutic agent derived from sea cucumber showing promising antiproliferative, antiinflammatory and antiangiogenic activities 2006. Fifth AACR International Conference on Frontiers in Cancer Prevention Research, Miami, Florida. AACR, A80.
  • Collin PD, Tilson MD. 2005. Methods for treating or preventing a vascular disease. 20080160099. [accessed 2020 Sept 09]. https://patents.justia.com/patent/20080160099.
  • Collin PD, Yang P, Newman RA. 2001. Methods and compositions for treating lipoxygenase-mediated disease states. 20020013368. [accessed 2020 Sept 09]. https://patents.justia.com/patent/20020013368.
  • Collin PD, Yang P, Newman RA. 2003. Methods and compositions for treating lipoxygenase-mediated disease states. 6541519. [accessed 2020 Sept 09]. https://patents.justia.com/patent/6541519.
  • Conand C. 1990. The fishery resources of Pacific island countries. Pt. 2: Holothurians. FAO Fisheries Technical Papers 272.2, FAO, Rome.
  • Conand C. 2004. Present status of world sea cucumber resources and utilization: An internationl overview. In Lovatelli, A., Conand, C., Purcell, S., Uthicke, S., Hamel, J.-F., and Mercier, A. (editors, Advances in sea cucumber aquaculture and management 463, Food and Agriculture Organization, Rome.
  • Conand C, Polidoro B, Mercier A, Gamboa R, Hamel J-F, P, S. 2014. The IUCN Red List assessment of aspidochirotid sea cucumbers and its implications. SPC Beche-de-mer Inf Bull. 34(2014):3–7.
  • Conand C. 2017. Expansion of global sea cucumber fisheries buoys exports. RBT. 65(1-1):1–10. doi:https://doi.org/10.15517/rbt.v65i1-1.31661
  • CSP. 1999. Transfert technologique en transformation du concombre de mer dans le cadre du projet, Étude de production de concombre de mer séché, Cucumaria frondosa Rapport présenté à Les Entreprises Ondine inc. Atkins et Frères. [in French].
  • Dallaire J-P, Hamel D, Mer L. 2013. C. Évaluation du potentiel de la pêche au concombre de mer (Cucumaria frondosa) en Minganie, nord du golfe du Saint-Laurent (Québec). Rapp Tech Can Sci Halieut Aquat. 3052: v:32. [in French].
  • David VMM, MacDonald BA. 2002. Seasonal biochemical composition of tissues from Cucumaria frondosa collected in the Bay of Fundy, Canada: feeding activity and reproduction. J Mar Biol Ass. 82(1):141–147.
  • Deart YV, Pereladov MV, Spiridonov VA, Antokhina TI, Rzhavsky AV, Britayev TA. 2018. Soft bottom communities in Marine Lakes Sisjajarvi and Linjalampi (Barents Sea). Dokl Biol Sci. Springer, 29–32.
  • Denisenko SG. 2004. Structurally-functional characteristics of the Barents Sea zoobenthos. Proc Zool Inst Russ Acad Sci. 300:43–52.
  • Desrosiers A, Lavallée J, Michaud J-C, Wilson JR. 1989. Évaluation du potentiel commercial du concombre de mer (Cucumaria frondosa). Rapport 32. Programme de développement de l’Est du Québec, Ministère des Pêches et Océans région du Québec, division du développement. [in French].
  • DFO. 2009. Southwest New Brunswick sea cucumber (Cucumaria frondosa) exploratory fishery assessment. DFO Can. Sci. Advis. Sec. Sci. Advis. Rep. 2009/014.
  • DFO. 2014. Assessment of the sea cucumber fishery in the Quebec's inshore waters in 2013. DFO Can Sci Advis Sec Sci Advis. 9. Rep. 2014/054.
  • DFO. 2017a. An assessment of the sea cucumber (Cucumaria frondosa) resource on the St. Pierre Bank (NAFO subdivision 3Ps) in 2016. DFO Can. Sci. Advis. Sec. Sci. Advis. Rep. 2017/029.
  • DFO. 2017b. An assessment of the sea cucumber (Cucumaria frondosa) resource on the St. Pierre Bank (NAFO subdivision 3Ps) in 2016. DFO Can. Sci. Advis. Sec. Sci. Advis. Rep:8. 2017/029.
  • DFO. 2017c. Assessment of the sea cucumber fishery in Quebec's inshore waters in 2016. DFO Can. Sci. Advis. Sec. Sci. Advis. Rep:12. 2017/050.
  • DFO. 2018. Sea cucumber stock status update in NAFO subdivision 3Ps. DFO Can. Sci. Advis. Sec. Sci. Advis. Rep:12. 2018/010.
  • DFO. 2019. Department of Fisheries and Oceans. 2019 Sea Cucumber 2019. (Southwest New Brunswick). [accessed 2019 Nov 02]. https://dfo-mpo.gc.ca/decisions/fm-2019-gp/atl-07-eng.htm.
  • DFO. 2020a. Sea Cucumber Newfoundland and Labrador Region 3Ps. [accessed 2020 June 17]. https://www.dfo-mpo.gc.ca/fisheries-peches/ifmp-gmp/sea_cucumber-holothuries/2019/index-eng.html#toc1. [Online].
  • DFO. 2020b. Update of sea cucumber stock status indicators for Areas B and C in the Gaspé Peninsula in 2019. DFO Can. Sci. Advis. Sec. Sci. Resp. 2020/038.
  • Ding L, Wang D, Zhou M, Du L, Xu J, Xue C, Wang Y. 2016. Comparative study of EPA-enriched phosphatidylcholine and EPA-enriched phosphatidylserine on lipid metabolism in mice. J Oleo Sci. 65(7):593–602.
  • Ding L, Zhang L, Shi H, Xue C, Yanagita T, Zhang T, Wang Y. 2020. EPA-enriched ethanolamine plasmalogen alleviates atherosclerosis via mediating bile acids metabolism. J Funct Foods. 66:103824.
  • Ding X-Z, Adrian TE, Collin PD. 2005. Compositions and methods for the treatment and prevention of Cancer 7335382. [accessed 2020 Sept 09]. https://patents.justia.com/patent/7335382
  • Doussantousse É, Pelletier É, Beaulieu L, Rainville L-C, Belzile C. 2011. Multixenobiotic resistance in coelomocytes from three echinoderm species. Aquat Biol. 12(1):81–96.
  • Doyle WL. 1967. Vesiculated axons in haemal vessels of an holothurian, Cucumaria frondosa. Biol Bull. 132(3):329–336. doi:https://doi.org/10.2307/1539638
  • Doyle WL, Mcniell GF. 1964. The fine structure of the respiratory tree in Cucumaria. Q J Microsc Sci. 3:7–11.
  • Du L, Yang Y-H, Wang Y-M, Xue C-H, Kurihara H, Takahashi K. 2015. Antitumour activity of EPA-enriched phospholipids liposomes against S180 ascitic tumour-bearing mice. J Funct Foods. 19:970–982.
  • Dyshlovoy SA, Madanchi R, Hauschild J, Otte K, Alsdorf WH, Schumacher U, Kalinin VI, Silchenko AS, Avilov SA, Honecker F, et al. 2017. The marine triterpene glycoside Frondoside A induces p53-independent apoptosis and inhibits autophagy in urothelial carcinoma cells. BMC Cancer. 17(1):93. doi:https://doi.org/10.1186/s12885-017-3085-z
  • Dyshlovoy SA, Rast S, Hauschild J, Otte K, Alsdorf WH, Madanchi R, Kalinin VI, Silchenko AS, Avilov SA, Dierlamm J, et al. 2017. Frondoside A induces AIF-associated caspase-independent apoptosis in Burkitt lymphoma cells. Leuk Lymphoma. 58(12):2905–2915. doi:https://doi.org/10.1080/10428194.2017.1317091
  • Edwards CL. 1910. Revision of the Holothurioidea. Cucumaria frondosa (Gunner) 1767. Zool Jahrb Abt f Syst Bd. 29:333–358.
  • Elner RW, Campbell A. 1987. Natural diets of lobster Homarus americanus from barren ground and macroalgal habitats off southwestern Nova Scotia, Canada. Mar Ecol Prog Ser. 37:131–140.
  • Fabinyi M. 2012. Historical, cultural and social perspectives on luxury seafood consumption in China. Environ Conserv. 39(1):83–92.
  • Feindel S. 2002. Status of the Maine sea cucumber (Cucumaria frondosa) fishery. Report to the standing legislative committee on marine resources. Maine: Department of Marine Resources.
  • Feindel S, Bennett T, Kanwit K. 2011. The Maine sea cucumber (Cucumaria frondosa) fishery. USA: Maine Department of Marine Reseources.
  • Filimonova GF, Tokin IB. 1980. Structural and functional peculiarities of the digestive system of Cucumaria frondosa (Echinodermata: Holothuroidea). Mar Biol. 60(1):9–16.
  • Foucher E. 2018. Evaluation des stocks de pétoncle d’Islande Chlamys islandica, peigne du Canada Placopecten magellanicus et concombre de mer Cucumaria frondosa du gisement du banc de Saint-Pierre (subdivision 3Ps de l’OPANO). Résultats de la campagne de prospection SPM2017-Hal. Port-En-Bessin: IFREMER [in French].
  • Francour P. 1997. Predation on holothurians: a literature review. Invertebr Biol. 116(1):52–60.
  • Fredalina BD, Ridzwan BH, Abidin AAZ, Kaswandi MA, Zaiton H, Zali I, Kittakoop P, Jais AMM. 1999. Fatty acid compositions in local sea cucumber, Stichopus chloronotus, for wound healing. Gen Pharmacol. 33(4):337–340.
  • Gajdosechova Z, Palmer CH, Dave D, Jiao G, Zhao Y, Tan Z, Chisholm J, Zhang J, Stefanova R, Hossain A, et al. 2020. Arsenic speciation in sea cucumbers: identification and quantitation of water-extractable species. Environ Pollut. 266:115190.
  • Garbul A, Garbul E, Indushko V. 2020. The reproductive cycle of Holothuria Cucumaria frondosa of the Barents Sea. KnE Life Sci. 396–404.
  • Garcia EG, Ragnarsson SA. 2007. Impact of scallop dredging on the macrobenthic community in Breiðafjörður, West Iceland. Bottom Trawling and Scallop Dredging in the Arctic, 129.
  • Garcia EG, Ragnarsson SA, Eiríksson H. 2006. Effects of scallop dredging on macrobenthic communities in west Iceland. ICES J Mar Sci. 63(3):434–443.
  • Gianasi BL. 2015. Fisheries and aquaculture related biometrics of the sea cucumber Cucumaria frondosa: tagging resistance to stress and influence of diet on lipid composition. MSc Thesis, Memorial University.
  • Gianasi BL. 2018. Exploring the potential of the sea cucumber Cucumaria frondosa as an aquaculture species. PhD Thesis, Memorial University.
  • Gianasi BL, Hamel J-F, Mercier A. 2016. Experimental test of optimal holding conditions for live transport of temperate sea cucumbers. Fish Res. 174:298–308.
  • Gianasi BL, Hamel J-F, Mercier A. 2018a. Full allogeneic fusion of embryos in a Holothuroid Echinoderm. Proc R Soc B 285(1879):20180339.
  • Gianasi BL, Hamel J-F, Mercier A. 2018b. Morphometric and behavioural changes in the early life stages of the sea cucumber Cucumaria frondosa. Aquaculture. 490:5–18.
  • Gianasi BL, Hamel J-F, Mercier A. 2018c. Triggers of spawning and oocyte maturation in the commercial sea cucumber Cucumaria frondosa. Aquaculture. 498:50–60.
  • Gianasi BL, Hamel J-F, Mercier A. 2019. Influence of environmental parameters on gametogenesis, spawning and embryo survival in the holothuroid Cucumaria frondosa. Aquaculture. 506:308–319.
  • Gianasi BL, Parrish CC, Hamel J-F, Mercier A. 2017. Influence of diet on growth, reproduction and lipid and fatty acid composition in the sea cucumber Cucumaria frondosa. Aquac Res. 48(7):3413–3432.
  • Gianasi BL, Verkaik K, Hamel J-F, Mercier A. 2015. Novel use of PIT tags in sea cucumbers: Promising results with the commercial species Cucumaria frondosa. PloS One. 10(5):e0127884. doi:https://doi.org/10.1371/journal.pone.0127884
  • Girard M, Bélanger J, ApSimon JW, Garneau F-X, Harvey C, Brisson J-R, Frondoside A. 1990. A novel triterpene glycoside from the holothurian Cucumaria frondosa. Can J Chem. 68(1):11–18.
  • Goddard CI, Greig IA, Goodwin MH. 1975. The use of artificial substrates in sampling estuarine benthos. Trans Am Fish Soc. 104(1):50–52.
  • Graham ER, Thompson JT. 2009. Deposit-and suspension-feeding sea cucumbers (Echinodermata) ingest plastic fragments. J Exp Mar Biol Ecol. 368(1):22–29.
  • Grant SM. 2006. Biological resource assessment of the orange footed sea cucumber (Cucumaria frondosa) occurring in the Strait of Belle Isle, Centre for Sustainable Aquatic Resources, Fisheries and Marine Institute of Memorial University.
  • Grant SM, Squire L, Keats C. 2006. Biological resource assessment of the orange footed sea cucumber (Cucumaria frondosa) occurring on the St. Pierre Bank. Centre for Sustainable Aquatic Resources, Fisheries and Marine Institute of Memorial University of Newfoundland, Canada. P-137 and P-172: 75p.
  • Gudimova E, Antsiferova A. 2006. Gonadal morphology and oogenic stages of Cucumaria frondosa from the Barents Sea: Comparative aspect In: Harris LG, Bottger, SA, W, WC, and Lesser MP, editors. Echinoderms: Durham: Proceedings of the 12th International Echinoderm Conference. New Hampshire, USA.
  • Gudimova EN. 1999. Голотурия Cucumaria Frondosa (Gunnerus) Баренцева моря: систематика, биология использование. PhD Thesis, СПб: ЗИН РАН. [in Russian].
  • Gudimova, EN. (2000).Distribution, resource and role commercial holothurian Cucumaria frondosa in the bottom communities of the Barents Sea. Proc. Symp. on Biol. Res. Russian Arctic Coast. Zone, Belomorsk; 27–30.
  • Gudimova EN, Gudimov A, Collin P. 2004. A study of the biology for fishery in two populations of Cucumaria frondosa: in the Barents Sea (Russia) and in the Gulf of Maine (USA) In Heinzeller T, Nebelsick J, editors, 11th International Echinoderm Conference, Munich. Taylor & Francis, 269–275.
  • Gudimova EN, A. V G. 1997. Sustainable exploitation of the population of the sea cucumber, Cucumaria frondosa, in the Barents Sea. Proc. Scient. & Pract. Conf. On Non-traditional Objects for Commercial Fisheries and Perspectives of their Uses, Murmansk, 33–36.
  • Gunnerus JE. 1767. Beskrifning på trenne Norrska Sjö-Kråk, Sjö-Pungar kallade. Kungl. Svenska Vetenskapsakademiens. Handlingar. 28:114–124. [in Swedish].
  • Hamel J-F, Becker P, Eeckhaut I, Mercier A. 2007. Exogonadal oogenesis in a temperate holothurian. Biol Bull. 213(2):101–109. doi:https://doi.org/10.2307/25066626
  • Hamel J-F, Conand C, Pawson DL, Mercier A. 2001. The sea cucumber Holothuria scabra (Holothuroidea: Echinodermata): its biology and exploitation as beche-de-mer. Adv Mar Biol. 41:131–201.
  • Hamel J-F, Mercier A. 1995. Spawning of the sea cucumber Cucumaria frondosa in the St. Lawrence Estuary, eastern Canada. SPC Beche-de-mer Inf Bull. 7:12–18.
  • Hamel J-F, Mercier A. 1996a. Early development, settlement, growth and spatial distribution of the sea cucumber Cucumaria frondosa (Echinodermata: Holothuroidea). Can J Fish Aquat Sci. 53(2):253–271.
  • Hamel J-F, Mercier A. 1996b. Evidence of chemical communication during the gametogenesis of holothuroids. Ecology. 77(5):1600–1616.
  • Hamel J-F, Mercier A. 1996c. Gamete dispersion and fertilisation success of the sea cucumber Cucumaria frondosa. SPC Beche-de-mer Inf Bull. 8:34–40.
  • Hamel J-F, Mercier A. 1996d. Gonad morphology and gametogenesis of the sea cucumber Cucumaria frondosa. SPC Beche-de-mer Inf Bull. 8:22–33.
  • Hamel J-F, Mercier A. 1997. Sea cucumbers: current fishery and prospects for aquaculture. Aquacult Mag. 23:42–53.
  • Hamel J-F, Mercier A. 1998. Diet and feeding behaviour of the sea cucumber Cucumaria frondosa in the St. Lawrence estuary, Eastern Canada. Can J Zool. 76(6):1194–1198.
  • Hamel J-F, Mercier A. 1999. Mucus as a mediator of gametogenic synchrony in the sea cucumber Cucumaria frondosa (Holothuroidea: Echinodermata). J Mar Biol Ass. 79(1):121–129.
  • Hamel J-F, Mercier A. 2008. Population status, fisheries and trade of sea cucumbers in temperate areas of the Northern Hemisphere In Toral-Granda V, Lovatelli A, Vasconcellos M, editors, Sea cucumbers: A global review of fisheries and trade. Rome: FAO Fisheries and Aquaculture, Rome.
  • Hamel JF, Sun J, Gianasi BL, Montgomery EM, Kenchington EL, Burel B, Rowe S, Winger PD, Mercier A. 2019. Active buoyancy adjustment increases dispersal potential in benthic marine animals. J Anim Ecol. 88(6):820–832.
  • Hamilton LC. 2001. Outport adaptations: social indicators through Newfoundland's cod crisis. Hum Ecol Rev. 8:1–11.
  • Han Q, Keesing JK, Liu D. 2016. A review of sea cucumber aquaculture, ranching, and stock enhancement in China. Rev Fish Sci Aquac. 24(4):326–341.
  • Harper DL, Bethoney ND, Stokesbury KD, Lundy M, McLean MF, Stokesbury MJ. 2020. Standard methods for the collection of morphometric data for the commercially fished sea cucumber Cucumaria frondosa in Eastern Canada. J Shellfish Res. 39(2):481–489.
  • Haug T, Kjuul AK, Styrvold OB, Sandsdalen E, Olsen ØM, Stensvåg K. 2002. Antibacterial activity in Strongylocentrotus droebachiensis (Echinoidea), Cucumaria frondosa (Holothuroidea), and Asterias rubens (Asteroidea). J Invertebr Pathol. 81(2):94–102.
  • Heinzeller T, Nebelsick JH. 2004. Aquaculture and fisheries Echinoderms. Munchen: CRC Press.
  • Higgins J. 2009. Cod moratorium. http://www.heritage.nf.ca/articles/economy/moratorium.php. Accessed on 12 March 2020 [Online].
  • Holt D, Ma X, Kundu N, Collin PD, Fulton AM. 2012. Modulation of host natural killer cell functions in breast cancer via prostaglandin E2 receptors EP2 and EP4. J Immunother. 35(2):179–188. doi:https://doi.org/10.1097/CJI.0b013e318247a5e9
  • Holtz EH, MacDonald BA. 2009. Feeding behaviour of the sea cucumber Cucumaria frondosa (Echinodermata: Holothuroidea) in the laboratory and the field: relationships between tentacle insertion rate, flow speed, and ingestion. Mar Biol. 156(7):1389–1398.
  • Hopcroft RR, Ward DB, Roff JC. 1985. The relative significance of body surface and cloacal respiration in Psolus fabricii (Holothuroidea: Dendrochirotida). Can J Zool. 63(12):2878–2881.
  • Hossain A, Dave D, Shahidi F. 2020. Northern sea cucumber (Cucumaria frondosa): A potential candidate for functional food, nutraceutical, and pharmaceutical sector. Mar Drugs. 18(5):274.
  • Hu S, Chang Y, Wang J, Xue C, Li Z, Wang Y. 2013. Fucosylated chondroitin sulfate from sea cucumber in combination with rosiglitazone improved glucose metabolism in the liver of the insulin-resistant mice. Biosci Biotechnol Biochem. 77(11):2263–2268. doi:https://doi.org/10.1271/bbb.130529
  • Hu S, Li S, Song W, Ji L, Cai L, Wang Y, Jiang W. 2016. Fucoidan from Cucumaria frondosa inhibits pancreatic islets apoptosis through mitochondrial signaling pathway in insulin resistant mice. FSTR. 22(4):507–517.
  • Hu S, Xu L, Shi D, Wang J, Wang Y, Lou Q, Xue C. 2014. Eicosapentaenoic acid-enriched phosphatidylcholine isolated from Cucumaria frondosa exhibits anti-hyperglycemic effects via activating phosphoinositide 3-kinase/protein kinase B signal pathway. J Biosci Bioeng. 117(4):457–463.
  • Hu X-Q, Xu J, Xue Y, Li Z-J, Wang J-F, Wang J-H, Xue C-H, Wang Y-M. 2012. Effects of bioactive components of sea cucumber on the serum, liver lipid profile and lipid absorption. Biosci Biotechnol Biochem. 76(12):2214–2218. doi:https://doi.org/10.1271/bbb.120495
  • Janakiram NB, Mohammed A, Bryant T, Lightfoot S, Collin PD, Steele VE, Rao CV. 2015a. Improved innate immune responses by frondanol A5, a sea cucumber extract, prevent intestinal tumorigenesis. Cancer Prev Res. 8(4):327–337.
  • Janakiram NB, Mohammed A, Rao CV. 2015b. Sea cucumbers metabolites as Potent Anti-Cancer Agents. Mar Drugs.Drugs13(5):2909–2923. doi:https://doi.org/10.3390/md13052909
  • Janakiram NB, Mohammed A, Zhang Y, Choi C-I, Woodward C, Collin P, Steele VE, Rao CV. 2010. Chemopreventive effects of Frondanol A5, a Cucumaria frondosa extract, against rat colon carcinogenesis and inhibition of human colon cancer cell growth. Cancer Prev Res. 3(1):82–91.
  • Jia Z, Song Y, Tao S, Cong P, Wang X, Xue C, Xu J. 2016. Structure of sphingolipids from sea cucumber Cucumaria frondosa and structure-specific cytotoxicity against human HepG2 cells. Lipids. 51(3):321–334. doi:https://doi.org/10.1007/s11745-016-4128-y
  • Jin J-O, Shastina VV, Shin S-W, Xu Q, Park J-I, Rasskazov VA, Avilov SA, Fedorov SN, Stonik VA, Kwak J-Y. 2009. Differential effects of triterpene glycosides, frondoside A and cucumarioside A2-2 isolated from sea cucumbers on caspase activation and apoptosis of human leukemia cells. FEBS Lett. 583(4):697–702. doi:https://doi.org/10.1016/j.febslet.2009.01.010]
  • Jordan AJ. 1972. On the ecology and behavior of Cucumaria frondosa (Echinodermata: Holothuroidea) at Lamoine Beach, Maine. PhD Thesis. University of Maine, Orono.
  • Jørgensen LL, Ljubin P, Skjoldal HR, Ingvaldsen RB, Anisimova NA, Manushin IE. 2015. Distribution of benthic megafauna in the Barents Sea: baseline for an ecosystem approach to management. ICES J Mar Sci. 72(2):595–613.
  • Joury MR. 2012. Influence of native Newfoundland sea cucumber Cucumaria frondosa on sediment mineralogy and texture 62 Atlantic University Geoscience Conference Nova Scotia, Canada. 1.
  • Kale V, Freysdottir J, Paulsen BS, Friðjónsson ÓH, Hreggviðsson GÓ, Omarsdottir S. 2013. Sulphated polysaccharide from the sea cucumber Cucumaria frondosa affect maturation of human dendritic cells and their activation of allogeneic CD4 (+) T cells in vitro. Bioact Carbohydr Diet Fibre. 2(2):108–117.
  • Kamyab E, Kellermann MY, Kunzmann A, Schupp PJ. 2020. Chemical biodiversity and bioactivities of saponins in echinodermata with an emphasis on sea cucumbers (Holothuroidea) In Jungblut S, Liebich V, Bode-Dalby M, editors, YOUMARES 9-The Oceans: Our Research, Our Future. Springer.
  • Ke PJ, Smith-Lall B, Hirtle RW, Kramer DE. 1987. Technical studies on resource utilization of Atlantic sea cucumber (Cucumaria frondosa). Can Inst Food Technol J. 20(1):4–8. doi:https://doi.org/10.1016/S0315-5463(87)70661-0
  • Kędra M, Renaud PE, Andrade H, Goszczko I, Ambrose WG. 2013. Benthic community structure, diversity, and productivity in the shallow Barents Sea bank (Svalbard Bank). Mar Biol. 160(4):805–819. doi:https://doi.org/10.1007/s00227-012-2135-y
  • Kiew PL, Don MM. 2012. Jewel of the seabed: Sea cucumbers as nutritional and drug candidates. Int J Food Sci Nutr. 63(5):616–636. doi:https://doi.org/10.3109/09637486.2011.641944
  • Kirshenbaum S, Feindel S, Chen Y. 2006. A study of tagging methods for the sea cucumber Cucumaria frondosa in the waters off Maine. Fish Bull. 104:299–302.
  • Kirshenbaum SR. 2005. Assessment and management of the maine sea cucumber (Cucumaria Frondosa). MSc Thesis, University of Maine.
  • Kiyko OA, V. B. Mapping Of P. bottom communities for ecological monitoring purposes: multivariate data classification 1997. Proceeding of the 18th Internetional Cartography Conference. Stockholm :326–334.
  • Klugh AB. 1923. The habits of Cucumaria frondosa. Can Field Nat. 37:76–77.
  • Kodama K, Aramaki T, Horiguchi T. 2018. Current status of the megabenthic community in coastal Fukushima Prefecture, Japan, in the wake of the Great East Japan Earthquake. Mar Environ Res. 140:358–374. doi:https://doi.org/10.1016/j.marenvres.2018.07.005
  • Koob-Emunds MM, Trotter JA, Koob TJ. 1996. Identification of stiffening and plasticizing factors in sea cucumber (Cucumaria frondosa) dermis. Bull Mt Desert Island Biol Lab. 35:101–104.
  • Koob TJ, Koob-Emunds MM, Trotter JA. 1999. Cell-derived stiffening and plasticizing factors in sea cucumber (Cucumaria frondosa) dermis. J Exp Biol. 202:2291–2301.
  • Lacalli T. 1981. Annual spawning cycles and planktonic larvae of benthic invertebrates from Passamaquoddy Bay, New Brunswick. Can J Zool. 59(3):433–440.
  • Lambert P. 1984. British Columbia marine faunistic survey report Holothurians from the Northeast Pacific. Can Tech Rep Fish Aquat Sci. 1234:1–30.
  • Lambert P. 1997. Sea cucumbers of British Columbia, Southeast Alaska and Puget Sound. Vancouver: UBC Press.
  • Lecomte J-B, Benoît HP, Etienne M-P, Bel L, Parent E. 2013. Modeling the habitat associations and spatial distribution of benthic macroinvertebrates: a hierarchical Bayesian model for zero-inflated biomass data. Ecol Model. 265:74–84.
  • Legault C, Himmelman JH. 1993. Relation between escape behaviour of benthic marine invertebrates and the risk of predation. J Exp Mar Biol Ecol. 170(1):55–74.
  • Levin VS. 1995. Japanese sea cucumber Cucumaria japonica in the eastern seas of Russia. SPC Beche-de-mer Inf Bull. 17:18–19.
  • Levin VS. 2003. Cucumaria okhotensis (Echinodermata: Holothuroidea) - a new species of holothurians from the Sea of Okhotsk. Russ J Mar Biol. 29(3):175–179. doi:https://doi.org/10.1023/A:1024624917325
  • Levin VS, Gudimova E. 1997. Taxonomic interrelations of holothurians Cucumaria frondosa and C. japonica (Dendrochirotida, Cucumariidae). Zool Zh 76:575–584.
  • Levin VS, Gudimova E. 2000. Taxonomic interrelations of holothurians Cucumaria frondosa and C. japonica (Dendrochirotida, Cucumariidae). SPC Beche-de-mer Inf Bull. 13:22–29.
  • Levin VS, Stepanov VG. 2005. Structure of genital papillae in the far eastern holothurians of the genus Cucumaria (Dendrochirotida: Cucumariidae). Russ J Mar Biol. 31(6):386–390. doi:https://doi.org/10.1007/s11179-006-0008-2
  • Li X, Roginsky AB, Ding XZ, Woodward C, Collin P, Newman RA, Bell RH, Jr, Adrian TE. 2008. Review of the apoptosis pathways in pancreatic cancer and the anti-apoptotic effects of the novel sea cucumber compound, Frondoside A. Ann N Y Acad Sci. 1138:181–198. doi:https://doi.org/10.1196/annals.1414.025
  • Liu X, Liu Y, Hao J, Zhao X, Lang Y, Fan F, Cai C, Li G, Zhang L, Yu G. 2016a. In vivo anti-cancer mechanism of low-molecular-weight fucosylated chondroitin sulfate (LFCS) from sea cucumber Cucumaria frondosa. Molecules. 21(5):625.
  • Liu X, Xue Y, Liu C, Lou Q, Wang J, Yanagita T, Xue C, Wang Y. 2013. Eicosapentaenoic acid-enriched phospholipid ameliorates insulin resistance and lipid metabolism in diet-induced-obese mice. Lipids Health Dis. 12:109. doi:https://doi.org/10.1186/1476-511X-12-109
  • Liu Y, Shi D, Liu Y, Zhao Y, Tian Y, Xu J, Wang J, Xue C. 2016b. Eicosapentaenoic acid-containing phosphatidylcholine alleviated lipid accumulation in orotic acid-induced non-alcoholic fatty liver. J Funct Foods. 23:294–305.
  • Lutz BR. 1930. The effect of low oxygen tension on the pulsations of the isolated holothurian cloaca. Biol Bull. 58(1):74–84.
  • M'Andrew R, Barrett L. 1857. VI.—List of the Echinodermata dredged between Drontheim and the North Cape. Ann Mag Nat History. 20(115):43–46.
  • Ma X, Kundu N, Collin PD, Goloubeva O, Fulton AM. 2012. Frondoside A inhibits breast cancer metastasis and antagonizes prostaglandin E receptors EP4 and EP2. Breast Cancer Res Treat. 132(3):1001–1008. doi:https://doi.org/10.1007/s10549-011-1675-z
  • Mamelona J, Pelletier E, Girard-Lalancette K, Legault J, Karboune S, Kermasha S. 2007. Quantification of phenolic contents and antioxidant capacity of Atlantic sea cucumber, Cucumaria frondosa. Food Chem. 104(3):1040–1047.
  • Mamelona J, Saint-Louis R, Pelletier É. É. 2009. Nutritional composition and antioxidant properties of protein hydrolysates prepared from echinoderm byproducts. Int J Food Sci Tech. 45(1):147–154.
  • Marzouqi N, Iratni R, Nemmar A, Arafat K, Sultan MA, Yasin J, Collin P, Mester J, Adrian TE, Attoub S. 2011. Frondoside A inhibits human breast cancer cell survival, migration, invasion and the growth of breast tumor xenografts. Eur J Pharmacol. 668(1-2):25–34. doi:https://doi.org/10.1016/j.ejphar.2011.06.023
  • Mayer LM, Schick LL, Self RFL, Jumars PA, Findlay RH, Chen Z, Sampson S. 1997. Digestive environments of benthic macroinvertebrate guts: enzymes, surfactants and dissolved organic matter. 55(4):785–812. doi:https://doi.org/10.1357/0022240973224247
  • Medeiros-Bergen DE, Miles E. 1997. Recruitment in the holothurian Cucumaria frondosa in the Gulf of Maine. Invertebr Reprod Dev. 31(1-3):123–133.
  • Medeiros ‐Bergen DE, Olson RR, Conroy JA, Kocher TD. 1995. Distribution of holothurian larvae determined with species‐specific genetic probes. Limnol Oceanogr. 40(7):1225–1235. doi:https://doi.org/10.4319/lo.1995.40.7.1225
  • Mercier A, Doncaster EJ, Hamel J-F. 2013. Contrasting predation rates on planktotrophic and lecithotrophic propagules by marine benthic invertebrates. J Exp Mar Biol Ecol. 449:100–110. doi:https://doi.org/10.1016/j.jembe.2013.09.007
  • Mercier A, Hamel J-F. 2010. Synchronized breeding events in sympatric marine invertebrates: role of behaviour and fine temporal windows in maintaining reproductive isolation. Behav Ecol Sociobiol 64(11):1749–1765.
  • MFRI. 2017. Assessment of sea cucumber - SAEBJÚGA, Cucumaria frondosa. Marine and Freshwater Research Institute.
  • MI. 2005. Determining water-loss in sea cucumbers. Prepared for the Department of Fisheries and Aquaculture. Marine Institute, Memorial University.
  • Montgomery EM, Hamel J-F, Mercier A. 2017a. Ontogenetic shifts in swimming capacity of echinoderm propagules: a comparison of species with planktotrophic and lecithotrophic larvae. Mar Biol. 164:43.
  • Montgomery EM, Hamel J-F, Mercier A. 2017b. Patterns and drivers of egg pigment intensity and colour diversity in the ocean: a meta-analysis of phylum Echinodermata. Adv Mar Biol. 76:41–104. doi:https://doi.org/10.1016/bs.amb.2016.10.001
  • Montgomery EM, Ferguson-Roberts JM, Gianasi BL, Hamel J-F, Kremenetskaia A, Mercier A. 2018a. Functional significance and characterization of sexual dimorphism in holothuroids. Invertebr. Reprod Dev. 62(4):191–201. doi:https://doi.org/10.1080/07924259.2018.1491898
  • Montgomery EM, Hamel J-F, Mercier A. 2018b. Ontogenetic variation in photosensitivity of developing echinoderm propagules. J Exp Mar Biol Ecol. 500:63–72. doi:https://doi.org/10.1016/j.jembe.2017.12.003
  • Montgomery EM, Small T, Hamel J-F, Mercier A. 2019. Albinism in orange-footed sea cucumber (Cucumaria frondosa) in Newfoundland. Can Field Nat. 133(2):113–117. doi:https://doi.org/10.22621/cfn.v133i2.2047
  • Morgunbladid. 2010. Increased sea cucumber fishing in Iceland. Iceland on review line. [accessed 2020 Jan 13]. http://icelandreview.com/news/2010/01/06/increased-sea-cucumber-fishing-iceland. [Online].
  • Mortensen T. 1932. The Godthaab expedition 1928. Echinoderms
  • Murillo FJ, Serrano A, Kenchington EL, Mora J. 2016. Epibenthic assemblages of the Tail of the Grand Bank and Flemish Cap (northwest Atlantic) in relation to environmental parameters and trawling intensity. Deep Sea Res Pt. 109:99–122.
  • Myers RA, Hutchings JA, Barrowman NJ. 1996. Hypotheses for the decline of cod in the North Atlantic. Mar Ecol Prog Ser. 138:293–308.
  • Nelson EJ, MacDonald BA, Robinson SMC. 2012a. The absorption efficiency of the suspension-feeding sea cucumber, Cucumaria frondosa, and its potential as an extractive integrated multi-trophic aquaculture (IMTA) species. Aquaculture. 370-371:19–25.
  • Nelson EJ, MacDonald BA, Robinson SMC. 2012b. A review of the Northern sea cucumber Cucumaria frondosa (Gunnerus, 1767) as a potential aquaculture species. Rev Fish Sci. 20(4):212–219. doi:https://doi.org/10.1080/10641262.2012.719043
  • Nicolaisen J-RS. 2011. Lipidklasser og fettsyresammensetning i brunpølse (Cucumaria frondosa). MSc, Universitetet i Tromsø. [in Swedish].
  • Noble PB. 1970. Coelomocyte aggregation in Cucumaria frondosa: effect of ethylenediaminetetraacetate, adenosine, and adenosine nucleotides. Biol Bull. 139(3):549–556. doi:https://doi.org/10.2307/1540373
  • Nunavut. 2012a. Nunavut coastal resource inventory: Arctic Bay. Department of Environment. Government of Nunavut.
  • Nunavut. 2012b. Nunavut coastal resource inventory: Grise Fiord. Department of Environment. Government of Nunavut.
  • Oganesyan SA, Grigorjev GV. 1998. Reproductive cycle of the holothuroid Cucumaria frondosa in the Barents Sea. In Balkema RA editor. Echinoderms: Proceedings of the 9th International Echinoderm Conference San Francisco, 489–492.
  • Olson RR, Runstadler JA, Kocher TD. 1991. Whose larvae? Nature. 351(6325):357–358. doi:https://doi.org/10.1038/351357b0
  • Osse M, Hamel J-F, Mercier A. 2018. Markers of oil exposure in cold-water benthic environments: Insights and challenges from a study with echinoderms. Ecotoxicol Environ Saf. 156:56–66. doi:https://doi.org/10.1016/j.ecoenv.2018.02.076
  • Ojeda FP, Dearborn JH. 1989. Community structure of macroinvertebrates inhabiting the rocky subtidal zone in the Gulf of Maine: seasonal and bathymetric distribution. Mar Ecol Prog Ser. 57:147–161.
  • Pawson DLH. 1982. In Parker SP editor, Synopsis and classification of living organisms. New York: McGraw-Hill.
  • Pawson DL, Fell HB. 1968. A revised classification of the dendrochirote holothurians. Breviora 2014:1–7.
  • Pearse JS, Cameron RA. 1991. Echinodermata: echinoidea. 513-662.
  • Purcell S, Hair CA, Mills DJ. 2012. Sea cucumber culture, farming and sea ranching in the tropics: progress, problems and opportunities. Aquaculture. 368-369:68–81.
  • Purcell SW. 2014. Value, market preferences and trade of beche-de-mer from Pacific Island sea cucumbers. PLoS One. 9(4):e95075. doi:https://doi.org/10.1371/journal.pone.0095075
  • Purcell SW, Lovatelli A, Vasconcellos M, Ye Y. 2010. Managing sea cucumber fisheries with an ecosystem approach, FAO Fisheries and Aquaculture, Rome, pp. 158.
  • Purcell SW, Mercier A, Conand C, Hamel J-F, Toral-Granda V, Lovatelli A, Uthicke S. 2013. Sea cucumber fisheries: global review of stock status, management measures and drivers of overfishing. Fish & Fisheries. 14(1):34–59.
  • Purcell SW, Polidoro BA, Hamel J-F, Gamboa RU, Mercier A. 2014. The cost of being valuable: Predictors of extinction risk in marine invertebrates exploited as luxury seafood. Proc R Soc B. 281(1781):20133296. doi:https://doi.org/10.1098/rspb.2013.3296
  • Purcell SW, Samyn Y, Conand C. 2012. Commercially important sea cucumbers of the world FAO Species Catalogue for Fishery Purposes. No. 6. Rome, FAO. 150 pp.
  • Rankin WM. 1901. Echinoderms collected off the west Coast of Greenland by the Princeton Arctic Expedition of 1899. Proc Acad Nat Sci. 53:169–181.
  • Roginsky A, Singh B, Ding X-Z, Collin P, Woodward C, Talamonti MS, Bell RH, Jr, Adrian TE. 2004. Frondanol a5p from the sea cucumber, Cucumaria frondosa induces cell cycle arrest and apoptosis in pancreatic cancer cells. Pancreas. 29:335.
  • Roginsky AB, Ding X-Z, Woodward C, Ujiki MB, Singh B, Bell RH, Collin P, Adrian TE. 2010. Anti-pancreatic cancer effects of a polar extract from the edible sea cucumber, Cucumaria frondosa. Pancreas. 39(5):646–652. doi:https://doi.org/10.1097/MPA.0b013e3181c72baf
  • Rosalyn. 2015. United Trans Limited. [accessed 2019 Aug 11]. http://www.unitedtrans.ca/web/en_productShow.asp?id=1338Accessed. [Online].
  • Ross DAN, Hamel J-F, Mercier A. 2013. Bathymetric and interspecific variability in maternal reproductive investment and diet of eurybathic echinoderms. Deep Sea Res Pt II. 94:333–342.
  • Ross K. 2011. Spawning patterns of Maine’s commercial sea cucumber, Cucumaria frondosa: timing, synchrony, and potential cues. Bar Harbor, ME: College of the Atlantic. chriswpetersen.
  • Rowe WE, O'Hara TD, Bardsley TM. Class Holothuroidea In: 2017. Byrne, M., and O'Hara, T. D. (eds.) Australian Echinoderms: Biology, ecology and evolution Melbourne and ABRS, Canberra: CSIRO Publishing.
  • Runnström J. 1920. Heteromorphosen bei Larven von Parechinus miliariv und von Cucumaria frondosa, Nilssen.
  • Runnström J, Runnström S. 1919. Uber die Entwicklung von Cucumaria frondosa Gunnerus und Psolus phantapus Strussenfeld. Bergens Museums Aarbok No. 5. Bergen, Norway [in German].
  • Runnström J, Runnström S. 1920. Über die Entwicklung von Cucumaria frondosa Gunnerus und Psolus phantapus Strussenfelt. Bergens Museum Aabok. 5:1–100. [in German].
  • Sajwani FH, Collin P, Adrian TE. 2017. Frondoside A potentiates the effects of conventional therapeutic agents in acute leukemia. Leuk Res. 63:98–108. doi:https://doi.org/10.1016/j.leukres.2017.11.002
  • SeafoodWatch. 2017. Orange-footed sea cucumber Cucumaria frondosa. Quebec, Canada.
  • Shackell NL, Brickman DW, Frank KT. 2013. Reserve site selection for data‐poor invertebrate fisheries using patch scale and dispersal dynamics: a case study of sea cucumber (Cucumaria frondosa). Aquat Conserv Mar Freshwat Ecosyst. 23:723–731.
  • Sigurosson P, Magnusson A, Baroarson B, Solmundsson J. 2014. Marine Research Institute #176. State of marine stocks in Icelandic waters 2013/2014 - Prospects for the quota year 2014/2015. Hafrannsóknastofnun.
  • Siiri SRB. 2019. Antimikrobielle forbindelser i Sjøstjernen Asterias Rubens og Sjøpølsen Cucumaria frondosa. MSc Thesis, UiT The Arctic University of Norway (2019). [in German].
  • Singh R, MacDonald BA, Lawton P, Thomas MLH. 1998. Feeding response of the dendrochirote sea cucumber Cucumaria frondosa (Echinodermata: Holothuroidea) to changing food concentrations in the laboratory. Can J Zool. 76(10):1842–1849.
  • Singh R, MacDonald BA, Lawton P, Thomas MLH. 2001. The reproductive biology of the dendrochirote sea cucumber Cucumaria frondosa (Echinodermata: Holothuriodea) using new quantitative methods. Invertebr Reprod Dev. 40(2-3):125–141.
  • Singh R, MacDonald BA, Thomas MLH, Lawton P. 1999. Patterns of seasonal and tidal feeding activity in the dendrochirote sea cucumber Cucumaria frondosa (Echinodermata: Holothuroidea) in the Bay of Fundy, Canada. Mar Ecol Prog Ser. 187:133–145.
  • Skjaeveland SH. 1973. Ecology of echinoderms in Borgenfjorden, North-Trøndelag, Norway. Det KGL. Norske Videnskabers Selskab Musset. Miscellanea 8. Trondheim.
  • Smith CC, Fretwell SD. 1974. The optimal balance between size and number of offspring. Am Nat. 108(962):499–506.
  • So JJ, Hamel J-F, Mercier A. 2010. Habitat utilisation, growth and predation of Cucumaria frondosa: implications for an emerging sea cucumber fishery. Fish Manage Ecol. 17(6):473–484.
  • So JJ, Uthicke S, Hamel J-F, Mercier A. 2011. Genetic population structure in a commercial marine invertebrate with long-lived lecithotrophic larvae: Cucumaria frondosa (Echinodermata: Holothuroidea). Mar Biol. 158(4):859–870.
  • Song Y, Cong P, Lu L, Wang Y, Tang Q, Zhang H, Xu J, Xue C. 2017. Effects of dietary glucocerebrosides from sea cucumber on the brain sphingolipid profiles of mouse models of Alzheimer's disease. Food Funct. 8(3):1271–1281. doi:https://doi.org/10.1039/c6fo01659f
  • Subramanya SB, Chandran S, Almarzooqi S, Raj V, Zahmi A, Salem A, Al Katheeri RA, Al Zadjali SA, Collin PD, Adrian TE. 2018. Frondanol, a nutraceutical extract from Cucumaria frondosa, attenuates colonic inflammation in a DSS-induced colitis model in mice. Mar Drugs. 16(5):148.
  • Sun J, Hamel J-F, Gianasi BL, Graham M, Mercier A. 2020. Growth, health, and biochemical composition of the sea cucumber Cucumaria frondosa after multi-year holding in effluent waters of land-based salmon culture. Aquacult Environ Interact. 12:139–151.
  • Sun J, Hamel J-F, Gianasi BL, Mercier A. 2019. Age determination in echinoderms: first evidence of annual growth rings in holothuroids. Proc R Soc B. 286(1906):20190858. doi:https://doi.org/10.1098/rspb.2019.0858
  • Sun J, Hamel J-F, Mercier A. 2018. Influence of flow on locomotion, feeding behaviour and spatial distribution of a suspension-feeding sea cucumber. J Exp Biol. 221:1–11.
  • Sun J, Hamel J-F, Stuckless B, Small TJ, Mercier A. 2020. Effect of light, phytoplankton, substrate types and colour on locomotion, feeding behaviour and microhabitat selection in the sea cucumber Cucumaria frondosa. Aquaculture 526:735369.
  • Sutterlin AM, Waddy S. 1976. Tentacle movement patterns involved in feeding behaviour of the sea cucumber, Cucumaria frondosa. Mar Behav Physiol. 4(1):17–24.
  • Suwanmala J, Lu S, Tang Q, Sukhsangchan C, Zheng R, Tunkijjanukij S, Xue C. 2016. Comparison of antifatigue activity of five sea cucumber species in a mouse model of intense exercise. J. Food Nutr. Res4:12–19.
  • Sze CP, Conand C. 2014. Sea cucumber products at the China Fisheries Seafood Expo. SPC Beche-de-mer Inf Bull. 35(2015):60–63.
  • Szulgit GK, Shadwick RE. 2000. Dynamic mechanical characterization of a mutable collagenous tissue: Response of sea cucumber dermis to cell lysis and dermal extracts. J Exp Biol. 203(Pt 10):1539–1550.
  • Taggart CT, Anderson J, Bishop C, Colbourne E, Hutchings J, Lilly G, Morgan J, Murphy E, Myers R, R. 1994. G. Overview of cod stocks, biology, and environment in the Northwest Atlantic region of Newfoundland, with emphasis on northern cod. ICES Mar Sci Symp. 198:140–157.
  • Teacă A, Ungureanu C, Mureşan M. 2017. Assessment of diversity and distribution of benthic communities in Hopavågen Bay, Sletvik area (Norway). Geo-Eco-Marina: 103-120.
  • Therkildsen NO, Petersen CW. 2006. A review of the emerging fishery for the sea cucumber Cucumaria frondosa: Biology, policy, and future prospects. SPC Beche-de-mer Inf Bull. 23:16–25.
  • Thouzeau G, Robert G, Ugarte R. 1991. Faunal assemblages of benthic megainvertebrates inhabiting sea scallop grounds from eastern Georges Bank, in relation to environmental factors. Mar Ecol Prog Ser. 74:61–82.
  • Tian Y, Hu S, Xu H, Wang J, Xue C, Wang Y. 2016. Long-chain bases from Cucumaria frondosa inhibit adipogenesis and regulate lipid metabolism in 3T3-L1 adipocytes. Food Sci Biotechnol. 25(6):1753–1760. doi:https://doi.org/10.1007/s10068-016-0267-4
  • Tipper JP, Lyons-Levy G, Atkinson MAL, Trotter JA. 2002. Purification, characterization and cloning of tensilin, the collagen-fibril binding and tissue-stiffening factor from Cucumaria frondosa dermis. Matrix Biol. 21(8):625–635.
  • Tremblay MJ, Black GAP, Branton RM. 2007. The distribution of common decapod crustaceans and other invertebrates recorded in annual ecosystem surveys of the Scotian Shelf 1999-2006. DFO Can. Tech. Rep. Fish. Aquat. Sci. 2762. 74 p.
  • Tripoteau L, Bedoux G, Gagnon J, Bourgougnon N. 2015. In vitro antiviral activities of enzymatic hydrolysates extracted from byproducts of the Atlantic holothurian Cucumaria frondosa. Process Biochem. 50(5):867–875.
  • Trotter JA, Lyons-Levy G, Chino K, Koob TJ, Keene DR, Atkinson MAL. 1999. Collagen fibril aggregation-inhibitor from sea cucumber dermis. Matrix Biol. 18(6):569–578.
  • Trotter JA, Lyons-Levy G, Luna D, Koob TJ, Keene DR, Atkinson MAL. 1996. Stiparin: A glycoprotein from sea cucumber dermis that aggregates collagen fibrils. Matrix Biol. 15(2):99–110.
  • Trotter JA, Lyons-Levy G, Thurmond FA, Koob TJ. 1995. Covalent composition of collagen fibrils from the dermis of the sea cucumber, Cucumaria frondosa, a tissue with mutable mechanical properties. Comp Biochem Physiol A. 112(3-4):463–478.
  • Tyurin SA, Drozdov AL. 2002. Spermatozoon ultrastructure of two holothurian species of the genus Cucumaria (Dendrochirotida, Holothuroidea) from the sea of Japan. Russ J Mar Biol. 28(1):61–64. doi:https://doi.org/10.1023/A:1014437832678
  • Ustyuzhanina NE, Bilan MI, Dmitrenok AS, Shashkov AS, Nifantiev NE, Usov AI. 2017. The structure of a fucosylated chondroitin sulfate from the sea cucumber Cucumaria frondosa. Carbohydr Polym. 165:7–12. doi:https://doi.org/10.1016/j.carbpol.2017.02.003
  • Uthicke S, Benzie J. 2001. Effect of bêche-de-mer fishing on densities and size structure of Holothuria nobilis (Echinodermata: Holothuroidea) populations on the Great Barrier Reef. Coral Reefs. 19(3):271–276.
  • Uthicke S, Welch D, Benzie JAH. 2004. Slow growth and lack of recovery in overfished holothurians on the Great Barrier Reef: evidence from DNA fingerprints and repeated large-scale surveys. Conserv Biol. 18(5):1395–1404.
  • Verkaik K, Hamel J-F, Mercier A. 2016. Carry-over effects of ocean acidification in a cold-water lecithotrophic holothuroid. Mar Ecol Prog Ser. 557:189–206.
  • Voparil IM, Mayer LM, Jumars PA. 2008. Emulsions versus micelles in the digestion of lipids by benthic invertebrates. Limnol Oceanogr. 53(1):387–394.
  • Wang J, Han H, Chen X, Yi Y, Sun H. 2014. Cytotoxic and apoptosis-inducing activity of triterpene glycosides from Holothuria scabra and Cucumaria frondosa against HepG2 cells. Mar Drugs. 12(8):4274–4290. doi:https://doi.org/10.3390/md12084274
  • Wang Y, Wang J, Zhao Y, Hu S, Shi D, Xue C. 2016. Fucoidan from sea cucumber Cucumaria frondosa exhibits anti-hyperglycemic effects in insulin resistant mice via activating the PI3K/PKB pathway and GLUT4. J Biosci Bioeng. 121(1):36–42. doi:https://doi.org/10.1016/j.jbiosc.2015.05.012
  • Weder C, Rowan SJ, Capadona JR, Tyler DJ, Shanmuganathan K, Van Den Berg O. 2013. Dynamic mechanical polymer nanocomposites. U. S. 20090318590; U. S. 20130165554. Case Western Reserve University and the United States of America as Represented by the Department of Veterans Affairs.
  • Wein EE, Freeman MMR, Makus JC. 1996. Use of and preference for traditional foods among the Belcher Island Inuit. Arctic. 49(3):264.
  • WoRMS. 2019. World Register of Marine Specie. Cucumaria frondosa (Gunnerus, 1767). [accesses 2018 Oct 02]. http://www.marinespecies.org/aphia.php?p=taxdetails&id=124612. [Online]. http://www.marinespecies.org/aphia.php?p=taxdetails&id=124612.
  • WoRMS. 2020. World Register of Marine Specie. Cucumaria frondosa (Gunnerus, 1767). [accesses 2020 Mar 21]. http://www.marinespecies.org/aphia.php?p=taxdetails&id=124612. [Online].
  • Wu F-J, Xue Y, Liu X-F, Xue C-H, Wang J-F, Du L, Takahashi K, Wang Y-M. 2014. The protective effect of eicosapentaenoic acid-enriched phospholipids from sea cucumber Cucumaria frondosa on oxidative stress in PC12 cells and SAMP8 mice. Neurochem Int. 64:9–17. doi:https://doi.org/10.1016/j.neuint.2013.10.015
  • Xu C, Zhang R, Wen Z. 2018. Bioactive compounds and biological functions of sea cucumbers as potential functional foods. J Funct Foods. 49:73–84.
  • Xu J, Duan J, Xue C, Feng T, Dong P, Sugawara T, Hirata T. 2011. Analysis and comparison of glucocerebroside species from three edible sea cucumbers using liquid chromatography-ion trap-time-of-flight mass spectrometry. J Agric Food Chem. 59(22):12246–12253. doi:https://doi.org/10.1021/jf203556s
  • Xu J, Guo S, Du L, Wang Y-M, Sugawara T, Hirata T, Xue C-H. 2013. Isolation of cytotoxic glucoerebrosides and long-chain bases from sea cucumber Cucumaria frondosa using high speed counter-current chromatography. J Oleo Sci. 62(3):133–142. doi:https://doi.org/10.5650/jos.62.133
  • Xu X, Xu L, Zhuang F, Yu D, Sun X, Zhang C, C. 2017. Y. Research of Cucumaria frondosa polypeptide organic chromium and auxiliary fall blood function on diabetic mice. Hans J Biomed. 7:37–45.
  • Yan M, Tao H, Qin S. 2016. Effect of enzyme type on the antioxidant activities and functional properties of enzymatic hydrolysates from sea cucumber (Cucumaria frondosa) viscera. J Aquat Food Prod Technol. 25(6):940–952. doi:https://doi.org/10.1080/10498850.2014.994083
  • Yang H, Hamel J-F, Mercier A. 2015. The sea cucumber Apostichopus japonicus: History, biology and aquaculture. Academic Press.
  • Yang P, Collin P, Madden T, Chan D, Sweeney ‐Gotsch B, McConkey D, Newman RA. 2003. Inhibition of proliferation of PC3 cells by the branched-chain fatty acid, 12-methyltetradecanoic acid, is associated with inhibition of 5-lipoxygenase. Prostate. 55(4):281–291. doi:https://doi.org/10.1002/pros.10243
  • Yu Z, Robinson S, MacDonald BA, Lander T, Smith C. 2019. Effect of diets on the feeding behavior and physiological properties of suspension-feeding sea cucumber Cucumaria frondosa. J Oceanol Limn. 1–11.
  • W¸Esławski JM, Zajączkowski M, Wiktor J, Szymelfenig M. 1997. Intertidal zone of Svalbard 3. Littoral of a subarctic oceanic island: Bjornoya. Polar Biol. 18(1):45–52.
  • Zhang L, Ding L, Shi H, Wang C, Xue C, Zhang T, Wang Y. 2020. Eicosapentaenoic acid‐enriched phospholipids suppressed lipid accumulation by specific inhibition of lipid droplets‐associated protein FSP27 in mice. J Sci Food Agric. 100(5):2244–2251.
  • Zhang L, Song X, Hamel J-F, Mercier A. 2015. Aquaculture, stock enhancement, and restocking In Yang H, Hamel J-F, Mercier A editors, The Sea Cucumber Apostichopus japonicus. History, biology and aquaculture. Academic Press.
  • Zhang Y, He S, Bonneil É, Simpson BK. 2020. Generation of antioxidative peptides from Atlantic sea cucumber using alcalase versus trypsin: In vitro activity, de novo sequencing, and in silico docking for in vivo function prediction. Food Chem. 306:125581.
  • Zhao Q, Wang JF, Xue Y, Wang Y, Gao S, Lei M, Xeu C-H. 2008. Comparative study on the bioactive components and immune function of three species of sea cucumber. J Fish Sci China. 15:154–159.
  • Zhong Y, Khan MA, Shahidi F. 2007. Compositional characteristics and antioxidant properties of fresh and processed sea cucumber (Cucumaria frondosa). J Agric Food Chem. 55(4):1188–1192. doi:https://doi.org/10.1021/jf063085h
  • Иебская ТК, Новиков В, Толкачева ВФ, Ильина ИП, Бекетова HА. 1999. Характеристика физико-химических свойств комплекса фосфолипидов с сапонинами и концентрата каротиноидов из внутренних органов Cucumaria frondosa Баренцева моря. Известия ТИНРО (Тихоокеанского научно-исследовательского рыбохозяйственного центра). 125:272–281. [in Russian].
  • Матишов ГГ. Промысловые и перспективные для использования водоросли и беспозвоночные Баренцева и Белого морей [Online]. ИНФОРМАЦИЯ О ПУБИИКАЦИИ. [accessed 2020 Apr 20]. https://elibrary.ru/item.asp?id=21118694. [in Russian].
  • Мухортова АМ, Узбекова ОР, Иыжов ИИ, Барышников АВ, Новиков ВЮ, Мухин ВА. 2018. Сравнительная технохимическая характеристика и перспективные направления переработки голотурий Molpadia arctica, Molpadia borealis и Cucumaria frondosa Баренцева и Карского морей. Рыбное хозяйство:36–39. [in Russian].
  • Ржавский АВ, Бритаев ТА, Павлова ИВ, Кузьмин СА, 2004. распределении некоторых видов макрозообентоса в губе Дальнезеленецкая (Баренцево море) после вселения камчатского краба. Изучение зообентоса шельфа. Информационное обеспечение экосистемных исследований:105–116., Куликова ВИО, and [in Russian].
  • Степанов ВГ, Шапорев РА. 2003. Сравнительный анализ формы спикул кожи тела шести видов голотурий рода Cucumaria (Echinodermata: Holothurioidea) Сохранение биоразнообразия Камчатки и прилегающих морей: материалы IV науч. конф.–Петропавловск-Камчатский: КамчатНИРО. 137–140. [In Russian].

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