Etomidate decreases adrenal gland apoptosis and necrosis associated with hemorrhagic shock in a rat model (Rattus norvegicus)

References

• Allolio, B., Dörr, H., Stuttmann, R., Knorr, D., Engelhardt, D., & Winkelmann, W. (1985). Effect of a single bolus of etomidate upon eight major corticosteroid hormones and plasma ACTH. Clinical Endocrinology, 22(3), 281–286.10.1111/j.1365-2265.1985.tb03241.x
   PubMed Web of Science ®Google Scholar
• Almeida, H., Ferreira, J., & Neves, D. (2004). Macrophages of the adrenal cortex: A morphological study of the effects of aging and dexamethasone administration. Annals of the New York Academy of Sciences, 1019, 135–140.10.1196/annals.1297.024
   PubMed Web of Science ®Google Scholar
• Almeida, H., Matos, L., Ferreira, J., & Neves, D. (2006). Age-related effects of dexamethasone administration in adrenal zona reticularis. Annals of the New York Academy of Sciences, 1067, 354–360.10.1196/annals.1354.050
   PubMed Web of Science ®Google Scholar
• Almeida, H., Matos, L., & Neves, D. (2007). Caspase-3 and Bcl-2 expression in aging in adrenal zona reticularis after dexamethasone administration. Annals of the New York Academy of Sciences, 1119, 190–195.10.1196/annals.1404.021
   PubMed Web of Science ®Google Scholar
• Bazzani, C., Bertolini, A., & Guarini, S. (1997). Inhibition of nitric oxide synthases enhances the effect of ACTH in hemorrhagic shock. Life Sciences, 61(19), 1889–1897.10.1016/S0024-3205(97)00828-X
   PubMed Web of Science ®Google Scholar
• Bertuglia, S., & Giusti, A. (2004). Influence of ACTH-(1-24) and plasma hyperviscosity on free radical production and capillary perfusion after hemorrhagic shock. Microcirculation, 11(3), 227–238.10.1080/10739680490425930
   PubMed Web of Science ®Google Scholar
• Bozzo, A., Soñez, C. A., Mugnaini, M. T., Pastorino, I. C., Rolando, A. N., Romanini, M. C., & Gauna, H. F. (2006). Chronic stress effects on the apoptotic index of the adrenal cortex of pregnant rats. Biocell, 30(3), 439–445.
   PubMed Web of Science ®Google Scholar
• Bruder, E. A., Ball, I. M., Ridi, S., Pickett, W., & Hohl, C. (2015). Single induction dose of etomidate versus other induction agents for endotracheal intubation in critically ill patients. The Cochrane database of systematic reviews, 1, CD010225.
   PubMed Web of Science ®Google Scholar
• Carsia, R. V., Macdonald, G. J., Gibney, J. A., Tilly, K. I., & Tilly, J. L. (1996). Apoptotic cell death in the rat adrenal gland: An in vivo and in vitro investigation. Cell Tissue Research, 283, 247–254.10.1007/s004410050535
   PubMed Web of Science ®Google Scholar
• Centurione, L., & Aiello, F. B. (2016). DNA repair and cytokines: TGF-β, IL-6, and thrombopoietin as different biomarkers of radioresistance. Frontiers Oncology, 6, 175.
   PubMed Web of Science ®Google Scholar
• Cherfan, A. J., Tamim, H. M., AlJumah, A., Rishu, A. H., Al-Abdulkareem, A., Al Knawy, B. A., … Arabi, Y. M. (2011). Etomidate and mortality in cirrhotic patients with septic shock. BMC Clinical Pharmacology, 11, 22.10.1186/1472-6904-11-22
   PubMedGoogle Scholar
• Cotton, B. A., Guillamondegui, O. D., Fleming, S. B., Carpenter, R. O., Patel, S. H., Morris, Jr., J. A., & Arbogast, P. G. (2008). Increased risk of adrenal insufficiency following etomidate exposure in critically injured patients. Archives of Surgery, 143, 62–67.10.1001/archsurg.143.1.62
   PubMedGoogle Scholar
• Crozier, T. A., Beck, D., Schlaeger, M., Wuttke, W., & Kettler, D. (1987). Endocrinological changes following etomidate, midazolam, or methohexital for minor surgery. Anesthesiology, 66, 628–635.10.1097/00000542-198705000-00006
   PubMed Web of Science ®Google Scholar
• den Brinker, M., Joosten, K. F., Liem, O., de Jong, F. H., Hop, W. C., Hazelzet, J. A., … Hokken-Koelega, A. C. (2005). Adrenal insufficiency in meningococcal sepsis: Bioavailable cortisol levels and impact of interleukin-6 levels and intubation with etomidate on adrenal function and mortality. The Journal of Clinical Endocrinology & Metabolism, 90, 5110–5117.10.1210/jc.2005-1107
   PubMed Web of Science ®Google Scholar
• den Brinker, M., Hokken-Koelega, A. C., Hazelzet, J. A., de Jong, F. H., Hop, W. C., & Joosten, K. F. (2008). One single dose of etomidate negatively influences adrenocortical performance for at least 24 h in children with meningococcal sepsis. Intensive Care Medicine, 34, 163–168.10.1007/s00134-007-0836-3
   PubMed Web of Science ®Google Scholar
• Dhingra, S., Bagchi, A. K., Ludke, A. L., Sharma, A. K., & Singal, P. K. (2011). Akt regulates IL-10 mediated suppression of TNFα-induced cardiomyocyte apoptosis by upregulating Stat3 phosphorylation. PLoS ONE, 6, e25009.10.1371/journal.pone.0025009
   PubMed Web of Science ®Google Scholar
• Didenko, V. V., Wang, X., Yang, L., & Hornsby, P. J. (1996). Expression of p21 (WAF1/CIP1/SDI1) and p53 in apoptotic cells in the adrenal cortex and induction by ischemia/reperfusion injury. Journal of Clinical Investigation, 97, 1723–1731.10.1172/JCI118599
   PubMed Web of Science ®Google Scholar
• Duprez, L., Takahashi, N., Van Hauwermeiren, F., Vandendriessche, B., Goossens, V., Vanden Berghe, T., … Vandenabeele, P. (2011). RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome. Immunity, 35(6), 908–918.10.1016/j.immuni.2011.09.020
   PubMed Web of Science ®Google Scholar
• Ergün, Y., Darendeli, S., Imrek, S., Kilinç, M., & Oksüz, H. (2010). The comparison of the effects of anesthetic doses of ketamine, propofol, and etomidate on ischemia-reperfusion injury in skeletal muscle. Fundamentals of Clinical Pharmacology, 24(2), 215–222.
   PubMed Web of Science ®Google Scholar
• Feige, J. J., Keramidas, M., & Chambaz, E. M. (1998). Hormonally regulated components of the adrenocortical cell environment and the control of adrenal cortex homeostasis. Hormone and Metabolic Research, 30, 421–425.10.1055/s-2007-978908
   PubMed Web of Science ®Google Scholar
• Félix, N. M., Goy-Thollot, I., Walton, R. S., Gil, S. A., Mateus, L. M., Matos, A. S., & Niza, M. M. R. E. (2016). Effects of etomidate in the adrenal and cytokine responses to hemorrhagic shock in rats. European Journal of Inflammation, 14(3), 147–161. doi:10.1177/1721727X16677604
   Web of Science ®Google Scholar
• Fiorentino, D. F., Zlotnik, A., Vieira, P., Mosmann, T. R., Howard, M., Moore, K. W., & O’Garra, A. (1991). IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. Journal of Immunology, 146, 3444–3451.
   PubMed Web of Science ®Google Scholar
• Flierl, M. A., Rittirsch, D., Chen, A. J., Nadeau, B. A., Day, D. E., Sarma, J. V., … Ward, P. A. (2008). The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis. PLoS ONE, 3, e2560. doi:10.1371/journal.pone.0002560
   PubMed Web of Science ®Google Scholar
• Forman, S. A. (2011). Clinical and molecular pharmacology of etomidate. Anesthesiology, 114, 695–707.10.1097/ALN.0b013e3181ff72b5
   PubMed Web of Science ®Google Scholar
• Formigli, L., Papucci, L., Tani, A., Schiavone, N., Tempestini, A., Orlandini, G. E., … Orlandini, S. Z. (2000). Aponecrosis: Morphological and biochemical exploration of a syncretic process of cell death sharing apoptosis and necrosis. Journal of Cellular Physiology, 182, 41–49.10.1002/(ISSN)1097-4652
   PubMed Web of Science ®Google Scholar
• Fuchs, A. C., Granowitz, E. V., Shapiro, L., Vannier, E., Lonnemann, G., Angel, J. B., … Dinarello, C. A. (1996). Clinical, hematologic, and immunologic effects of interleukin-10 in humans. Journal of Clinical Immunology, 16, 291–303.10.1007/BF01541395
   PubMed Web of Science ®Google Scholar
• Fukuzuka, K., Rosenberg, J. J., Gaines, G. C., Edwards, C. K., 3rd, Clare-Salzler, M., MacKay, S. L., … Mozingo, D. W. (1999). Caspase-3–dependent organ apoptosis early after burn injury. Annals of Surgery, 229, 851–858.10.1097/00000658-199906000-00012
   PubMed Web of Science ®Google Scholar
• Galluzzi, L., Vitale, I., Abrams, J. M., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., … Kroemer, G. (2012). Molecular definitions of cell death subroutines: Recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death and Differentiation, 19, 107–120.10.1038/cdd.2011.96
   PubMed Web of Science ®Google Scholar
• Guarini, S., Bazzani, C., Ricigliano, G. M., Bini, A., Tomasi, A., & Bertolini, A. (1996). Influence of ACTH-(1-24) on free radical levels in the blood of haemorrhage-shocked rats: Direct ex vivo detection by electron spin resonance spectrometry. British Journal of Pharmacology, 119(1), 29–34.10.1111/bph.1996.119.issue-1
   PubMed Web of Science ®Google Scholar
• Guarini, S., Cainazzo, M. M., Giuliani, D., Mioni, C., Altavilla, D., Marini, H., … Bertolini, A. (2004). Adrenocorticotropin reverses hemorrhagic shock in anesthetized rats through the rapid activation of a vagal anti-inflammatory pathway. Cardiovascular Research, 63(2), 357–365.10.1016/j.cardiores.2004.03.029
   PubMed Web of Science ®Google Scholar
• Hamaji, M., Nakamura, M., Izukura, M., Nakaba, H., Hashimoto, T., Tanaka, Y., … Harrison, T. S. (1986). Autoregulation and regional blood flow of the dog during hemorrhagic shock. Circulatory Shock, 19(3), 245–255.
   PubMedGoogle Scholar
• Hermoso, M. A., & Cidlowski, J. A. (2003). Putting the brake on inflammatory responses: The role of glucocorticoids. IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), 55, 497–504.10.1080/15216540310001642072
   Google Scholar
• Hirano, T., Ishihara, K., & Hibi, M. (2000). Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene, 19, 2548–2556.10.1038/sj.onc.1203551
   PubMed Web of Science ®Google Scholar
• Hoen, S., Asehnoune, K., Brailly-Tabard, S., Mazoit, J. X., Benhamou, D., Moine, P., & Edouard, A. R. (2002). Cortisol response to corticotropin stimulation in trauma patients: Influence of hemorrhagic shock. Anesthesiology, 97, 807–813.10.1097/00000542-200210000-00010
   PubMed Web of Science ®Google Scholar
• Jameson, P., Desborough, J. P., Bryant, A. E., & Hall, G. M. (1997). The effect of cortisol suppression on interleukin-6 and white blood cell responses to surgery. Acta Anaesthesiologica Scandinavica, 41, 304–308.10.1111/aas.1997.41.issue-2
   PubMed Web of Science ®Google Scholar
• Jasper, M. S., McDermott, P., Gann, D. S., & Engeland, W. C. (1990). Measurement of blood flow to the adrenal capsule, cortex and medulla in dogs after hemorrhage by fluorescent microspheres. Journal of the Autonomic Nervous System, 30(2), 159–167.10.1016/0165-1838(90)90140-E
   PubMedGoogle Scholar
• John, C. D., & Buckingham, J. C. (2003). Cytokines: Regulation of the hypothalamo-pituitary-adrenocortical axis. Current Opinion in Pharmacology, 3(1), 78–84.10.1016/S1471-4892(02)00009-7
   PubMed Web of Science ®Google Scholar
• Kajihara, H., Hirata, S., & Miyoshi, N. (1977). Changes in blood catecholamine levels and ultrastructure of dog adrenal medullary cells during hemorrhagic shock. Virchows Archives B Cell Pathology, 23(1), 1–16.
   PubMedGoogle Scholar
• Kajihara, H., Malliwah, J. A., Matsumura, M., Taguchi, K., & Iijima, S. (1983). Changes in blood cortisol and aldosterone levels and ultrastructure of the adrenal cortex during hemorrhagic shock. Pathology, Research and Practice, 176, 324–340.10.1016/S0344-0338(83)80022-3
   PubMed Web of Science ®Google Scholar
• Kamiyama, K., Matsuda, N., Yamamoto, S., Takano, K., Takano, Y., Yamazaki, H., … Hattori, Y. (2008). Modulation of glucocorticoid receptor expression, inflammation, and cell apoptosis in septic guinea pig lungs using methylprednisolone. AJP: Lung Cellular and Molecular Physiology, 295, 998–1006.10.1152/ajplung.00459.2007
   Google Scholar
• Kanczkowski, W., Chatzigeorgiou, A., Grossklaus, S., Sprott, D., Bornstein, S. R., & Chavakis, T. (2013). Role of the endothelial-derived endogenous anti-inflammatory factor Del-1 in inflammation-mediated adrenal gland dysfunction. Endocrinology, 154(3), 1181–1189.10.1210/en.2012-1617
   PubMed Web of Science ®Google Scholar
• Kanczkowski, W., Chatzigeorgiou, A., Samus, M., Tran, N., Zacharowski, K., Chavakis, T., & Bornstein, S. R. (2013). Characterization of the LPS-induced inflammation of the adrenal gland in mice. Molecular and Cellular Endocrinology, 371, 228–235.10.1016/j.mce.2012.12.020
   PubMed Web of Science ®Google Scholar
• Keramidas, M., Feige, J. J., & Thomas, M. (2004). Coordinated regression of adrenocortical endocrine and endothelial compartments under adrenocorticotropin deprivation. Endocrine Research, 30(4), 543–549.10.1081/ERC-200043623
   PubMed Web of Science ®Google Scholar
• Klemcke, H. G., Joe, B., Calderon, M. L., Rose, R., Oh, T., Aden, J., & Ryan, K. L. (2011). Genetic influences on survival time after severe haemorrhage in inbred rat strains. Physiological Genomics, 43, 758–765.10.1152/physiolgenomics.00245.2010
   PubMed Web of Science ®Google Scholar
• Koldzic-Zivanovic, N., Tu, H., Juelich, T. L., Rady, P. L., Tyring, S. K., Hudnall, S. D., … Hughes, T. K. (2006). Regulation of adrenal glucocorticoid synthesis by interleukin-10: A preponderance of IL-10 receptor in the adrenal zona fasciculata. Brain, Behavior, and Immunity, 20(5), 460–468.10.1016/j.bbi.2005.09.003
   PubMed Web of Science ®Google Scholar
• Krajewski, S., Krajewska, M., & Reed, J. C. (1996). Immunohistochemical analysis of in vivo patterns of Bak expression, a proapoptotic member of the Bcl-2 protein family. Cancer Research, 56, 2849–2855.
   PubMed Web of Science ®Google Scholar
• Kugawa, F., Arae, K., Ueno, A., & Aoki, M. (1998). Buprenorphine hydrochloride induces apoptosis in NG108-15 nerve cells. European Journal of Pharmacology, 347, 105–112.10.1016/S0014-2999(98)00080-6
   PubMed Web of Science ®Google Scholar
• Kugawa, F., Nakamura, M., Ueno, A., & Aoki, M. (2004). Over-expressed Bcl-2 cannot suppress apoptosis via the mitochondria in buprenorphine hydrochloride-treated NG108-15 cells. Biological & Pharmaceutical Bulletin, 27, 1340–1347.10.1248/bpb.27.1340
   PubMed Web of Science ®Google Scholar
• Liu, N., Zhang, Y., Xiong, J. Y., Liu, S., Zhu, J., & Lv, S. (2016). The pituitary adenylate cyclase-activating polypetide (PACAP) protects adrenal function in septic rats administered etomidate. Neuropeptides, 58, 53–59.10.1016/j.npep.2016.03.005
   PubMed Web of Science ®Google Scholar
• Liu, S., Zhang, X. P., Han, N. N., Lv, S., & Xiong, J. Y. (2015). Pretreatment with low dose etomidate prevents etomidate-induced rat adrenal insufficiency by regulating oxidative stress-related MAPKs and apoptosis. Environmental Toxicology and Pharmacology, 39(3), 1212–1220.10.1016/j.etap.2015.04.014
   PubMed Web of Science ®Google Scholar
• Marik, P. E. (2009). Critical illness-related corticosteroid insufficiency. Chest, 135, 181–193.10.1378/chest.08-1149
   PubMed Web of Science ®Google Scholar
• Mees, S. T., Gwinner, M., Marx, K., Faendrich, F., Schroeder, J., Haier, J., & Kahlke, V. (2008). Influence of sex and age on morphological organ damage after hemorrhagic shock. Shock, 29, 670–674.
   PubMed Web of Science ®Google Scholar
• Mikhaylova, I. V., Kuulasmaa, T., Jääskeläinen, J., & Voutilainen, R. (2007). Tumor necrosis factor-alpha regulates steroidogenesis, apoptosis, and cell viability in the human adrenocortical cell line NCI-H295R. Endocrinology, 148(1), 386–392.10.1210/en.2006-0726
   PubMed Web of Science ®Google Scholar
• Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O’Garra, A. (2001). Interleukin-10 and the interleukin-10 receptor. Annual Review of Immunology, 19, 683–765.10.1146/annurev.immunol.19.1.683
   PubMed Web of Science ®Google Scholar
• Moran, A., Tsimelzon, A. I., Mastrangelo, M. A., Wu, Y., Yu, B., Hilsenbeck, S. G., … Tweardy, D. J. (2009). Prevention of trauma/hemorrhagic shock-induced lung apoptosis by IL-6-mediated activation of Stat3. Clinical and Translational Science, 2, 41–49.10.1111/cts.2009.2.issue-1
   PubMed Web of Science ®Google Scholar
• Mosier, M. J., Lasinski, A. M., & Gamelli, R. L. (2015). Suspected adrenal insufficiency in critically ill burned patients: Etomidate-induced or critical illness-related corticosteroid insufficiency?-A review of the literature. Journal of Burn & Care Research, 36(2), 272–278.10.1097/BCR.0000000000000099
   PubMed Web of Science ®Google Scholar
• Motta, P., Muto, M., & Fujita, T. (1979). Three-dimensional organization of mammalian adrenal cortex. A scanning electron microscopic study. Cell Tissue Research, 30, 23–38.
   Google Scholar
• Ottani, A., Galantucci, M., Ardimento, E., Neri, L., Canalini, F., Calevro, A., … Guarini, S. (2013). Modulation of the JAK/ERK/STAT signaling in melanocortin-induced inhibition of local and systemic responses to myocardial ischemia/reperfusion. Pharmacological Research, 72, 1–8.10.1016/j.phrs.2013.03.005
   PubMed Web of Science ®Google Scholar
• Papathanassoglou, E. D., Moynihan, J. A., & Ackerman, M. H. (2000). Does programmed cell death (apoptosis) play a role in the development of multiple organ dysfunction in critically ill patients? A review and a theoretical framework. Critical Care Medicine, 28, 537–549.10.1097/00003246-200002000-00042
   PubMed Web of Science ®Google Scholar
• Päth, G., Bornstein, S. R., Ehrhart-Bornstein, M., & Scherbaum, W. A. (1997). Interleukin-6 and the interleukin-6 receptor in the human adrenal gland: Expression and effects on steroidogenesis. Journal of Clinical Endocrinology and Metabolism, 82(7), 2343–2349.
   PubMed Web of Science ®Google Scholar
• Pejo, E., Feng, Y., Chao, W., Cotten, J. F., Le Ge, R., & Raines, D. E. (2012). Differential effects of etomidate and its pyrrole analogue carboetomidate on the adrenocortical and cytokine responses to endotoxemia. Critical Care Medicine, 40, 187–192.10.1097/CCM.0b013e31822d7924
   PubMed Web of Science ®Google Scholar
• Polito, A., Lorin de la Grandmaison, G., Mansart, A., Louiset, E., Lefebvre, H., Sharshar, T., & Annane, D. (2010). Human and experimental septic shock are characterized by depletion of lipid droplets in the adrenals. Intensive Care Medicine, 36, 1852–1858.10.1007/s00134-010-1987-1
   PubMed Web of Science ®Google Scholar
• Porter, A. G., & Jänicke, R. U. (1999). Emerging roles of caspase-3 in apoptosis. Cell Death Differentiation, 6, 99–104.10.1038/sj.cdd.4400476
   PubMed Web of Science ®Google Scholar
• Preziosi, P., & Vacca, M. (1982). Etomidate and corticotrophic axis. Archives Internationales de Pharmacodynamie et de Therapie, 256, 308–310.
   PubMedGoogle Scholar
• Roesslein, M., Schibilsky, D., Muller, L., Goebel, U., Schwer, C., Humar, M., … Loop, T. (2008). Thiopental protects human T lymphocytes from apoptosis in vitro via the expression of heat shock protein 70. Journal of Pharmacology and Experimental Therapeutics, 325, 217–225.10.1124/jpet.107.133108
   PubMed Web of Science ®Google Scholar
• Rollwagen, F. M., Yu, Z. Y., Li, Y. Y., & Pacheco, N. D. (1998). IL-6 rescues enterocytes from hemorrhage induced apoptosis in vivo and in vitro by a bcl-2 mediated mechanism. Clinical Immunology Immunopathology, 89, 205–213.10.1006/clin.1998.4600
   PubMedGoogle Scholar
• Rushing, G. D., & Britt, L. D. (2007). Inhibition of NF-KB does not induce c-Jun N-Terminal kinase-mediated apoptosis in reperfusion injury. Journal of the American College of Surgeons, 204(5), 964–967.10.1016/j.jamcollsurg.2007.01.029
   PubMed Web of Science ®Google Scholar
• Rushing, G. D., Britt, R. C., & Britt, L. D. (2006). Effects of hemorrhagic shock on adrenal response in a rat model. Annals of Surgery, 243, 652–656.10.1097/01.sla.0000216759.36819.1b
   PubMed Web of Science ®Google Scholar
• Sharma, A., Matsuo, S., Yang, W. L., Wang, Z., & Wang, P. (2014). Receptor-interacting protein kinase 3 deficiency inhibits immune cell infiltration and attenuates organ injury in sepsis. Critical Care, 18(4), R142.10.1186/cc13970
   PubMed Web of Science ®Google Scholar
• Si, J., Ge, Y., Zhuang, S., Wang, L.J., Chen, S., & Gong, R. (2013). Adrenocorticotropic hormone ameliorates acute kidney injury by steroidogenic-dependent and -independent mechanisms. Kidney International, 83, 635–646.10.1038/ki.2012.447
   PubMed Web of Science ®Google Scholar
• Smart, N., Mojet, M. H., Latchman, D. S., Marber, M. S., Duchen, M. R., & Heads, R. J. (2006). IL-6 induces PI 3-kinase and nitric oxide-dependent protection and preserves mitochondrial function in cardiomyocytes. Cardiovascular Research, 69, 164–177.10.1016/j.cardiores.2005.08.017
   PubMed Web of Science ®Google Scholar
• Sparrow, R. A., & Coupland, R. E. (1987). Blood flow to the adrenal gland of the rat: Its distribution between the cortex and the medulla before and after haemorrhage. Journal Anatomy, 155, 51–61.
   PubMed Web of Science ®Google Scholar
• Squadrito, F., Guarini, S., Altavilla, D., Squadrito, G., Campo, G. M., Arlotta, M., … Caputi, A. P. (1999). Adrenocorticotropin reverses vascular dysfunction and protects against splanchnic artery occlusion shock. British Journal of Pharmacology, 128(3), 816–822.10.1038/sj.bjp.0702848
   PubMed Web of Science ®Google Scholar
• Stein, D. M., Jessie, E. M., Crane, S., Kufera, J. A., Timmons, T., Rodriguez, C. J., … Scalea, T. M. (2013). Hyperacute adrenal insufficiency after hemorrhagic shock exists and is associated with poor outcomes. Journal of Trauma Acute Care Surgery, 74(2), 363–370.10.1097/TA.0b013e31827e2aaf
   PubMed Web of Science ®Google Scholar
• Thacker, S. A., Robinson, P., Abel, A., & Tweardy, D. J. (2013). Modulation of the unfolded protein response during hepatocyte and cardiomyocyte apoptosis in trauma/hemorrhagic shock. Scientific Reports, 3, 1.10.1038/srep01187
   Web of Science ®Google Scholar
• Thompson, C. D., Zurko, J. C., Hanna, B. F., Hellenbrand, D. J., & Hanna, A. (2013). The therapeutic role of interleukin-10 after spinal cord injury. Journal of Neurotrauma, 30(15), 1311–1324.10.1089/neu.2012.2651
   PubMed Web of Science ®Google Scholar
• Tkachenko, I. V., Jääskeläinen, T., Jääskeläinen, J., Palvimo, J. J., & Voutilainen, R. (2011). Interleukins 1α and 1β as regulators of steroidogenesis in human NCI-H295R adrenocortical cells. Steroids, 76(10-11), 1103–1115.10.1016/j.steroids.2011.04.018
   PubMed Web of Science ®Google Scholar
• Turnbull, A. V., & Rivier, C. L. (1999). Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: Actions and mechanisms of action. Physiological Reviews, 79(1), 1–71.
   PubMed Web of Science ®Google Scholar
• Vanlangenakker, N., Berghe, T. V., Krysko, D. V., Festjens, N., & Vandenabeele, P. (2008). Molecular mechanisms and pathophysiology of necrotic cell death. Current Molecular Medicine, 8, 207–220.10.2174/156652408784221306
   PubMed Web of Science ®Google Scholar
• Vignali, D.A. (2000). Multiplexed particle-based flow cytometric assays. Journal of Immunological Methods, 243, 243–255.10.1016/S0022-1759(00)00238-6
   PubMed Web of Science ®Google Scholar
• Vinson, G. P. (2016). Functional zonation of the adult mammalian adrenal cortex. Frontiers Neuroscience, 10, 238.
   PubMed Web of Science ®Google Scholar
• Wagner, R. L., White, P. F., Kan, P. B., Rosenthal, M. H., & Feldman, D. (1984). Inhibition of adrenal steroidogenesis by the anesthetic etomidate. New England Journal of Medicine, 310(22), 1415–1421.10.1056/NEJM198405313102202
   PubMed Web of Science ®Google Scholar
• Wang, P., Ba, Z. F., Jarrar, D., Cioffi, W.G., Bland, K. I., & Chaudry, I. H. (1999). Mechanism of adrenal insufficiency following trauma and severe hemorrhage: Role of hepatic 11beta-hydroxysteroid dehydrogenase. Archives of Surgery, 134, 394–401.10.1001/archsurg.134.4.394
   PubMedGoogle Scholar
• Wang, C. N., Duan, G. L., Liu, Y. J., Yu, Q., Tang, X. L., Zhao, W., … Ni, X. (2015). Overproduction of nitric oxide by endothelial cells and macrophages contributes to mitochondrial oxidative stress in adrenocortical cells and adrenal insufficiency during endotoxemia. Free Radical Biology & Medicine, 83, 31–40.10.1016/j.freeradbiomed.2015.02.024
   PubMed Web of Science ®Google Scholar
• Wang, X., Jin, A., An, M., Ding, Y., Tuo, Y., & Qiu, Y. (2014). Etomidate deteriorates the toxicity of advanced glycation end products to human endothelial Eahy926 cells. The Journal of Toxicological Sciences, 39(6), 887–896.10.2131/jts.39.887
   PubMed Web of Science ®Google Scholar
• Wolkersdörfer, G. W., Ehrhart-Bornstein, M., Brauer, S., Marx, C., Scherbaum, W. A., & Bornstein, S. R. (1996). Differential regulation of apoptosis in the normal human adrenal gland. Journal Clinical Endocrinology Metabolism, 81, 4129–4136.
   PubMed Web of Science ®Google Scholar
• Wu, R. S., Wu, K. C., Yang, J. S., Chiou, S. M., Yu, C. S., Chang, S. J., … Chung, J. G. (2011). Etomidate induces cytotoxic effects and gene expression in a murine leukemia macrophage cell line (RAW264.7). Anticancer Research, 31, 2203–2208.
   PubMed Web of Science ®Google Scholar
• Xu, H., Chen, S., Luo, W., & Firoj, K. M. (2014). Effect of stress on myocardial apoptosis in ischemic preconditioning in rabbit hearts. Zhong Nan da Xue Xue Bao Yi Xue Ban, 39, 477–482.
   PubMedGoogle Scholar
• Yagmurdur, H., Cakan, T., Bayrak, A., Arslan, M., Baltaci, B., Inan, N., & Kilinc, K. (2004). The effects of etomidate, thiopental and propofol in induction on hypoperfusion-reperfsuion phenomenon during laparoscopic cholecystectomy. Acta Anaesthesiologica Scandinavica, 48(6), 772–777.10.1111/aas.2004.48.issue-6
   PubMed Web of Science ®Google Scholar
• Yu, J., Xu, S., Wang, W. X., Deng, W. H., Jin, H., Chen, X. Y., … Sun, H. T. (2012). Changes of inflammation and apoptosis in adrenal gland after experimental injury in rats with acute necrotizing pancreatitis. Inflammation, 35, 11–22.10.1007/s10753-010-9284-2
   PubMed Web of Science ®Google Scholar
• Yu, J., Zuo, T., Deng, W., Shi, Q., Ma, P., Chen, C., … Wang, W. (2016). Poly(ADP-ribose) polymerase inhibition suppresses inflammation and promotes recovery from adrenal injury in a rat model of acute necrotizing pancreatitis. BMC Gastroenterology, 16(1), 11.10.1186/s12876-016-0493-5
   PubMed Web of Science ®Google Scholar
• Yu, Q., Zhou, Q., Huang, H., Wang, Y., Tian, S., & Duan, D. (2010). Protective effect of etomidate on spinal cord ischemia–reperfusion injury induced by aortic occlusion in rabbits. Annals of Vascular Surgery, 24(2), 225–232.10.1016/j.avsg.2009.06.023
   PubMed Web of Science ®Google Scholar
• Zhang, X., Xiong, J., Jiao, Y., Wang, G., & Zuo, Z. (2010). Involvement of mitochondrial ATP-sensitive potassium channels in etomidate preconditioning-induced protection in human myeloid HL-60 cells. Environmental Toxicology and Pharmacology, 29(3), 320–322.10.1016/j.etap.2010.02.003
   PubMed Web of Science ®Google Scholar
• Zhang, Y., Li, R., Zhu, J., Wang, Z., Lv, S., & Xiong, J. Y. (2015). Etomidate increases mortality in septic rats through inhibition of nuclear factor kappa-B rather than by causing adrenal insufficiency. Journal of Surgical Research, 193(1), 399–406.10.1016/j.jss.2014.07.001
   PubMed Web of Science ®Google Scholar