5-Flurouracil microencapsulation and impregnation in hyaluronic acid hydrogel as composite drug delivery system for ocular fibrosis

References

• Arias, J. L. (2008). Novel strategies to improve the anticancer action of 5-Fluorouracil by using drug delivery systems. Molecules, 13, 2340–2369.10.3390/molecules13102340
   Google Scholar
• Bae, J. W., Go, D. H., Park, K. D., & Lee, S. J. (2006). Thermosensitive chitosan as an injectable carrier for local drug delivery. Macromolecular Research, 14, 461–465.10.1007/BF03219111
   Google Scholar
• Caicco, M. J., Cooke, M. J., Wang, Y., Tuladhar, A., Morshead, C. M., & Shoichet, M. S. (2013). A hydrogel composite system for sustained epi-cortical delivery of cyclosporin a to the brain for treatment of stroke. Journal of Controlled Release, 166, 197–202.10.1016/j.jconrel.2013.01.002
   Google Scholar
• Chang, E., McClellan, A. J., Farley, W. J., Li, D. Q., Pflugfelder, S. C., & de Paiva, C. S. (2011). Biodegradable PLGA-based drug delivery systems for modulating ocular surface disease under experimental murine dry eye. Journal of Clinical & Experimental Ophthalmology, 2, 191–196.
   Google Scholar
• Chiang, C. H., Tung, S. H., Lu, D. W., & Yeh, M. K. (2001). In vitro and in vivo evaluation of an ocular delivery system of 5-Fluorouracil microspheres. Journal of Ocular Pharmacology and Therapeutics, 17, 545–553.10.1089/10807680152729239
   Google Scholar
• Choi, J. S., Seo, K., & Yoo, J. W. (2012). Recent advances in PLGA particulate systems for drug delivery. Journal of Pharmaceutical Investigation, 42, 155–163.10.1007/s40005-012-0024-5
   Google Scholar
• Cook, C., & Foster, P. (2012). Epidemiology of glaucoma: What’s new? Canadian Journal of Ophthalmology, 47, 223–226.10.1016/j.jcjo.2012.02.003
   Google Scholar
• Cui, L., Sun, N., Li, X., Huang, J., & Yang, J. (2008). Subconjunctival sustained release 5-fluorouracil for glaucoma filtration surgery. Acta Pharmacologica Sinica, 29, 1021–1028.10.1111/aphs.2008.29.issue-9
   Google Scholar
• Faisant, N., Siepmann, J., & Benoit, J. P. (2002). PLGA-based microparticles: Elucidation of mechanisms and a new, simple mathematical model quantifying drug release. European Journal of Pharmaceutical Sciences, 15, 355–366.10.1016/S0928-0987(02)00023-4
   Google Scholar
• Fredenberg, S., Wahlgren, M., Reslow, M., & Axelsson, A. (2011). The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems–A review. International Journal of Pharmaceutics, 415, 34–52.10.1016/j.ijpharm.2011.05.049
   Google Scholar
• Galeska, I., Kim, T. K., Patil, S. D., Bhardwaj, U., Chatttopadhyay, D., Papadimitrakopoulos, F., & Burgess, D. J. (2005). Controlled release of dexamethasone from PLGA microspheres embedded within polyacid-containing PVA hydrogels. The AAPS Journal, 7, E231–E240.10.1208/aapsj070122
   Google Scholar
• Gooch, N., Molokhia, S. A., Condie, R., Burr, R. M., Archer, B., Ambati, B. K., & Wirostko, B. (2012). Ocular drug delivery for glaucoma management. Pharmaceutics, 4, 197–211.10.3390/pharmaceutics4010197
   Google Scholar
• Green, E., Wilkins, M., Bunce, C., & Wormald, R. (2014). 5-Fluorouracil for glaucoma surgery. The Cochrane Database of Systematic Reviews,(2), 1–62. doi:10.1002/14651858.CD001132.pub2
   Google Scholar
• Hoare, T. R., & Kohane, D. S. (2008). Hydrogels in drug delivery: Progress and challenges. Polymer, 49, 1993–2007.10.1016/j.polymer.2008.01.027
   Google Scholar
• Hou, Q., Chau, D. Y., Pratoomsoot, C., Tighe, P. J., Dua, H. S., Shakesheff, K. M., & Rose, F. R. (2008). In situ gelling hydrogels incorporating microparticles as drug delivery carriers for regenerative medicine. Journal of Pharmaceutical Sciences, 97, 3972–3980.10.1002/jps.21310
   Google Scholar
• How, A., Chua, J. L. L., Charlton, A., Su, R., Lim, M., Kumar, R. S., … Wong, T. T. (2010). Combined treatment with bevacizumab and 5-fluorouracil attenuates the postoperative scarring response after experimental glaucoma filtration surgery. Investigative Ophthalmology & Visual Science, 51, 928–932.
   Google Scholar
• Howard, D., Buttery, L. D., Shakesheff, K. M., & Roberts, S. J. (2008). Tissue engineering: Strategies, stem cells and scaffolds. Journal of Anatomy, 213, 66–72.10.1111/joa.2008.213.issue-1
   Google Scholar
• Huhtala, A. R. S., Rönkkö, S., Teräsvirta, M., Puustjärvi, T., Sihvola, R., Vehanen, K., … Uusitalo, H. (2009). The effects of 5-fluorouracil on ocular tissues in vitro and in vivo after controlled release from a multifunctional implant. Investigative Opthalmology & Visual Science, 50, 2216–2223.10.1167/iovs.08-3016
   Google Scholar
• Jacob, J. T., LaCour, O. J., & Burgoyne, C. F. (2001). Slow release of the antimetabolite 5-fluorouracil (5-FU) from modified Baerveldt glaucoma drains to prolong drain function. Biomaterials, 22, 3329–3335.10.1016/S0142-9612(01)00170-3
   Google Scholar
• Jin, Y. J., Ubonvan, T., & Kim, D. D. (2010). Hyaluronic acid in drug delivery systems. Journal of Pharmaceutical Investigation, 40, 33–43.10.4333/KPS.2010.40.S.033
   Google Scholar
• Joung, Y. K., Choi, J. H., Park, K. M., & Park, K. D. (2007). PLGA microparticle-embedded thermosensitive hydrogels for sustained release of hydrophobic drugs. Biomedical Materials, 2, 269–273.10.1088/1748-6041/2/4/010
   Google Scholar
• Ju, R., Wen, Y., Gou, R., Wang, Y., & Xu, Q. (2014). The experimental therapy on brain ischemia by improvement of local angiogenesis with tissue engineering in the mouse. Cell Transplantation, 23, S83–S95.10.3727/096368914X684998
   Google Scholar
• Kimura, H., & Ogura, Y. (2001). Biodegradable polymers for ocular drug delivery. Ophthalmologica, 215, 143–155.10.1159/000050849
   Google Scholar
• Kingman, S. (2004). Glaucoma is second leading cause of blindness globally. Bulletin of the World Health Organization, 82, 887–888.
   Google Scholar
• Kogan, G., Soltes, L., Stern, R., & Gemeiner, P. (2007). Hyaluronic acid: A natural biopolymer with a broad range of biomedical and industrial applications. Biotechnology Letters, 29, 17–25.
   Google Scholar
• Kondo, M., & Aroie, M. (1989). Iontophoresis of 5-fluorourocil into the conjunctiva ond sclero. Investigative Ophthalmology & Visual Science, 30, 583–585.
   Google Scholar
• Kozobolis, V., Konstantinidis, A., & Labiris, G. (2013). Combined cataract-glaucoma surgery. In: S. Rumelt (Ed.) Glaucoma–basic and clinical aspects.(pp. 473–510). Israel: InTech.
   Google Scholar
• Lagarce, F., Faisant, N., Desfontis, J. C., Marescaux, L., Gautier, F., Richard, j., … Benoit, J. P. (2005). Baclofen-loaded microspheres in gel suspensions for intrathecal drug delivery: In vitro and in vivo evaluation. European Journal of Pharmaceutics and Biopharmaceutics, 61, 171–180.10.1016/j.ejpb.2005.04.004
   Google Scholar
• Lee, D. A., Hersh, P., Kersten, D., & Melamed, S. (1987). Complications of subconjunctival 5-fluorouracil following glaucoma filtering surgery. Ophthalmic Surgery, 18, 187–190.
   Google Scholar
• Lin, Y., Sun, J., Jiang, G., Zan, J., & Ding, F. (2007). In vitro evaluation of lysozyme-loaded microspheres in methylcellulose hydrogel. Chinese Journal of Chemical Engineering, 15, 566–572.10.1016/S1004-9541(07)60125-6
   Google Scholar
• Longley, D. B., Harkin, D. P., & Johnston, P. G. (2003). 5-Fluorouracil: Mechanisms of action and clinical strategies. Nature Reviews Cancer, 3, 330–338.10.1038/nrc1074
   Google Scholar
• Lu, D. W., Chang, C. J., Chiang, C. H., Yeh, M. K., & Chou, P. I. (2000). Wound modulation after trabeculectomy by different formulations of antimetabolites in rabbits. Journal of Ocular Pharmacology and Therapeutics, 16, 529–538.10.1089/jop.2000.16.529
   Google Scholar
• Mahoney, B. P., Raghunand, N., Baggett, B., & Gillies, R. J. (2003). Tumor acidity, ion trapping and chemotherapeutics I. Acid pH affects the distribution of chemotherapeutic agents in vitro. Biochemical Pharmacology, 66, 1207–1218.10.1016/S0006-2952(03)00467-2
   Google Scholar
• Makadia, H. K., & Siegel, S. J. (2011). Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier. Polymers, 3, 1377–1397.10.3390/polym3031377
   Google Scholar
• Mead, A. L., Wong, T. T. L., Cordeiro, M. F., Anderson, I. K., & Khaw, P. T. (2003). Evaluation of anti-TGF-2 antibody as a new postoperative anti-scarring agent in glaucoma surgery. Investigative Ophthalmology & Visual Science, 44, 3394–3401.
   Google Scholar
• Moritera, T., Ogura, Y., Honda, Y., Wada, R., Hyon, S. H., & Ikada, Y. (1991). Microspheres of biodegradable polymers as a drug-delivery system in the vitreous. Investigative Ophthalmology & Visual Science, 32, 1785–1790.
   Google Scholar
• Mufamadi, M. S., Pillay, V., Choonara, Y. E., Du Toit, L. C., Modi, G., Naidoo, D., & Ndesendo, V. M. (2011). A review on composite liposomal technologies for specialized drug delivery. Journal of Drug Delivery, 2011, 1–19.10.1155/2011/939851
   Google Scholar
• Mundargi, R. C., Babu, V. R., Rangaswamy, V., Patel, P., & Aminabhavi, T. M. (2008). Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives. Journal of Controlled Release, 125, 193–209.10.1016/j.jconrel.2007.09.013
   Google Scholar
• Naguib, Y. W., Kumar, A., & Cui, Z. (2014). The effect of microneedles on the skin permeability and antitumor activity of topical 5-fluorouracil. Acta Pharmaceutica Sinica B, 4, 94–99.10.1016/j.apsb.2013.12.013
   Google Scholar
• Nasr, M., Ghorab, M. K., & Abdelazem, A. (2015). In vitro and in vivo evaluation of cubosomes containing 5-fluorouracil for liver targeting. Acta Pharmaceutica Sinica B, 5, 79–88.10.1016/j.apsb.2014.12.001
   Google Scholar
• Nath, S. D., Linh, N. T., Sadiasa, A., & Lee, B. T. (2014). Encapsulation of simvastatin in PLGA microspheres loaded into hydrogel loaded BCP porous spongy scaffold as a controlled drug delivery system for bone tissue regeneration. Journal of Biomaterials Applications, 28, 1151–1163.10.1177/0885328213499272
   Google Scholar
• Nettles, D. L., Vail, T. P., Morgan, M. T., Grinstaff, M. W., & Setton, L. A. (2004). Photocrosslinkable hyaluronan as a scaffold for articular cartilage repair. Annals of Biomedical Engineering, 32, 391–397.10.1023/B:ABME.0000017552.65260.94
   Google Scholar
• Patterson, J., Stayton, P. S., & Li, X. (2009). In situ characterization of the degradation of PLGA microspheres in hyaluronic acid hydrogels by optical coherence tomography. IEEE Transactions on Medical Imaging, 28, 74–81.10.1109/TMI.2008.927356
   Google Scholar
• Perucho-Martínez, S., Gutiérrez-Díaz, E., Montero-Rodríguez, M., Mencía-Gutiérrez, E., & Lago-Llinás, M. D. (2006). Needle revision of late failing filtering blebs after glaucoma surgery. Archives of the Spanish Society of Ophthalmology, 81, 517–522.
   Google Scholar
• Peyman, G. A., Conway, M., Khoobehi, B., & Soike, K. (1992). Clearance of microsphere-entrapped 5-fluorouracil and cytosine arabinoside from the vitreous of primates. International Ophthalmology, 16, 109–113.10.1007/BF00918942
   Google Scholar
• Quigley, H. A. (2011). Glaucoma. The Lancet, 377, 1367–1377.10.1016/S0140-6736(10)61423-7
   Google Scholar
• Quigley, H. A., & Borman, A. T. (2006). The number of people with glaucoma worldwide in 2010 and 2020. British Journal of Ophthalmology, 90, 262–267.10.1136/bjo.2005.081224
   Google Scholar
• Ranganath, S. H., Kee, I., Krantz, W. B., Chow, P. K., & Wang, C. H. (2009). Hydrogel matrix entrapping PLGA-paclitaxel microspheres: Drug delivery with near zero-order release and implantability advantages for malignant brain tumour chemotherapy. Pharmaceutical Research, 26, 2101–2114.10.1007/s11095-009-9922-2
   Google Scholar
• Rocíoh, V. (2011). Microparticles as drug delivery systems for the back of the eye. In B. E. H. F. Kompellau (Ed.), Drug product development for the back of the eye (pp. 231–259). New York, NY: American Association of Pharmaceutical Scientists.
   Google Scholar
• Samadi, N., Abbadessa, A., Di Stefano, A., van Nostrum, C. F., Vermonden, T., Rahimian, S., … Hennink, W. E. (2013). The effect of lauryl capping group on protein release and degradation of poly(D,L-lactic-co-glycolic acid) particles. Journal of Controlled Release, 172, 436–443.10.1016/j.jconrel.2013.05.034
   Google Scholar
• Shelke, N. B., Kadam, R., Tyagi, P., Rao, V. R., & Kompella, U. B. (2011). Intravitreal poly(L-lactide) microparticles sustain retinal and choroidal delivery of TG-0054, a hydrophilic drug intended for neovascular diseases. Drug Delivery and Translational Research, 1, 76–90.10.1007/s13346-010-0009-8
   Google Scholar
• Siegelr, A., & Rathbonem, J. (2012). Overview of controlled release mechanisms. In J. Siepmann, A. Siegelr, & J. Rathbonem (Eds.), Fundamentals and applications of controlled release drug delivery, advances in delivery science and technology. (pp. 19–43). New York, NY: Springer.
   Google Scholar
• Smeds, K. A., Pfister-Serres, A., Miki, D., Dastgheib, K., Inoue, M., Hatchell, D. L., & Grinstaff, M. W. (2000). Photocrosslinkable polysaccharides for in situ hydrogel formation. Journal of Biomedical Materials Research, 54, 115–121.
   Google Scholar
• Tous, E., Weber, H. M., Lee, M. H., Koomalsingh, K. J., Shuto, T., Kondo, N., … Burdick, J. A. (2012). Tunable hydrogel-microsphere composites that modulate local inflammation and collagen bulking. Acta Biomaterialia, 8, 3218–3227.10.1016/j.actbio.2012.05.027
   Google Scholar
• Wang, G., Tucker, I. G., Roberts, M. S., & Hirst, L. W. (1996). In vitro and in vivo evaluation in rabbits of a controlled release 5-fluorouracil subconjunctival implant based on poly(D,L-lactide-co-glycolide). Pharmaceutical Research, 13, 1059–1064.10.1023/A:1016062825360
   Google Scholar
• Wang, Y., Wei, Y. T., Zu, Z. H., Ju, R. K., Guo, M. Y., Wang, X. M., … Cui, F. Z. (2011). Combination of hyaluronic acid hydrogel scaffold and PLGA microspheres for supporting survival of neural stem cells. Pharmaceutical Research, 28, 1406–1414.10.1007/s11095-011-0452-3
   Google Scholar
• Widjaja, L. K., Bora, M., Chan, P. N., Lipik, V., Wong, T. T., & Venkatraman, S. S. (2014). Hyaluronic acid-based nanocomposite hydrogels for ocular drug delivery applications. Journal of Biomedical Materials Research Part A, 102, 3056–3065.10.1002/jbm.a.v102.9
   Google Scholar
• Wormald, R., Wilkins, M., & Bunce, C. (2001). Post-operative 5-fluorouracil for glaucoma surgery. The Cochrane Database of Systematic Reviews,(3), 1–33. doi:10.1002/14651858.CD001132.pub2
   Google Scholar
• Yeh, M. K., Tung, S. M., Lu, D. W., Chen, J. L., & Chiang, C. H. (2001). Formulation factors for preparing ocular biodegradable delivery system of 5-fuorouracil microparticles. Journal of Microencapsulation, 18, 507–519.
   Google Scholar
• You, H., Lee, E. U., Kim, Y. K., Kim, B. C., Park, J. Y., Lim, H. C., … Choi, S. H. (2014). Biocompatibility and resorption pattern of newly developed hyaluronic acid hydrogel reinforced three-layer poly (lactide-co-glycolide) membrane: Histologic observation in rabbit calvarial defect model. Biomaterials Research, 18, 12–18.10.1186/2055-7124-18-12
   Google Scholar
• Zhao, J., Guo, B., & Ma, P. X. (2014). Injectable alginate microsphere/PLGA–PEG–PLGA composite hydrogels for sustained drug release. RSC Advances, 4, 17736–17742.10.1039/c4ra00788c
   Google Scholar
• Zimmer, A., & Kreuter, J. (1995). Microspheres and nanoparticles used in ocular delivery systems. Advanced Drug Delivery Reviews, 16, 61–73.10.1016/0169-409X(95)00017-2
   Google Scholar