1,047
Views
10
CrossRef citations to date
0
Altmetric
Research Paper

Prostaglandin transporter in the rat brain: its localization and induction by lipopolysaccharide

, , , , &
Pages 425-434 | Received 07 Mar 2015, Accepted 10 Jun 2015, Published online: 13 Oct 2015

References

  • Coceani F, Lees J, Bishai I. Further evidence implicating prostaglandin E2 in the genesis of pyrogen fever. Am J Physiol 1988; 254:R463-R9; PMID:3279826
  • Furuyashiki T, Narumiya S. Stress responses: the contribution of prostaglandin E(2) and its receptors. Nat Rev Endocrinol 2011; 7:163-75; PMID:21116297; http://dx.doi.org/10.1038/nrendo.2010.194
  • Ivanov AI, Romanovsky AA. Prostaglandin E2 as a mediator of fever: synthesis and catabolism. Front Biosc 2004; 9:1977-93; PMID:14977603; http://dx.doi.org/10.2741/1383
  • Milton AS. Prostaglandins in fever and the mode of action of antipyretic drugs. In: Milton AS, ed. Pyretics and antipyretics. Berlin: Springer-Verlag, 1982:259-67
  • Saper CB, Romanovsky AA, Scammell TE. Neural circuitry engaged by prostaglandins during the sickness syndrome. Nat Neurosci 2012; 5:1088-95; PMID:22837039; http://dx.doi.org/10.1038/nn.3159
  • Stitt JT. Prostaglandin E as the neural mediator of the febrile response. Yale J Biol Med 1986; 59:137-49; PMID:3739372
  • Dinarello CA. Cytokines as endogenous pyrogen. J Infect Dis 1999; 179 suppl 2:S294-304; PMID:10081499; http://dx.doi.org/10.1086/513856
  • Matsumura K, Cao C, Ozaki M, Morii H, Nakadate K, Watanabe Y. Brain endothelial cells express cyclooxygenase-2 during lipopolysaccharide-induced fever: light and electron microscopic immunocytochemical studies. J Neurosci 1998; 18:6279-89; PMID:9698320
  • Ek M, Engblom D, Saha S, Blomqvist A, Jakobsson PJ, Ericsson-Dahlstrand A. Inflammatory response: pathway across the blood-brain barrier. Nature 2001; 410:430-1; PMID:11260702; http://dx.doi.org/10.1038/35068632
  • Inoue W, Matsumura K, Yamagata K, Takemiya T, Shiraki T, Kobayashi S. Brain-specific endothelial induction of prostaglandin E(2) synthesis enzymes and its temporal relation to fever. Neurosci Res 2002; 44:51-61; PMID:12204293; http://dx.doi.org/10.1016/S0168-0102(02)00083-4
  • Matsumura K, Yamagata K, Takemiya T, Kobayashi S. COX-2 and mPGES in brain endothelial cells: potential targets of anti-inflammatory drugs. Curr Med Chem-Anti-Inflammatory Anti-Allergy Agents 2002; 1:161-6; PMID:NOT_FOUND; http://dx.doi.org/10.2174/1568014023355890
  • Yamagata K, Matsumura K, Inoue W, Shiraki T, Suzuki K, Yasuda S, Sugiura H, Cao C, Watanabe Y, Kobayashi S. Coexpression of microsomal-type prostaglandin E synthase with cyclooxygenase-2 in brain endothelial cells of rats during endotoxin-induced fever. J Neurosci 2001; 21:2669-77; PMID:11306620
  • Ushikubi F, Segi E, Sugimoto Y, Murata T, Matsuoka T, Kobayashi T, Hizaki H, Tuboi K, Katsuyama M, Ichikawa A, et al. Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature 1998; 395:281-4; PMID:9751056; http://dx.doi.org/10.1038/26233
  • Nakamura K, Matsumura K, Kaneko T, Kobayashi S, Katoh H, Negishi M. The rostral raphe pallidus nucleus mediates pyrogenic transmission from the preoptic area. J Neurosci 2002; 22:4600-10; PMID:12040067
  • Bito LZ, Davson H, Hollingsworth JR. Facilitated transport of prostaglandins across the blood-cerebrospinal fluid and blood-brain barriers. J Physiol 1976; 256:273-85; PMID:16992503; http://dx.doi.org/10.1113/jphysiol.1976.sp011325
  • Bito LZ, Baroody RA. Impermeability of rabbit erythrocytes to prostaglandins. Am J Physiol 1975; 229:1580-4; PMID:1211490
  • Schuster VL. Prostaglandin transport. Prostaglandins Other Lipid Mediat 2002; 68–69:633-47; PMID:12432949
  • Wallenstein MC, Bito LZ. Hyperthermic effects of supracortically applied prostaglandins after systemic pretreatment with inhibitors of prostaglandin transport and synthesis. J Pharmacol Exp Ther 1978; 204:454-60; PMID:621674
  • Sirko S, Bishai I, Coceani F. Prostaglandin formation in the hypothalamus in vivo: effect of pyrogens. Am J Physiol 1989; 256:R616-24; PMID:2784289
  • Kanai N, Lu R, Satriano JA, Bao Y, Wolkoff AW, Schuster VL. Identification and characterization of a prostaglandin transporter. Science 1995; 268:866-9; PMID:7754369; http://dx.doi.org/10.1126/science.7754369
  • Lu R, Kanai N, Bao Y, Schuster VL. Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT). J Clin Invest 1996; 98:1142-9; PMID:8787677; http://dx.doi.org/10.1172/JCI118897
  • Pucci ML, Bao Y, Chan B, Itoh S, Lu R, Copeland NG, Gilbert DJ, Jenkins NA, Schuster VL. Cloning of mouse prostaglandin transporter PGT cDNA: species-specific substrate affinities. Am J Physiol 1999; 277:R734-41; PMID:10484490
  • Chan BS, Satriano JA, Pucci M, Schuster VL. Mechanism of prostaglandin E2 transport across the plasma membrane of HeLa cells and Xenopus oocytes expressing the prostaglandin transporter “PGT.” J Biol Chem 1998; 273:6689-97; PMID:9506966; http://dx.doi.org/10.1074/jbc.273.12.6689
  • Chi Y, Schuster VL. The prostaglandin transporter PGT transports PGH(2). Biochemical and biophysical research communications 2010; 395:168-72; PMID:20346915; http://dx.doi.org/10.1016/j.bbrc.2010.03.108
  • Nomura T, Lu R, Pucci ML, Schuster VL. The two-step model of prostaglandin signal termination: in vitro reconstitution with the prostaglandin transporter and prostaglandin 15 dehydrogenase. Mol Pharmacol 2004; 65:973-8; PMID:15044627; http://dx.doi.org/10.1124/mol.65.4.973
  • Schuster VL. Molecular mechanisms of prostaglandin transport. Annu Rev Physiol 1998; 60:221-42; PMID:9558462; http://dx.doi.org/10.1146/annurev.physiol.60.1.221
  • Ivanov AI, Scheck AC, Romanovsky AA. Expression of genes controlling transport and catabolism of prostaglandin E2 in lipopolysaccharide fever. Am J Physiol Regul Integr Comp Physiol 2003; 284:R698-706; PMID:12399253; http://dx.doi.org/10.1152/ajpregu.00570.2002
  • Endo S, Nomura T, Chan BS, Lu R, Pucci ML, Bao Y, Schuster VL. Expression of PGT in MDCK cell monolayers: polarized apical localization and induction of active PG transport. Am J Physiol Renal Physiol 2002; 282:F618-22; PMID:11880322; http://dx.doi.org/10.1152/ajprenal.00150.2001
  • Kochel TJ, Fulton AM. Multiple drug resistance-associated protein 4 (MRP4), prostaglandin transporter (PGT), and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as determinants of PGE levels in cancer. Prostaglandins Other Lipid Mediat 2014; PMID:25433169
  • Lacroix-Pepin N, Danyod G, Krishnaswamy N, Mondal S, Rong PM, Chapdelaine P, Fortier MA. The multidrug resistance-associated protein 4 (MRP4) appears as a functional carrier of prostaglandins regulated by oxytocin in the bovine endometrium. Endocrinology 2011; 152:4993-5004; PMID:21990316; http://dx.doi.org/10.1210/en.2011-1406
  • Ohkura N, Shigetani Y, Yoshiba N, Yoshiba K, Okiji T. Prostaglandin transporting protein-mediated prostaglandin E2 transport in lipopolysaccharide-inflamed rat dental pulp. Journal of endodontics 2014; 40:1112-7; PMID:25069917; http://dx.doi.org/10.1016/j.joen.2013.12.024
  • Reid G, Wielinga P, Zelcer N, van der Heijden I, Kuil A, de Haas M, Wijnholds J, Borst P. The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A 2003; 100:9244-9; PMID:12835412; http://dx.doi.org/10.1073/pnas.1033060100
  • Romanovsky AA, Ivanov AI, Karman EK. Blood-borne, albumin-bound prostaglandin E2 may be involved in fever. Am J Physiol 1999; 276:R1840-4; PMID:10362768
  • Steiner AA, Ivanov AI, Serrats J, Hosokawa H, Phayre AN, Robbins JR, Roberts JL, Kobayashi S, Matsumura K, Sawchenko PE, et al. Cellular and molecular bases of the initiation of fever. PLoS Biol 2006; 4:e284; PMID:16933973; http://dx.doi.org/10.1371/journal.pbio.0040284
  • Chan BS, Endo S, Kanai N, Schuster VL. Identification of lactate as a driving force for prostanoid transport by prostaglandin transporter PGT. Am J Physiol Renal Physiol 2002; 282:F1097-102; PMID:11997326; http://dx.doi.org/10.1152/ajprenal.00151.2001
  • Bao Y, Pucci ML, Chan BS, Lu R, Ito S, Schuster VL. Prostaglandin transporter PGT is expressed in cell types that synthesize and release prostanoids. Am J Physiol Renal Physiol 2002; 282:F1103-10; PMID:11997327; http://dx.doi.org/10.1152/ajprenal.00152.2001
  • Ghersi-Egea JF, Leininger-Muller B, Cecchelli R, Fenstermacher JD. Blood-brain interfaces: relevance to cerebral drug metabolism. Toxicol Lett 1995; 82-83:645-53; PMID:8597122
  • Topper JN, Cai J, Stavrakis G, Anderson KR, Woolf EA, Sampson BA, Schoen FJ, Falb D, Gimbrone MA, Jr. Human prostaglandin transporter gene (hPGT) is regulated by fluid mechanical stimuli in cultured endothelial cells and expressed in vascular endothelium in vivo. Circulation 1998; 98:2396-403; PMID:9832484; http://dx.doi.org/10.1161/01.CIR.98.22.2396
  • Nishio T, Adachi H, Nakagomi R, Tokui T, Sato E, Tanemoto M, Fujiwara K, Okabe M, Onogawa T, Suzuki T, et al. Molecular identification of a rat novel organic anion transporter moat1, which transports prostaglandin D(2), leukotriene C(4), and taurocholate. Biochem Biophys Res Commun 2000; 275:831-8; PMID:10973807; http://dx.doi.org/10.1006/bbrc.2000.3377
  • Tachikawa M, Ozeki G, Higuchi T, Akanuma S, Tsuji K, Hosoya K. Role of the blood-cerebrospinal fluid barrier transporter as a cerebral clearance system for prostaglandin E(2) produced in the brain. J Neurochem 2012; 123:750-60; PMID:22978524; http://dx.doi.org/10.1111/jnc.12018
  • Chi Y, Min J, Jasmin JF, Lisanti MP, Chang YT, Schuster VL. Development of a high-affinity inhibitor of the prostaglandin transporter. J Pharmacol Exp Ther 2011; 339:633-41; PMID:21849625; http://dx.doi.org/10.1124/jpet.111.181354