Neural circuit for psychological stress-induced hyperthermia

References

• Bishop D. Warm up I: potential mechanisms and the effects of passive warm up on exercise performance. Sports Med 2003; 33:439-54; PMID:12744717; http://dx.doi.org/10.2165/00007256-200333060-00005
   PubMed Web of Science ®Google Scholar
• Timmerman RJ, Thompson J, Noordzij HM, van der Meer JW. Psychogenic periodic fever. Neth J Med 1992; 41:158-60; PMID:1470287
   PubMed Web of Science ®Google Scholar
• Oka T, Oka K. Mechanisms of psychogenic fever. Adv Neuroimmune Biol 2012; 3:3-17; http://dx.doi.org/10.3233/NIB-2012-011030
   Google Scholar
• Nozu T, Uehara A. The diagnoses and outcomes of patients complaining of fever without any abnormal findings on diagnostic tests. Intern Med 2005; 44:901-2; PMID:16157998; http://doi.org/10.2169/internalmedicine.44.901
   PubMed Web of Science ®Google Scholar
• Nakamura K. Central circuitries for body temperature regulation and fever. Am J Physiol Regul Integr Comp Physiol 2011; 301, R1207-28; PMID:21900642; http://dx.doi.org/10.1152/ajpregu.00109.2011
   PubMed Web of Science ®Google Scholar
• Nicholls DG, Locke RM. Thermogenic mechanisms in brown fat. Physiol Rev. 1984; 64:1-64; PMID:6320232
   PubMed Web of Science ®Google Scholar
• Rothwell NJ. Eicosanoids, thermogenesis and thermoregulation. Prostaglandins Leukot Essent Fatty Acids 1992; 46:1-7; PMID:1321446; http://dx.doi.org/10.1016/0952-3278(92)90051-J
   PubMed Web of Science ®Google Scholar
• van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, Drossaerts JMAFL, Kemerink GJ, Bouvy ND, Schrauwen P, Teule GJJ. Cold-activated brown adipose tissue in healthy men. N Engl J Med 2009; 360:1500-8; PMID:19357405; http://dx.doi.org/10.1056/NEJMoa0808718
   PubMed Web of Science ®Google Scholar
• Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009; 360:1509-17; PMID:19357406; http://dx.doi.org/10.1056/NEJMoa0810780
   PubMed Web of Science ®Google Scholar
• Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, Taittonen M, Laine J, Savisto NJ, Enerbäck S, et al. Functional brown adipose tissue in healthy adults. N Engl J Med 2009; 360:1518-25; PMID:19357407; http://dx.doi.org/10.1056/NEJMoa0808949
   PubMed Web of Science ®Google Scholar
• Saito M, Okamatsu-Ogura Y, Matsushita M, Watanabe K, Yoneshiro T, Nio-Kobayashi J, Iwanaga T, Miyagawa M, Kameya T, Nakada K, et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 2009; 58:1526-231; PMID:19401428; http://dx.doi.org/10.2337/db09-0530
   PubMed Web of Science ®Google Scholar
• Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev 2004; 84:277-359; PMID:14715917; http://dx.doi.org/10.1152/physrev.00015.2003
   PubMed Web of Science ®Google Scholar
• Lkhagvasuren B, Nakamura Y, Oka T, Sudo N, Nakamura K. Social defeat stress induces hyperthermia through activation of thermoregulatory sympathetic premotor neurons in the medullary raphe region. Eur J Neurosci 2011; 34:1442-52; PMID:21978215; http://dx.doi.org/10.1111/j.1460-9568.2011.07863.x
   PubMed Web of Science ®Google Scholar
• Kataoka N, Hioki H, Kaneko T, Nakamura K. Psychological stress activates a dorsomedial hypothalamus-medullary raphe circuit driving brown adipose tissue thermogenesis and hyperthermia. Cell Metab 2014; 20:346-58; PMID:24981837; http://dx.doi.org/10.1016/j.cmet.2014.05.018
   PubMed Web of Science ®Google Scholar
• Ootsuka Y, Blessing WW, Nalivaiko E. Selective blockade of 5-HT2A receptors attenuates the increased temperature response in brown adipose tissue to restraint stress in rats. Stress 2008; 11:125-33; PMID:18311601; http://dx.doi.org/10.1080/10253890701638303
   PubMed Web of Science ®Google Scholar
• Yu YH, Blessing WW. Cutaneous vasoconstriction in conscious rabbits during alerting responses detected by hippocampal theta-rhythm. Am J Physiol 1997; 272:R208-16: PMID:9039011
   PubMed Web of Science ®Google Scholar
• Vianna DM, Carrive P. Changes in cutaneous and body temperature during and after conditioned fear to context in the rat. Eur J Neurosci 2005; 21:2505-12; PMID:15932607; http://dx.doi.org/10.1111/j.1460-9568.2005.04073.x
   PubMed Web of Science ®Google Scholar
• Zethof TJJ, Van der Heyden JAM, Tolboom JTBM, Olivier B. Stress-induced hyperthermia as a putative anxiety model. Eur J Pharmacol 1995; 294:125-35; PMID:8788424; http://dx.doi.org/10.1016/0014-2999(95)00520-X
   PubMed Web of Science ®Google Scholar
• Morrison SF, Nakamura K. Central neural pathways for thermoregulation. Front Biosci (Landmark Ed) 2011; 16:74-104; PMID:21196160; http://dx.doi.org/10.2741/3677
   PubMed Web of Science ®Google Scholar
• Charmandari E, Tsigos C, Chrousos G. Endocrinology of the stress response. Annu Rev Physiol 2005; 67:259-84; PMID:15709959; http://dx.doi.org/10.1146/annurev.physiol.67.040403.120816
   PubMed Web of Science ®Google Scholar
• Silva JE. Thermogenic mechanisms and their hormonal regulation. Physiol Rev 2006; 86:435-64; PMID:16601266; http://dx.doi.org/10.1152/physrev.00009.2005
   PubMed Web of Science ®Google Scholar
• Nakamura K, Matsumura K, Hübschle T, Nakamura Y, Hioki H, Fujiyama F, Boldogköi Z, König M, Thiel H-J, Gerstberger R, et al. Identification of sympathetic premotor neurons in medullary raphe regions mediating fever and other thermoregulatory functions. J Neurosci 2004; 24:5370-80; PMID:15190110; http://dx.doi.org/10.1523/JNEUROSCI.1219-04.2004
   PubMed Web of Science ®Google Scholar
• Nakamura K, Matsumura K, Kobayashi S, Kaneko T. Sympathetic premotor neurons mediating thermoregulatory functions. Neurosci Res 2005; 51:1-8; PMID:15596234; http://dx.doi.org/10.1016/j.neures.2004.09.007
   PubMed Web of Science ®Google Scholar
• Stornetta RL, Rosin DL, Simmons JR, McQuiston TJ, Vujovic N, Weston MC, Guyenet PG. Coexpression of vesicular glutamate transporter-3 and gamma-aminobutyric acidergic markers in rat rostral medullary raphe and intermediolateral cell column. J Comp Neurol 2005; 492:477-94; PMID:16228993; http://dx.doi.org/10.1002/cne.20742
   PubMed Web of Science ®Google Scholar
• Björkqvist K. Social defeat as a stressor in humans. Physiol Behav 2001; 73:435-42; PMID:11438372; http://dx.doi.org/10.1016/S0031-9384(01)00490-5
   PubMed Web of Science ®Google Scholar
• Morrison SF. RVLM and raphe differentially regulate sympathetic outflows to splanchnic and brown adipose tissue. Am J Physiol Regul Integr Comp Physiol 1999; 276:R962-73; PMID:10198373
   PubMed Web of Science ®Google Scholar
• Blessing WW, Nalivaiko E. Raphe magnus/pallidus neurons regulate tail but not mesenteric arterial blood flow in rats. Neuroscience 2001; 105:923-9; PMID:11530230; http://dx.doi.org/10.1016/S0306-4522(01)00251-2
   PubMed Web of Science ®Google Scholar
• Zaretsky DV, Zaretskaia MV, Samuels BC, Cluxton LK, DiMicco JA. Microinjection of muscimol into raphe pallidus suppresses tachycardia associated with air stress in conscious rats. J Physiol 2003; 546, 243-50; PMID:12509492; http://dx.doi.org/10.1113/jphysiol.2002.032201
   PubMed Web of Science ®Google Scholar
• Pham-Le NM, Cockburn C, Nowell K, Brown J. Activation of GABAA or 5HT1A receptors in the raphé pallidus abolish the cardiovascular responses to exogenous stress in conscious rats. Brain Res Bull 2011; 86, 360-6; PMID:21982918; http://dx.doi.org/10.1016/j.brainresbull.2011.09.018
   PubMed Web of Science ®Google Scholar
• Lkhagvasuren B, Oka T, Nakamura Y, Hayashi H, Sudo N, Nakamura K. Distribution of Fos-immunoreactive cells in rat forebrain and midbrain following social defeat stress and diazepam treatment. Neuroscience 2014; 272:34-57; PMID:24797330; http://dx.doi.org/10.1016/j.neuroscience.2014.04.047
   PubMed Web of Science ®Google Scholar
• Sarkar S, Zaretskaia MV, Zaretsky DV, Moreno M, DiMicco JA. Stress- and lipopolysaccharide-induced c-fos expression and nNOS in hypothalamic neurons projecting to medullary raphe in rats: a triple immunofluorescent labeling study. Eur J Neurosci 2007; 26:2228-38; PMID:17927775; http://dx.doi.org/10.1111/j.1460-9568.2007.05843.x
   PubMed Web of Science ®Google Scholar
• Stotz-Potter EH, Willis LR, DiMicco JA. Muscimol acts in dorsomedial but not paraventricular hypothalamic nucleus to suppress cardiovascular effects of stress. J Neurosci 1996; 16:1173-9; PMID:8558246
   PubMed Web of Science ®Google Scholar
• Stotz-Potter EH, Morin SM, DiMicco JA. Effect of microinjection of muscimol into the dorsomedial or paraventricular hypothalamic nucleus on air stress-induced neuroendocrine and cardiovascular changes in rats. Brain Res 1996; 742:219-24; PMID:9117398; http://dx.doi.org/10.1016/S0006-8993(96)01011-6
   PubMed Web of Science ®Google Scholar
• McDougall SJ, Widdop RE, Lawrence AJ. Medial prefrontal cortical integration of psychological stress in rats. Eur J Neurosci 2004; 20:2430-40; PMID:15525283; http://dx.doi.org/10.1111/j.1460-9568.2004.03707.x
   PubMed Web of Science ®Google Scholar
• Lin JY, Lin MZ, Steinbach P, Tsien RY. (2009). Characterization of engineered channelrhodopsin variants with improved propertiesand kinetics. Biophys J 2009; 96:1803-14; PMID:19254539; http://dx.doi.org/10.1016/j.bpj.2008.11.034
   PubMed Web of Science ®Google Scholar
• Horiuchi J, McAllen RM, Allen AM, Killinger S, Fontes MAP, Dampney RAL. Descending vasomotor pathways from the dorsomedial hypothalamic nucleus: role of medullary raphe and RVLM. Am J Physiol Regul Integr Comp Physiol 2004; 287, R824-32; PMID:15205184; http://dx.doi.org/10.1152/ajpregu.00221.2004
   PubMedGoogle Scholar
• de Lecea L, Kilduff TS, Peyron C, Gao XB, Foye PE, Danielson PE, Fukuhara C, Battenberg ELF, Gautvik VT, Bartlett FS 2nd, et al. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA 1998; 95:322-7; PMID:9419374
   PubMed Web of Science ®Google Scholar
• Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 1998; 92:573-85; PMID:9491897; http://dx.doi.org/10.1016/S0092-8674(00)80949-6
   PubMed Web of Science ®Google Scholar
• Berthoud HR, Patterson LM, Sutton GM, Morrison C, Zheng H. Orexin inputs to caudal raphé neurons involved in thermal, cardiovascular, and gastrointestinal regulation. Histochem Cell Biol 2005; 123:147-56; PMID:15742197; http://dx.doi.org/10.1007/s00418-005-0761-x
   PubMed Web of Science ®Google Scholar
• Tupone D, Madden CJ, Cano G, Morrison SF. An orexinergic projection from perifornical hypothalamus to raphe pallidus increases rat brown adipose tissue thermogenesis. J Neurosci 2011; 31:15944-55; PMID:22049437; http://dx.doi.org/10.1523/JNEUROSCI.3909-11.2011
   PubMed Web of Science ®Google Scholar
• Zhang W, Sunanaga J, Takahashi Y, Mori T, Sakurai T, Kanmura Y, Kuwaki T. Orexin neurons are indispensable for stress-induced thermogenesis in mice. J Physiol 2010; 588:4117-29; PMID:20807795; http://dx.doi.org/10.1113/jphysiol.2010.195099
   PubMed Web of Science ®Google Scholar
• Mohammed M, Ootsuka Y, Yanagisawa M, Blessing W. Reduced brown adipose tissue thermogenesis during environmental interactions in transgenic rats with ataxin-3-mediated ablation of hypothalamic orexin neurons. Am J Physiol Regul Integr Comp Physiol 2014; 307:R978-89; PMID:25324552; http://dx.doi.org/10.1152/ajpregu.00260.2014
   PubMed Web of Science ®Google Scholar
• Luong LN, Carrive P. Orexin microinjection in the medullary raphe increases heart rate and arterial pressure but does not reduce tail skin blood flow in the awake rat. Neuroscience 2012; 202:209-17; PMID:22178985; http://dx.doi.org/10.1016/j.neuroscience.2011.11.073
   PubMed Web of Science ®Google Scholar
• Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, Sutcliffe JG, Kilduff TS. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 1998; 18:9996-10015; PMID:9822755
   PubMed Web of Science ®Google Scholar
• van den Pol AN. Hypothalamic hypocretin (orexin): robust innervation of the spinal cord. J Neurosci 1999; 19:3171-82; PMID:10191330
   PubMed Web of Science ®Google Scholar
• Sellayah D, Bharaj P, Sikder D. Orexin is required for brown adipose tissue development, differentiation, and function. Cell Metab 2011; 14:478-90; http://dx.doi.org/10.1016/j.cmet.2011.08.010; PMID:21982708
   PubMed Web of Science ®Google Scholar
• Nakamura K, Matsumura K, Kaneko T, Kobayashi S, Katoh H, Negishi M. The rostral raphe pallidus nucleus mediates pyrogenic transmission from the preoptic area. J Neurosci 2002; 22:4600-10; PMID:12040067
   PubMed Web of Science ®Google Scholar
• Morrison SF. Raphe pallidus neurons mediate prostaglandin E2-evoked increases in brown adipose tissue thermogenesis. Neuroscience 2003; 121:17-24; PMID:12946696; http://dx.doi.org/10.1016/S0306-4522(03)00363-4
   PubMed Web of Science ®Google Scholar
• Zaretskaia MV, Zaretsky DV, DiMicco JA. Role of the dorsomedial hypothalamus in thermogenesis and tachycardia caused by microinjection of prostaglandin E2 into the preoptic area in anesthetized rats. Neurosci Lett. 2003; 340:1-4; PMID:12648744; http://dx.doi.org/10.1016/S0304-3940(03)00047-8
   PubMed Web of Science ®Google Scholar
• Madden CJ, Morrison SF. Excitatory amino acid receptors in the dorsomedial hypothalamus mediate prostaglandin-evoked thermogenesis in brown adipose tissue. Am J Physiol Regul Integr Comp Physiol 2004; 286:R320-5; PMID:14563660; http://dx.doi.org/10.1152/ajpregu.00515.2003
   PubMed Web of Science ®Google Scholar
• Nakamura Y, Nakamura K, Matsumura K, Kobayashi S, Kaneko T, Morrison SF. Direct pyrogenic input from prostaglandin EP3 receptor-expressing preoptic neurons to the dorsomedial hypothalamus. Eur J Neurosci 2005; 22:3137-46; PMID:16367780; http://dx.doi.org/10.1111/j.1460-9568.2005.04515.x
   PubMed Web of Science ®Google Scholar
• Nakamura K, Morrison SF. Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue. Am J Physiol Regul Integr Comp Physiol 2007; 292:R127-36; PMID:16931649; http://dx.doi.org/10.1152/ajpregu.00427.2006
   PubMed Web of Science ®Google Scholar
• Rathner JA, Madden CJ, Morrison SF. Central pathway for spontaneous and prostaglandin E2-evoked cutaneous vasoconstriction. Am J Physiol Regul Integr Comp Physiol 2008; 295:R343-54; PMID:18463193; http://dx.doi.org/10.1152/ajpregu.00115.2008
   PubMed Web of Science ®Google Scholar
• Yoshida K, Li X, Cano G, Lazarus M, Saper CB. Parallel preoptic pathways for thermoregulation. J Neurosci 2009; 29:11954-64; PMID:19776281; http://dx.doi.org/10.1523/JNEUROSCI.2643-09.2009
   PubMed Web of Science ®Google Scholar
• Nakamura K, Morrison SF. Central efferent pathways for cold-defensive and febrile shivering. J Physiol 2011; 589:3641-58; PMID:21610139; http://dx.doi.org/10.1113/jphysiol.2011.210047
   PubMed Web of Science ®Google Scholar
• Nakamura K, Morrison SF. A thermosensory pathway that controls body temperature. Nat Neurosci 2008; 11 :62-71; PMID:18084288; http://dx.doi.org/10.1038/nn2027
   PubMed Web of Science ®Google Scholar
• Nakamura K, Morrison SF. A thermosensory pathway mediating heat-defense responses. Proc Natl Acad Sci U S A 2010; 107:8848-53; PMID:20421477; http://dx.doi.org/10.1073/pnas.0913358107
   PubMed Web of Science ®Google Scholar
• Herman JP, Cullinan WE. Neurocircuitry of stress: central control of the hypothalamo-pituitary-adrenocortical axis. Trends Neurosci 1997; 20:78-84; PMID:9023876; http://dx.doi.org/10.1016/S0166-2236(96)10069-2
   PubMed Web of Science ®Google Scholar
• Morin SM, Stotz-Potter EH, DiMicco JA. Injection of muscimol in dorsomedial hypothalamus and stress-induced Fos expression in paraventricular nucleus. Am J Physiol Regul Integr Comp Physiol 2001; 280:R1276-84; PMID:11294744
   PubMed Web of Science ®Google Scholar
• Elmquist JK, Ahima RS, Elias CF, Flier JS, Saper CB. Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei. Proc Natl Acad Sci USA 1998; 95:741-6; PMID:9435263
   PubMed Web of Science ®Google Scholar
• Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS. Role of leptin in the neuroendocrine response to fasting. Nature 1996; 382:250-2; PMID:8717038; http://dx.doi.org/10.1038/382250a0
   PubMed Web of Science ®Google Scholar
• Dodd GT, Worth AA, Nunn N, Korpal AK, Bechtold DA, Allison MB, Myers MG Jr, Statnick MA, Luckman SM. The thermogenic effect of leptin is dependent on a distinct population of prolactin-releasing peptide neurons in the dorsomedial hypothalamus. Cell Metab 2014; 20:639-49; PMID:25176149; http://dx.doi.org/10.1016/j.cmet.2014.07.022
   PubMed Web of Science ®Google Scholar
• Nakamura K, Kaneko T, Yamashita Y, Hasegawa H, Katoh H, Ichikawa A, Negishi M. Immunocytochemical localization of prostaglandin EP3 receptor in the rat hypothalamus. Neurosci Lett 1999; 260:117-20; PMID:10025713; http://dx.doi.org/10.1016/S0304-3940(98)00962-8
   PubMed Web of Science ®Google Scholar
• Nakamura K, Kaneko T, Yamashita Y, Hasegawa H, Katoh H, Negishi M. Immunohistochemical localization of prostaglandin EP3 receptor in the rat nervous system. J Comp Neurol 2000; 421:543-69; PMID:10842213; http://dx.doi.org/10.1002/(SICI)1096-9861(20000612)421: 4<543::AID-CNE6>3.0.CO;2-3
   PubMed Web of Science ®Google Scholar
• Lazarus M, Yoshida K, Coppari R, Bass CE, Mochizuki T, Lowell BB, Saper CB. EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses. Nat Neurosci 2007; 10:1131-1133; PMID:17676060; http://dx.doi.org/10.1038/nn1949
   PubMed Web of Science ®Google Scholar
• Matsumura K, Cao C, Ozaki M, Morii H, Nakadate K, Watanabe Y. Brain endothelial cells express cyclooxygenase-2 during lipopolysaccharide-induced fever: light and electron microscopic immunocytochemical studies. J Neurosci 1998; 18:6279-89; PMID:9698320
   PubMed Web of Science ®Google Scholar
• Yamagata K, Matsumura K, Inoue W, Shiraki T, Suzuki K, Yasuda S, Sugiura H, Cao C, Watanabe Y, Kobayashi S. Coexpression of microsomal-type prostaglandin E synthase with cyclooxygenase-2 in brain endothelial cells of rats during endotoxin-induced fever. J Neurosci 2001; 21:2669-77; PMID:11306620
   PubMed Web of Science ®Google Scholar
• Wilhelms DB, Kirilov M, Mirrasekhian E, Eskilsson A, Kugelberg UÖ, Klar C, Ridder DA, Herschman HR, Schwaninger M, Blomqvist A, et al. Deletion of prostaglandin E2 synthesizing enzymes in brain endothelial cells attenuates inflammatory fever. J Neurosci 2014; 34:11684-90; PMID:25164664; http://dx.doi.org/10.1523/JNEUROSCI.1838-14.2014
   PubMed Web of Science ®Google Scholar
• Wilkinson MF, Kasting NW. Vasopressin release within the ventral septal area of the rat brain during drug-induced antipyresis. Am J Physiol 1993; 264:R1133-8; PMID:8322966
   PubMedGoogle Scholar
• Zampronio AR, Silva CAA, Cunha FQ, Ferreira SH, Pelá IR, Souza GEP. Indomethacin blocks the febrile response induced by interleukin-8 in rabbits. Am J Physiol 1995; 269:R1469-74; PMID:8594951
   PubMedGoogle Scholar
• Steiner AA, Branco LGS. Central CO-heme oxygenase pathway raises body temperature by a prostaglandin-independent way. J Appl Physiol 2000; 88:1607-13; PMID:10797120
   PubMed Web of Science ®Google Scholar
• Vinkers CH, Groenink L, van Bogaert MJV, Westphal KGC, Kalkman CJ, van Oorschot R, Oosting RS, Olivier B, Korte SM. Stress-induced hyperthermia and infection-induced fever: two of a kind? Physiol Behav 2009; 98:37-43; PMID:19375439; http://dx.doi.org/10.1016/j.physbeh.2009.04.004
   PubMed Web of Science ®Google Scholar
• Oka T, Oka K, Kobayashi T, Sugimoto Y, Ichikawa A, Ushikubi F, Narumiya S, Saper CB. Characteristics of thermoregulatory and febrile responses in mice deficient in prostaglandin EP1 and EP3 receptors. J Physiol 2003; 551:945-54; PMID:12837930; http://dx.doi.org/10.1111/j.1469-7793.2003.00945.x
   PubMed Web of Science ®Google Scholar
• Olivier B, Zethof T, Pattij T, van Boogaert M, van Oorschot R, Leahy C, Oosting R, Bouwknecht A, Veening J, van der Gugten J, Groenink L. Stress-induced hyperthermia and anxiety: pharmacological validation. Eur J Pharmacol 2003; 463:117-32; PMID:12600705; http://dx.doi.org/10.1016/S0014-2999(03)01326-8
   PubMed Web of Science ®Google Scholar
• Hiramoto T, Oka T, Yoshihara K, Kubo C. Pyrogenic cytokines did not mediate a stress interview-induced hyperthermic response in a patient with psychogenic fever: a case report. Psychosom Med 2009; 71:932-6; PMID:19875636; http://dx.doi.org/10.1097/PSY.0b013e3181bfb02b
   PubMed Web of Science ®Google Scholar
• Thompson RH, Swanson LW. Organization of inputs to the dorsomedial nucleus of the hypothalamus: a reexamination with Fluorogold and PHAL in the rat. Brain Res Brain Res Rev 1998; 27:89-118; PMID:9622601; http://dx.doi.org/10.1016/S0165-0173(98)00010-1
   PubMed Web of Science ®Google Scholar
• Myers B, Mark Dolgas C, Kasckow J, Cullinan WE, Herman JP. Central stress-integrative circuits: forebrain glutamatergic and GABAergic projections to the dorsomedial hypothalamus, medial preoptic area, and bed nucleus of the stria terminalis. Brain Struct Funct 2014; 219:1287-303; PMID:23661182; http://dx.doi.org/10.1007/s00429-013-0566-y
   PubMed Web of Science ®Google Scholar
• Gerrits M, Westenbroek C, Fokkema DS, Jongsma ME, Den Boer JA, Ter Horst GJ. Increased stress vulnerability after a prefrontal cortex lesion in female rats. Brain Res Bull 2003; 61:627-35; PMID:14519460; http://dx.doi.org/10.1016/j.brainresbull.2003.08.004
   PubMed Web of Science ®Google Scholar
• Nakamura Y, Nakamura K, Morrison SF. Different populations of prostaglandin EP3 receptor-expressing preoptic neurons project to two fever-mediating sympathoexcitatory brain regions. Neuroscience 2009; 161:614-20; PMID:19327390; http://dx.doi.org/10.1016/j.neuroscience.2009.03.041
   PubMed Web of Science ®Google Scholar
• Anthony TE, Dee N, Bernard A, Lerchner W, Heintz N, Anderson DJ. Control of stress-induced persistent anxiety by an extra-amygdala septohypothalamic circuit. Cell 2014; 156:522-36; PMID:24485458; http://dx.doi.org/10.1016/j.cell.2013.12.040
   PubMed Web of Science ®Google Scholar
• Ootsuka Y, Mohammed M. Activation of the habenula complex evokes autonomic physiological responses similar to those associated with emotional stress. Physiol Rep 2015; 3:e12297; PMID:25677551; http://dx.doi.org/10.14814/phy2.12297
   PubMedGoogle Scholar
• Johnson PL, Shekhar A. Panic-prone state induced in rats with GABA dysfunction in the dorsomedial hypothalamus is mediated by NMDA receptors. J Neurosci 2006; 26:7093-104; PMID:16807338; http://dx.doi.org/10.1523/JNEUROSCI.0408-06.2006
   PubMed Web of Science ®Google Scholar