Vagal afferent activation decreases brown adipose tissue (BAT) sympathetic nerve activity and BAT thermogenesis

References

• Morrison SF, Madden CJ. Central nervous system regulation of brown adipose tissue. Compr Physiol 2014; 4:1677-713; PMID:25428857; http://dx.doi.org/10.1002/cphy.c140013
   PubMed Web of Science ®Google Scholar
• Nakamura, K, Morrison SF. A thermosensory pathway that controls body temperature. Nat Neurosci 2008; 11:62-71; PMID:18084288; http://dx.doi.org/10.1038/nn2027
   PubMed Web of Science ®Google Scholar
• Nakamura K, Morrison SF. A thermosensory pathway mediating heat-defense responses. Proc Natl Acad Sci U S A 2010; 107:8848-53; PMID:20421477; http://dx.doi.org/http://dx.doi.org/10.1073/pnas.0913358107
   PubMed Web of Science ®Google Scholar
• Madden CJ, Morrison SF. Hypoxic activation of arterial chemoreceptors inhibits sympathetic outflow to brown adipose tissue in rats. J Physiol 2005; 566:559-73; PMID:15878945; http://dx.doi.org/10.1113/jphysiol.2005.086322
   PubMed Web of Science ®Google Scholar
• Blatteis CM, Sehic E, Li S. Afferent pathways of pyrogen signaling. Ann N Y Acad Sci 1998; 856:95-107; PMID:9917870
   PubMed Web of Science ®Google Scholar
• Romanovsky AA, Ivanov AI, Szekely M. Neural route of pyrogen signaling to the brain. Clin Infect Dis 2000; 31:S162-7; PMID:11113019; http://dx.doi.org/10.1086/317515
   PubMed Web of Science ®Google Scholar
• Szekely M. The vagus nerve in thermoregulation and energy metabolism. Auton Neurosci 2000; 85:26-38; PMID:11189024; http://dx.doi.org/10.1016/S1566-0702(00)00217-4
   PubMed Web of Science ®Google Scholar
• Blouet C, Schwartz GJ. Duodenal lipid sensing activates vagal afferents to regulate non-shivering brown fat thermogenesis in rats. PLoS One 2012; 7:e51898; PMID:23251649; http://dx.doi.org/10.1371/journal.pone.0051898
   PubMed Web of Science ®Google Scholar
• Tsukita S, Yamada T, Uno K, Takahashi K, Kaneko K, Ishigaki Y, Imai J, Hasegawa Y, Sawada S, Ishihara H, et al. Hepatic glucokinase modulates obesity predisposition by regulating BAT thermogenesis via neural signals. Cell Metab 2012; 16:825-32; PMID:23217261; http://dx.doi.org/10.1016/j.cmet.2012.11.006
   PubMed Web of Science ®Google Scholar
• Madden CJ, Morrison SF. A high-fat diet impairs cooling-evoked brown adipose tissue activation via a vagal afferent mechanism. Am J Physiol Endocrinol Metab 2016; 311:E287-92; PMID:27354235; http://dx.doi.org/10.1152/ajpendo.00081.2016
   PubMed Web of Science ®Google Scholar
• Berthoud HR. The vagus nerve, food intake and obesity. Regul Pept 2008; 149:15-25; PMID:18482776; http://dx.doi.org/10.1016/j.regpep.2007.08.024
   PubMedGoogle Scholar
• Pardo JV, Sheikh SA, Kuskowski MA, Surerus-Johnson C, Hagen MC, Lee JT, Rittberg BR, Adson DE. Weight loss during chronic, cervical vagus nerve stimulation in depressed patients with obesity: an observation. Int J Obes (Lond) 2007; 31:1756-9; PMID:17563762; http://dx.doi.org/10.1038/sj.ijo.0803666
   PubMed Web of Science ®Google Scholar
• Li H, Zhang JB, Xu C, Tang QQ, Shen WX, Zhou JZ, Chen JD, Wang YP. Effects and mechanisms of auricular vagus nerve stimulation on high-fat-diet–induced obese rats. Nutrition 2015; 31:1416-22; PMID:26429664; http://dx.doi.org/10.1016/j.nut.2015.05.007
   PubMed Web of Science ®Google Scholar
• Koren MS, Holmes MD. Vagus nerve stimulation does not lead to significant changes in body weight in patients with epilepsy. Epilepsy Behav 2006; 8:246-9; PMID:16343997; http://dx.doi.org/10.1016/j.yebeh.2005.10.001
   PubMed Web of Science ®Google Scholar
• Vijgen GH, Bouvy ND, Leenen L, Rijkers K, Cornips E, Majoie M, Brans B, van Marken Lichtenbelt WD. Vagus nerve stimulation increases energy expenditure: relation to brown adipose tissue activity. PLoS One 2013; 8:e77221; PMID:24194874; http://dx.doi.org/10.1371/journal.pone.0077221
   PubMed Web of Science ®Google Scholar
• Madden CJ, Morrison SF. Neurons in the paraventricular nucleus of the hypothalamus inhibit sympathetic outflow to brown adipose tissue. Am J Physiol Regul Integr Comp Physiol 2009; 296:R831-43; PMID:19129373; http://dx.doi.org/10.1152/ajpregu.91007.2008
   PubMed Web of Science ®Google Scholar
• Nakamura K, Morrison SF. Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue. Am J Physiol Regul Integr Comp Physiol 2007; 292:R127-36; PMID:16931649; http://dx.doi.org/10.1152/ajpregu.00427.2006
   PubMed Web of Science ®Google Scholar
• Morrison SF, Sved AF, Passerin AM. GABA-mediated inhibition of raphe pallidus neurons regulates sympathetic outflow to brown adipose tissue. Am J Physiol 1999; 276:R290-7; PMID:9950904
   PubMed Web of Science ®Google Scholar
• Cao WH, Fan W, Morrison SF. Medullary pathways mediating specific sympathetic responses to activation of dorsomedial hypothalamus. Neuroscience 2004; 126:229-40.
   PubMed Web of Science ®Google Scholar
• Andresen MC, Kunze DL. Nucleus tractus solitarius–gateway to neural circulatory control. Annu Rev Physiol 1994; 56:93-116; PMID:7912060; http://dx.doi.org/10.1146/annurev.ph.56.030194.000521
   PubMed Web of Science ®Google Scholar
• Cao WH, Madden CJ, Morrison SF. Inhibition of brown adipose tissue thermogenesis by neurons in the ventrolateral medulla and in the nucleus tractus solitarius. Am J Physiol Regul Integr Comp Physiol 2010; 299:R277-90; PMID:20410479; http://dx.doi.org/10.1152/ajpregu.00039.2010
   PubMed Web of Science ®Google Scholar
• Kong D, Tong Q, Ye C, Koda S, Fuller PM, Krashes MJ, Vong L, Ray RS, Olson DP, Lowell BB. GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure. Cell 2012; 151:645-57; PMID:23101631; http://dx.doi.org/10.1016/j.cell.2012.09.020
   PubMed Web of Science ®Google Scholar
• Tupone D, Madden CJ, Morrison SF. Central activation of the A1 adenosine receptor (A1AR) induces a hypothermic, torpor-like state in the rat. J Neurosci 2013; 33:14512-25; PMID:24005302; http://dx.doi.org/10.1523/JNEUROSCI.1980-13.2013
   PubMed Web of Science ®Google Scholar
• Ikramuddin S., Blackstone RP, Brancatisano A, Toouli J, Shah SN, Wolfe BM, Fujioka K, Maher JW, Swain J, Que FG, et al. Effect of reversible intermittent intra-abdominal vagal nerve blockade on morbid obesity: the ReCharge randomized clinical trial. JAMA 2014; 312:915-22; PMID:25182100; http://dx.doi.org/10.1001/jama.2014.10540
   PubMed Web of Science ®Google Scholar
• Mano-Otagiri A, Ohata H, Iwasaki-Sekino A, Nemoto T, Shibasaki T. Ghrelin suppresses noradrenaline release in the brown adipose tissue of rats. J Endocrinol 2009; 201:341-9; PMID:19351665; http://dx.doi.org/10.1677/JOE-08-0374
   PubMed Web of Science ®Google Scholar
• Habara H, Hayashi Y, Inomata N, Niijima A, Kangawa K. Organ-specific activation of the gastric branch of the efferent vagus nerve by ghrelin in urethane-anesthetized rats. J Pharmacol Sci 2014; 124:31-9; PMID:24366191
   PubMed Web of Science ®Google Scholar
• Paxinos G, Watson C. The rat brain in stereotaxic coordinates. Ed 6. Sydney: Academic; 2007.
   Google Scholar