Tissue oxidative metabolism can increase the difference between local temperature and arterial blood temperature by up to 1.3^oC: Implications for brain, brown adipose tissue, and muscle physiology

References

• Pennes HH. Analysis of tissue and arterial blood temperatures in the resting human forearm. J Appl Physiol. 1948;1:93–122. Epub 1948/08/01. doi:10.1152/jappl.1948.1.2.93. PMID:18887578
   PubMed Web of Science ®Google Scholar
• Goswami DY. The CRC handbook of mechanical engineering, 2nd ed. Boca Raton, FL: CRC Press; 2004.
   Google Scholar
• Wissler EH. Pennes' 1948 paper revisited. J Appl Physiol (1985). 1998;85:35–41. doi:10.1152/jappl.1998.85.1.35. PMID:9655751
   PubMed Web of Science ®Google Scholar
• Dominguez de Villota ED, Ruiz Carmona MT, Rubio JJ, et al. Equality of the in vivo and in vitro oxygen-binding capacity of haemoglobin in patients with severe respiratory disease. Br J Anaesth. 1981;53:1325–1328. Epub 1981/12/01. doi:10.1093/bja/53.12.1325. PMID:7317251
   PubMed Web of Science ®Google Scholar
• Larimer J. Hemoglobin Concentration and Oxygen Capacity of Mammalian Blood. J Mitchell Soc. 1959;75:174–177.
   Google Scholar
• Lusk G. The elements of the science of nutrition. 4th ed. Philadelphia: W.B. Saunders Company; 1928.
   Google Scholar
• Blake AS, Petley GW, Deakin CD. Effects of changes in packed cell volume on the specific heat capacity of blood: implications for studies measuring heat exchange in extracorporeal circuits. Br J Anaesth. 2000;84:28–32. Epub 2000/03/31. doi:10.1093/oxfordjournals.bja.a013376. PMID:10740543
   PubMed Web of Science ®Google Scholar
• Cao WH, Madden CJ, Morrison SF. Inhibition of brown adipose tissue thermogenesis by neurons in the ventrolateral medulla and in the nucleus tractus solitarius. Am J Physiol Regul Integr Comp Physiol. 2010;299:R277–R290. Epub 2010/04/23. doi:10.1152/ajpregu.00039.2010. PMID:20410479
   PubMed Web of Science ®Google Scholar
• Donhoffer S. Homeothermia of the brain: cerebral blood flow, metabolic rate, and brain temperature in the cold: the possible role of Neuroglia. Budapest: Akadémiai Kiadó; 1980.
   Google Scholar
• Romanovsky AA. Temperature regulation. In: Petersen O, editor. Lecture Notes on Human Physiology. 5th ed. Oxford, UK: Blackwell; 2007. p. 603–615.
   Google Scholar
• Wittenberg JB, Wittenberg BA. Myoglobin function reassessed. J Exp Biol. 2003;206:2011–2020. Epub 2003/05/21. doi:10.1242/jeb.00243. PMID:12756283
   PubMed Web of Science ®Google Scholar
• Society TFfRoITi. Heat Capacity of Biological Tissues. 2016. [cited 2017 07/02]. Available from: http://www.itis.ethz.ch/virtual-population/tissue-properties/database/heat-capacity/.
   Google Scholar
• Todd MM, Weeks JB, Warner DS. The influence of intravascular volume expansion on cerebral blood flow and blood volume in normal rats. Anesthesiology. 1993;78:945–953. Epub 1993/05/01. doi:10.1097/00000542-199305000-00020. PMID:8489067
   PubMed Web of Science ®Google Scholar
• Lautt WW, Greenway CV. Conceptual review of the hepatic vascular bed. Hepatology. 1987;7:952–963. Epub 1987/09/01. doi:10.1002/hep.1840070527. PMID:3308669
   PubMed Web of Science ®Google Scholar
• Carneiro JJ, Donald DE. Blood reservoir function of dog spleen, liver, and intestine. Am J Physiol. 1977;232:H67–H72. Epub 1977/01/01. PMID:835722
   PubMedGoogle Scholar
• Barcroft J, Stephens JG. Observations upon the size of the spleen. J Physiol. 1927;64:1–22. Epub 1927/10/05. doi:10.1113/jphysiol.1927.sp002414. PMID:16993897
   PubMedGoogle Scholar
• Barcroft J, Poole LT. The blood in the spleen pulp. J Physiol. 1927;64:23–29. Epub 1927/10/05. doi:10.1113/jphysiol.1927.sp002415. PMID:16993898
   PubMedGoogle Scholar
• Gonzalez-Alonso J, Quistorff B, Krustrup P, et al. Heat production in human skeletal muscle at the onset of intense dynamic exercise. J Physiol. 2000;524(Pt 2):603–615. Epub 2000/04/15. doi:10.1111/j.1469-7793.2000.00603.x. PMID:10766936
   PubMed Web of Science ®Google Scholar
• Leenders KL, Perani D, Lammertsma AA, et al. Cerebral blood flow, blood volume and oxygen utilization. Normal values and effect of age. Brain. 1990;113(Pt 1):27–47. Epub 1990/02/01. doi:10.1093/brain/113.1.27. PMID:2302536
   PubMedGoogle Scholar
• Fonseca CG, Pires W, Lima MR, et al. Hypothalamic temperature of rats subjected to treadmill running in a cold environment. PLoS One. 2014;9:e111501. Epub 2014/11/05. doi:10.1371/journal.pone.0111501. PMID:25365556
   PubMed Web of Science ®Google Scholar
• Kiyatkin EA, Brown PL, Wise RA. Brain temperature fluctuation: a reflection of functional neural activation. Eur J Neurosci. 2002;16:164–168. Epub 2002/08/03. doi:10.1046/j.1460-9568.2002.02066.x. PMID:12153543
   PubMed Web of Science ®Google Scholar
• Hayward JN, Baker MA. A comparative study of the role of the cerebral arterial blood in the regulation of brain temperature in five mammals. Brain Res. 1969;16:417–440. Epub 1969/12/01. doi:10.1016/0006-8993(69)90236-4. PMID:4311724
   PubMed Web of Science ®Google Scholar
• Hayward JN, Baker MA. Role of cerebral arterial blood in the regulation of brain temperature in the monkey. Am J Physiol. 1968;215:389–403. Epub 1968/08/01. PMID:4969787
   PubMed Web of Science ®Google Scholar
• Wang H, Wang B, Normoyle KP, et al. Brain temperature and its fundamental properties: a review for clinical neuroscientists. Front Neurosci. 2014;8:307. Epub 2014/10/24. doi:10.3389/fnins.2014.00307. PMID:25339859
   PubMed Web of Science ®Google Scholar
• Ootsuka Y, de Menezes RC, Zaretsky DV, et al. Brown adipose tissue thermogenesis heats brain and body as part of the brain-coordinated ultradian basic rest-activity cycle. Neuroscience. 2009;164:849–861. Epub 2009/08/15. doi:10.1016/j.neuroscience.2009.08.013. PMID:19679172
   PubMed Web of Science ®Google Scholar
• Behrouzvaziri A, Zaretskaia MV, Rusynia DE, et al. Circadian variability of body temperature responses to methamphetamine. Am J Physiol Regul Integr Comp Physiol. 2018;314:R43–R48. Epub 2017/09/06. doi:10.1152/ajpregu.00170.2017. PMID:28877870
   PubMed Web of Science ®Google Scholar
• Hasegawa H, Takatsu S, Ishiwata T, et al. Continuous monitoring of hypothalamic neurotransmitters and thermoregulatory responses in exercising rats. J Neurosci Methods. 2011;202:119–123. Epub 2011/06/21. doi:10.1016/j.jneumeth.2011.05.024. PMID:21683095
   PubMed Web of Science ®Google Scholar
• Tanaka H, Yanase M, Nakayama T. Body temperature regulation in rats during exercise of various intensities at different ambient temperatures. Jpn J Physiol. 1988;38:167–177. Epub 1988/01/01. doi:10.2170/jjphysiol.38.167. PMID:3172577
   PubMedGoogle Scholar
• Zaretsky DV, Brown MB, Zaretskaia MV, et al. The ergogenic effect of amphetamine. Temperature. 2014;1:242–247. doi:10.4161/23328940.2014.987564.
   PubMedGoogle Scholar
• Zaretsky DV, Zaretskaia MV, Durant PJ, et al. Treadmill running restores MDMA-mediated hyperthermia prevented by inhibition of the dorsomedial hypothalamus. Brain Res. 2015;1608:75–81. Epub 2015/03/01. doi:10.1016/j.brainres.2015.02.037. PMID:25725382
   PubMed Web of Science ®Google Scholar
• Morozova E, Yoo Y, Behrouzvaziri A, et al. Amphetamine enhances endurance by increasing heat dissipation. Physiol Rep. 2016;4. doi:10.14814/phy2.12955. PMID:27604402
   PubMed Web of Science ®Google Scholar
• Molkov YI, Zaretsky DV. Why is it easier to run in the cold? Temperature. 2016;3:509–511. doi:10.1080/23328940.2016.1201182.
   PubMedGoogle Scholar
• Molkov YI, Zaretskaia MV, Zaretsky DV. Meth math: modeling temperature responses to methamphetamine. Am J Physiol Regul Integr Comp Physiol. 2014;306:R552–R566. Epub 2014/02/07. doi:10.1152/ajpregu.00365.2013. PMID:24500434
   PubMed Web of Science ®Google Scholar
• Molkov YI, Zaretsky DV. Balanced excitation and inhibition in temperature responses to meth. Temperature. 2014;1:154–156. doi:10.4161/2167549X.2014.968483.
   PubMedGoogle Scholar
• Behrouzvaziri A, Fu D, Tan P, et al. Orexinergic neurotransmission in temperature responses to methamphetamine and stress: mathematical modeling as a data assimilation approach. PLoS One. 2015;10:e0126719. Epub 2015/05/21. doi:10.1371/journal.pone.0126719. PMID:25993564
   PubMed Web of Science ®Google Scholar
• Wang H, Kim M, Normoyle KP, et al. Thermal regulation of the brain—an anatomical and physiological review for clinical neuroscientists. Front Neurosci. 2015;9:528. Epub 2016/02/03. PMID:26834552
   PubMed Web of Science ®Google Scholar
• Schell RM, Cole DJ. Cerebral monitoring: jugular venous oximetry. Anesth Analg. 2000;90:559–566. Epub 2000/03/07. doi:10.1097/00000539-200003000-00012. PMID:10702437
   PubMed Web of Science ®Google Scholar
• Olszewski J. The Thalamus of the Macaca Mulatta. An Atlas for Use with the Stereotaxic Instrument. Montreal, QC: Karger; 1952.
   Google Scholar
• Romanovsky AA, Blatteis CM. Biphasic fever: what triggers the second temperature rise? Am J Physiol. 1995;269:R280–R286. Epub 1995/08/01. PMID:7653648
   PubMedGoogle Scholar
• Meyer CW, Ootsuka Y, Romanovsky AA. Body temperature measurements for metabolic phenotyping in mice. Front Physiol. 2017;8:520. Epub 2017/08/22. doi:10.3389/fphys.2017.00520. PMID:28824441
   PubMed Web of Science ®Google Scholar
• Romanovsky AA. Skin temperature: its role in thermoregulation. Acta Physiol. (Oxford, England). 2014;210:498–507. Epub 2014/04/10. doi:10.1111/apha.12231. PMID:24716231
   PubMed Web of Science ®Google Scholar
• Law J, Chalmers J, Morris D, et al. The use of infrared thermography in the measurement and characterization of brown adipose tissue activation. Temperature. Epub 2018/01/29. doi:10.1080/23328940.2017.1397085
   Google Scholar
• Nedergaard J, Bengtsson T, Cannon B. Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab. 2007;293:E444–E452. Epub 2007/05/03. doi:10.1152/ajpendo.00691.2006. PMID:17473055
   PubMed Web of Science ®Google Scholar
• Saito M, Okamatsu-Ogura Y, Matsushita M, et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes. 2009;58:1526–1531. Epub 2009/04/30. doi:10.2337/db09-0530. PMID:19401428
   PubMed Web of Science ®Google Scholar
• Romanovsky AA, Ivanov AI, Shimansky YP. Selected contribution: ambient temperature for experiments in rats: a new method for determining the zone of thermal neutrality. J Appl Physiol (1985). 2002;92:2667–2679. Epub 2002/05/17. doi:10.1152/japplphysiol.01173.2001. PMID:12015388
   PubMed Web of Science ®Google Scholar
• Commission IT. Glossary of terms for thermal physiology: third edition. Jpn J Physiol. 2001;51:245–280.
   Google Scholar
• Romanovsky AA, Kulchitsky VA, Simons CT, et al. Cold defense mechanisms in vagotomized rats. Am J Physiol. 1997;273:R784–R789. Epub 1997/08/01. PMID:9277569
   PubMedGoogle Scholar
• Szekely M, Szelenyi Z. Endotoxin fever in the rat. Acta Physiol Acad Sci Hung. 1979;53:265–277. Epub 1979/01/01. PMID:396758
   PubMedGoogle Scholar
• Szekely M, Szelenyi Z, Sumegi I. Brown adipose tissue as a source of heat during pyrogen-induced fever. Acta Physiol Acad Sci Hung. 1973;43:85–88. Epub 1973/01/01. PMID:4589011
   PubMedGoogle Scholar
• Almeida MC, Hew-Butler T, Soriano RN, et al. Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J Neurosci. 2012;32:2086–2099. Epub 2012/02/11. doi:10.1523/JNEUROSCI.5606-11.2012. PMID:22323721
   PubMed Web of Science ®Google Scholar
• Sulzer FG. Versuch Einer Naturgeschichte des Hamsters. Göttingen & Gotha: J. C. Dieterich.; 1774.
   Google Scholar
• Smith RE, Horwitz BA. Brown fat and thermogenesis. Physiol Rev. 1969;49:330–425. Epub 1969/04/01. doi:10.1152/physrev.1969.49.2.330. PMID:4888392
   PubMed Web of Science ®Google Scholar
• Donhoffer S, Szelenyi Z. The role of brown adipose tissue in thermoregulatory heat production in the warm- and cold-adapted adult rat. Acta Physiol Acad Sci Hung. 1967;32:53–60. Epub 1967/01/01. PMID:6082980
   PubMedGoogle Scholar
• Zaretskaia MV, Zaretsky DV, Shekhar A, et al. Chemical stimulation of the dorsomedial hypothalamus evokes non-shivering thermogenesis in anesthetized rats. Brain Res. 2002;928:113–125. Epub 2002/02/15. doi:10.1016/S0006-8993(01)03369-8. PMID:11844478
   PubMed Web of Science ®Google Scholar
• Zaretsky DV, Zaretskaia MV, Durant PJ, et al. Inhibition of the dorsomedial hypothalamus, but not the medullary raphe pallidus, decreases hyperthermia and mortality from MDMA given in a warm environment. Pharmacol Res Perspect. 2014;2:e00031. Epub 2014/04/26. doi:10.1002/prp2.31.
   PubMedGoogle Scholar
• Yoo Y, LaPradd M, Kline H, et al. Exercise activates compensatory thermoregulatory reaction in rats: a modeling study. J Appl Physiol (1985). 2015;119:1400–1410. doi:10.1152/japplphysiol.00392.2015. PMID:26472864
   PubMed Web of Science ®Google Scholar
• Cotter JD, Sleivert GG, Roberts WS, et al. Effect of pre-cooling, with and without thigh cooling, on strain and endurance exercise performance in the heat. Comp Biochem Physiol A Mol Integr Physiol. 2001;128:667–677. Epub 2001/04/03. doi:10.1016/S1095-6433(01)00273-2.
   PubMed Web of Science ®Google Scholar