Advanced search
Publication Cover
Molecular & Cellular Oncology Volume 3, 2016 - Issue 4
Submit an article Journal homepage
725
Views
5
CrossRef citations to date
0
Altmetric
Author's Views

Co-activation of AMPK and mTORC1 as a new therapeutic option for acute myeloid leukemia

Pierre SujobertINSERM U1016, Institut Cochin, CNRS UMR8104, Paris, France;Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, Paris, France;Equipe Labellisée Ligue Nationale Contre le Cancer (LNCC), Paris, FranceCorrespondence[email protected] [email protected]
&
Jerome TamburiniINSERM U1016, Institut Cochin, CNRS UMR8104, Paris, France;Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, Paris, France;Equipe Labellisée Ligue Nationale Contre le Cancer (LNCC), Paris, FranceCorrespondence[email protected] [email protected]
Article: e1071303 | Received 25 Jun 2015, Accepted 26 Jun 2015, Published online: 31 May 2016

References

  • Sujobert P, Poulain L, Paubelle E, Zylbersztejn F, Grenier A, Lambert M, Townsend EC, Brusq JM, Nicodeme E, Decrooqc J, et al. Co-activation of AMPK and mTORC1 induces cytotoxicity in acute myeloid leukemia. Cell Rep 2015; 11:1446-57; PMID:26004183; http://dx.doi.org/10.1016/j.celrep.2015.04.063
  • Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell 2012; 149:274-93; PMID:22500797; http://dx.doi.org/10.1016/j.cell.2012.03.017
  • Green AS, Chapuis N, Maciel TT, Willems L, Lambert M, Arnoult C, Boyer O, Bardet V, Park S, Foretz M, et al. The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation. Blood 2010; 116:4262-73; PMID:20668229; http://dx.doi.org/10.1182/blood-2010-02-269837
  • Hardie DG. The LKB1-AMPK pathway-friend or foe in cancer? Cancer Cell 2013; 23:131-2; PMID:23410967; http://dx.doi.org/10.1016/j.ccr.2013.01.009
  • Scotland S, Saland E, Skuli N, de Toni F, Boutzen H, Micklow E, Senegas I, Peyraud R, Peyriga L, Theodoro F, et al. Mitochondrial energetic and AKT status mediate metabolic effects and apoptosis of metformin in human leukemic cells. Leukemia 2013; 27:2129-38; PMID:23568147; http://dx.doi.org/10.1038/leu.2013.107
  • Recher C, Beyne-Rauzy O, Demur C, Chicanne G, Dos Santos C, Mas VM, Benzaquen D, Laurent G, Huguet F, Payrastre B. Antileukemic activity of rapamycin in acute myeloid leukemia. Blood 2005; 105:2527-34; PMID:15550488; http://dx.doi.org/10.1182/blood-2004-06-2494
  • Liu X, Chhipa RR, Pooya S, Wortman M, Yachyshin S, Chow LM, Kumar A, Zhou X, Sun Y, Quinn B, et al. Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK. Proc Natl Acad Sci U S A 2014; 111:E435-44; PMID:24474794; http://dx.doi.org/10.1073/pnas.1311121111
  • Kaelin WG Jr. The concept of synthetic lethality in the context of anticancer therapy. Nat Rev Cancer 2005; 5:689-98; PMID:16110319; http://dx.doi.org/10.1038/nrc1691
  • van Vliet AR, Martin S, Garg AD, Agostinis P. The PERKs of damage-associated molecular patterns mediating cancer immunogenicity: from sensor to the plasma membrane and beyond. Semin Cancer Biol 2015; PMID:25882379
  • Ansell SM, Lesokhin AM, Borrello I, Halwani A, Scott EC, Gutierrez M, Schuster SJ, Millenson MM, Cattry D, Freeman GJ, et al. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin’s lymphoma. New Engl J Med 2015; 372:311-9; PMID:25482239; http://dx.doi.org/10.1056/NEJMoa1411087

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.