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Molecular & Cellular Oncology Volume 5, 2018 - Issue 4
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Complex role of SIRT6 in NF-κB pathway regulation

Irene Santos-BarriopedroChromatin Biology Laboratory, Cancer Epigenetics and Biology Program (PEBC), Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, SPAINView further author information
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Alejandro VaqueroChromatin Biology Laboratory, Cancer Epigenetics and Biology Program (PEBC), Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, SPAINCorrespondence[email protected]
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Article: e1445942 | Received 13 Feb 2018, Accepted 20 Feb 2018, Published online: 24 May 2018

References

  • Hoesel B, Schmid JA. The complexity of NF-κB signaling in inflammation and cancer. Mol Cancer. 2013;12:86. doi:10.1186/1476-4598-12-86. PMID:23915189
  • Kugel S, Mostoslavsky R. Chromatin and beyond : the multitasking roles for SIRT6. Trends Biochem Sci. 2014;39:72–81. doi:10.1016/j.tibs.2013.12.002. PMID:24438746
  • Kawahara TLA, Michishita E, Adler AS, Damian M, Berber E, Lin M, McCord RA, Ongaigui KC, Boxer LD, Chang HY, et al. SirT6 links histone H3 lysine 9 deacetylation to NF-kB-dependent gene expression and organismal lifespan. Cell. 2009;136:62–74. doi:10.1016/j.cell.2008.10.052. PMID:19135889.
  • Santos-Barriopedro I, Bosch-Presegué L, Marazuela-Duque A, de la, Torre C, Colomer C, Vazquez BN, Fuhrmann T, Martínez-Pastor B, Lu W, Braun T, et al. SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway. Nat Commun. 2018;9:101. doi:10.1038/s41467-017-02586-x. PMID:29317652
  • Rao VK, Pal A, Taneja R. A drive in SUVs: From development to disease. Epigenetics. 2017;12:177–86. doi:10.1080/15592294.2017.1281502. PMID:28106510
  • Sen R, Smale ST. Selectivity of the NF-κB response. Cold Spring Harb Perspect Biol. 2010;2:a000257. doi: 10.1101/cshperspect.a000257. PMID: 20452937.
  • Bosch-Presegué L, Raurell-Vila H, Marazuela-Duque A, Kane-Goldsmith N, Valle A, Oliver J, Serrano L, Vaquero A. Stabilization of Suv39H1 by SirT1 is part of oxidative stress response and ensures genome protection. Mol Cell. 2011;42:210–23. doi:10.1016/j.molcel.2011.02.034. PMID:21504832
  • McDowell GS, Philpott A. Non-canonical ubiquitylation: mechanisms and consequences. Int J Biochem Cell Biol. 2013;45:1833–42. doi:10.1016/j.biocel.2013.05.026. PMID:23732108
  • Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KK, Flores LG, Shao Y, et al. The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis. Cell. 2012; 149:1098–111. doi: 10.1016/j.cell.2012.02.065. PMID: 22632973.
  • Ecker K, Hengst L. Skp2: caught in the Akt. Nat Cell Biol. 2009;11:377–9. doi:10.1038/ncb0409-377. PMID:19337320

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