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Molecular & Cellular Oncology Volume 5, 2018 - Issue 4
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PTPN2 as a promoter of colon carcinoma via reduction of inflammasome activation

Marianne R. SpalingerDepartment for Gastroenterology and Hepatology, University Hospital Zurich, and University of Zurich, Zurich, Switzerland
&
Michael ScharlDepartment for Gastroenterology and Hepatology, University Hospital Zurich, and University of Zurich, Zurich, SwitzerlandCorrespondence[email protected]
Article: e1465013 | Received 27 Mar 2018, Accepted 29 Mar 2018, Published online: 06 Jun 2018

References

  • Spalinger MR, McCole DF, Rogler G, Scharl M. Role of protein tyrosine phosphatases in regulating the immune system: implications for chronic intestinal inflammation. Inflamm Bowel Dis. 2015;21:645–55. doi:10.1097/MIB.0000000000000297. PMID:25581833.
  • You-Ten KE, Muise ES, Itie A, Michaliszyn E, Wagner J, Jothy S, Lapp WS, Tremblay ML. Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice. J Exp Med. 1997;186:683–93. doi:10.1084/jem.186.5.683. PMID:9271584.
  • Spalinger MR, Manzini R, Hering L, Riggs JB, Gottier C, Lang S, Atrott K, Fettelschoss A, Olomski F, Kündig TM, et al. PTPN2 Regulates Inflammasome Activation and Controls Onset of Intestinal Inflammation and Colon Cancer. Cell Rep. 2018;22:1835–48. doi:10.1016/j.celrep.2018.01.052. PMID:29444435.
  • Martinon F, Mayor A, Tschopp J. The inflammasomes: guardians of the body. Annu Rev Immunol. 2009;27:229–65. doi:10.1146/annurev.immunol.021908.132715. PMID:19302040.
  • Takeda K, Tsutsui H, Yoshimoto T, Adachi O, Yoshida N, Kishimoto T, Okamura H, Nakanishi K, Akira S. Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity. 1998;8:383–90. doi:10.1016/S1074-7613(00)80543-9. PMID:9529155.
  • Hara H, Tsuchiya K, Kawamura I, Fang R, Hernandez-Cuellar E, Shen Y, Mizuguchi J, Schweighoffer E, Tybulewicz V, Mitsuyama M. Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity. Nat Immunol. 2013;14:1247–55. doi:10.1038/ni.2749. PMID:24185614.
  • Genard G, Lucas S, Michiels C. Reprogramming of Tumor-Associated Macrophages with Anticancer Therapies: Radiotherapy versus Chemo- and Immunotherapies. Front Immunol. 2017;8:828. doi:10.3389/fimmu.2017.00828. PMID:28769933.
  • Manguso RT, Pope HW, Zimmer MD, Brown FD, Yates KB, Miller BC, Collins NB, Bi K, LaFleur MW, Juneja VR, et al. In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target. Nature. 2017;547:413–8. doi:10.1038/nature23270. PMID:28723893.

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