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Molecular & Cellular Oncology Volume 5, 2018 - Issue 4
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Killing two birds with one stone: Blocking the mitochondrial pyruvate carrier to inhibit lactate uptake by cancer cells and radiosensitize tumors

Catherine Vander LindenPole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain, 53 Avenue E. Mounier B1.53.09, B-1200Brussels, Belgium
&
Cyril CorbetPole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain, 53 Avenue E. Mounier B1.53.09, B-1200Brussels, BelgiumCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-8795-9131
ORCID Icon
Article: e1465016 | Received 09 Apr 2018, Accepted 11 Apr 2018, Published online: 22 May 2018

References

  • Draoui N, Feron, O. Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments. Dis Model Mech. 2011;4:727–32. doi:10.1242/dmm.007724. PMID:22065843.
  • Faubert B, et al. Lactate metabolism in human lung tumors. Cell. 2017;171:358–371 e359. doi:10.1016/j.cell.2017.09.019.
  • Hui S, et al. Glucose feeds the TCA cycle via circulating lactate. Nature. 2017;551:115–8. doi:10.1038/nature24057. PMID:29045397.
  • Allen E. et al. Metabolic symbiosis enables adaptive resistance to anti-angiogenic therapy that is dependent on mTOR signaling. Cell Rep. 2016;15:1144–60. doi:10.1016/j.celrep.2016.04.029. PMID:27134166.
  • Pisarsky L, et al. Targeting metabolic symbiosis to overcome resistance to anti-angiogenic therapy. Cell Rep. 2016;15:1161–74. doi:10.1016/j.celrep.2016.04.028. PMID:27134168.
  • Draoui N, et al. Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux. Mol Cancer Ther. 2014;13:1410–8. doi:10.1158/1535-7163.MCT-13-0653. PMID:24672058.
  • Corbet C, et al. Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects. Nat Commun. 2018;9:1208. doi:10.1038/s41467-018-03525-0. PMID:29572438.
  • Corbet C. Stem cell metabolism in cancer and healthy tissues: pyruvate in the limelight. Front Pharmacol. 2017;8:958. doi:10.3389/fphar.2017.00958. PMID:29403375.
  • Corbet C, Feron O. Cancer cell metabolism and mitochondria: Nutrient plasticity for TCA cycle fueling. Biochim Biophys Acta. 2017;1868:7–15. PMID:28110019.
  • Corbet, C, Feron O. Emerging roles of lipid metabolism in cancer progression. Curr Opin Clin Nutr Metab Care. 2017;20:254–60. doi:10.1097/MCO.0000000000000381. PMID:28403011.

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