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Molecular & Cellular Oncology Volume 5, 2018 - Issue 5
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Novel insights into the epigenetics of diffuse glioma

Carla DanussiDepartment of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USAView further author information
&
Jason T. HuseDepartment of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA;Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USACorrespondence[email protected]
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Article: e1472055 | Received 12 Apr 2018, Accepted 15 Apr 2018, Published online: 24 Aug 2018

References

  • Huse JT, Aldape KD. The molecular landscape of diffuse glioma and prospects for biomarker development. Expert Opin Med Diagn. 2013;7(6):573–587. doi:10.1517/17530059.2013.846321.
  • Ceccarelli M, Barthel FP, Malta TM, Sabedot TS, Salama SR, Murray BA, Morozova O, Newton Y, Radenbaugh A, Pagnotta SM, et al. Molecular profiling reveals biologically discrete subsets and pathways of progression in diffuse glioma. Cell. 2016; 164(3): 550–563.doi:10.1016/j.cell.2015.12.028.
  • Brat DJ, Verhaak RG, Aldape KD, Yung WK, Salama SR, Cooper LA, Rheinbay E, Miller CR, Vitucci M, et al. Comprehensive, integrative genomic analysis of diffuse lower- grade gliomas. N Engl J Med. 2015;372(26): 2481–2498. doi:10.1056/NEJMoa1402121.
  • Kannan K, Inagaki A, Silber J, Gorovets D, Zhang J, Kastenhuber ER, Heguy A, Petrini JH, Chan TA, Huse JT. Whole exome sequencing identified ATRX mutation as a key molecular determinant in lower-grade glioma. Oncotarget. 2012;3(10):1194–1203. doi:10.18632/oncotarget.689.
  • Schwartzentruber J, Korshunov A, Liu XY, Jones DT, Pfaff E, Jacob K, Sturm D, Fontebasso AM, Quang DA, Tönjes M, et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature. 2012; 482(7384): 226–231.doi:10.1038/nature10833.
  • Heaphy CM, De Wilde RF, Jiao Y, Klein AP, Edil BH, Shi C, Bettegowda C, Rodriguez FJ, Eberhart CG, Hebbar S, et al. Altered telomeres in tumors with ATRX and DAXX mutations. Science. 2011; 333(6041): 425.doi:10.1126/science.1207313.
  • Danussi C, Bose P, Parthasarathy PT, Silberman PC, Van Arnam JS, Vitucci M, Tang OY, Heguy A, Wang Y, Chan TA, et al. Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling. Nat Commun. 2018; 9(1): 1057.doi:10.1038/s41467-018-03476-6.
  • Kelly P, Casey PJ, Meigs TE. Biologic functions of the G12 subfamily of heterotrimeric g proteins: growth, migration, and metastasis. Biochemistry. 2007;46(23):6677–6687. doi:10.1021/bi700235f.
  • Watson LA, Goldberg H, Bérubé NG. Emerging roles of ATRX in cancer. Epigenomics. 2015;7(8):1365–1378. doi:10.2217/epi.15.82.
  • Morera L, Lübbert M, Jung M. Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy. Clin Epigenetics. 2016;8:.57. doi:10.1186/s13148-016-0223-4.

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