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Review Article

Pitfalls in studies of eosinopenia and neutrophil-to-lymphocyte count ratio

ORCID Icon, , &
Pages 163-174 | Received 22 Aug 2017, Accepted 30 Sep 2017, Published online: 26 Oct 2017

References

  • Bass DA. Behavior of eosinophil leukocytes in acute inflammation. II. eosinophil dynamics during acute inflammation. J Clin Invest. 1975;56:870–879.
  • Bass DA, Gonwa TA, Szejda P, et al. Eosinopenia of acute infection: production of eosinopenia by chemotactic factors of acute inflammation. J Clin Invest. 1980;65:1265–1271.
  • Best WR, Muehrcke RC, Kark RM. Studies on adrenocortical eosinopenia: a clinical and statistical evaluation of four-hour eosinophil response test. J Clin Invest. 1952;31:733–742.
  • Hills AG, Forsham PH, Finch CA. Changes in circulating leukocytes induced by the administration of pituitary adrenocorticotrophic hormone in man. Blood. 1948;3:755–768.
  • Dreyfuss F, Feldman S. Eosinopenia induced by emotional stress. Acta Med Scand. 1952;144:107–113.
  • Summers C, Rankin SM, Condliffe AM, et al. Neutrophil kinetics in health and disease. Trends Immunol. 2010;31:318–324.
  • Zahorec R. Ratio of neutrophil to lymphocyte counts-rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 2001;102:5–14.
  • Naess A, Nilssen SS, Mo R, et al. Role of neutrophil to lymphocyte and monocyte to lymphocyte ratios in the diagnosis of bacterial infection in patients with fever. Infection. 2017;45:299–307.
  • Naess A, Mo R, Nilssen SS, et al. Infections in patients hospitalized for fever as related to duration and other predictors at admittance. Infection. 2014;42:485–492.
  • Abidi K, Khoudri I, Belayachi J, et al. Eosinopenia is a reliable marker of sepsis on admission to medical intensive care units. Crit Care. 2008;12:R59.
  • Gil H, Magy N, Mauny F, et al. Value of eosinopenia in inflammatory disorders: an "old" marker revisited. Rev Med Interne. 2003;24:431–435.
  • Smithson A, Perello R, Nicolas JM. Is eosinopenia a reliable marker of sepsis? Crit Care. 2009;13:409.
  • Shaaban H, Daniel S, Sison R, et al. Eosinopenia: is it a good marker of sepsis in comparison to procalcitonin and C-reactive protein levels for patients admitted to a critical care unit in an urban hospital? J Crit Care. 2010;25:570–575.
  • Garnacho-Montero J, Huici-Moreno MJ, Gutierrez-Pizarraya A, et al. Prognostic and diagnostic value of eosinopenia, C-reactive protein, procalcitonin, and circulating cell-free DNA in critically ill patients admitted with suspicion of sepsis. Crit Care. 2014;18:R116.
  • Anand D, Ray S, Bhargava S, et al. Exploration of eosinopenia as a diagnostic parameter to differentiate sepsis from systemic inflammatory response syndrome: results from an observational study. Indian J Crit Care Med. 2016;20:285–290.
  • Lavoignet CE, Le Borgne P, Slimani H, et al. Relevance of eosinopenia as marker of sepsis in the Emergency Department. Rev Med Interne. 2016;37:730–734.
  • Efstathiou SP, Pefanis AV, Tsiakou AG, et al. Fever of unknown origin: discrimination between infectious and non-infectious causes. Eur J Intern Med. 2010;21:137–143.
  • Gucyetmez B, Atalan HK. C-reactive protein and hemogram parameters for the non-sepsis systemic inflammatory response syndrome and sepsis: what do they mean? PLoS One. 2016;11:e0148699.
  • Ljungstrom L, Pernestig AK, Jacobsson G, et al. Diagnostic accuracy of procalcitonin, neutrophil-lymphocyte count ratio, C-reactive protein, and lactate in patients with suspected bacterial sepsis. PLoS One. 2017;12:e0181704.
  • Merino CA, Martinez FT, Cardemil F, et al. Absolute eosinophils count as a marker of mortality in patients with severe sepsis and septic shock in an intensive care unit. J Crit Care. 2012;27:394–399.
  • Abidi K, Belayachi J, Derras Y, et al. Eosinopenia, an early marker of increased mortality in critically ill medical patients. Intensive Care Med. 2011;37:1136–1142.
  • Terradas R, Grau S, Blanch J, et al. Eosinophil count and neutrophil-lymphocyte count ratio as prognostic markers in patients with bacteremia: a retrospective cohort study. PLoS One. 2012;7:e42860.
  • Rahimi-Rad MH, Asgari B, Hosseinzadeh N, et al. Eosinopenia as a marker of outcome in acute exacerbations of chronic obstructive pulmonary sisease. Maedica (Buchar). 2015;10:10–13.
  • Steer J, Gibson J, Bourke SC. The DECAF Score: predicting hospital mortality in exacerbations of chronic obstructive pulmonary disease. Thorax. 2012;67:970–976.
  • Hwang SY, Shin TG, Jo IJ, et al. Neutrophil-to-lymphocyte ratio as a prognostic marker in critically-ill septic patients. Am J Emerg Med. 2017;35:234–239.
  • Escobar-Valdivia EJ, Gonzalez-Aguirre JE, Carrillo-Cisneros ER, et al. Eosinophil count at intensive care unit admission was not predictor of hospital mortality: results of a case control study. J Intensive Care. 2015;3:27.
  • Davido B, Makhloufi S, Matt M, et al. Changes in eosinophil count during bacterial infection: revisiting an old marker to assess the efficacy of antimicrobial therapy. Int J Infect Dis. 2017;61:62–66.
  • Ho KM, Towler SC. A comparison of eosinopenia and C-reactive protein as a marker of bloodstream infections in critically ill patients: a case control study. Anaesth Intensive Care. 2009;37:450–456.
  • Setterberg MJ, Newman W, Potti A, et al. Utility of eosinophil count as predictor of bacteremia. Clin Infect Dis. 2004;38:460–461.
  • Wibrow BA, Ho KM, Flexman JP, et al. Eosinopenia as a diagnostic marker of bloodstream infection in hospitalised paediatric and adult patients: a case-control study. Anaesth Intensive Care. 2011;39:224–230.
  • Lowsby R, Gomes C, Jarman I, et al. Neutrophil to lymphocyte count ratio as an early indicator of blood stream infection in the emergency department. Emerg Med J. 2015;32:531–534.
  • de Jager CP, Wever PC, Gemen EF, et al. The neutrophil-lymphocyte count ratio in patients with community-acquired pneumonia. PLoS One. 2012;7:e46561.
  • Matono T, Kutsuna S, Kato Y, et al. Role of classic signs as diagnostic predictors for enteric fever among returned travellers: relative bradycardia and eosinopenia. PLoS One. 2017;12:e0179814.
  • Farmakiotis D, Varughese J, Sue P, et al. Typhoid Fever in an inner city hospital: a 5-year retrospective review. J Travel Med. 2013;20:17–21.
  • Farmakiotis D, Ntouloulis C, Mihailidis N, et al. Diagnostic value of eosinopenia in non-Typhi Salmonella enteritis. Clin Infect Dis. 2014;59:1197–1198.
  • Flick H, Drescher M, Prattes J, et al. Predictors of H1N1 influenza in the emergency department: proposition for a modified H1N1 case definition. Clin Microbiol Infect. 2014;20:105–108.
  • Yip B, Ho KM. Eosinopenia as a predictor of unexpected re-admission and mortality after intensive care unit discharge. Anaesth Intensive Care. 2013;41:231–241.
  • Altman LC, Hill JS, Hairfield WM, et al. Effects of corticosteroids on eosinophil chemotaxis and adherence. J Clin Invest. 1981;67:28–36.
  • Shoenfeld Y, Gurewich Y, Gallant LA, et al. Prednisone-induced leukocytosis. Influence of dosage, method and duration of administration on the degree of leukocytosis. Am J Med. 1981;71:773–778.
  • Karakonstantis S, Kalemaki D. Correspondence to "Role of neutrophil to lymphocyte and monocyte to lymphocyte ratios in the diagnosis of bacterial infection in patients with fever". Infection. 2017 Sep 8. [Epub ahead of print].
  • Naess A, Eide GE, Sjursen H. Reply to Drs. Karakonstantis and Kalemaki. Infection. 2017.
  • Kirkeby K. Diagnostic and prognostic significance of eosinopenia in acute myocardial infarction. Am J Med Sci. 1956;232:50–56.
  • Lee MJ, Park SD, Kwon SW, et al. Relation between neutrophil-to-lymphocyte ratio and index of microcirculatory resistance in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Am J Cardiol. 2016;118:1323–1328.
  • Bolayir A, Cigdem B, Gokce SF, et al. The effect of eosinopenia on mortality in patients with intracerebral hemorrhage. J Stroke Cerebrovasc Dis. 2017;26:2248–2255.
  • Wang F, Hu S, Ding Y, et al. Neutrophil-to-lymphocyte ratio and 30-day mortality in patients with acute intracerebral hemorrhage. J Stroke Cerebrovasc Dis. 2016;25:182–187.
  • Sun Y, You S, Zhong C, et al. Neutrophil to lymphocyte ratio and the hematoma volume and stroke severity in acute intracerebral hemorrhage patients. Am J Emerg Med. 2017;35:429–433.
  • Dilektasli E, Inaba K, Haltmeier T, et al. The prognostic value of neutrophil-to-lymphocyte ratio on mortality in critically ill trauma patients. J Trauma Acute Care Surg. 2016;81:882–888.
  • Chen W, Yang J, Li B, etet al. Neutrophil to lymphocyte ratio as a novel predictor of outcome in patients with severe traumatic brain injury. J Head Trauma Rehabil. 2017. [Epub ahead of print]. doi: 10.1097/HTR.0000000000000320
  • Blumenthal KG, Youngster I, Rabideau DJ, et al. Peripheral blood eosinophilia and hypersensitivity reactions among patients receiving outpatient parenteral antibiotics. J Allergy Clin Immunol. 2015;136:1288–1294 e1.
  • Ramirez E, Medrano-Casique N, Tong HY, et al. Eosinophilic drug reactions detected by a prospective pharmacovigilance programme in a tertiary hospital. Br J Clin Pharmacol. 2017;83:400–415.
  • Warrington R, Silviu-Dan F. Drug allergy. Allergy Asthma Clin Immunol. 2011;7:S10.
  • Kovalszki A, Weller PF. Eosinophilia. Prim Care. 2016;43:607–617.
  • Amundsen EK, Urdal P, Henriksson CE. Poor accuracy of the eosinophil count of hematology instruments limits the use of eosinopenia as a marker of bacterial infection or increased mortality. Int Jnl Lab Hem. 2015;37:e119–e122.

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