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Infectious Diseases Volume 51, 2019 - Issue 1
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Brief Report

Limited anti-HIV neutralizing antibody breadth and potency before and after HIV superinfection in Danish men who have sex with men

Andrew D. ReddLaboratory of Immunoregulation, Division of Intramural Research, NIAID, NIH, Bethesda, USA; ;Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Correspondence[email protected]
View further author information
,
Marie HellebergDepartment of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Denmark; View further author information
,
Matthew SieversDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; View further author information
,
Stephen D. SchmidtVaccine Research Center, NIAID, NIH, Bethesda, MD, USA; View further author information
,
Nicole A. Doria-RoseVaccine Research Center, NIAID, NIH, Bethesda, MD, USA; View further author information
,
Daniel BrunoGenomics Unit, Research Technologies Branch, Rocky Mountain Laboratories, Division of Intramural Research, NIAID, NIH, Hamilton, MT, USA; View further author information
,
Shelby TraegerGenomics Unit, Research Technologies Branch, Rocky Mountain Laboratories, Division of Intramural Research, NIAID, NIH, Hamilton, MT, USA; View further author information
,
Craig MartensGenomics Unit, Research Technologies Branch, Rocky Mountain Laboratories, Division of Intramural Research, NIAID, NIH, Hamilton, MT, USA; View further author information
,
Jannik FonagerSection for Virus Surveillance and Research, Department of Virus & Microbiological Special Diagnostics, Infectious Disease Preparedness, Statens Serum Institut, Copenhagen, Denmark; View further author information
,
Gitte KronborgDepartment of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Denmark; View further author information
,
Zoe PackmanDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USAView further author information
,
John R. MascolaVaccine Research Center, NIAID, NIH, Bethesda, MD, USA; View further author information
,
Stephen F. PorcellaGenomics Unit, Research Technologies Branch, Rocky Mountain Laboratories, Division of Intramural Research, NIAID, NIH, Hamilton, MT, USA; View further author information
,
Jan GerstoftDepartment of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Denmark; View further author information
&
Thomas C. QuinnLaboratory of Immunoregulation, Division of Intramural Research, NIAID, NIH, Bethesda, USA; ;Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; View further author information
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Pages 56-61 | Received 18 May 2018, Accepted 04 Jul 2018, Published online: 14 Oct 2018

References

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  • Salado-Rasmussen K, Katzenstein TL, Gerstoft J, et al. Risk of HIV or second syphilis infection in Danish men with newly acquired syphilis in the period 2000–2010. Sex Transm Infect. 2013;89:372–376.
  • Wagner GA, Landais E, Caballero G, et al. Intrasubtype B HIV-1 superinfection correlates with delayed neutralizing antibody response. J Virol. 2017;91:e00475–17.
  • Connor RI, Montefiori DC, Binley JM, et al. Temporal analyses of virus replication, immune responses, and efficacy in rhesus macaques immunized with a live, attenuated simian immunodeficiency virus vaccine. J Virol. 1998;72:7501–7509.
  • Cornelissen M, Euler Z, van den Kerkhof TL, et al. The neutralizing antibody response in an individual with triple HIV-1 infection remains directed at the first infecting subtype. AIDS Res Hum Retroviruses. 2016;32:1135–1142.

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