References
- Bodmer D, Brors D, Pak K, et al. Inflammatory signals increase Fas ligand expression by inner ear cells. J Neuroimmunol. 2002;129(1–2):10–17.
- Hayashi Y, Onomoto K, Narita R, et al. Virus-induced expression of retinoic acid inducible gene-I and melanoma differentiation-associated gene 5 in the cochlear sensory epithelium. Microbes Infect. [Internet]. 2013;15(8–9):592–598. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1286457913000890
- Nyberg S, Joan Abbott N, Shi X, et al. Delivery of therapeutics to the inner ear: the challenge of the blood-labyrinth barrier. Sci Transl Med. 2019;11(482):eaao0935.
- Wang L, Kempton JB, Brigande JV. Gene therapy in mouse models of deafness and balance dysfunction. Front Mol Neurosci. [Internet]. 2018 [cited 2019 Jan 29];11:300. Available from: http://www.ncbi.nlm.nih.gov/pubmed/30210291
- Lustig L, Akil O. Cochlear gene therapy. Cold Spring Harb Perspect Med. [Internet]. 2018 [cited 2019 Feb 3];a033191. Available from: http://www.ncbi.nlm.nih.gov/pubmed/30323014
- Sloan-Heggen CM, Bierer AO, Shearer AE, et al. Comprehensive genetic testing in the clinical evaluation of 1119 patients with hearing loss. Hum Genet. 2016;135(4):441–450.
- Miyagawa M, Nishio S-Y, Usami S-I. A comprehensive study on the etiology of patients receiving cochlear implantation with special emphasis on genetic epidemiology. Otol Neurotol. [Internet]. 2016;37(2):e126–e134. Available from: http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00129492-201602000-00032.
- Shearer AE, Eppsteiner RW, Frees K, et al. Genetic variants in the peripheral auditory system significantly affect adult cochlear implant performance. Hear Res. [Internet]. 2017 [cited 2017 Dec 3];348:138–142. Available from: http://www.sciencedirect.com/science/article/pii/S0378595516306001
- Bermingham N, Hassan B, Price S. Math1: an essential gene for the generation of inner ear hair cells. Science. 1999;284(5421):1837–1841. cited 2017 Jun 7. Available from: http://science.sciencemag.org/content/284/5421/1837.short
- Breuskin I, Bodson M, Thelen N, et al. Strategies to regenerate hair cells: identification of progenitors and critical genes. Hear Res. [Internet]. 2008;236(1–2):1–10. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17920797
- Niemiec AJ, Raphael Y, Moody DB. Return of auditory function following structural regeneration after acoustic trauma: behavioral measures from quail. Hear Res. [Internet]. 1994;79(1–2):1–16. Available from: http://www.ncbi.nlm.nih.gov/pubmed/7806472.
- Izumikawa M, Minoda R, Kawamoto K, et al. Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals. Nat Med. [Internet]. 2005;11(3):271–276. [cited 2017 Jun 7]. Available from: http://www.nature.com/nm/journal/v11/n3/abs/nm1193.html
- Schlecker C, Praetorius M, Brough DE, et al. Selective atonal gene delivery improves balance function in a mouse model of vestibular disease. Gene Ther. 2011;18(9):884–890.
- White PM, Doetzlhofer A, Lee YS, et al. Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells. Nature. [Internet]. 2006;441(7096):984–987. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16791196
- Staecker H, Schlecker C, Kraft S, et al. Optimizing atoh1-induced vestibular hair cell regeneration. Laryngoscope. 2014;124(S5):S1-S12.
- Staecker H, Praetorius M, Baker K, et al. Vestibular hair cell regeneration and restoration of balance function induced by math1 gene transfer. Otol Neurotol. 2007;28(2):223–231.
- Baker K, Brough DE, Staecker H. Repair of the vestibular system via adenovector delivery of atoh1: A potential treatment for balance disorders. Adv Otorhinolaryngol. 2009;66:52–63. doi: 10.1159/000218207. Epub 2009 Jun 2.
- Taylor RR, Jagger DJ, Forge A. Defining the cellular environment in the organ of Corti following extensive hair cell loss: a basis for future sensory cell replacement in the Cochlea. PLoS One. [Internet]. 2012;7(1):e30577. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22299045.
- Oesterle EC. Changes in the adult vertebrate auditory sensory epithelium after trauma. Hear Res. 2013;297:91–98.
- Izumikawa M, Batts S, Miyazawa T, et al. Response of the flat cochlear epithelium to forced expression of Atoh1. Hear Res. [Internet]. 2008;240(1–2):52–56. [cited 2017 Jun 7]; Available from: http://www.sciencedirect.com/science/article/pii/S0378595508000439
- Shearer AE, Hildebrand MS, Smith RJ. Hereditary hearing loss and deafness overview. [ [Internet]. GeneReviews®. Seattle: University of Washington; 1993. [cited 2018 Dec 22]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20301607.
- Gubbels S, Woessner D, Mitchell J, et al. Functional auditory hair cells produced in the mammalian cochlea by in utero gene transfer. Nature. [Internet]. 2008;455(7212):537–541. [cited 2017 Jun 7]; Available from: http://www.nature.com/nature/journal/v455/n7212/abs/nature07265.html
- Depreux FF, Wang L, Jiang H, et al. Antisense oligonucleotides delivered to the amniotic cavity in utero modulate gene expression in the postnatal mouse. Nucleic Acids Res. [Internet]. 2016 [cited 2019 Jun 3];44:gkw867. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27683224
- Miwa T, Minoda R, Ise M, et al. Mouse otocyst transuterine gene transfer restores hearing in mice with connexin 30 deletion-associated hearing loss. Mol Ther. [Internet]. 2013;21(6):1142–1150. [cited 2017 Jun 7]; Available from: http://www.nature.com/mt/journal/v21/n6/full/mt201362a.html
- Bedrosian J, Gratton M, Brigande J, et al. In vivo delivery of recombinant viruses to the fetal murine cochlea: transduction characteristics and long-term effects on auditory function. Molecular. [Internet]. 2006 [cited 2017 Jun 7]; Available from: http://www.nature.com/mt/journal/v14/n3/abs/mt20061303a.html
- Flake AW, Adzick NS. Fetal surgery. Rickham’s Neonatal Surg. [Internet]. London: Springer London; 2018 [cited 2019 Jan 26]. p. 369–386. Available from. : ; . . p. . : DOI:10.1007/978-1-4471-4721-3_14
- Maeda Y, Fukushima K, Nishizaki K. In vitro and in vivo suppression of GJB2 expression by RNA interference. Hum Mol. [Internet]. 2005 [cited 2017 Jun 7]; Available from. ;14(12):1641–1650. : http://hmg.oxfordjournals.org/content/14/12/1641.short
- Yoshimura H, Shibata SB, Ranum PT, et al. Targeted allele suppression prevents progressive hearing loss in the mature murine model of human TMC1 deafness. Mol Ther. [Internet]. 2019;27(3):681–690. [cited 2019 Jan 29]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/30686588
- Gao X, Tao Y, Lamas V, et al. Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents. Nature. [Internet]. 2017 [cited 2017 Jan 31];553(7687):217–221. Available from: http://www.ncbi.nlm.nih.gov/pubmed/29258297
- Kawamoto K, Sha S-H, Minoda R, et al. Antioxidant gene therapy can protect hearing and hair cells from ototoxicity. Mol Ther. [Internet]. 2004 [cited 2019 Feb 25];9(2):173–181. Available from: http://www.ncbi.nlm.nih.gov/pubmed/14759801
- Cooper LB, Chan DK, Roediger FC, et al. AAV-mediated delivery of the caspase inhibitor XIAP protects against cisplatin ototoxicity. Otol Neurotol. [Internet]. 2006;27:484–490. [cited 2019 Feb 25]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16791039
- Chen -G-G, Mao M, Qiu L-Z, et al. Gene transfection mediated by polyethyleneimine-polyethylene glycol nanocarrier prevents cisplatin-induced spiral ganglion cell damage. Neural Regen Res. [Internet]. 2015 [cited 2019 Feb 25];10(3):425–431. Available from: http://www.nrronline.org/text.asp?2015/10/3/425/153691
- Rejali D, Lee VA, Abrashkin KA, et al. Cochlear implants and ex vivo BDNF gene therapy protect spiral ganglion neurons. Hear Res. 2007;228(1–2):180–187.
- Leake PA, Stakhovskaya O, Hetherington A, et al. Effects of Brain-Derived Neurotrophic Factor (BDNF) and electrical stimulation on survival and function of cochlear spiral ganglion neurons in deafened, developing cats. J Assoc Res Otolaryngol. [Internet]. 2013 [cited 2018 Jan 19];14(2):187–211. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23392612
- Wise AK, Tu T, Atkinson PJ, et al. The effect of deafness duration on neurotrophin gene therapy for spiral ganglion neuron protection. Hear Res. [Internet]. 2011 [cited 2017 Aug 7];278(1–2):69–76. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21557994
- Budenz CL, Wong HT, Swiderski DL, et al. Differential effects of AAV.BDNF and AAV.Ntf3 in the deafened adult guinea pig ear. Sci Rep. [Internet]. 2015 [cited 2018 Sep 23];5(1):8619. Available from: http://www.nature.com/articles/srep08619
- Fukui H, Wong HT, Beyer LA, et al. BDNF gene therapy induces auditory nerve survival and fiber sprouting in deaf Pou4f3 mutant mice. Sci Rep. [Internet]. 2012 [cited 2017 Aug 7];2(1):838. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23150788.
- Takada Y, Beyer LA, Swiderski DL, et al. Connexin 26 null mice exhibit spiral ganglion degeneration that can be blocked by BDNF gene therapy. Hear Res. [Internet]. 2014 [cited 2019 Feb 25];309:124–135. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0378595513002827
- Zhong C, Jiang Z, Guo Q, et al. Protective effect of adenovirus-mediated erythropoietin expression on the spiral ganglion neurons in the rat inner ear. Int J Mol Med. [Internet]. 2018 [cited 2019 Feb 25];41:2669–2677. Available from: http://www.spandidos-publications.com/10.3892/ijmm.2018.3455
- Seyyedi M, Viana LM, Nadol JB. Within-subject comparison of word recognition and spiral ganglion cell count in bilateral cochlear implant recipients. Otol Neurotol. [Internet]. 2014;1. [cited 2018 Sep 23]. Available from: http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00129492-900000000-97894
- Staecker H, Garnham C. Neurotrophin therapy and cochlear implantation: translating animal models to human therapy. Exp Neurol. 2010;226(1):1–5.
- Leake PA, Rebscher SJ, Dore‘ C, et al. AAV-mediated neurotrophin gene therapy promotes improved survival of cochlear spiral ganglion neurons in neonatally deafened cats: comparison of AAV2-hBDNF and AAV5-hGDNF. J Assoc Res Otolaryngol. [Internet]. 2019;1–21. [cited 2019 Jun 27]. Doi:10.1007/s10162-019-00723-5
- Pfingst BE, Colesa DJ, Swiderski DL, et al. Neurotrophin gene therapy in deafened ears with cochlear implants: long-term effects on nerve survival and functional measures. J Assoc Res Otolaryngol. [Internet]. 2017 [cited 2018 Sep 23];18(6):731–750.
- Pfingst BE, Zhou N, Colesa DJ, et al. Importance of cochlear health for implant function. Hear Res. 2015;322:77–88.
- Pietola L, Aarnisalo AA, Joensuu J, et al. HOX-GFP and WOX-GFP lentivirus vectors for inner ear gene transfer. Acta Otolaryngol. [Internet]. 2008 [cited 2019 Feb 23];128(6):613–620.
- Han M, Yu D, Song Q, et al. Polybrene: observations on cochlear hair cell necrosis and minimal lentiviral transduction of cochlear hair cells. Neurosci Lett. [Internet]. 2015;600:164–170. [cited 2019 Feb 23]. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0304394015004541
- Maass JC, Berndt FA, Canovas J, et al. p27Kip1 knockdown induces proliferation in the organ of Corti in culture after efficient shRNA lentiviral transduction. J Assoc Res Otolaryngol. [Internet]. 2013;14(4):495–508. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23612739
- Han JJ, Mhatre AN, Wareing M, et al. Transgene expression in the guinea pig cochlea mediated by a lentivirus-derived gene transfer vector. Hum Gene Ther. [Internet]. 1999;10(11):1867–1873. [cited 2019 Feb 23].
- Hacein-Bey-Abina S, Garrigue A, Wang GP, et al. Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. J Clin Invest. [Internet]. 2008;118(9):3132–3142. [cited 2019 Feb 23]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18688285
- Biffi A, Montini E, Lorioli L, et al. Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy. Science. 2013;341(6148):1233158. cited 2019 Feb 23. Available from: http://science.sciencemag.org/content/341/6148/1233158.short?casa_token=kgx1HcQ0J0kAAAAA:taIGWKreDrVaW6ci4WCgDc1VCis8hclW2hNwh8cL6Xo8RqMnN0NrQxWg1JKpJXfqYVdwd5ORqTuvt1A
- Cartier N, HaceinBeyAbina S, Bartholomae C. Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy. Science. 2009;326(5954):818–823. cited 2019 Feb 23. Available from: http://science.sciencemag.org/content/326/5954/818.short?casa_token=RgEfYdWNsWQAAAAA:jHRWjHIvW-r9hJKJu5eI6UU-pHL9dgIK7TBE9cz_OPC8bzndeae6FuWzeqyqQNvLwxS6CFmGE_bL7To
- Kumar M, Keller B, Makalou N, et al. Systematic determination of the packaging limit of lentiviral vectors. Hum Gene Ther. [Internet]. 2001 [cited 2019 Feb 23];12(15):1893–1905.
- Sinn P, Sauter S, Jr PM. Gene therapy progress and prospects: development of improved lentiviral and retroviral vectors–design, biosafety, and production. Gene Ther. [Internet]. 2005;12(14):1089–1098. [cited 2019 Feb 23]; Available from: https://www.nature.com/articles/3302570
- Matrai J, Chuah M, VandenDriessche T. Recent advances in lentiviral vector development and applications. Mol Ther. [Internet]. 2010;18(3):477–490. [cited 2019 Feb 23]; Available from: https://www.sciencedirect.com/science/article/pii/S1525001616322961
- Husseman J, Raphael Y. Gene therapy in the inner ear using adenovirus vectors. Adv Otorhinolaryngol. [Internet]. 2009;66:37–51. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19494571
- Praetorius M, Brough DE, Hsu C, et al. Adenoviral vectors for improved gene delivery to the inner ear. Hear Res. 2009;248(1–2):31–38.
- Reddy PS, Sakhuja K, Ganesh S, et al. Sustained human factor VIII expression in hemophilia a mice following systemic delivery of a gutless adenoviral vector. Mol Ther. [Internet]. 2002 [cited 2019 Feb 3];5(1):63–73. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11786047
- Büning H, Srivastava A. Capsid modifications for targeting and improving the efficacy of AAV vectors. Mol Ther Methods Clin Dev. [Internet]. 2019 [cited 2019 Mar 1];12:248–265. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2329050119300117
- Grimm D, Kern A, Rittner K. Novel tools for production and purification of recombinant adenoassociated virus vectors. Hum Gene. [Internet]. 1998 [cited 2017 Jun 7]. Doi:10.1089/hum.1998.9.18-2745
- Grimm D, Büning H. Small but increasingly mighty: latest advances in AAV vector research, design, and evolution. Hum Gene Ther. [Internet]. 2017;28(11):1075–1086. [cited 2019 Feb 3]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28835125.
- Ballana E, Wang J, Venail F, et al. Efficient and specific transduction of cochlear supporting cells by adeno-associated virus serotype 5. Neurosci Lett. [Internet]. 2008;442(2):134–139. [cited 2017 May 30]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18601973
- Kilpatrick LA, Li Q, Yang J, et al. Adeno-associated virus-mediated gene delivery into the scala media of the normal and deafened adult mouse ear. Gene Ther. [Internet]. 2011;18(6):569–578. [cited 2017 May 30]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21209625
- Akil O, Seal R, Burke K, et al. Restoration of hearing in the VGLUT3 knockout mouse using virally mediated gene therapy. Neuron. [Internet]. 2012;75(2):283–293. [cited 2017 Jun 7]; Available from: http://www.sciencedirect.com/science/article/pii/S0896627312004850
- Geng R, Omar A, Gopal SR, et al. Modeling and preventing progressive hearing loss in usher syndrome III. Sci Rep. [Internet]. 2017;7(1):13480. [cited 2019 Feb 3]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/29044151
- Lalwani A, Walsh B, Reilly P, et al. Long-term in vivo cochlear transgene expression mediated by recombinant adeno-associated virus. Gene. [Internet]. 1998. [cited 2017 Jun 7]; Available from: https://www.researchgate.net/profile/Nicholas_Muzyczka/publication/13704852_Long-term_in_vivo_cochlear_transgene_expression_mediated_by_recombinant_adeno-associated_virus/links/540f36050cf2d8daaad09d46.pdf
- Stone I, Lurie D, Kelley M, et al. Adeno-associated virus-mediated gene transfer to hair cells and support cells of the murine cochlea. Mol Ther. [Internet]. 2005;11(6):843–848. [cited 2017 Jun 7]; Available from: http://www.nature.com/mt/journal/v11/n6/full/mt2005103a.html
- Shu Y, Tao Y, Wang Z, et al. Identification of adeno-associated viral vectors that target neonatal and adult mammalian inner ear cell subtypes. Hum Gene Ther. [Internet]. 2016;27(9):687–699. [cited 2018 Jan 31]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27342665
- Landegger LD, Pan B, Askew C, et al. A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear. Nat Biotechnol. [Internet]. 2017;35:280–284. [cited 2018 Jan 31]. Available from. ;(3):. : http://www.ncbi.nlm.nih.gov/pubmed/28165475
- Suzuki J, Hashimoto K, Xiao R, et al. Cochlear gene therapy with ancestral AAV in adult mice: complete transduction of inner hair cells without cochlear dysfunction. Sci Rep. [Internet]. 2017;7(1):45524. [cited 2018 Jan 31]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28367981
- Isgrig K, McDougald DS, Zhu J, et al. AAV2.7m8 is a powerful viral vector for inner ear gene therapy. Nat Commun. [Internet]. 2019;10(1):427. [cited 2019 Jan 29]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/30683875
- György B, Sage C, Indzhykulian AA, et al. Rescue of hearing by gene delivery to inner-ear hair cells using exosome-associated AAV. Mol Ther. [Internet]. 2017 [cited 2018 Jan 31];25:379–391. Available from. ;(2):. : http://www.ncbi.nlm.nih.gov/pubmed/28082074
- Al-Moyed H, Cepeda AP, Jung S, et al. A dual-AAV approach restores fast exocytosis and partially rescues auditory function in deaf otoferlin knock-out mice. EMBO Mol Med. [Internet]. 2013;11(1). [cited 2019 Jan 29]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/30509897.
- Akil O, Dyka F, Calvet C, et al. Dual AAV-mediated gene therapy restores hearing in a DFNB9 mouse model. Proc. [Internet]. 2019 [cited 2019 Mar 1]. Available from: https://www.pnas.org/content/early/2019/02/14/1817537116.short
- Akil O, Blits B, Lustig LR, et al. Virally mediated overexpression of glial-derived neurotrophic factor elicits age- and dose-dependent neuronal toxicity and hearing loss. Hum Gene Ther. [Internet]. 2019;30(1):88–105. [cited 2019 Feb 3]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/30183384
- Lee MY, Kurioka T, Nelson MM, et al. Viral-mediated Ntf3 overexpression disrupts innervation and hearing in nondeafened guinea pig cochleae. Mol Ther Methods Clin Dev. [Internet]. 2016;3:16052. [cited 2018 Jan 31]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27525291
- Praetorius M, Hsu C, Baker K, et al. Adenovector-mediated hair cell regeneration is affected by promoter type. Acta Otolaryngol. 2010;130(2):215–222.
- Nist-Lund CA, Pan B, Patterson A, et al. Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders. Nat Commun. [Internet]. 2019;10(1):236. [cited 2019 Jan 29]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/30670701
- Pfeiffer A, Thalheimer F. In vivo generation of human CD19‐CAR T cells results in B‐cell depletion and signs of cytokine release syndrome. EMBO Mol. [ [Internet]. 2018;10. [cited 2019 Mar 1]; Available from: http://embomolmed.embopress.org/content/10/11/e9158.abstract.
- Bender RR, Muth A, Schneider IC, et al. Receptor-targeted nipah virus glycoproteins improve cell-type selective gene delivery and reveal a preference for membrane-proximal cell attachment. Plemper RK, editor. PLOS Pathog. [ [Internet]. 2016 [cited 2019 Mar 1];12(6):e1005641.
- Buchholz C, Friedel T, Buning H. Surface-engineered viral vectors for selective and cell type-specific gene delivery. Trends Biotechnol. [ [Internet]. 2015;33(12):777–790. [cited 2019 Mar 1]. Available from: https://www.sciencedirect.com/science/article/pii/S0167779915001948
- Hosoya M, Fujioka M, Ogawa K, et al. Distinct expression patterns of causative genes responsible for hereditary progressive hearing loss in non-human primate cochlea. Sci Rep. [Internet]. 2016;6(1):1–12.
- Liu W, Edin F, Blom H, et al. Super-resolution structured illumination fluorescence microscopy of the lateral wall of the cochlea: the Connexin26/30 proteins are separately expressed in man. Cell Tissue Res. [Internet]. 2016 [cited 2019 Feb 3].
- Jero J, Mhatre AN, Tseng CJ, et al. Cochlear gene delivery through an intact round window membrane in mouse. Hum Gene Ther. [Internet]. 2001 [cited 2019 Feb 3];12:539–548. Available from. ;(5):…
- Shibata SB, Yoshimura H, Ranum PT, et al. Intravenous rAAV2/9 injection for murine cochlear gene delivery. Sci Rep. [Internet]. 2017 [cited 2019 Mar 1];7:9609. Available from. ;(1):. : http://www.nature.com/articles/s41598-017-09805-x
- Yoshimura H, Shibata S, Ranum P, et al. Enhanced viral-mediated cochlear gene delivery in adult mice by combining canal fenestration with round window membrane inoculation. Sci Rep. [Internet]. 2018 [cited 2019 Feb 25]; Available from. ;8(1). . : https://www.nature.com/articles/s41598-018-21233-z
- Ritter FN, Lawrence M. A histological and experimental study of cochlear aqueduct patency in the adult human. Laryngoscope. [Internet]. 1965;75(8):1224???1233. [cited 2019 Dec 7].
- Gopen Q, Rosowski JJ, Merchant SN. Anatomy of the normal human cochlear aqueduct with functional implications. Hear Res. 2007;28(1–2):9–22.
- Marchbanks RJ, Reid A. Cochlear and cerebrospinal fluid pressure: their inter-relationship and control mechanisms. Br J Audiol. 2012;7(3):179–187.
- Avci E, Nauwelaers T, Lenarz T, et al. Variations in microanatomy of the human cochlea. J Comp Neurol. [Internet]. 2014;522(14):3245–3261. [cited 2019 Dec 7].
- Staecker H, Klickstein L, Brough DE. Developing a molecular therapeutic for hearing loss. In: Colleen G, Le PrellEdward LobarinasArthur N, PopperRichard R. Fay, editors. Springer Handbook of Auditory Research Vol 58, Springer Verlag, New York. 2016. p. 197–217.
- Dai C, Lehar M, Sun DQ, et al. Rhesus cochlear and vestibular functions are preserved after inner ear injection of saline volume sufficient for gene therapy delivery. JARO J Assoc Res Otolaryngol. 2017;18(4):601–617.
- Gassner D, Durham D, Pfannenstiel SC, et al. Canalostomy as a surgical approach for cochlear gene therapy in the rat. Anat Rec. 2012;295(11):1830–1836.
- Shi X, Wu N, Zhang Y, et al. Adeno-associated virus transformation into the normal miniature pig and the normal guinea pigs cochlea via scala tympani. Acta Otolaryngol. [Internet]. 2017;137(9):910–916. [cited 2018 Jan 28].
- Bedrosian JC, Gratton MA, Brigande JV, et al. In vivo delivery of recombinant viruses to the fetal murine cochlea: transduction characteristics and long-term effects on auditory function. Mol Ther. [Internet]. 2006;14(3):328–335. [cited 2019 Feb 23]. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1525001606001419
- Tornabene P, Trapani I, Minopoli R. Intein-mediated protein trans-splicing expands adeno-associated virus transfer capacity in the retina. Sci Transl. [Internet]. 2019;11(492):eaav4523. [cited 2019 Dec 12]. Available from: https://stm.sciencemag.org/content/11/492/eaav4523.abstract
- Zou B, Mittal R, Grati M, et al. The application of genome editing in studying hearing loss. Hear Res. [[Internet]. 2015;327:102–108. [cited 2017 May 30]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25987504