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Expert Review of Precision Medicine and Drug Development
Personalized medicine in drug development and clinical practice
Volume 9, 2024 - Issue 1
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Review

Precision Medicine Paradigms in Allergic Rhinitis: Navigating Immunotherapy and Digital Healthcare

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Pages 29-41 | Received 28 Dec 2023, Accepted 25 Jun 2024, Published online: 21 Jul 2024

References

  • Wang X, Du K, She W, et al. Recent advances in the diagnosis of allergic rhinitis. Expert Rev Clin Immunol. 2018;14(11):957–964. doi: 10.1080/1744666X.2018.1530113
  • Proper SP, Azouz NP, Mersha TB. Mersha TBJFiI. Achieving precision medicine in allergic disease: progress and challenges. Front Immunol. 2021;12:720746. doi: 10.3389/fimmu.2021.720746
  • Council NR, Earth Do, Studies L, et al. Toward precision medicine: building a knowledge network for biomedical research and a new taxonomy of disease. 2011.
  • Rubin MAJN. Health: make precision medicine work for cancer care. Nature. 2015;520(7547):290–291. doi: 10.1038/520290a
  • Khoury MJ, Iademarco MF, WTJAjopm R. Precision public health for the era of precision medicine. 2016;50(3):398. doi: 10.1016/j.amepre.2015.08.031
  • Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med. 2001;344(11):783–792. doi: 10.1056/NEJM200103153441101
  • Flory JH, Sleiman PM, Christie JD, et al. 17q12-21 variants interact with smoke exposure as a risk factor for pediatric asthma but are equally associated with early-onset versus late-onset asthma in North Americans of European ancestry. J Allergy Clin Immunol. 2009;124(3):605–607. doi: 10.1016/j.jaci.2009.05.047
  • Beccia F, Causio FA, Hoxhaj I, et al. Integrating China in the international consortium for personalised medicine. A position paper on healthcare professionals’ education and citizens’ empowerment in personalised medicine. 2023;23(1):438. doi: 10.1186/s12909-023-04420-z
  • König IR, Fuchs O, Hansen G, et al. What is precision medicine? Eur Respir J. 2017;50(4):1700391. doi: 10.1183/13993003.00391-2017
  • Montella S, Baraldi E, Cazzato S, et al. Severe asthma features in children: a case–control online survey. Ital J Pediatr. 2016;42(1):1–9. doi: 10.1186/s13052-016-0217-z
  • von Mutius E. von Mutius EJJoa, immunology c. Influences in allergy: epidemiology and the environment. 2004;113(3):373–379. doi: 10.1016/j.jaci.2003.12.040
  • Wise SK, Damask C, Roland LT, et al., editors. International consensus statement on allergy and rhinology: allergic rhinitis–2023. In International forum of allergy & rhinology. Wiley Online Library; 2023.
  • Bauchau V, Sjerj D. Prevalence and rate of diagnosis of allergic rhinitis in Europe. Eur Respir J. 2004;24(5):758–764. doi: 10.1183/09031936.04.00013904
  • Licari A, Caimmi S, Bosa L, et al. Rhinosinusitis and asthma: a very long engagement. Int J Immunopathol Pharmacol. 2014;27(4):499–508. doi: 10.1177/039463201402700405
  • Bousquet J, Pfaar O, Agache I, et al. ARIA‐EAACI care pathways for allergen immunotherapy in respiratory allergy. 2021;11(4):e12014.
  • Cirillo I, Marseglia G, Klersy C, et al. Allergic patients have more numerous and prolonged respiratory infections than nonallergic subjects. Allergy. 2007;62(9):1087–1090. doi: 10.1111/j.1398-9995.2007.01401.x
  • Brambilla I, Pusateri A, Pagella F, et al. Adenoids in children: advances in immunology, diagnosis, and surgery. 2014;27(3):346–352. doi: 10.1002/ca.22373
  • Marseglia GL, Pagella F, Klersy C, et al. The 10-day mark is a good way to diagnose not only acute rhinosinusitis but also adenoiditis, as confirmed by endoscopy. 2007;71(4):581–583. doi: 10.1016/j.ijporl.2006.12.003
  • Hoyte FC, Hsjf N. Recent advances in allergic rhinitis. F1000Res. 2018;7:1333. doi: 10.12688/f1000research.15367.1
  • Ortiz RA, Kcji B, Clinics A. Genetics of allergic diseases. Immunol Allergy Clin North Am. 2015;35(1):19–44. doi: 10.1016/j.iac.2014.09.014
  • Qin Z, Xie L, Li W, et al. New Insights into Mechanisms Traditional Chinese Medicine for Allergic Rhinitis by Regulating Inflammatory and Oxidative Stress Pathways. J Asthma Allergy. 2024;Volume 17:97–112. doi: 10.2147/JAA.S444923
  • Watanabe K, Matsuura K, Gao P, et al. Traditional Japanese Kampo medicine: clinical research between modernity and traditional medicine—the state of research and methodological suggestions for the future. Evidence-Based Complementary Altern Med. 2011;2011(1). doi: 10.1093/ecam/neq067
  • Dahanayake JM, Perera PK, Galappaththy P, et al. Efficacy and safety of two Ayurvedic dosage forms for allergic rhinitis: Study protocol for an open-label randomized controlled trial. Trials. 2020;21(1):1–8. doi: 10.1186/s13063-019-4004-1
  • Mahomoodally MFJE-bc, medicine a. Traditional medicines in Africa: an appraisal of ten potent African medicinal plants. 2013;
  • Rasool R, Shera IA, Nissar S, et al. Role of skin prick test in allergic disorders: a prospective study in kashmiri population in light of review. 2013;58(1):12–17. doi: 10.4103/0019-5154.105276
  • Ansotegui IJ, Melioli G, Canonica GW, et al. IgE allergy diagnostics and other relevant tests in allergy. World Allergy Organ Position Pap. 2020;13(2):100080. doi: 10.1016/j.waojou.2019.100080
  • Agache I, Bilò M, Braunstahl GJ, et al. In vivo diagnosis of allergic diseases-allergen provocation tests. Allergy. 2015;70(4):355–365. doi: 10.1111/all.12586
  • González-Pérez R, El-Qutob D, Letrán A, et al. Precision medicine in mite allergic rhinitis Front. Allergy. 2021;2:724727. doi: 10.3389/falgy.2021.724727
  • Angjeli E, Gomes P, Lane KJ, et al. Technical and clinical validation of the Allergen BioCube® for Timothy grass. 2017;5(1):78–84. doi: 10.1002/iid3.143
  • Jeon H, Jung JH, Kim Y, et al. Allergen microarrays for in vitro diagnostics of allergies: comparison with ImmunoCAP and AdvanSure. 2018;38(4):338. doi: 10.3343/alm.2018.38.4.338
  • Anto JM, Bousquet J, Akdis M, et al. Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes. 2017;139(2):388–399. doi: 10.1016/j.jaci.2016.12.940
  • Hoffmann H, Santos A, Mayorga C, et al. The clinical utility of basophil activation testing in diagnosis and monitoring of allergic disease. 2015;70(11):1393–1405. doi: 10.1111/all.12698
  • Bousquet J, Pfaar O, Togias A, et al. 2019 ARIA Care pathways for allergen immunotherapy. Alergologia 2019;4(3):2087–2102. doi: 10.26416/Aler.3.4.2019.2749
  • Allen K, Canonica GW, Ansotegui IJ, et al. A WAO-ARIA-GA2LEN consensus document on molecular-based allergy diagnostics. 2013;6(1).
  • Matricardi P, Kleine‐Tebbe J, Hoffmann H, et al. EAACI molecular allergology user’s guide. 2016;27:1–250. doi: 10.1111/pai.12563
  • Luengo O, Cardona VJC, allergy t. Component resolved diagnosis: when should it be used? Clin Transl Allergy. 2014;4(1):1–9. doi: 10.1186/2045-7022-4-28
  • Barber D, Moreno C, Ledesma A, et al. Degree of olive pollen exposure and sensitization patterns. Clin Implic. 2007;17(Suppl 1):11–16.
  • Douladiris N, Savvatianos S, Roumpedaki I, et al. A molecular diagnostic algorithm to guide pollen immunotherapy in southern Europe: towards component-resolved management of allergic diseases. 2013;162(2):163–172. doi: 10.1159/000353113
  • Kucuksezer UC, Ozdemir C, Cevhertas L, et al. Mechanisms of allergen-specific immunotherapy and allergen tolerance. 2020;69(4):549–560. doi: 10.1016/j.alit.2020.08.002
  • Johnson L, Duschl A, Himly MJV. Nanotechnology-based vaccines for allergen-specific immunotherapy: Potentials and challenges of conventional and novel adjuvants under research. 2020;8(2):237. doi: 10.3390/vaccines8020237
  • Tsabouri S, Tseretopoulou X, Priftis K, et al. Omalizumab for the treatment of inadequately controlled allergic rhinitis: a systematic review and meta-analysis of randomized clinical trials. J Allergy Clin Immunol Pract. 2014;2(3):332–340. e1. doi: 10.1016/j.jaip.2014.02.001
  • Tsetsos N, Goudakos JK, Daskalakis D, et al. Monoclonal antibodies for the treatment of chronic rhinosinusitis with nasal polyposis: a systematic review. 2018;56(1):11–21. doi: 10.4193/Rhin17.156
  • Khwaja S, Kumar B, Philpott C, et al. Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials. 2019.
  • Ghadersohi STan BKJOCoNA. Contemporary pharmacotherapy for allergic rhinitis and chronic rhinosinusitis. Otolaryngol Clin North Am. 2017;50(6):1135–1151. doi: 10.1016/j.otc.2017.08.009
  • Oakley GM, Harvey RJ, VJJCa L, et al. The role of macrolides in chronic rhinosinusitis (CRSsNP and CRSwNP). Curr Allergy Asthma Rep. 2017;17(5):1–10. doi: 10.1007/s11882-017-0696-z
  • Hellings PW, Klimek L, Cingi C, et al. Non‐allergic rhinitis: position paper of the European Academy of Allergy and Clinical Immunology. 2017;72(11):1657–1665. doi: 10.1111/all.13200
  • Klimek L, Dollner R, Pfaar O, et al. Aspirin desensitization: useful treatment for chronic rhinosinusitis with nasal polyps (CRSwNP) in aspirin-exacerbated respiratory disease (AERD)? Curr Allergy Asthma Rep. 2014;14(6):1–9. doi: 10.1007/s11882-014-0441-9
  • Malmberg H, Grahne B, Holopainen E, et al. Ipratropium (Atrovent) in the treatment of vasomotor rhinitis of elderly patients. 1983;8(4):273–276. doi: 10.1111/j.1365-2273.1983.tb01441.x
  • Van Gerven L, Steelant B, Hellings PJA. Nasal hyperreactivity in rhinitis: A diagnostic and therapeutic challenge. 2018;73(9):1784–1791. doi: 10.1111/all.13453
  • Agache I, CAJTJoci A. Precision medicine and phenotypes, endotypes, genotypes, regiotypes, and theratypes of allergic diseases. J Clin Investigation. 2019;129(4):1493–1503. doi: 10.1172/JCI124611
  • Shiraishi Y, Takeda K, Domenico J, et al. Role of prostaglandin D2 and CRTH2 blockade in early- and late-phase nasal responses. Clin Exp Allergy. 2014;44(8):1076–1082. doi: 10.1111/cea.12280
  • Krug N, Gupta A, Badorrek P, et al. Efficacy of the oral chemoattractant receptor homologous molecule on TH2 cells antagonist BI 671800 in patients with seasonal allergic rhinitis. J Allergy Clin Immunol. 2014;133(2):414–419. e8. doi: 10.1016/j.jaci.2013.10.013
  • Ratner P, Andrews CP, Hampel FC, et al. Efficacy and safety of setipiprant in seasonal allergic rhinitis: results from Phase 2 and Phase 3 randomized, double-blind, placebo-and active-referenced studies. Allergy, Asthma & Clin Immunol. 2017;13(1):1–15. doi: 10.1186/s13223-017-0183-z
  • Voukantsis D, Berger U, Tzima F, et al. Personalized symptoms forecasting for pollen-induced allergic rhinitis sufferers. Int J Biometeorol. 2015;59(7):889–897. doi: 10.1007/s00484-014-0905-6
  • Meurs H, Zaagsma J, Maarsingh H, et al. Recent patents in allergy/immunology: use of arginase inhibitors in the treatment of asthma and allergic rhinitis. 2019;74(6):1206. doi: 10.1111/all.13770
  • Liu AH, Anderson WC III, Dutmer CM, et al. Advances in asthma 2015: Across the lifespan. 2016;138(2):397–404. doi: 10.1016/j.jaci.2016.06.013
  • Brockow KJA. Dilemmas of allergy diagnosis in perioperative anaphylaxis. 2014;69(10):1265–1266. doi: 10.1111/all.12485
  • Vidal C, Porras-Hurtado L, Cruz R, et al. Association of thromboxane A1 synthase (TBXAS1) gene polymorphism with acute urticaria induced by nonsteroidal anti-inflammatory drugs. 2013;132(4):989–991. doi: 10.1016/j.jaci.2013.04.045
  • Khan DA, EjjjoA P, Immunology C. Pharmacogenomic biomarkers in allergy and immunology practice. J Allergy Clin Immunol. 2020;146(3):509–512. doi: 10.1016/j.jaci.2020.05.050
  • Murrison LB, Brandt EB, Myers JB, et al. Environmental exposures and mechanisms in allergy and asthma development. 2019;129(4):1504–1515. doi: 10.1172/JCI124612
  • Bousquet J, Devillier P, Arnavielhe S, et al. Treatment of allergic rhinitis using mobile technology with real‐world data: the MASK observational pilot study. 2018;73(9):1763–1774. doi: 10.1111/all.13406
  • Munteanu LA, Frandes M, Timar B, et al. The efficacy of a mobile phone application to improve adherence to treatment and self-management in people with chronic respiratory disease in Romanian population–a pilot study. BMC Health Serv Res. 2020;20(1):1–11. doi: 10.1186/s12913-020-05340-0
  • Nebeker C, Parrish EM, Graham S. The AI-powered digital health sector: ethical and regulatory considerations when developing digital mental health tools for the older adult demographic. In: Artificial Intelligence in Brain and Mental Health: Philosophical, Ethical & Policy Issues. Springer; 2022. p. 159–176.
  • Breiteneder H, Diamant Z, Eiwegger T, et al. Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care. 2019;74(12):2293–2311. doi: 10.1111/all.13851
  • Licari A, Castagnoli R, Tosca MA, et al. Personalized therapies for the treatment of allergic rhinitis. 2019;4(5):275–281. doi: 10.1080/23808993.2019.1681896
  • Zhang Y, Lan F, Zhang LJA. Advances and highlights in allergic rhinitis. 2021;76(11):3383–3389. doi: 10.1111/all.15044
  • Li H, Chen S, Cheng L, et al. Chinese guideline on sublingual immunotherapy for allergic rhinitis and asthma. 2019;11(12):4936.
  • Dhami S, Nurmatov U, Arasi S, et al. Allergen immunotherapy for allergic rhinoconjunctivitis: a systematic review and meta‐analysis. 2017;72(11):1597–1631. doi: 10.1111/all.13201
  • Rudin RS, Fischer SH, Y SHI, et al. Trends in the use of clinical decision support by health system–affiliated ambulatory clinics in the united states. 2019;7(4):4–10.
  • Sutton RT, Pincock D, Baumgart DC, et al. An overview of clinical decision support systems: benefits, risks, and strategies for success. 2020;3(1):17. doi: 10.1038/s41746-020-0221-y
  • Prgomet M, Li L, Niazkhani Z, et al. Impact of commercial computerized provider order entry (CPOE) and clinical decision support systems (CDSSs) on medication errors, length of stay, and mortality in intensive care units: a systematic review and meta-analysis. 2017;24(2):413–422. doi: 10.1093/jamia/ocw145
  • Dramburg S, Marchante Fernández M, Potapova E, et al. The potential of clinical decision support systems for prevention, diagnosis, and monitoring of allergic diseases. 2020;11:575892. doi: 10.3389/fimmu.2020.02116
  • Costa C, Menesatti P, Brighetti M, et al. Pilot study on the short-term prediction of symptoms in children with hay fever monitored with e-Health technology. Eur Ann Allergy Clin Immunol. 2014;46(6):216–225.
  • Matricardi PM, Dramburg S, Alvarez‐Perea A, et al. The role of mobile health technologies in allergy care: An EAACI position paper. 2020;75(2):259–272. doi: 10.1111/all.13953
  • Correia de Sousa J. ARIA 2016: care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle. 2016.
  • Ridolo E, Incorvaia C, Pucciarini F, et al. Current treatment strategies for seasonal allergic rhinitis: where are we heading? 2022;20(1):9. doi: 10.1186/s12948-022-00176-x
  • Shamji MH, Valenta R, Jardetzky T, et al. The role of allergen‐specific IgE, IgG and IgA in allergic disease. 2021;76(12):3627–3641. doi: 10.1111/all.14908
  • Kauppinen Z, Rautiainen T, Mäntyjärvi V, et al. Mutant derivatives of the main respiratory allergen of cow are less allergenic than the intact molecule. Clin & Exp Allergy. 1999;29(7):989–996. doi: 10.1046/j.1365-2222.1999.00605.x
  • Shen L, Kapsogeorgou EK, Yu M, et al. Evaluation of salivary gland protein 1 antibodies in patients with primary and secondary Sjogren’s syndrome. 2014;155(1):42–46. doi: 10.1016/j.clim.2014.08.009
  • Yen C-Y, Yu C-H, Tsai J-J, et al. Effects of local nasal immunotherapy with FIP-fve peptide and denatured Tyrophagus putrescentiae for storage mite-induced airway inflammation. 2022;70(1):6. doi: 10.1007/s00005-022-00645-w
  • Kasemsuk N, Ngaotepprutaram P, Kanjanawasee D, et al., editors. Local nasal immunotherapy for allergic rhinitis: a systematic review and meta‐analysis. In International Forum of Allergy & Rhinology. Wiley Online Library; 2022.
  • Ridolo E, Incorvaia C, Heffler E, et al. The present and future of allergen immunotherapy in personalized medicine. 2022;12(5):774.
  • Dhami S, Kakourou A, Asamoah F, et al. Allergen immunotherapy for allergic asthma: a systematic review and meta‐analysis. 2017;72(12):1825–1848. doi: 10.1111/all.13208
  • Larenas‐Linnemann D, Antolín‐Amérigo D, Parisi C, et al. National clinical practice guidelines for allergen immunotherapy: an international assessment applying AGREE‐II. 2018;73(3):664–672. doi: 10.1111/all.13316
  • Huang Y, Wang C, Wang X, et al. Efficacy and safety of subcutaneous immunotherapy with house dust mite for allergic rhinitis: a meta‐analysis of randomized controlled trials. 2019;74(1):189–192. doi: 10.1111/all.13583
  • Jarkvist J, Salehi C, Akin C, et al. Venom immunotherapy in patients with clonal mast cell disorders: IgG4 correlates with protection. 2020;75(1):169–177. doi: 10.1111/all.13980
  • Tam H, Calderon MA, Manikam L, et al. Specific allergen immunotherapy for the treatment of atopic eczema. Database Systematic Rev. 2016 2;2016(2). doi: 10.1002/14651858.CD008774.pub2
  • Reier‐Nilsen T, Michelsen MM, Lødrup Carlsen KC, et al. Feasibility of desensitizing children highly allergic to peanut by high‐dose oral immunotherapy. 2019;74(2):337–348. doi: 10.1111/all.13604
  • Chu DK, Wood RA, French S, et al. Oral immunotherapy for peanut allergy (PACE): a systematic review and meta-analysis of efficacy and safety. 2019;393(10187):2222–2232. doi: 10.1016/S0140-6736(19)30420-9
  • Senti G, Freiburghaus AU, Larenas-Linnemann D, et al. Intralymphatic immunotherapy: update and unmet needs. 2019;178(2):141–149. doi: 10.1159/000493647
  • Witten M, Malling H-J, Blom L, et al. Is intralymphatic immunotherapy ready for clinical use in patients with grass pollen allergy? J Allergy And Clin Immunol. 2013;132(5):1248–1252. e5. doi: 10.1016/j.jaci.2013.07.033
  • Jones SM, Sicherer SH, Burks AW, et al. Epicutaneous immunotherapy for the treatment of peanut allergy in children and young adults. J Allergy Clin Immunol. 2017;139(4):1242–1252. e9. doi: 10.1016/j.jaci.2016.08.017
  • Pongracic JA, Gagnon R, Sussman G, et al. Safety of epicutaneous immunotherapy in peanut-allergic children: REALISE randomized clinical trial results. J Allergy Clin Immunol Pract. 2022;10(7):1864–1873. e10. doi: 10.1016/j.jaip.2021.11.017
  • Mondoulet L, Dioszeghy V, Busato F, et al. Gata3 hypermethylation and Foxp3 hypomethylation are associated with sustained protection and bystander effect following epicutaneous immunotherapy in peanut‐sensitized mice. 2019;74(1):152–164. doi: 10.1111/all.13479
  • Spergel JM, Elci OU, Muir AB, et al. Efficacy of epicutaneous immunotherapy in children with milk-induced eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2020;18(2):328–336. e7. doi: 10.1016/j.cgh.2019.05.014
  • Jeny F, Uzunhan Y, Lacroix M, et al. Predictors of mortality in fibrosing pulmonary sarcoidosis. 2020;169:105997. doi: 10.1016/j.rmed.2020.105997
  • Fricke-Galindo I, Ortega-Vázquez A, Monroy-Jaramillo N, et al. Allele and genotype frequencies of genes relevant to anti-epileptic drug therapy in Mexican-Mestizo healthy volunteers. 2016;17(17):1913–1930.
  • AJIrop G. Complexities of CYP2D6 gene analysis and interpretation. Int Rev Psychiatry. 2013;25(5):534–553. doi: 10.3109/09540261.2013.825581
  • Sim S, Kacevska M, Ingelman-Sundberg MJTpj. Pharmacogenomics of drug-metabolizing enzymes: a recent update on clinical implications and endogenous effects. Pharmacogenomics J. 2013;13(1):1–11. doi: 10.1038/tpj.2012.45