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Toxicology Communications Volume 3, 2019 - Issue 1
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Case Reports

Massive lamotrigine and bupropion overdose resulting in status epilepticus without cardiovascular collapse

Rebecca E. BruccoleriDivision of General Pediatrics, Boston Children’s Hospital, Boston, MA, USA; Correspondence[email protected]
View further author information
,
Bradley L. DemeterEmergency Medicine, Brigham and Women’s Hospital, Boston, MA, USA; View further author information
,
Peter R. ChaiEmergency Medicine, Beverly Hospital, Beverly, MA, USA; View further author information
&
Michele M. BurnsEmergency Medicine, Program in Medical Toxicology, Boston Children’s Hospital, Boston, MA, USAView further author information
Pages 102-105 | Published online: 22 Dec 2019

References

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  • Catalano G, Catalano MC, Hanley PF. Seizures associated with buspirone overdose: case report and literature review. Clin Neuropharmacol. 1998;21(6):347–350.
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  • Moore PW, Donovan JW, Burkhart KK, et al. A case series of patients with lamotrigine toxicity at one center from 2003-2012. Clin Toxicol. 2013;51(7):545–549.
  • Chavez P, Casso Dominguez A, Herzog E. Evolving electrographic changes in lamotrigine overdose: a case report and literature review. Cardiovasc Toxicol. 2015;15(4):394–398.
  • Hajiali F, Nassiri-Asl M. Report of sever menorrhagia following maximum amount of lamotrigine overdose. Iran J Pharmaceut Res. 2015;14(4):1289–1293.
  • Sirianni AJ, Osterhoudt KC, Calello DP, et al. Use of lipid emulsion in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotrigine. Ann Emerg Med. 2008;51(4):412–415.
  • Castanares-Zapatero D, Wittebole X, Huberlant V, et al. Lipid emulsion therapy as rescue therapy in lamotrigine overdose. J Emerg Med. 2012;42(1):48–51.
  • Alyahya B, Friesen M, Nauche B, et al. Acute lamotrigine overdose: a systematic review of published adult and pediatric cases. Clin Toxicol. 2018;56(2):81–89.
  • Sethi NK, Douyon P, Kaunzner U, Sethi PK, et al. Delayed status epilepticus due to bupropion and lamotrigine overdose. East J Med 2013;18:142–144.

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