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Toxicology Communications Volume 4, 2020 - Issue 1
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Case Report

Use of fomepizole as an adjunct in the treatment of acetaminophen overdose: a case series

Garrett Rampona Saint Louis University School of Medicine, SSM Health Saint Louis University Hospital, SSM Health Cardinal Glennon Children’s Hospital, Saint Louis, MO, USA;b Department of Internal Medicine, SSM Health Saint Louis University Hospital, SSM Health Cardinal Glennon Children’s Hospital, Saint Louis, MO, USACorrespondence[email protected]
,
Haley Wartmana Saint Louis University School of Medicine, SSM Health Saint Louis University Hospital, SSM Health Cardinal Glennon Children’s Hospital, Saint Louis, MO, USA
,
Stephen Osmona Saint Louis University School of Medicine, SSM Health Saint Louis University Hospital, SSM Health Cardinal Glennon Children’s Hospital, Saint Louis, MO, USA;b Department of Internal Medicine, SSM Health Saint Louis University Hospital, SSM Health Cardinal Glennon Children’s Hospital, Saint Louis, MO, USA;c Division of Pulmonary & Critical Care, SSM Health Saint Louis University Hospital, SSM Health Cardinal Glennon Children’s Hospital, Saint Louis, MO, USA
&
Anthony Scalzoa Saint Louis University School of Medicine, SSM Health Saint Louis University Hospital, SSM Health Cardinal Glennon Children’s Hospital, Saint Louis, MO, USA;b Department of Internal Medicine, SSM Health Saint Louis University Hospital, SSM Health Cardinal Glennon Children’s Hospital, Saint Louis, MO, USA;d Division of Toxicology, SSM Health Saint Louis University Hospital, SSM Health Cardinal Glennon Children’s Hospital, Saint Louis, MO, USA
Pages 1-4 | Published online: 25 Dec 2019

References

  • McGill MR, Jaeschke H. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. Pharm Res. 2013; 30(9):2174–2187.
  • Heard KJ. Acetylcysteine for acetaminophen poisoning. N Engl J Med. 2008;359(3):285–292.
  • Rumack BH, Bateman DN. Acetaminophen and acetylcysteine dose and duration: past, present and future. Clin Toxicol. 2012;50(2):91–98.
  • Doyon S, Klein-Schwartz W. Hepatotoxicity despite early administration of intravenous N-acetylcysteine for acute acetaminophen overdose. Acad Emerg Med. 2009;16(1):34–39.
  • Whyte IM, Francis B, Dawson AH. Safety and efficacy of intravenous N-acetylcysteine for acetaminophen overdose: analysis of the Hunter Area Toxicology Service (HATS) database. Curr Med Res Opin. 2007;23(10):2359–2368.
  • McMartin KE, Sebastian CS, Dies D, et al. Kinetics and metabolism of fomepizole in healthy humans. Clin Toxicol. 2012;50(5):375–383.
  • Hazai E, Vereczkey L, Monostory K. Reduction of toxic metabolite formation of acetaminophen. Biochem Biophys Res Commun. 2002;291(4):1089–1094.
  • Akakpo JY, Ramachandran A, Kandel SE, et al. 4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes. Hum Exp Toxicol. 2018;37(12):1310–1322.
  • Akakpo JY, Ramachandran A, Duan L, et al. Delayed treatment with 4-methylpyrazole protects against acetaminophen hepatotoxicity in mice by inhibition of c-Jun n-Terminal Kinase. Toxicol Sci. 2019;170(1):57–68.
  • Yip L, Heard K. Potential adjunct treatment for high-risk acetaminophen overdose. Clin Toxicol. 2016;54(5):459–459. [Epub 2016 Feb 26].
  • Johnson MT, McCammon CA, Mullins ME, et al. Evaluation of a simplified N-acetylcysteine dosing regimen for the treatment of acetaminophen toxicity. Ann Pharmacother. 2011;45(6):713–720.
  • Mullins ME, Yarema MC, Sivilotti MLA, et al. Comment on “transition to two-bag intravenous acetylcysteine for acetaminophen overdose”. Clin Toxiocol. 2019:1–3. doi: 10.1080/15563650.2019.1649418
  • Kiernan EA, Fritzges JA, Henry KA, et al. A case report of massive acetaminophen poisoning treated with a novel “triple therapy: N-acetylcysteine, 4-methypyrazole and hemodialysis”. Case Rep Emerg Med. 2019;2019:1–4.
  • Gosselin S, on behalf of the Extrip Workgroup, Juurlink DN, Kielstein JT, Ghannoum M, Laverge V, Nolin TD, Hoffman RS, Extrip W. Extracorporeal treatment of acetaminophen poisoning: recommendations from the EXTRIP workgroup. Clin Toxicol. 2014;52(8):856–867.

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