Adverse reactions in patients treated with the one-bag method of N-acetylcysteine for acetaminophen ingestion

References

• Gummin DD, Mowry JB, Spyker DA, et al. 2018 Annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 36th annual report. Clin Toxicol (Phila). 2019;57(12):1220–1413.
   PubMed Web of Science ®Google Scholar
• Myers RP, Li B, Fong A, et al. Hospitalizations for acetaminophen overdose: a Canadian population-based study from 1995 to 2004. BMC Public Health 2007;7(1):143.
   Google Scholar
• Prescott LF, Illingworth RN, Critchley JA, et al. Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning. Br Med J. 1979; 2(6198):1097–1100.
   PubMed Web of Science ®Google Scholar
• Acetadote® package insert. Nashville (TN): Cumberland Pharmaceuticals Inc. [accessed 2019 31 May]. Available from: http://acetadote.com/acetadote-prescribing-information-11-2016.pdf.
   Google Scholar
• Bonfiglio MF, Traeger SM, Hulisz DT, et al. Anaphylactoid reaction to intravenous acetylcysteine associated with electrocardiographic abnormalities. Ann Pharmacother. 1992;26(1):22–25. https://journals.sagepub.com/doi/10.1177/106002809202600105
   Web of Science ®Google Scholar
• Sandilands EA, Morrison EE, Bateman DN. Adverse reactions to intravenous acetylcysteine in paracetamol poisoning. Adv Drug React Bull. 2016; 297:1147–1150.
   Google Scholar
• Yarema M, Chopra J, Sivilotti MLA, et al. Anaphylactoid reactions to intravenous N-acetylcysteine during treatment for acetaminophen poisoning. J Med Toxicol. 2018;14(2):120–127.
   PubMed Web of Science ®Google Scholar
• Mullins ME, Dribben WH, Halcomb SE, et al. Comment: frequency of medication errors with intravenous acetylcysteine for acetaminophen overdose. Ann Pharmacother. 2008;42(12):1914–1915.
   Web of Science ®Google Scholar
• Johnson MT, McCammon CA, Mullins ME, et al. Evaluation of a simplified N-acetylcysteine dosing regimen for the treatment of acetaminophen toxicity. Ann Pharmacother. 2011;45(6):713–720.
   PubMed Web of Science ®Google Scholar
• Schwarz ES, Mullins ME, Liss DB. When two is not better than one. Br J Clin Pharmacol. 2017;83(10):2310–2311.
   Web of Science ®Google Scholar
• Mullins ME, Yarema MC, Sivilotti MLA, et al. Comment on “Transition to two-bag intravenous acetylcysteine for acetaminophen overdose". Clin Toxicol (Phila). 2020;58(5):433–435.
   PubMed Web of Science ®Google Scholar
• Benchimol EI, Smeeth L, Guttmann A, et al., RECORD Working Committee. The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) Statement. PLoS Med. 2015; 12(10):e1001885.
   PubMed Web of Science ®Google Scholar
• Hayes BD, Klein-Schwartz W, Doyon S. Frequency of medication errors with intravenous acetylcysteine for acetaminophen overdose. Ann Pharmacother. 2008;42(6):766–770.
   PubMed Web of Science ®Google Scholar
• Ferner RE, Langford NJ, Anton C, et al. Random and systematic medication errors in routine clinical practice: a multicentre study of infusions, using acetylcysteine as an example. Br J Clin Pharmacol. 2001;52(5):573–577.
   PubMed Web of Science ®Google Scholar
• Bailey GP, Wood DM, Archer JR, et al. An assessment of the variation in the concentration of acetylcysteine in infusions for the treatment of paracetamol overdose. Br J Clin Pharmacol. 2017;83(2):393–399.
   Web of Science ®Google Scholar
• Bailey GP, Najafi J, Elamin MEMO, et al. Delays during the administration of acetylcysteine for the treatment of paracetamol overdose. Br J Clin Pharmacol. 2016;82(5):1358–1363.
   PubMed Web of Science ®Google Scholar
• Awad NI, Geib AJ, Roy A, et al. Protocol deviations in intravenous acetylcysteine therapy for acetaminophen toxicity. Am J Emerg Med. 2020. (online ahead of print). DOI:10.1016/j.ajem.2019.158405
   Web of Science ®Google Scholar
• Bailey B, Blais R, Letarte A. Status epilepticus after a massive intravenous N-acetylcysteine overdose leading to intracranial hypertension and death. Ann Emerg Med. 2004;44(4):401–406.
   PubMed Web of Science ®Google Scholar
• Heard K, Schaeffer TH. Massive acetylcysteine overdose associated with cerebral edema and seizures. Clin Toxicol (Phila). 2011;49(5):423–425.
   Web of Science ®Google Scholar
• Mullins ME, Vitkovitsky IV. Hemolysis and hemolytic uremic syndrome following five-fold N-acetylcysteine overdose. Clin Toxicol (Phila). 2011;49(8):755–759.
   Web of Science ®Google Scholar
• Personne M. A 10-fold dose of N-acetylcysteine with fatal consequences. Clin Toxicol (Phila). 2018;56(6):446–446.
   PubMed Web of Science ®Google Scholar
• Thanacoody HKR, Gray A, Dear JW, et al. Scottish and Newcastle antiemetic pre-treatment for paracetamol poisoning study (SNAP). BMC Pharmacol Toxicol. 2013; 14(20):20–12.
   Google Scholar
• Chiew AL, Isbister GK, Duffull SB, et al. Evidence for the changing regimens of acetylcysteine. Br J Clin Pharmacol. 2016;81(3):471–481.
   PubMed Web of Science ®Google Scholar
• Wong A, Graudins A. Simplification of the standard three-bag intravenous acetylcysteine regimen for paracetamol poisoning results in a lower incidence of adverse drug reactions. Clin Toxicol (Phila). 2016;54(2):115–119.
   PubMed Web of Science ®Google Scholar
• McNulty R, Lim JME, Chandru P, et al. Fewer adverse effects with a modified two-bag acetylcysteine protocol in paracetamol overdose. Clin Toxicol (Phila). 2018;56(7):618–621.
   PubMed Web of Science ®Google Scholar
• Schmidt LE, Rasmussen DN, Petersen TS, et al. Fewer adverse effects associated with a modified two-bag intravenous acetylcysteine protocol compared to traditional three-bag regimen in paracetamol overdose. Clin Toxicol. 2018;56(11):1128–1134.
   PubMed Web of Science ®Google Scholar
• Kao LW, Kirk MA, Furbee RB, et al. What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?. Ann Emerg Med. 2003; 42:742–750.
   Web of Science ®Google Scholar
• Hendrickson RG. What is the most appropriate dose of N-acetylcysteine after massive acetaminophen overdose?. Clin Toxicol. 2019;57(8):686-691. DOI:10.1080/15563650.2019.1579914
   Web of Science ®Google Scholar
• Dawson AH, Henry DA, McEwen J. Adverse reactions to N-acetylcysteine during treatment for paracetamol poisoning. Med J Aust. 1989;150(6):329–331.
   Web of Science ®Google Scholar
• Lynch RM, Robertson R. Anaphylactoid reactions to intravenous N-acetylcysteine: a prospective case controlled study. Accid Emerg Nurs. 2004;12(1):10–15.
   Google Scholar
• Waring WS, Stephen AF, Robinson OD, et al. Lower incidence of anaphylactoid reactions to N-acetylcysteine in patients with high acetaminophen concentrations after overdose. Clin Toxicol (Phila). 2008;46(6):496–500.
   PubMed Web of Science ®Google Scholar
• Pakravan N, Waring WS, Sharma S, et al. Risk factors and mechanisms of anaphylactoid reactions to acetylcysteine in acetaminophen overdose. Clin Toxicol (Phila). 2008;46(8):697–702.
   PubMed Web of Science ®Google Scholar
• Schmidt LE. Identification of patients at risk of anaphylactoid reactions to N-acetylcysteine in the treatment of paracetamol overdose. Clin Toxicol. 2013;51(6):467–472.
   PubMed Web of Science ®Google Scholar