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Toxicology Communications Volume 5, 2021 - Issue 1
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Rapid Communication

Brodifacoum pharmacokinetics in acute human poisoning: implications for estimating duration of vitamin K therapy

Daniel G. Nosala Linus Pauling Institute, Oregon State University, Corvallis, OR, USAView further author information
,
Richard B. van Breemena Linus Pauling Institute, Oregon State University, Corvallis, OR, USAView further author information
,
John W. Haffnerb Department of Emergency Medicine, University of Illinois, Peoria, IL, USAView further author information
,
Israel Rubinsteinc Department of Medicine, University of Illinois, Chicago, IL, USA;d Jesse Brown VA Medical Center, Chicago, IL, USAView further author information
&
Douglas L. Feinsteind Jesse Brown VA Medical Center, Chicago, IL, USA;e Department of Anesthesiology, University of Illinois, Chicago, IL, USACorrespondence[email protected]
View further author information
Pages 69-72 | Published online: 01 Mar 2021

References

  • Kelkar AH, Smith NA, Martial A, et al. An outbreak of synthetic cannabinoid-associated coagulopathy in Illinois. N Engl J Med. 2018;379(13):1216–1223.
  • Moritz E, Austin C, Wahl M, et al. Notes from the field: outbreak of severe illness linked to the vitamin K antagonist brodifacoum and use of synthetic cannabinoids – Illinois, March-April 2018. MMWR Morb Mortal Wkly Rep. 2018;67(21):607–608.
  • Devgun JM, Rasin A, Kim T, et al. An outbreak of severe coagulopathy from synthetic cannabinoids tainted with long-acting anticoagulant rodenticides. Clin Toxicol. 2019;4:1–8.
  • Watt BE, Proudfoot AT, Bradberry SM, et al. Anticoagulant rodenticides. Toxicol Rev. 2005;24(4):259–269.
  • Yip L, Stanton NV, Middleberg RA. Vitamin K1 treatment duration in patients with brodifacoum poisoning. N Engl J Med. 2020;382(18):1764–1765.
  • Okour M, Brundage RC. Modeling enterohepatic circulation. Curr Pharmacol Rep. 2017;3(5):301–313.
  • Feinstein DL, Nosal DG, Ramanathan S, et al. Effects of vitamin K1 treatment on plasma concentrations of long-acting anticoagulant rodenticide enantiomers following inhalation of contaminated synthetic cannabinoids. Clin Toxicol. 2019;18:1–9.
  • Gunja N, Coggins A, Bidny S. Management of intentional superwarfarin poisoning with long-term vitamin K and brodifacoum levels. Clin Toxicol. 2011;49(5):385–390.
  • Olmos V, Lopez CM. Brodifacoum poisoning with toxicokinetic data. Clin Toxicol. 2007;45(5):487–489.
  • Bruno GR, Howland MA, McMeeking A, et al. Long-acting anticoagulant overdose: brodifacoum kinetics and optimal vitamin K dosing. Ann Emerg Med. 2000;36(3):262–267.
  • Rubinstein I, Weinberg G, van Breemen R, et al. Treatment for long acting anticoagulant rodenticide poisoning – beyond INR monitoring? Toxicol Commun. 2018;2(1):59–61.
  • Wilson E, Stanton NV, Roach M, et al. Coagulopathy caused by brodifacoum rodenticide poisoning among persons who smoke synthetic cannabinoids. Wisconsin, 2018. 2019 CSTE Annual Conference, Raleigh, NC, June 2-6, 2019. cste.confex.com/cste/2019/meetingapp.cgi/Paper/11239.

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